Ganesh Srinivasan Anand

Associate Professor of Chemistry

Ganesh Srinivasan Anand

Research Summary

Dynamics of large biomolecular complexes; uncovering what drives their assembly, regulation and function through mass spectrometry.

Huck Affiliations

Links

Most Recent Publications

Dynamics, allostery, and stabilities of whole virus particles by amide hydrogen/deuterium exchange mass spectrometry (HDXMS)

Varun Venkatakrishnan, Sean M. Braet, Ganesh S. Anand, 2024, Current Opinion in Structural Biology

Nutrient conditions influence allelopathic capabilities of Ludwigia adscendens and other tropical macrophytes against Microcystis aeruginosa

Darren Z.H. Sim, Maxine A.D. Mowe, Simon M. Mitrovic, Nikhil K. Tulsian, Ganesh S. Anand, Darren C.J. Yeo, 2024, Freshwater Biology on p. 538-555

Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein

Mariana Sacerdoti, Lissy Z.F. Gross, Andrew Riley, Karin Zehnder, Abhijeet Ghode, Sebastián Klinke, Ganesh Srinivasan Anand, Kristina Paris, Angelika Winkel, Amanda K. Herbrand, Yasmin Godage, Gyles E. Cozier, Evelyn Süß, Jörg O. Schulze, Daniel Pastor-Flores, Mariela Bollini, María Victoria Cappellari, Dmitri Svergun, Melissa A. Gräwert, Pedro F. Aramendia, Alejandro E. Leroux, Barry V.L. Potter, Carlos J. Camacho, Ricardo M. Biondi, 2023, Science's STKE : signal transduction knowledge environment

Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk with altered NTD dynamics

Sean Braet, Theresa Buckley, Varun Venkatakrishnan, Kim Dam, Pamela Bjorkman, Ganesh Anand, 2023, eLife

Asymmetric viral genomic RNA egress from a spring-loaded virus through rubonucleoprotein rearrangements

Sean Braet, Varun Venkatakrishnan, Ranita Ramesh, Palur Raghuvamsi, Ganesh S. Anand, 2023, Biophysical Journal on p. 10a

Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk and enhanced NTD dynamics

Ganesh S. Anand, Sean Braet, Theresa Buckley, Varun Venkatakrishnan, Kim Marie Dam, Pamela J. Bjorkman, 2023, Biophysical Journal on p. 188a

5-adenosine monophosphate promotes signal adaptation in PKA signaling

Varun Venkatakrishnan, Ganesh S. Anand, 2023, Biophysical Journal on p. 331a

Impaired cAMP processivity by phosphodiesterase-protein kinase A complexes in acrodysostosis

Varun Venkatakrishnan, Abhijeet Ghode, Nikhil K. Tulsian, Ganesh S. Anand, 2023, Frontiers in Molecular Biosciences

A pH-dependent cluster of charges in a conserved cryptic pocket on flaviviral envelopes

Lorena Zuzic, Jan K. Marzinek, Ganesh S. Anand, Jim Warwicker, Peter J. Bond, 2023, eLife

The ganglioside GM1a functions as a coreceptor/attachment factor for dengue virus during infection

Sarala Neomi Tantirimudalige, Palur Venkata Raghuvamsi, Kamal Kant Sharma, Jonathan Chua Wei Bao, Ganesh S. Anand, Thorsten Wohland, 2022, Journal of Biological Chemistry

Most-Cited Papers

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

Glenn R. Masson, John E. Burke, Natalie G. Ahn, Ganesh S. Anand, Christoph Borchers, Sébastien Brier, George M. Bou-Assaf, John R. Engen, S. Walter Englander, Johan Faber, Rachel Garlish, Patrick R. Griffin, Michael L. Gross, Miklos Guttman, Yoshitomo Hamuro, Albert J.R. Heck, Damian Houde, Roxana E. Iacob, Thomas J.D. Jørgensen, Igor A. Kaltashov, Judith P. Klinman, Lars Konermann, Petr Man, Leland Mayne, Bruce D. Pascal, Dana Reichmann, Mark Skehel, Joost Snijder, Timothy S. Strutzenberg, Eric S. Underbakke, Cornelia Wagner, Thomas E. Wales, Benjamin T. Walters, David D. Weis, Derek J. Wilson, Patrick L. Wintrode, Zhongqi Zhang, Jie Zheng, David C. Schriemer, Kasper D. Rand, 2019, Nature Methods on p. 595-602

Sars-cov-2 s protein:Ace2 interaction reveals novel allosteric targets

Palur V. Raghuvamsi, Nikhil K. Tulsian, Firdaus Samsudin, Xinlei Qian, Kiren Purushotorman, Gu Yue, Mary M. Kozma, Wong Y. Hwa, Julien Lescar, Peter J. Bond, Paul A. Macary, Ganesh S. Anand, 2021, eLife on p. 1-47

EnvZ/OmpR two-component signaling: An archetype system that can function noncanonically

Linda J. Kenney, Ganesh S. Anand, 2020, EcoSal Plus on p. 1-30

Conformational changes in intact dengue virus reveal serotype-specific expansion

Xin Xiang Lim, Arun Chandramohan, Xin Ying Elisa Lim, Nirmalya Bag, Kamal Kant Sharma, Melissa Wirawan, Thorsten Wohland, Shee Mei Lok, Ganesh S. Anand, 2017, Nature Communications

