Francesca Chiaromonte
Director of the Genome Sciences Institute; Huck Chair in Statistics for the Life Sciences; Professor of Statistics
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0325 Thomas
University Park, PA - fxc11@psu.edu
- 814-865-7075
Research Summary
Developing methods for the analysis of large, high-dimensional and complex data.
Huck Affiliations
Links
Most Recent Papers
Non-B DNA: a major contributor to small- and large-scale variation in nucleotide substitution frequencies across the genome.
W Guiblet, M Cremona, R Harris, D Chen, K Eckert, Francesca Chiaromonte, Y Huang, K Makova, 2021, Nucleic Acids Research on p. 1497-1516
MIP-BOOST
Ana Kenney, Francesca Chiaromonte, Giovanni Felici, 2021, Journal of Computational and Graphical Statistics
Covariate Information Number for Feature Screening in Ultrahigh-Dimensional Supervised Problems
Debmalya Nandy, Francesca Chiaromonte, Runze Li, 2021, Journal of the American Statistical Association
Give more data, awareness and control to individual citizens, and they will help COVID-19 containment
Mirco Nanni, Gennady Andrienko, Albert László Barabási, Chiara Boldrini, Francesco Bonchi, Ciro Cattuto, Francesca Chiaromonte, Giovanni Comandé, Marco Conti, Mark Coté, Frank Dignum, Virginia Dignum, Josep Domingo-Ferrer, Paolo Ferragina, Fosca Giannotti, Riccardo Guidotti, Dirk Helbing, Kimmo Kaski, Janos Kertesz, Sune Lehmann, Bruno Lepri, Paul Lukowicz, Stan Matwin, David Megías Jiménez, Anna Monreale, Katharina Morik, Nuria Oliver, Andrea Passarella, Andrea Passerini, Dino Pedreschi, Alex Pentland, Fabio Pianesi, Francesca Pratesi, Salvatore Rinzivillo, Salvatore Ruggieri, Arno Siebes, Vicenc Torra, Roberto Trasarti, Jeroen van den Hoven, Alessandro Vespignani, 2021, Ethics and Information Technology
Knowledge and social relatedness shape research portfolio diversification
Giorgio Tripodi, Francesca Chiaromonte, Fabrizio Lillo, 2020, Scientific Reports
Human L1 transposition dynamics unraveled with functional data analysis
Di Chen, Marzia A. Cremona, Zongtai Qi, Robi D. Mitra, Francesca Chiaromonte, Kateryna D. Makova, 2020, Molecular Biology and Evolution on p. 3576-3600
Learning the properties of adaptive regions with functional data analysis
Mehreen R. Mughal, Hillary Koch, Jinguo Huang, Francesca Chiaromonte, Michael DeGiorgio, 2020, PLoS Genetics
Age-related accumulation of de novo mitochondrial mutations in mammalian oocytes and somatic tissues
Barbara Arbeithuber, James Hester, Marzia A. Cremona, Nicholas Stoler, Arslan Zaidi, Bonnie Higgins, Kate Anthony, Francesca Chiaromonte, Francisco J. Diaz, Kateryna D. Makova, 2020, PLoS Biology
On the bias of H-scores for comparing biclusters, and how to correct it
Jacopo Di Iorio, Francesca Chiaromonte, Francesca Chiaromonte, Marzia A. Cremona, Marzia Cremona, 2020, Bioinformatics on p. 2955-2957
Give more data, awareness and control to individual citizens, and they will help COVID-19 containment
Mirco Nanni, Gennady Andrienko, Albert Làszlò Barabàsi, Chiara Boldrini, Francesco Bonchi, Ciro Cattuto, Francesca Chiaromonte, Giovanni Comandé, Marco Conti, Mark Coté, Frank Dignum, Virginia Dignum, Josep Domingo-Ferrer, Paolo Ferragina, Fosca Giannotti, Riccardo Guidotti, Dirk Helbing, Kimmo Kaski, Janos Kertesz, Sune Lehmann, Bruno Lepri, Paul Lukowicz, Stan Matwin, David Megías, Anna Monreale, Katharina Morik, Nuria Oliver, Andrea Passarella, Andrea Passerini, Dino Pedreschi, Alex Pentland, Fabio Pianesi, Francesca Pratesi, Salvatore Rinzivillo, Salvatore Ruggieri, Arno Siebes, Vicenҫ Torra, Roberto Trasarti, Jeroen Van Den Hoven, Alessandro Vespignani, 2020, Transactions on Data Privacy on p. 61-66
