Ganesh Srinivasan Anand
Associate Professor of Chemistry
Research Summary
Dynamics of large biomolecular complexes; uncovering what drives their assembly, regulation and function through mass spectrometry.
Huck Affiliations
Publication Tags
Proteins Phosphotransferases Deuterium Phosphoric Diester Hydrolases Mass Spectrometry Hydrogen Cyclic Amp Dependent Protein Kinases Hydrolysis Silk Cyclic Nucleotides Dengue Virus Cyclic Amp Viruses Serogroup Dna Protein Kinases Amides Assays Membranes Peptide Hydrolases Nuclear Magnetic Resonance Oligomerization Polymerization Histidine Kinase GenesMost Recent Papers
Dengue virus 2 capsid protein chaperones the strand displacement of 5′-3′ cyclization sequences
Xin Ee Yong, V. Raghuvamsi Palur, Ganesh S. Anand, Thorsten Wohland, Kamal K. Sharma, 2021, Nucleic Acids Research on p. 5832-5844
Development of phosphodiesterase–protein-kinase complexes as novel targets for discovery of inhibitors with enhanced specificity
Nikhil K. Tulsian, Valerie Jia En Sin, Hwee Ling Koh, Ganesh S. Anand, 2021, International Journal of Molecular Sciences
Antibody affinity versus dengue morphology influences neutralization
Guntur Fibriansah, Elisa X.Y. Lim, Jan K. Marzinek, Thiam Seng Ng, Joanne L. Tan, Roland G. Huber, Xin Ni Lim, Valerie S.Y. Chew, Victor A. Kostyuchenko, Jian Shi, Ganesh S. Anand, Peter J. Bond, James E. Crowe, Shee Mei Lok, 2021, PLoS Pathogens
Sars-cov-2 s protein:Ace2 interaction reveals novel allosteric targets
Palur V. Raghuvamsi, Nikhil K. Tulsian, Firdaus Samsudin, Xinlei Qian, Kiren Purushotorman, Gu Yue, Mary M. Kozma, Wong Y. Hwa, Julien Lescar, Peter J. Bond, Paul A. Macary, Ganesh S. Anand, 2021, eLife on p. 1-47
Dengue virus strain 2 capsid protein switches the annealing pathway and reduces intrinsic dynamics of the conserved 5’ untranslated region
Xin Ee Yong, Palur Venkata Raghuvamsi, Ganesh S. Anand, Thorsten Wohland, Kamal K. Sharma, 2021, RNA Biology on p. 718-731
Disrupting enzyme fluidity
Ganesh Srinivasan Anand, 2021, eLife on p. 1-3
Synergistic Allostery in Multiligand-Protein Interactions
Abhijeet Ghode, Lissy Z.F. Gross, Wei Ven Tee, Enrico Guarnera, Igor N. Berezovsky, Ricardo M. Biondi, Ganesh S. Anand, 2020, Biophysical Journal on p. 1833-1848
Adenylate control in cAMP signaling
Nikhil K. Tulsian, Abhijeet Ghode, Ganesh S. Anand, 2020, Biochemical Journal on p. 2981-2998
An NMR based phosphodiesterase assay
Madoka Akimoto, Tianning Yu, Kody Moleschi, Katherine Van, Ganesh S. Anand, Giuseppe Melacini, 2020, Chemical Communications on p. 8091-8094
Structural basis of oligomerization of n-terminal domain of spider aciniform silk protein
Rusha Chakraborty, Jing Song Fan, Chong Cheong Lai, Palur Venkata Raghuvamsi, Pin Xuan Chee, Ganesh Srinivasan Anand, Daiwen Yang, 2020, International Journal of Molecular Sciences on p. 1-15
Most-Cited Papers
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments
Glenn R. Masson, John E. Burke, Natalie G. Ahn, Ganesh S. Anand, Christoph Borchers, Sébastien Brier, George M. Bou-Assaf, John R. Engen, S. Walter Englander, Johan Faber, Rachel Garlish, Patrick R. Griffin, Michael L. Gross, Miklos Guttman, Yoshitomo Hamuro, Albert J.R. Heck, Damian Houde, Roxana E. Iacob, Thomas J.D. Jørgensen, Igor A. Kaltashov, Judith P. Klinman, Lars Konermann, Petr Man, Leland Mayne, Bruce D. Pascal, Dana Reichmann, Mark Skehel, Joost Snijder, Timothy S. Strutzenberg, Eric S. Underbakke, Cornelia Wagner, Thomas E. Wales, Benjamin T. Walters, David D. Weis, Derek J. Wilson, Patrick L. Wintrode, Zhongqi Zhang, Jie Zheng, David C. Schriemer, Kasper D. Rand, 2019, Nature Methods on p. 595-602
The inner membrane histidine kinase EnvZ senses osmolality via helix-coil transitions in the cytoplasm
