Ganesh Srinivasan Anand

Associate Professor of Chemistry

Research Summary

Dynamics of large biomolecular complexes; uncovering what drives their assembly, regulation and function through mass spectrometry.

Huck Affiliations

Publication Tags

Proteins Protein Phosphotransferases Deuterium Mass Spectrometry Hydrogen Phosphoric Diester Hydrolases Cyclic Amp Dependent Protein Kinases Hydrolysis Dengue Virus Silk Cyclic Nucleotides Serogroup Viruses Deuterium(.) Dna Amides Hydrogen Deuterium Exchange Mass Spectrometry Antibodies Assays Membranes Capsid Proteins Peptide Hydrolases Dengue Rna

Most Recent Papers

Dengue virus 2 capsid protein chaperones the strand displacement of 5′-3′ cyclization sequences

Xin Ee Yong, V. Raghuvamsi Palur, Ganesh S. Anand, Thorsten Wohland, Kamal K. Sharma, 2021, Nucleic Acids Research on p. 5832-5844

Development of phosphodiesterase–protein-kinase complexes as novel targets for discovery of inhibitors with enhanced specificity

Nikhil K. Tulsian, Valerie Jia En Sin, Hwee Ling Koh, Ganesh S. Anand, 2021, International Journal of Molecular Sciences

Antibody affinity versus dengue morphology influences neutralization

Guntur Fibriansah, Elisa X.Y. Lim, Jan K. Marzinek, Thiam Seng Ng, Joanne L. Tan, Roland G. Huber, Xin Ni Lim, Valerie S.Y. Chew, Victor A. Kostyuchenko, Jian Shi, Ganesh S. Anand, Peter J. Bond, James E. Crowe, Shee Mei Lok, 2021, PLoS Pathogens

Sars-cov-2 s protein:Ace2 interaction reveals novel allosteric targets

Palur V. Raghuvamsi, Nikhil K. Tulsian, Firdaus Samsudin, Xinlei Qian, Kiren Purushotorman, Gu Yue, Mary M. Kozma, Wong Y. Hwa, Julien Lescar, Peter J. Bond, Paul A. Macary, Ganesh S. Anand, 2021, eLife on p. 1-47

Dengue virus strain 2 capsid protein switches the annealing pathway and reduces intrinsic dynamics of the conserved 5’ untranslated region

Xin Ee Yong, Palur Venkata Raghuvamsi, Ganesh S. Anand, Thorsten Wohland, Kamal K. Sharma, 2021, RNA Biology on p. 718-731

Disrupting enzyme fluidity

Ganesh Srinivasan Anand, 2021, eLife on p. 1-3

Synergistic Allostery in Multiligand-Protein Interactions

Abhijeet Ghode, Lissy Z.F. Gross, Wei Ven Tee, Enrico Guarnera, Igor N. Berezovsky, Ricardo M. Biondi, Ganesh S. Anand, 2020, Biophysical Journal on p. 1833-1848

Adenylate control in cAMP signaling

Nikhil K. Tulsian, Abhijeet Ghode, Ganesh S. Anand, 2020, Biochemical Journal on p. 2981-2998

An NMR based phosphodiesterase assay

Madoka Akimoto, Tianning Yu, Kody Moleschi, Katherine Van, Ganesh S. Anand, Giuseppe Melacini, 2020, Chemical Communications on p. 8091-8094

Structural basis of oligomerization of n-terminal domain of spider aciniform silk protein

Rusha Chakraborty, Jing Song Fan, Chong Cheong Lai, Palur Venkata Raghuvamsi, Pin Xuan Chee, Ganesh Srinivasan Anand, Daiwen Yang, 2020, International Journal of Molecular Sciences on p. 1-15