Interlaboratory Comparison of Hydrogen-Deuterium Exchange Mass Spectrometry Measurements of the Fab Fragment of NISTmAb

Jeffrey W. Hudgens, Elyssia S. Gallagher, Ioannis Karageorgos, Kyle W. Anderson, James J. Filliben, Richard Y.C. Huang, Guodong Chen, George M. Bou-Assaf, Alfonso Espada, Michael J. Chalmers, Eduardo Harguindey, Hui Min Zhang, Benjamin T. Walters, Jennifer Zhang, John Venable, Caitlin Steckler, Inhee Park, Ansgar Brock, Xiaojun Lu, Ratnesh Pandey, Arun Chandramohan, Ganesh Srinivasan Anand, Sasidhar N. Nirudodhi, Justin B. Sperry, Jason C. Rouse, James A. Carroll, Kasper D. Rand, Ulrike Leurs, David D. Weis, Mohammed A. Al-Naqshabandi, Tyler S. Hageman, Daniel Deredge, Patrick L. Wintrode, Malvina Papanastasiou, John D. Lambris, Sheng Li, Sarah Urata, 2019, Analytical Chemistry on p. 7336-7345

Sumo suppresses the activity of the jasmonic acid receptor CORONATINE INSENSITIVE1

Anjil Kumar Srivastava, Beatriz Orosa, Prashant Singh, Ian Cummins, Charlotte Walsh, Cunjin Zhang, Murray Grant, Michael R. Roberts, Ganesh Srinivasan Anand, Elaine Fitches, Ari Sadanandom, 2018, Plant Cell on p. 2099-2115

Mechanism of Enhanced Immature Dengue Virus Attachment to Endosomal Membrane Induced by prM Antibody

Melissa Wirawan, Guntur Fibriansah, Jan K. Marzinek, Xin Xiang Lim, Thiam Seng Ng, Adelene Y.L. Sim, Qian Zhang, Victor A. Kostyuchenko, Jian Shi, Scott A. Smith, Chandra S. Verma, Ganesh Anand, James E. Crowe, Peter J. Bond, Shee Mei Lok, 2019, Structure with Folding & design on p. 253-267.e8

Epitope and Paratope Mapping Reveals Temperature-Dependent Alterations in the Dengue-Antibody Interface

Xin Xiang Lim, Arun Chandramohan, Xin Ying Elisa Lim, James E. Crowe, Shee Mei Lok, Ganesh S. Anand, 2017, Structure with Folding & design on p. 1391-1402.e3

Structural insight and flexible features of NS5 proteins from all four serotypes of Dengue virus in solution

Wuan Geok Saw, Giancarlo Tria, Ardina Grüber, Malathy Sony Subramanian Manimekalai, Yongqian Zhao, Arun Chandramohan, Ganesh Srinivasan Anand, Tsutomu Matsui, Thomas M. Weiss, Subhash G. Vasudevan, Gerhard Grüber, 2015, Acta Crystallographica Section D: Biological Crystallography on p. 2309-2327

Architecture of a dsDNA viral capsid in complex with its maturation protease

David Veesler, Reza Khayat, Srinath Krishnamurthy, Joost Snijder, Rick K. Huang, Albert J.R. Heck, Ganesh S. Anand, John E. Johnson, 2014, Structure with Folding & design on p. 230-237

News Articles Featuring Ganesh Srinivasan Anand

Mar 31, 2023

A tighter core stabilizes SARS-CoV-2 spike protein in new emergent variants

Just as a tight core is a component of good physical fitness for humans, helping to stabilize our bodies, mutations that tightened the core of the SARS-CoV-2 spike protein in new variants may have increased the virus’s fitness, according to new research led by Penn State scientists.

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Apr 06, 2022

First round of funded projects announced from the Benkovic Research Initiative

Four projects have been announced as recipients of funding from the Patricia and Stephen Benkovic Research Initiative, which supports risky, highly innovative investigation at the interface of chemistry and the life sciences.

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Nov 30, 2021

Distortion: Researchers discover new strategy for antibodies to disable viruses

It is widely understood that antibodies neutralize viruses by latching onto their surfaces and blocking them from infecting host cells. But new research reveals that this barrier method isn’t the only way that antibodies disable viruses. An international team of researchers led by Penn State has discovered that antibodies also distort viruses, thereby preventing them from properly attaching to and entering cells.

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Mar 15, 2021

Lab Bench to Commercialization grant recipients announced

Two faculty members have been selected to receive Lab Bench to Commercialization (LB2C) grants from the Eberly College of Science in 2021. The competitive program provides funding for researchers in the college, enabling them to enhance the commercial potential of ongoing research and prepare them to translate their intellectual property to the marketplace.

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Feb 23, 2021

Researchers discover potential therapeutic targets on SARS-CoV-2 Spike protein

The COVID-19 pandemic has prompted considerable investigation into how the SARS-CoV-2 Spike protein attaches to a human cell during the infection process, as this knowledge is useful in designing vaccines and therapeutics. Now, a team of scientists has discovered additional locations on the Spike protein that may not only help to explain how certain mutations make emerging variants more infectious but also could be used as additional targets for therapeutic intervention.

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Nov 09, 2020

Ganesh Anand joins Department of Chemistry as associate professor

Ganesh Anand will be joining the Eberly College of Science this November as an associate professor of chemistry.

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