Loo Chien Wang, Leslie K. Morgan, Pahan Godakumbura, Linda J. Kenney, Ganesh S. Anand, 2012, EMBO Journal on p. 2648-2659
Salmonella enterica response regulator SsrB relieves H-NS silencing by displacing H-NS bound in polymerization mode and directly activates transcription
Don Walthers, You Li, Yingjie Liu, Ganesh Anand, Jie Yan, Linda J. Kenney, 2011, Journal of Biological Chemistry on p. 1895-1902
Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation
Suguna Badireddy, Gao Yunfeng, Mark Ritchie, Pearl Akamine, Jian Wu, Choel W. Kim, Susan S. Taylor, Lin Qingsong, Kunchithapadam Swaminathan, Ganesh S. Anand, 2011, Molecular and Cellular Proteomics
Heart extracellular matrix supports cardiomyocyte differentiation of mouse embryonic stem cells
Sayaka Higuchi, Qingsong Lin, Jigang Wang, Teck Kwang Lim, Shashikant B. Joshi, Ganesh Srinivasan Anand, Maxey C.M. Chung, Michael P. Sheetz, Hideaki Fujita, 2013, Journal of Bioscience and Bioengineering on p. 320-325
Phosphodiesterases catalyze hydrolysis of cAMP-bound to regulatory subunit of protein kinase A and mediate signal termination
Balakrishnan Shenbaga Moorthy, Yunfeng Gao, Ganesh S. Anand, 2011, Molecular and Cellular Proteomics
Conformational changes in intact dengue virus reveal serotype-specific expansion
Xin Xiang Lim, Arun Chandramohan, Xin Ying Elisa Lim, Nirmalya Bag, Kamal Kant Sharma, Melissa Wirawan, Thorsten Wohland, Shee Mei Lok, Ganesh S. Anand, 2017, Nature Communications
Architecture of a dsDNA viral capsid in complex with its maturation protease
David Veesler, Reza Khayat, Srinath Krishnamurthy, Joost Snijder, Rick K. Huang, Albert J.R. Heck, Ganesh S. Anand, John E. Johnson, 2014, Structure with Folding & design on p. 230-237
Structural insight and flexible features of NS5 proteins from all four serotypes of Dengue virus in solution
Wuan Geok Saw, Giancarlo Tria, Ardina Grüber, Malathy Sony Subramanian Manimekalai, Yongqian Zhao, Arun Chandramohan, Ganesh Srinivasan Anand, Tsutomu Matsui, Thomas M. Weiss, Subhash G. Vasudevan, Gerhard Grüber, 2015, Acta Crystallographica Section D: Structural Biology on p. 2309-2327
Active site coupling in PDE:PKA complexes promotes resetting of mammalian cAMP signaling
Srinath Krishnamurthy, Balakrishnan Shenbaga Moorthy, Lim Xin Xiang, Lim Xin Shan, Kavitha Bharatham, Nikhil Kumar Tulsian, Ivana Mihalek, Ganesh S. Anand, 2014, Biophysical Journal on p. 1426-1440
News Articles Featuring Ganesh Srinivasan Anand
Mar 15, 2021
Lab Bench to Commercialization grant recipients announced
Two faculty members have been selected to receive Lab Bench to Commercialization (LB2C) grants from the Eberly College of Science in 2021. The competitive program provides funding for researchers in the college, enabling them to enhance the commercial potential of ongoing research and prepare them to translate their intellectual property to the marketplace.
Full Article
Feb 23, 2021
Researchers discover potential therapeutic targets on SARS-CoV-2 Spike protein
The COVID-19 pandemic has prompted considerable investigation into how the SARS-CoV-2 Spike protein attaches to a human cell during the infection process, as this knowledge is useful in designing vaccines and therapeutics. Now, a team of scientists has discovered additional locations on the Spike protein that may not only help to explain how certain mutations make emerging variants more infectious but also could be used as additional targets for therapeutic intervention.
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Nov 09, 2020
Ganesh Anand joins Department of Chemistry as associate professor
Ganesh Anand will be joining the Eberly College of Science this November as an associate professor of chemistry.
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