Francesca Chiaromonte

Director of the Genome Sciences Institute; Huck Chair in Statistics for the Life Sciences; Professor of Statistics

Francesca Chiaromonte

Research Summary

Developing methods for the analysis of large, high-dimensional and complex data.

Huck Affiliations

Links

Most Recent Papers

Give more data, awareness and control to individual citizens, and they will help COVID-19 containment.

M Nanni, G Andrienko, A Barabási, C Boldrini, F Bonchi, C Cattuto, Francesca Chiaromonte, G Comandé, M Conti, M Coté, F Dignum, V Dignum, J Domingo-Ferrer, P Ferragina, F Giannotti, R Guidotti, D Helbing, K Kaski, J Kertesz, S Lehmann, B Lepri, P Lukowicz, S Matwin, D Jiménez, A Monreale, K Morik, N Oliver, A Passarella, A Passerini, D Pedreschi, A Pentland, F Pianesi, F Pratesi, S Rinzivillo, S Ruggieri, A Siebes, V Torra, R Trasarti, Hoven JVD, A Vespignani, 2021, Ethics and information technology on p. 1-6

Covariate Information Number for Feature Screening in Ultrahigh-Dimensional Supervised Problems

Debmalya Nandy, Francesca Chiaromonte, R Li, 2021, Journal of the American Statistical Association

Knowledge and social relatedness shape research portfolio diversification

Giorgio Tripodi, Francesca Chiaromonte, Fabrizio Lillo, 2020, Scientific Reports

Learning the properties of adaptive regions with functional data analysis

Mehreen R. Mughal, Hillary Koch, Jinguo Huang, Francesca Chiaromonte, Michael DeGiorgio, 2020, PLoS Genetics

Give more data, awareness and control to individual citizens, and they will help COVID-19 containment

Mirco Nanni, Gennady Andrienko, Albert Làszlò Barabàsi, Chiara Boldrini, Francesco Bonchi, Ciro Cattuto, Francesca Chiaromonte, Giovanni Comandé, Marco Conti, Mark Coté, Frank Dignum, Virginia Dignum, Josep Domingo-Ferrer, Paolo Ferragina, Fosca Giannotti, Riccardo Guidotti, Dirk Helbing, Kimmo Kaski, Janos Kertesz, Sune Lehmann, Bruno Lepri, Paul Lukowicz, Stan Matwin, David Megías, Anna Monreale, Katharina Morik, Nuria Oliver, Andrea Passarella, Andrea Passerini, Dino Pedreschi, Alex Pentland, Fabio Pianesi, Francesca Pratesi, Salvatore Rinzivillo, Salvatore Ruggieri, Arno Siebes, Vicenҫ Torra, Roberto Trasarti, Jeroen Van Den Hoven, Alessandro Vespignani, 2020, Transactions on Data Privacy on p. 61-66

On the bias of H-scores for comparing biclusters, and how to correct it.

J Di Iorio, Francesca Chiaromonte, M Cremona, 2020, Bioinformatics (Oxford, England)

High satellite repeat turnover in great apes studied with short- and long-read technologies.

Monika Cechova, Robert S. Harris, Marta Tomaszkiewicz, Barbara Arbeithuber, Francesca Chiaromonte, Kateryna D. Makova, 2019, Molecular Biology and Evolution on p. 2415-2431

Evidence for sharp increase in the economic damages of extreme natural disasters

Matteo Coronese, Francesco Lamperti, Klaus Keller, Francesca Chiaromonte, Andrea Roventini, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 21450-21455

Covariate information matrix for sufficient dimension reduction

Weixin Yao, Debmalya Nandy, Bruce G. Lindsay, Francesca Chiaromonte, 2019, Journal of the American Statistical Association on p. 1752-1764

Functional data analysis for computational biology

Marzia Cremona, Hongyan Xu, Kateryna Dmytrivna Makova, Matthew Logan Reimherr, Francesca Chiaromonte, Pedro Madrigal, 2019, Bioinformatics on p. 3211-3213

