Ganesh Srinivasan Anand

Associate Professor of Chemistry

Research Summary

Dynamics of large biomolecular complexes; uncovering what drives their assembly, regulation and function through mass spectrometry.

Huck Affiliations

Publication Tags

Proteins Deuterium Hydrogen Mass Spectrometry Protein Dengue Virus Deuterium(.) Phosphotransferases Serogroup Antibodies Viruses Hydrogen Deuterium Exchange Mass Spectrometry Peptide Hydrolases Membranes Dengue Stem Cells Phosphoric Diester Hydrolases Jasmonic Acid Histidine Kinase Proteolysis Cyclic Nucleotides Epitopes Ubiquitin Tissue Temperature

Most Recent Papers

Guanine Nucleotide-Dependent Conformational Selection Regulates Distinct Alternate Ribosome Bound States of the Translation Factor BipA

Giancarlo Montovano, Theresa S. Buckley, Mahmoud Sharawy, Eric R. May, Ganesh S. Anand, Victoria L. Robinson, 2022, FASEB Journal

Structural and Biophysical Mechanisms Driving Differential Hormone Response in Steroid Receptors

Sabab H. Khan, Sean M. Braet, Stephen J. Koehler, Elizabeth Elacqua, Ganesh S. Anand, Denise Okafor, 2022, FASEB Journal

Protein Kinase A Catalytic subunit:Smoothened interface - Role of a parallel holoenzyme in negative feedback in Hedgehog Signaling

Varun Venkatakrishnan, Corvin Arveseth, Benjamin Myers, Ganesh S. Anand, 2022, FASEB Journal

Identification of putative binding interface of PI(3,5)P<sub>2</sub> lipid on rice black-streaked dwarf virus (RBSDV) P10 protein

Haoqiu Liu, Xin Yi Peck, Yeu Khai Choong, Woei Shyuan Ng, Wilfried Engl, Palur Venkata Raghuvamsi, Ziqing Winston Zhao, Ganesh S. Anand, Yijun Zhou, J. Sivaraman, Qiufang Xu, Sek Man Wong, 2022, Virology on p. 81-95

Asymmetric RNA Egress Site in Expanded RNA Virus by Cryo-EM and HDXMS

Sean Braet, Varun Venkatakrishnan, Ranita Ramesh, Palur Raghuvamsi, Ganesh Anand, 2022, FASEB Journal

Human antibody C10 neutralizes by diminishing Zika but enhancing dengue virus dynamics

Xin Xiang Lim, Bo Shu, Shuijun Zhang, Aaron W.K. Tan, Thiam Seng Ng, Xin Ni Lim, Valerie S.Y. Chew, Jian Shi, Gavin R. Screaton, Shee Mei Lok, Ganesh S. Anand, 2021, Cell on p. 6067-6080

Botanical Medicine and Natural Products Used for Erectile Dysfunction

Valerie Jia En Sin, Ganesh Srinivasan Anand, Hwee Ling Koh, 2021, Sexual Medicine Reviews on p. 568-592

Dengue virus 2 capsid protein chaperones the strand displacement of 5′-3′ cyclization sequences

Xin Ee Yong, V. Raghuvamsi Palur, Ganesh S. Anand, Thorsten Wohland, Kamal K. Sharma, 2021, Nucleic Acids Research on p. 5832-5844

Development of phosphodiesterase–protein-kinase complexes as novel targets for discovery of inhibitors with enhanced specificity

Nikhil K. Tulsian, Valerie Jia En Sin, Hwee Ling Koh, Ganesh S. Anand, 2021, International Journal of Molecular Sciences

Antibody affinity versus dengue morphology influences neutralization

Guntur Fibriansah, Elisa X.Y. Lim, Jan K. Marzinek, Thiam Seng Ng, Joanne L. Tan, Roland G. Huber, Xin Ni Lim, Valerie S.Y. Chew, Victor A. Kostyuchenko, Jian Shi, Ganesh S. Anand, Peter J. Bond, James E. Crowe, Shee Mei Lok, 2021, PLoS Pathogens

Most-Cited Papers

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

Glenn R. Masson, John E. Burke, Natalie G. Ahn, Ganesh S. Anand, Christoph Borchers, Sébastien Brier, George M. Bou-Assaf, John R. Engen, S. Walter Englander, Johan Faber, Rachel Garlish, Patrick R. Griffin, Michael L. Gross, Miklos Guttman, Yoshitomo Hamuro, Albert J.R. Heck, Damian Houde, Roxana E. Iacob, Thomas J.D. Jørgensen, Igor A. Kaltashov, Judith P. Klinman, Lars Konermann, Petr Man, Leland Mayne, Bruce D. Pascal, Dana Reichmann, Mark Skehel, Joost Snijder, Timothy S. Strutzenberg, Eric S. Underbakke, Cornelia Wagner, Thomas E. Wales, Benjamin T. Walters, David D. Weis, Derek J. Wilson, Patrick L. Wintrode, Zhongqi Zhang, Jie Zheng, David C. Schriemer, Kasper D. Rand, 2019, Nature Methods on p. 595-602

The inner membrane histidine kinase EnvZ senses osmolality via helix-coil transitions in the cytoplasm

Loo Chien Wang, Leslie K. Morgan, Pahan Godakumbura, Linda J. Kenney, Ganesh S. Anand, 2012, EMBO Journal on p. 2648-2659