Most-Cited Papers
Maternal age effect and severe germ-line bottleneck in the inheritance of human mitochondrial DNA
Boris Rebolledo-Jaramillo, Marcia Shu Wei Su, Nicholas Stoler, Jennifer A. McElhoe, Benjamin Dickins, Daniel Blankenberg, Thorfinn S. Korneliussen, Francesca Chiaromonte, Rasmus Nielsen, Mitchell M. Holland, Ian M. Paul, Anton Nekrutenko, Kateryna D. Makova, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 15474-15479
Computational pan-genomics
Tobias Marschall, Manja Marz, Thomas Abeel, Louis Dijkstra, Bas E. Dutilh, Ali Ghaffaari, Paul Kersey, Wigard P. Kloosterman, Veli Mäkinen, Adam M. Novak, Benedict Paten, David Porubsky, Eric Rivals, Can Alkan, Jasmijn A. Baaijens, Paul I.W. De Bakker, Valentina Boeva, Raoul J.P. Bonnal, Francesca Chiaromonte, Rayan Chikhi, Francesca D. Ciccarelli, Robin Cijvat, Erwin Datema, Cornelia M. Van Duijn, Evan E. Eichler, Corinna Ernst, Eleazar Eskin, Erik Garrison, Mohammed El-Kebir, Gunnar W. Klau, Jan O. Korbel, Eric Wubbo Lameijer, Benjamin Langmead, Marcel Martin, Paul Medvedev, John C. Mu, Pieter Neerincx, Klaasjan Ouwens, Pierre Peterlongo, Nadia Pisanti, Sven Rahmann, Ben Raphael, Knut Reinert, Dick de Ridder, Jeroen de Ridder, Matthias Schlesner, Ole Schulz-Trieglaff, Ashley D. Sanders, Siavash Sheikhizadeh, Carl Shneider, 2018, Briefings in Bioinformatics on p. 118-135
A genome-wide analysis of common fragile sites
Arkarachai Fungtammasan, Erin Walsh, Francesca Chiaromonte, Kristin A. Eckert, Kateryna D. Makova, 2012, Genome Research on p. 993-1005
Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration
Weisheng Wu, Yong Cheng, Cheryl A. Keller Capone, Jason Ernst, Swathi Ashok Kumar, Tejaswini Mishra, Christapher Morrissey, Christine M. Dorman, Kuan Bei Chen, Daniela Drautz, Belinda Giardine, Yoichiro Shibata, Lingyun Song, Max Pimkin, Gregory E. Crawford, Terrence S. Furey, Manolis Kellis, Webb Miller, James Taylor, Stephan C. Schuster, Yu Zhang, Francesca Chiaromonte, Gerd A. Blobel, Mitchell J. Weiss, Ross Cameron Hardison, 2011, Genome Research on p. 1659-1671
A matter of life or death
Yogeshwar D. Kelkar, Kristin A. Eckert, Francesca Chiaromonte, Kateryna D. Makova, 2011, Genome Research on p. 2038-2048
A general theory for nonlinear sufficient dimension reduction
Kuang Yao Lee, Bing Li, Francesca Chiaromonte, 2013, Annals of Statistics on p. 221-249
Evidence for sharp increase in the economic damages of extreme natural disasters
Matteo Coronese, Francesco Lamperti, Klaus Keller, Francesca Chiaromonte, Andrea Roventini, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 21450-21455
Distinct mutational behaviors differentiate short tandem repeats from micro satellites in the human genome
Guruprasad Ananda, Erin Walsh, Kimberly D. Jacob, Maria Krasilnikova, Kristin A. Eckert, Francesca Chiaromonte, Kateryna D. Makova, 2013, Genome Biology and Evolution on p. 606-620
Rescuing Alu
Bradley J. Wagstaff, Dale J. Hedges, Rebecca S. Derbes, Rebeca Campos Sanchez, Francesca Chiaromonte, Kateryna D. Makova, Astrid M. Roy-Engel, 2012, PLoS Genetics
A genome-wide view of mutation rate co-variation using multivariate analyses
Guruprasad Ananda, Francesca Chiaromonte, Kateryna D. Makova, 2011, Genome Biology
News Articles Featuring Francesca Chiaromonte
Feb 04, 2021
Unusual DNA folding increases the rates of mutations
