Ganesh Srinivasan Anand
Associate Professor of Chemistry
Research Summary
Dynamics of large biomolecular complexes; uncovering what drives their assembly, regulation and function through mass spectrometry.
Huck Affiliations
Publication Tags
Proteins Hydrogen Protein Mass Spectrometry Deuterium Deuterium(.) Dengue Virus Hydrogen Deuterium Exchange Mass Spectrometry Viruses Serogroup Antibodies Membranes Peptide Hydrolases Rna Phosphotransferases Jasmonic Acid Histidine Kinase Stem Cells Capsid Proteolysis Ubiquitin Amides Tissue Capsid Proteins AmideMost Recent Publications
Hyperosmotic Stress Allosterically Reconfigures Betaine Binding Pocket in BetP
Sarala Tantirimudalige, Theresa Sophia Claire Buckley, Arun Chandramohan, Rebecca Michaela Richter, Christine Ziegler, Ganesh S. Anand, 2022, Journal of Molecular Biology
Uncovering cryptic pockets in the SARS-CoV-2 spike glycoprotein
Lorena Zuzic, Firdaus Samsudin, Aishwary T. Shivgan, Palur V. Raghuvamsi, Jan K. Marzinek, Alister Boags, Conrado Pedebos, Nikhil K. Tulsian, Jim Warwicker, Paul MacAry, Max Crispin, Syma Khalid, Ganesh S. Anand, Peter J. Bond, 2022, Structure with Folding & design on p. 1062-1074.e4
Guanine Nucleotide-Dependent Conformational Selection Regulates Distinct Alternate Ribosome Bound States of the Translation Factor BipA
Giancarlo Montovano, Theresa S. Buckley, Mahmoud Sharawy, Eric R. May, Ganesh S. Anand, Victoria L. Robinson, 2022, FASEB Journal
Protein Kinase A Catalytic subunit:Smoothened interface - Role of a parallel holoenzyme in negative feedback in Hedgehog Signaling
Varun Venkatakrishnan, Corvin Arveseth, Benjamin Myers, Ganesh S. Anand, 2022, FASEB Journal
Identification of putative binding interface of PI(3,5)P<sub>2</sub> lipid on rice black-streaked dwarf virus (RBSDV) P10 protein
Haoqiu Liu, Xin Yi Peck, Yeu Khai Choong, Woei Shyuan Ng, Wilfried Engl, Palur Venkata Raghuvamsi, Ziqing Winston Zhao, Ganesh S. Anand, Yijun Zhou, J. Sivaraman, Qiufang Xu, Sek Man Wong, 2022, Virology on p. 81-95
Asymmetric RNA Egress Site in Expanded RNA Virus by Cryo-EM and HDXMS
Sean Braet, Varun Venkatakrishnan, Ranita Ramesh, Palur Raghuvamsi, Ganesh Anand, 2022, FASEB Journal
Structural and Biophysical Mechanisms Driving Differential Hormone Response in Steroid Receptors
Sabab H. Khan, Sean M. Braet, Stephen J. Koehler, Elizabeth Elacqua, Ganesh S. Anand, Denise Okafor, 2022, FASEB Journal
Human antibody C10 neutralizes by diminishing Zika but enhancing dengue virus dynamics
Xin Xiang Lim, Bo Shu, Shuijun Zhang, Aaron W.K. Tan, Thiam Seng Ng, Xin Ni Lim, Valerie S.Y. Chew, Jian Shi, Gavin R. Screaton, Shee Mei Lok, Ganesh S. Anand, 2021, Cell on p. 6067-6080
Botanical Medicine and Natural Products Used for Erectile Dysfunction
Valerie Jia En Sin, Ganesh Srinivasan Anand, Hwee Ling Koh, 2021, Sexual Medicine Reviews on p. 568-592
Dengue virus 2 capsid protein chaperones the strand displacement of 5′-3′ cyclization sequences
Xin Ee Yong, V. Raghuvamsi Palur, Ganesh S. Anand, Thorsten Wohland, Kamal K. Sharma, 2021, Nucleic Acids Research on p. 5832-5844
Most-Cited Papers
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments
Glenn R. Masson, John E. Burke, Natalie G. Ahn, Ganesh S. Anand, Christoph Borchers, Sébastien Brier, George M. Bou-Assaf, John R. Engen, S. Walter Englander, Johan Faber, Rachel Garlish, Patrick R. Griffin, Michael L. Gross, Miklos Guttman, Yoshitomo Hamuro, Albert J.R. Heck, Damian Houde, Roxana E. Iacob, Thomas J.D. Jørgensen, Igor A. Kaltashov, Judith P. Klinman, Lars Konermann, Petr Man, Leland Mayne, Bruce D. Pascal, Dana Reichmann, Mark Skehel, Joost Snijder, Timothy S. Strutzenberg, Eric S. Underbakke, Cornelia Wagner, Thomas E. Wales, Benjamin T. Walters, David D. Weis, Derek J. Wilson, Patrick L. Wintrode, Zhongqi Zhang, Jie Zheng, David C. Schriemer, Kasper D. Rand, 2019, Nature Methods on p. 595-602
The inner membrane histidine kinase EnvZ senses osmolality via helix-coil transitions in the cytoplasm
Loo Chien Wang, Leslie K. Morgan, Pahan Godakumbura, Linda J. Kenney, Ganesh S. Anand, 2012, EMBO Journal on p. 2648-2659
Conformational changes in intact dengue virus reveal serotype-specific expansion
Xin Xiang Lim, Arun Chandramohan, Xin Ying Elisa Lim, Nirmalya Bag, Kamal Kant Sharma, Melissa Wirawan, Thorsten Wohland, Shee Mei Lok, Ganesh S. Anand, 2017, Nature Communications
Heart extracellular matrix supports cardiomyocyte differentiation of mouse embryonic stem cells
Sayaka Higuchi, Qingsong Lin, Jigang Wang, Teck Kwang Lim, Shashikant B. Joshi, Ganesh Srinivasan Anand, Maxey C.M. Chung, Michael P. Sheetz, Hideaki Fujita, 2013, Journal of Bioscience and Bioengineering on p. 320-325