Conformational changes in intact dengue virus reveal serotype-specific expansion

Xin Xiang Lim, Arun Chandramohan, Xin Ying Elisa Lim, Nirmalya Bag, Kamal Kant Sharma, Melissa Wirawan, Thorsten Wohland, Shee Mei Lok, Ganesh S. Anand, 2017, Nature Communications

Heart extracellular matrix supports cardiomyocyte differentiation of mouse embryonic stem cells

Sayaka Higuchi, Qingsong Lin, Jigang Wang, Teck Kwang Lim, Shashikant B. Joshi, Ganesh Srinivasan Anand, Maxey C.M. Chung, Michael P. Sheetz, Hideaki Fujita, 2013, Journal of Bioscience and Bioengineering on p. 320-325

Structural insight and flexible features of NS5 proteins from all four serotypes of Dengue virus in solution

Wuan Geok Saw, Giancarlo Tria, Ardina Grüber, Malathy Sony Subramanian Manimekalai, Yongqian Zhao, Arun Chandramohan, Ganesh Srinivasan Anand, Tsutomu Matsui, Thomas M. Weiss, Subhash G. Vasudevan, Gerhard Grüber, 2015, Acta Crystallographica Section D: Structural Biology on p. 2309-2327

Interlaboratory Comparison of Hydrogen-Deuterium Exchange Mass Spectrometry Measurements of the Fab Fragment of NISTmAb

Jeffrey W. Hudgens, Elyssia S. Gallagher, Ioannis Karageorgos, Kyle W. Anderson, James J. Filliben, Richard Y.C. Huang, Guodong Chen, George M. Bou-Assaf, Alfonso Espada, Michael J. Chalmers, Eduardo Harguindey, Hui Min Zhang, Benjamin T. Walters, Jennifer Zhang, John Venable, Caitlin Steckler, Inhee Park, Ansgar Brock, Xiaojun Lu, Ratnesh Pandey, Arun Chandramohan, Ganesh Srinivasan Anand, Sasidhar N. Nirudodhi, Justin B. Sperry, Jason C. Rouse, James A. Carroll, Kasper D. Rand, Ulrike Leurs, David D. Weis, Mohammed A. Al-Naqshabandi, Tyler S. Hageman, Daniel Deredge, Patrick L. Wintrode, Malvina Papanastasiou, John D. Lambris, Sheng Li, Sarah Urata, 2019, Analytical Chemistry on p. 7336-7345

Architecture of a dsDNA viral capsid in complex with its maturation protease

David Veesler, Reza Khayat, Srinath Krishnamurthy, Joost Snijder, Rick K. Huang, Albert J.R. Heck, Ganesh S. Anand, John E. Johnson, 2014, Structure with Folding & design on p. 230-237

Epitope and Paratope Mapping Reveals Temperature-Dependent Alterations in the Dengue-Antibody Interface

Xin Xiang Lim, Arun Chandramohan, Xin Ying Elisa Lim, James E. Crowe, Shee Mei Lok, Ganesh S. Anand, 2017, Structure with Folding & design on p. 1391-1402.e3

Sumo suppresses the activity of the jasmonic acid receptor CORONATINE INSENSITIVE1

Anjil Kumar Srivastava, Beatriz Orosa, Prashant Singh, Ian Cummins, Charlotte Walsh, Cunjin Zhang, Murray Grant, Michael R. Roberts, Ganesh Srinivasan Anand, Elaine Fitches, Ari Sadanandom, 2018, Plant Cell on p. 2099-2115

Sars-cov-2 s protein:Ace2 interaction reveals novel allosteric targets

Palur V. Raghuvamsi, Nikhil K. Tulsian, Firdaus Samsudin, Xinlei Qian, Kiren Purushotorman, Gu Yue, Mary M. Kozma, Wong Y. Hwa, Julien Lescar, Peter J. Bond, Paul A. Macary, Ganesh S. Anand, 2021, eLife on p. 1-47

News Articles Featuring Ganesh Srinivasan Anand

First round of funded projects announced from the Benkovic Research Initiative

Four projects have been announced as recipients of funding from the Patricia and Stephen Benkovic Research Initiative, which supports risky, highly innovative investigation at the interface of chemistry and the life sciences.

Distortion: Researchers discover new strategy for antibodies to disable viruses

It is widely understood that antibodies neutralize viruses by latching onto their surfaces and blocking them from infecting host cells. But new research reveals that this barrier method isn’t the only way that antibodies disable viruses. An international team of researchers led by Penn State has discovered that antibodies also distort viruses, thereby preventing them from properly attaching to and entering cells.

Lab Bench to Commercialization grant recipients announced

Two faculty members have been selected to receive Lab Bench to Commercialization (LB2C) grants from the Eberly College of Science in 2021. The competitive program provides funding for researchers in the college, enabling them to enhance the commercial potential of ongoing research and prepare them to translate their intellectual property to the marketplace.

Researchers discover potential therapeutic targets on SARS-CoV-2 Spike protein

The COVID-19 pandemic has prompted considerable investigation into how the SARS-CoV-2 Spike protein attaches to a human cell during the infection process, as this knowledge is useful in designing vaccines and therapeutics. Now, a team of scientists has discovered additional locations on the Spike protein that may not only help to explain how certain mutations make emerging variants more infectious but also could be used as additional targets for therapeutic intervention.

Ganesh Anand joins Department of Chemistry as associate professor

Ganesh Anand will be joining the Eberly College of Science this November as an associate professor of chemistry.