Ganesh Srinivasan Anand

Associate Professor of Chemistry

Research Summary

Dynamics of large biomolecular complexes; uncovering what drives their assembly, regulation and function through mass spectrometry.

Huck Affiliations

Publication Tags

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Hydrogen Deuterium Mass Spectrometry Proteins Dengue Virus Viruses Deuterium(.) Protein Antibodies Peptide Hydrolases Serogroup Hydrogen Deuterium Exchange Mass Spectrometry Jasmonic Acid Proteolysis Ubiquitin Membranes Temperature Virus Diseases Amide Peptide Surface Amides Flavivirus Dengue Infections

Most Recent Publications

Dynamics, allostery, and stabilities of whole virus particles by amide hydrogen/deuterium exchange mass spectrometry (HDXMS)

Varun Venkatakrishnan, Sean M. Braet, Ganesh S. Anand, 2024, Current Opinion in Structural Biology

Darren Z.H. Sim, Maxine A.D. Mowe, Simon M. Mitrovic, Nikhil K. Tulsian, Ganesh S. Anand, Darren C.J. Yeo, 2024, Freshwater Biology

Mariana Sacerdoti, Lissy Z.F. Gross, Andrew Riley, Karin Zehnder, Abhijeet Ghode, Sebastián Klinke, Ganesh Srinivasan Anand, Kristina Paris, Angelika Winkel, Amanda K. Herbrand, Yasmin Godage, Gyles E. Cozier, Evelyn Süß, Jörg O. Schulze, Daniel Pastor-Flores, Mariela Bollini, María Victoria Cappellari, Dmitri Svergun, Melissa A. Gräwert, Pedro F. Aramendia, Alejandro E. Leroux, Barry V.L. Potter, Carlos J. Camacho, Ricardo M. Biondi, 2023, Science's STKE : signal transduction knowledge environment

Sean Braet, Theresa Buckley, Varun Venkatakrishnan, Kim Dam, Pamela Bjorkman, Ganesh Anand, 2023, eLife

Sean Braet, Varun Venkatakrishnan, Ranita Ramesh, Palur Raghuvamsi, Ganesh S. Anand, 2023, Biophysical Journal on p. 10a

Ganesh S. Anand, Sean Braet, Theresa Buckley, Varun Venkatakrishnan, Kim Marie Dam, Pamela J. Bjorkman, 2023, Biophysical Journal on p. 188a

Varun Venkatakrishnan, Ganesh S. Anand, 2023, Biophysical Journal on p. 331a

Varun Venkatakrishnan, Abhijeet Ghode, Nikhil K. Tulsian, Ganesh S. Anand, 2023, Frontiers in Molecular Biosciences

Lorena Zuzic, Jan K. Marzinek, Ganesh S. Anand, Jim Warwicker, Peter J. Bond, 2023, eLife

Sarala Neomi Tantirimudalige, Palur Venkata Raghuvamsi, Kamal Kant Sharma, Jonathan Chua Wei Bao, Ganesh S. Anand, Thorsten Wohland, 2022, Journal of Biological Chemistry

Most-Cited Papers

Glenn R. Masson, John E. Burke, Natalie G. Ahn, Ganesh S. Anand, Christoph Borchers, Sébastien Brier, George M. Bou-Assaf, John R. Engen, S. Walter Englander, Johan Faber, Rachel Garlish, Patrick R. Griffin, Michael L. Gross, Miklos Guttman, Yoshitomo Hamuro, Albert J.R. Heck, Damian Houde, Roxana E. Iacob, Thomas J.D. Jørgensen, Igor A. Kaltashov, Judith P. Klinman, Lars Konermann, Petr Man, Leland Mayne, Bruce D. Pascal, Dana Reichmann, Mark Skehel, Joost Snijder, Timothy S. Strutzenberg, Eric S. Underbakke, Cornelia Wagner, Thomas E. Wales, Benjamin T. Walters, David D. Weis, Derek J. Wilson, Patrick L. Wintrode, Zhongqi Zhang, Jie Zheng, David C. Schriemer, Kasper D. Rand, 2019, Nature Methods on p. 595-602

Palur V. Raghuvamsi, Nikhil K. Tulsian, Firdaus Samsudin, Xinlei Qian, Kiren Purushotorman, Gu Yue, Mary M. Kozma, Wong Y. Hwa, Julien Lescar, Peter J. Bond, Paul A. Macary, Ganesh S. Anand, 2021, eLife on p. 1-47

Xin Xiang Lim, Arun Chandramohan, Xin Ying Elisa Lim, Nirmalya Bag, Kamal Kant Sharma, Melissa Wirawan, Thorsten Wohland, Shee Mei Lok, Ganesh S. Anand, 2017, Nature Communications