Sars-cov-2 s protein:Ace2 interaction reveals novel allosteric targets
Palur V. Raghuvamsi, Nikhil K. Tulsian, Firdaus Samsudin, Xinlei Qian, Kiren Purushotorman, Gu Yue, Mary M. Kozma, Wong Y. Hwa, Julien Lescar, Peter J. Bond, Paul A. Macary, Ganesh S. Anand, 2021, eLife on p. 1-47
Interlaboratory Comparison of Hydrogen-Deuterium Exchange Mass Spectrometry Measurements of the Fab Fragment of NISTmAb
Jeffrey W. Hudgens, Elyssia S. Gallagher, Ioannis Karageorgos, Kyle W. Anderson, James J. Filliben, Richard Y.C. Huang, Guodong Chen, George M. Bou-Assaf, Alfonso Espada, Michael J. Chalmers, Eduardo Harguindey, Hui Min Zhang, Benjamin T. Walters, Jennifer Zhang, John Venable, Caitlin Steckler, Inhee Park, Ansgar Brock, Xiaojun Lu, Ratnesh Pandey, Arun Chandramohan, Ganesh Srinivasan Anand, Sasidhar N. Nirudodhi, Justin B. Sperry, Jason C. Rouse, James A. Carroll, Kasper D. Rand, Ulrike Leurs, David D. Weis, Mohammed A. Al-Naqshabandi, Tyler S. Hageman, Daniel Deredge, Patrick L. Wintrode, Malvina Papanastasiou, John D. Lambris, Sheng Li, Sarah Urata, 2019, Analytical Chemistry on p. 7336-7345
Structural insight and flexible features of NS5 proteins from all four serotypes of Dengue virus in solution
Wuan Geok Saw, Giancarlo Tria, Ardina Grüber, Malathy Sony Subramanian Manimekalai, Yongqian Zhao, Arun Chandramohan, Ganesh Srinivasan Anand, Tsutomu Matsui, Thomas M. Weiss, Subhash G. Vasudevan, Gerhard Grüber, 2015, Acta Crystallographica Section D: Structural Biology on p. 2309-2327
Sumo suppresses the activity of the jasmonic acid receptor CORONATINE INSENSITIVE1
Anjil Kumar Srivastava, Beatriz Orosa, Prashant Singh, Ian Cummins, Charlotte Walsh, Cunjin Zhang, Murray Grant, Michael R. Roberts, Ganesh Srinivasan Anand, Elaine Fitches, Ari Sadanandom, 2018, Plant Cell on p. 2099-2115
Epitope and Paratope Mapping Reveals Temperature-Dependent Alterations in the Dengue-Antibody Interface
Xin Xiang Lim, Arun Chandramohan, Xin Ying Elisa Lim, James E. Crowe, Shee Mei Lok, Ganesh S. Anand, 2017, Structure with Folding & design on p. 1391-1402.e3
Architecture of a dsDNA viral capsid in complex with its maturation protease
David Veesler, Reza Khayat, Srinath Krishnamurthy, Joost Snijder, Rick K. Huang, Albert J.R. Heck, Ganesh S. Anand, John E. Johnson, 2014, Structure with Folding & design on p. 230-237
News Articles Featuring Ganesh Srinivasan Anand
Apr 06, 2022
First round of funded projects announced from the Benkovic Research Initiative
Four projects have been announced as recipients of funding from the Patricia and Stephen Benkovic Research Initiative, which supports risky, highly innovative investigation at the interface of chemistry and the life sciences.
Full Article
Nov 30, 2021
Distortion: Researchers discover new strategy for antibodies to disable viruses
It is widely understood that antibodies neutralize viruses by latching onto their surfaces and blocking them from infecting host cells. But new research reveals that this barrier method isn’t the only way that antibodies disable viruses. An international team of researchers led by Penn State has discovered that antibodies also distort viruses, thereby preventing them from properly attaching to and entering cells.
Full Article
Mar 15, 2021
Lab Bench to Commercialization grant recipients announced
Two faculty members have been selected to receive Lab Bench to Commercialization (LB2C) grants from the Eberly College of Science in 2021. The competitive program provides funding for researchers in the college, enabling them to enhance the commercial potential of ongoing research and prepare them to translate their intellectual property to the marketplace.
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Feb 23, 2021
Researchers discover potential therapeutic targets on SARS-CoV-2 Spike protein
The COVID-19 pandemic has prompted considerable investigation into how the SARS-CoV-2 Spike protein attaches to a human cell during the infection process, as this knowledge is useful in designing vaccines and therapeutics. Now, a team of scientists has discovered additional locations on the Spike protein that may not only help to explain how certain mutations make emerging variants more infectious but also could be used as additional targets for therapeutic intervention.
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Nov 09, 2020
Ganesh Anand joins Department of Chemistry as associate professor
Ganesh Anand will be joining the Eberly College of Science this November as an associate professor of chemistry.
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