Ganesh Srinivasan Anand
Associate Professor of Chemistry
Research Summary
Dynamics of large biomolecular complexes; uncovering what drives their assembly, regulation and function through mass spectrometry.
Huck Affiliations
Publication Tags
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Proteins Hydrogen Deuterium Mass Spectrometry Dengue Virus Protein Viruses Deuterium(.) Antibodies Hydrogen Deuterium Exchange Mass Spectrometry Serogroup Jasmonic Acid Stem Cells Membranes Proteolysis Ubiquitin Tissue Temperature Peptide Hydrolases Amides Virus Diseases Sars Virus Liver Peptide AmideMost Recent Publications
Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein
Mariana Sacerdoti, Lissy Z.F. Gross, Andrew Riley, Karin Zehnder, Abhijeet Ghode, Sebastián Klinke, Ganesh Srinivasan Anand, Kristina Paris, Angelika Winkel, Amanda K. Herbrand, Yasmin Godage, Gyles E. Cozier, Evelyn Süß, Jörg O. Schulze, Daniel Pastor-Flores, Mariela Bollini, María Victoria Cappellari, Dmitri Svergun, Melissa A. Gräwert, Pedro F. Aramendia, Alejandro E. Leroux, Barry V.L. Potter, Carlos J. Camacho, Ricardo M. Biondi, 2023, Science's STKE : signal transduction knowledge environment
Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk with altered NTD dynamics
Sean M. Braet, Theresa S.C. Buckley, Varun Venkatakrishnan, Kim Marie A. Dam, Pamela J. Bjorkman, Ganesh S. Anand, 2023, eLife
Asymmetric viral genomic RNA egress from a spring-loaded virus through rubonucleoprotein rearrangements
Sean Braet, Varun Venkatakrishnan, Ranita Ramesh, Palur Raghuvamsi, Ganesh S. Anand, 2023, Biophysical Journal on p. 10a
Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk and enhanced NTD dynamics
Ganesh S. Anand, Sean Braet, Theresa Buckley, Varun Venkatakrishnan, Kim Marie Dam, Pamela J. Bjorkman, 2023, Biophysical Journal on p. 188a
5-adenosine monophosphate promotes signal adaptation in PKA signaling
Varun Venkatakrishnan, Ganesh S. Anand, 2023, Biophysical Journal on p. 331a
A pH-dependent cluster of charges in a conserved cryptic pocket on flaviviral envelopes
Lorena Zuzic, Jan K. Marzinek, Ganesh S. Anand, Jim Warwicker, Peter J. Bond, 2023, eLife
The ganglioside GM1a functions as a coreceptor/attachment factor for dengue virus during infection
Sarala Neomi Tantirimudalige, Palur Venkata Raghuvamsi, Kamal Kant Sharma, Jonathan Chua Wei Bao, Ganesh S. Anand, Thorsten Wohland, 2022, Journal of Biological Chemistry
Hyperosmotic Stress Allosterically Reconfigures Betaine Binding Pocket in BetP
Sarala Tantirimudalige, Theresa Sophia Claire Buckley, Arun Chandramohan, Rebecca Michaela Richter, Christine Ziegler, Ganesh S. Anand, 2022, Journal of Molecular Biology
SARS-CoV-2 spike protein as a bacterial lipopolysaccharide delivery system in an overzealous inflammatory cascade
Firdaus Samsudin, Palur Raghuvamsi, Ganna Petruk, Manoj Puthia, Jitka Petrlova, Paul Macary, Ganesh S. Anand, Peter J. Bond, Artur Schmidtchen, 2022, Journal of Molecular Cell Biology
Uncovering cryptic pockets in the SARS-CoV-2 spike glycoprotein
Lorena Zuzic, Firdaus Samsudin, Aishwary T. Shivgan, Palur V. Raghuvamsi, Jan K. Marzinek, Alister Boags, Conrado Pedebos, Nikhil K. Tulsian, Jim Warwicker, Paul MacAry, Max Crispin, Syma Khalid, Ganesh S. Anand, Peter J. Bond, 2022, Structure with Folding & design on p. 1062-1074.e4