Most-Cited Papers

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

Glenn R. Masson, John E. Burke, Natalie G. Ahn, Ganesh S. Anand, Christoph Borchers, Sébastien Brier, George M. Bou-Assaf, John R. Engen, S. Walter Englander, Johan Faber, Rachel Garlish, Patrick R. Griffin, Michael L. Gross, Miklos Guttman, Yoshitomo Hamuro, Albert J.R. Heck, Damian Houde, Roxana E. Iacob, Thomas J.D. Jørgensen, Igor A. Kaltashov, Judith P. Klinman, Lars Konermann, Petr Man, Leland Mayne, Bruce D. Pascal, Dana Reichmann, Mark Skehel, Joost Snijder, Timothy S. Strutzenberg, Eric S. Underbakke, Cornelia Wagner, Thomas E. Wales, Benjamin T. Walters, David D. Weis, Derek J. Wilson, Patrick L. Wintrode, Zhongqi Zhang, Jie Zheng, David C. Schriemer, Kasper D. Rand, 2019, Nature Methods on p. 595-602

The inner membrane histidine kinase EnvZ senses osmolality via helix-coil transitions in the cytoplasm

Loo Chien Wang, Leslie K. Morgan, Pahan Godakumbura, Linda J. Kenney, Ganesh S. Anand, 2012, EMBO Journal on p. 2648-2659

Salmonella enterica response regulator SsrB relieves H-NS silencing by displacing H-NS bound in polymerization mode and directly activates transcription

Don Walthers, You Li, Yingjie Liu, Ganesh Anand, Jie Yan, Linda J. Kenney, 2011, Journal of Biological Chemistry on p. 1895-1902

Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation

Suguna Badireddy, Gao Yunfeng, Mark Ritchie, Pearl Akamine, Jian Wu, Choel W. Kim, Susan S. Taylor, Lin Qingsong, Kunchithapadam Swaminathan, Ganesh S. Anand, 2011, Molecular and Cellular Proteomics

Heart extracellular matrix supports cardiomyocyte differentiation of mouse embryonic stem cells

Sayaka Higuchi, Qingsong Lin, Jigang Wang, Teck Kwang Lim, Shashikant B. Joshi, Ganesh Srinivasan Anand, Maxey C.M. Chung, Michael P. Sheetz, Hideaki Fujita, 2013, Journal of Bioscience and Bioengineering on p. 320-325

Phosphodiesterases catalyze hydrolysis of cAMP-bound to regulatory subunit of protein kinase A and mediate signal termination

Balakrishnan Shenbaga Moorthy, Yunfeng Gao, Ganesh S. Anand, 2011, Molecular and Cellular Proteomics

Conformational changes in intact dengue virus reveal serotype-specific expansion

Xin Xiang Lim, Arun Chandramohan, Xin Ying Elisa Lim, Nirmalya Bag, Kamal Kant Sharma, Melissa Wirawan, Thorsten Wohland, Shee Mei Lok, Ganesh S. Anand, 2017, Nature Communications

Structural insight and flexible features of NS5 proteins from all four serotypes of Dengue virus in solution

Wuan Geok Saw, Giancarlo Tria, Ardina Grüber, Malathy Sony Subramanian Manimekalai, Yongqian Zhao, Arun Chandramohan, Ganesh Srinivasan Anand, Tsutomu Matsui, Thomas M. Weiss, Subhash G. Vasudevan, Gerhard Grüber, 2015, Acta Crystallographica Section D: Structural Biology on p. 2309-2327

Architecture of a dsDNA viral capsid in complex with its maturation protease

David Veesler, Reza Khayat, Srinath Krishnamurthy, Joost Snijder, Rick K. Huang, Albert J.R. Heck, Ganesh S. Anand, John E. Johnson, 2014, Structure with Folding & design on p. 230-237

Epitope and Paratope Mapping Reveals Temperature-Dependent Alterations in the Dengue-Antibody Interface

Xin Xiang Lim, Arun Chandramohan, Xin Ying Elisa Lim, James E. Crowe, Shee Mei Lok, Ganesh S. Anand, 2017, Structure with Folding & design on p. 1391-1402.e3