DNA sequences that can fold into shapes other than the classic double helix tend to have higher mutation rates than other regions in the human genome. New research by a team of Penn State scientists shows that the elevated mutation rate in these sequences plays a major role in determining regional variation in mutation rates across the genome.
Full Article
Sep 29, 2020
Scientists take a step toward understanding 'jumping genes' effect on the genome
Using state-of-the-art statistical methods, a team of researchers said they may have taken a leap closer to understanding a class of jumping genes, sequences that move to different locations in the human genome, which is the body’s complete set of DNA.
Full Article
Dec 12, 2019
Hurricanes Wreak Greater Havoc as Temperatures Soar
Devastation caused by the most powerful hurricanes has increased by up to twentyfold, according to a newly-identified pattern in natural disasters.
Full Article
Oct 08, 2019
Cost of natural disasters like hurricanes Katrina, Maria are increasing at high end
According to an international team of researchers, The costs of major disasters like hurricanes Katrina, Maria and Dorian or the massive tornado swarms in the Midwest have increased to a disproportionately larger extent than those of lesser events, and these major disasters have become far more expensive.
Full Article
Oct 07, 2019
Data scientists put a staggering price tag on climate change's effects
Hurricanes, floods, and other natural disasters can destroy and displace communities. Beyond the human cost, this damage is unimaginably expensive for many who are affected. New research out Monday puts a price tag on how bad things might get.
Full Article
Oct 07, 2019
Costs of natural disasters are increasing at the high end
While the economic cost of natural disasters has not increased much on average, averages can be deceptive. The costs of major disasters like hurricanes Katrina, Maria and Dorian or the massive tornado swarms in the Midwest have increased to a disproportionately larger extent than those of lesser events, and these major disasters have become far more expensive, according to an international team of researchers.
Full Article
Sep 17, 2019
Francesca Chiaromonte named Huck Chair in Statistics for the Life Sciences
Francesca Chiaromonte, professor of statistics at Penn State, was recently named Lloyd and Dorothy Foehr Huck Chair in Statistics by the University’s Huck Institutes of the Life Sciences.
Full Article
Sep 21, 2018
Mouth bacteria in toddlers may predict obesity, study says
Bacteria in a toddler's mouth might help predict later obesity, new research suggests. Scientists at Penn State University found the composition of microorganisms in the mouths of 2-year-olds offers clues to the child's future weight.
Full Article
Sep 20, 2018
Swabbing a child’s mouth for bacteria could predict how likely they are to become obese
A swab of a toddler’s mouth may predict their odds of growing into obese children, a new study suggests. Scientists at Pennsylvania State University discovered that the harmless microorganisms living in a two-year-old’s mouth were less diverse if they had gained more weight more quickly than most since birth.
Full Article
Sep 19, 2018
Child Weight Gain Trajectories Linked To Oral Microbiota Composition
Gut and oral microbiota perturbations have been observed in obese adults and adolescents; less is known about their influence on weight gain in young children.
Full Article