Most-Cited Papers
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments
Glenn R. Masson, John E. Burke, Natalie G. Ahn, Ganesh S. Anand, Christoph Borchers, Sébastien Brier, George M. Bou-Assaf, John R. Engen, S. Walter Englander, Johan Faber, Rachel Garlish, Patrick R. Griffin, Michael L. Gross, Miklos Guttman, Yoshitomo Hamuro, Albert J.R. Heck, Damian Houde, Roxana E. Iacob, Thomas J.D. Jørgensen, Igor A. Kaltashov, Judith P. Klinman, Lars Konermann, Petr Man, Leland Mayne, Bruce D. Pascal, Dana Reichmann, Mark Skehel, Joost Snijder, Timothy S. Strutzenberg, Eric S. Underbakke, Cornelia Wagner, Thomas E. Wales, Benjamin T. Walters, David D. Weis, Derek J. Wilson, Patrick L. Wintrode, Zhongqi Zhang, Jie Zheng, David C. Schriemer, Kasper D. Rand, 2019, Nature Methods on p. 595-602
Sars-cov-2 s protein:Ace2 interaction reveals novel allosteric targets
Palur V. Raghuvamsi, Nikhil K. Tulsian, Firdaus Samsudin, Xinlei Qian, Kiren Purushotorman, Gu Yue, Mary M. Kozma, Wong Y. Hwa, Julien Lescar, Peter J. Bond, Paul A. Macary, Ganesh S. Anand, 2021, eLife on p. 1-47
Conformational changes in intact dengue virus reveal serotype-specific expansion
Xin Xiang Lim, Arun Chandramohan, Xin Ying Elisa Lim, Nirmalya Bag, Kamal Kant Sharma, Melissa Wirawan, Thorsten Wohland, Shee Mei Lok, Ganesh S. Anand, 2017, Nature Communications
Heart extracellular matrix supports cardiomyocyte differentiation of mouse embryonic stem cells
Sayaka Higuchi, Qingsong Lin, Jigang Wang, Teck Kwang Lim, Shashikant B. Joshi, Ganesh Srinivasan Anand, Maxey C.M. Chung, Michael P. Sheetz, Hideaki Fujita, 2013, Journal of Bioscience and Bioengineering on p. 320-325
EnvZ/OmpR two-component signaling: An archetype system that can function noncanonically
Linda J. Kenney, Ganesh S. Anand, 2020, EcoSal Plus on p. 1-30
Interlaboratory Comparison of Hydrogen-Deuterium Exchange Mass Spectrometry Measurements of the Fab Fragment of NISTmAb
Jeffrey W. Hudgens, Elyssia S. Gallagher, Ioannis Karageorgos, Kyle W. Anderson, James J. Filliben, Richard Y.C. Huang, Guodong Chen, George M. Bou-Assaf, Alfonso Espada, Michael J. Chalmers, Eduardo Harguindey, Hui Min Zhang, Benjamin T. Walters, Jennifer Zhang, John Venable, Caitlin Steckler, Inhee Park, Ansgar Brock, Xiaojun Lu, Ratnesh Pandey, Arun Chandramohan, Ganesh Srinivasan Anand, Sasidhar N. Nirudodhi, Justin B. Sperry, Jason C. Rouse, James A. Carroll, Kasper D. Rand, Ulrike Leurs, David D. Weis, Mohammed A. Al-Naqshabandi, Tyler S. Hageman, Daniel Deredge, Patrick L. Wintrode, Malvina Papanastasiou, John D. Lambris, Sheng Li, Sarah Urata, 2019, Analytical Chemistry on p. 7336-7345
Sumo suppresses the activity of the jasmonic acid receptor CORONATINE INSENSITIVE1
Anjil Kumar Srivastava, Beatriz Orosa, Prashant Singh, Ian Cummins, Charlotte Walsh, Cunjin Zhang, Murray Grant, Michael R. Roberts, Ganesh Srinivasan Anand, Elaine Fitches, Ari Sadanandom, 2018, Plant Cell on p. 2099-2115
Mechanism of Enhanced Immature Dengue Virus Attachment to Endosomal Membrane Induced by prM Antibody
Melissa Wirawan, Guntur Fibriansah, Jan K. Marzinek, Xin Xiang Lim, Thiam Seng Ng, Adelene Y.L. Sim, Qian Zhang, Victor A. Kostyuchenko, Jian Shi, Scott A. Smith, Chandra S. Verma, Ganesh Anand, James E. Crowe, Peter J. Bond, Shee Mei Lok, 2019, Structure with Folding & design on p. 253-267.e8