Linda J. Kenney, Ganesh S. Anand, 2020, EcoSal Plus on p. 1-30

Jeffrey W. Hudgens, Elyssia S. Gallagher, Ioannis Karageorgos, Kyle W. Anderson, James J. Filliben, Richard Y.C. Huang, Guodong Chen, George M. Bou-Assaf, Alfonso Espada, Michael J. Chalmers, Eduardo Harguindey, Hui Min Zhang, Benjamin T. Walters, Jennifer Zhang, John Venable, Caitlin Steckler, Inhee Park, Ansgar Brock, Xiaojun Lu, Ratnesh Pandey, Arun Chandramohan, Ganesh Srinivasan Anand, Sasidhar N. Nirudodhi, Justin B. Sperry, Jason C. Rouse, James A. Carroll, Kasper D. Rand, Ulrike Leurs, David D. Weis, Mohammed A. Al-Naqshabandi, Tyler S. Hageman, Daniel Deredge, Patrick L. Wintrode, Malvina Papanastasiou, John D. Lambris, Sheng Li, Sarah Urata, 2019, Analytical Chemistry on p. 7336-7345

Anjil Kumar Srivastava, Beatriz Orosa, Prashant Singh, Ian Cummins, Charlotte Walsh, Cunjin Zhang, Murray Grant, Michael R. Roberts, Ganesh Srinivasan Anand, Elaine Fitches, Ari Sadanandom, 2018, Plant Cell on p. 2099-2115

Xin Xiang Lim, Arun Chandramohan, Xin Ying Elisa Lim, James E. Crowe, Shee Mei Lok, Ganesh S. Anand, 2017, Structure with Folding & design on p. 1391-1402.e3

Melissa Wirawan, Guntur Fibriansah, Jan K. Marzinek, Xin Xiang Lim, Thiam Seng Ng, Adelene Y.L. Sim, Qian Zhang, Victor A. Kostyuchenko, Jian Shi, Scott A. Smith, Chandra S. Verma, Ganesh Anand, James E. Crowe, Peter J. Bond, Shee Mei Lok, 2019, Structure with Folding & design on p. 253-267.e8

Wuan Geok Saw, Giancarlo Tria, Ardina Grüber, Malathy Sony Subramanian Manimekalai, Yongqian Zhao, Arun Chandramohan, Ganesh Srinivasan Anand, Tsutomu Matsui, Thomas M. Weiss, Subhash G. Vasudevan, Gerhard Grüber, 2015, Acta Crystallographica Section D: Biological Crystallography on p. 2309-2327

David Veesler, Reza Khayat, Srinath Krishnamurthy, Joost Snijder, Rick K. Huang, Albert J.R. Heck, Ganesh S. Anand, John E. Johnson, 2014, Structure with Folding & design on p. 230-237

News Articles Featuring Ganesh Srinivasan Anand

A tighter core stabilizes SARS-CoV-2 spike protein in new emergent variants

Just as a tight core is a component of good physical fitness for humans, helping to stabilize our bodies, mutations that tightened the core of the SARS-CoV-2 spike protein in new variants may have increased the virus’s fitness, according to new research led by Penn State scientists.

First round of funded projects announced from the Benkovic Research Initiative

Four projects have been announced as recipients of funding from the Patricia and Stephen Benkovic Research Initiative, which supports risky, highly innovative investigation at the interface of chemistry and the life sciences.

Distortion: Researchers discover new strategy for antibodies to disable viruses

It is widely understood that antibodies neutralize viruses by latching onto their surfaces and blocking them from infecting host cells. But new research reveals that this barrier method isn’t the only way that antibodies disable viruses. An international team of researchers led by Penn State has discovered that antibodies also distort viruses, thereby preventing them from properly attaching to and entering cells.

Lab Bench to Commercialization grant recipients announced

Two faculty members have been selected to receive Lab Bench to Commercialization (LB2C) grants from the Eberly College of Science in 2021. The competitive program provides funding for researchers in the college, enabling them to enhance the commercial potential of ongoing research and prepare them to translate their intellectual property to the marketplace.

Researchers discover potential therapeutic targets on SARS-CoV-2 Spike protein

The COVID-19 pandemic has prompted considerable investigation into how the SARS-CoV-2 Spike protein attaches to a human cell during the infection process, as this knowledge is useful in designing vaccines and therapeutics. Now, a team of scientists has discovered additional locations on the Spike protein that may not only help to explain how certain mutations make emerging variants more infectious but also could be used as additional targets for therapeutic intervention.

Ganesh Anand joins Department of Chemistry as associate professor

Ganesh Anand will be joining the Eberly College of Science this November as an associate professor of chemistry.