Epitope and Paratope Mapping Reveals Temperature-Dependent Alterations in the Dengue-Antibody Interface
Xin Xiang Lim, Arun Chandramohan, Xin Ying Elisa Lim, James E. Crowe, Shee Mei Lok, Ganesh S. Anand, 2017, Structure with Folding & design on p. 1391-1402.e3
Structural insight and flexible features of NS5 proteins from all four serotypes of Dengue virus in solution
Wuan Geok Saw, Giancarlo Tria, Ardina Grüber, Malathy Sony Subramanian Manimekalai, Yongqian Zhao, Arun Chandramohan, Ganesh Srinivasan Anand, Tsutomu Matsui, Thomas M. Weiss, Subhash G. Vasudevan, Gerhard Grüber, 2015, Acta Crystallographica Section D: Structural Biology on p. 2309-2327
News Articles Featuring Ganesh Srinivasan Anand
Mar 31, 2023
A tighter core stabilizes SARS-CoV-2 spike protein in new emergent variants
Just as a tight core is a component of good physical fitness for humans, helping to stabilize our bodies, mutations that tightened the core of the SARS-CoV-2 spike protein in new variants may have increased the virus’s fitness, according to new research led by Penn State scientists.
Full Article
Apr 06, 2022
First round of funded projects announced from the Benkovic Research Initiative
Four projects have been announced as recipients of funding from the Patricia and Stephen Benkovic Research Initiative, which supports risky, highly innovative investigation at the interface of chemistry and the life sciences.
Full Article
Nov 30, 2021
Distortion: Researchers discover new strategy for antibodies to disable viruses
It is widely understood that antibodies neutralize viruses by latching onto their surfaces and blocking them from infecting host cells. But new research reveals that this barrier method isn’t the only way that antibodies disable viruses. An international team of researchers led by Penn State has discovered that antibodies also distort viruses, thereby preventing them from properly attaching to and entering cells.
Full Article
Mar 15, 2021
Lab Bench to Commercialization grant recipients announced
Two faculty members have been selected to receive Lab Bench to Commercialization (LB2C) grants from the Eberly College of Science in 2021. The competitive program provides funding for researchers in the college, enabling them to enhance the commercial potential of ongoing research and prepare them to translate their intellectual property to the marketplace.
Full Article
Feb 23, 2021
Researchers discover potential therapeutic targets on SARS-CoV-2 Spike protein
The COVID-19 pandemic has prompted considerable investigation into how the SARS-CoV-2 Spike protein attaches to a human cell during the infection process, as this knowledge is useful in designing vaccines and therapeutics. Now, a team of scientists has discovered additional locations on the Spike protein that may not only help to explain how certain mutations make emerging variants more infectious but also could be used as additional targets for therapeutic intervention.
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Nov 09, 2020
Ganesh Anand joins Department of Chemistry as associate professor
Ganesh Anand will be joining the Eberly College of Science this November as an associate professor of chemistry.
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