Most-Cited Papers

Maternal age effect and severe germ-line bottleneck in the inheritance of human mitochondrial DNA

Boris Rebolledo-Jaramillo, Marcia Shu Wei Su, Nicholas Stoler, Jennifer A. McElhoe, Benjamin Dickins, Daniel Blankenberg, Thorfinn S. Korneliussen, Francesca Chiaromonte, Rasmus Nielsen, Mitchell M. Holland, Ian M. Paul, Anton Nekrutenko, Kateryna D. Makova, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 15474-15479

Computational pan-genomics

Tobias Marschall, Manja Marz, Thomas Abeel, Louis Dijkstra, Bas E. Dutilh, Ali Ghaffaari, Paul Kersey, Wigard P. Kloosterman, Veli Mäkinen, Adam M. Novak, Benedict Paten, David Porubsky, Eric Rivals, Can Alkan, Jasmijn A. Baaijens, Paul I.W. De Bakker, Valentina Boeva, Raoul J.P. Bonnal, Francesca Chiaromonte, Rayan Chikhi, Francesca D. Ciccarelli, Robin Cijvat, Erwin Datema, Cornelia M. Van Duijn, Evan E. Eichler, Corinna Ernst, Eleazar Eskin, Erik Garrison, Mohammed El-Kebir, Gunnar W. Klau, Jan O. Korbel, Eric Wubbo Lameijer, Benjamin Langmead, Marcel Martin, Paul Medvedev, John C. Mu, Pieter Neerincx, Klaasjan Ouwens, Pierre Peterlongo, Nadia Pisanti, Sven Rahmann, Ben Raphael, Knut Reinert, Dick de Ridder, Jeroen de Ridder, Matthias Schlesner, Ole Schulz-Trieglaff, Ashley D. Sanders, Siavash Sheikhizadeh, Carl Shneider, 2018, Briefings in Bioinformatics on p. 118-135

A genome-wide analysis of common fragile sites

Arkarachai Fungtammasan, Erin Walsh, Francesca Chiaromonte, Kristin A. Eckert, Kateryna D. Makova, 2012, Genome Research on p. 993-1005

Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration

Weisheng Wu, Yong Cheng, Cheryl A. Keller Capone, Jason Ernst, Swathi Ashok Kumar, Tejaswini Mishra, Christapher Morrissey, Christine M. Dorman, Kuan Bei Chen, Daniela Drautz, Belinda Giardine, Yoichiro Shibata, Lingyun Song, Max Pimkin, Gregory E. Crawford, Terrence S. Furey, Manolis Kellis, Webb Miller, James Taylor, Stephan C. Schuster, Yu Zhang, Francesca Chiaromonte, Gerd A. Blobel, Mitchell J. Weiss, Ross Cameron Hardison, 2011, Genome Research on p. 1659-1671

A matter of life or death

Yogeshwar D. Kelkar, Kristin A. Eckert, Francesca Chiaromonte, Kateryna D. Makova, 2011, Genome Research on p. 2038-2048

A general theory for nonlinear sufficient dimension reduction

Kuang Yao Lee, Bing Li, Francesca Chiaromonte, 2013, Annals of Statistics on p. 221-249

Distinct mutational behaviors differentiate short tandem repeats from micro satellites in the human genome

Guruprasad Ananda, Erin Walsh, Kimberly D. Jacob, Maria Krasilnikova, Kristin A. Eckert, Francesca Chiaromonte, Kateryna D. Makova, 2013, Genome Biology and Evolution on p. 606-620

Rescuing Alu

Bradley J. Wagstaff, Dale J. Hedges, Rebecca S. Derbes, Rebeca Campos Sanchez, Francesca Chiaromonte, Kateryna D. Makova, Astrid M. Roy-Engel, 2012, PLoS Genetics

A genome-wide view of mutation rate co-variation using multivariate analyses

Guruprasad Ananda, Francesca Chiaromonte, Kateryna D. Makova, 2011, Genome Biology

Evidence for sharp increase in the economic damages of extreme natural disasters

Matteo Coronese, Francesco Lamperti, Klaus Keller, Francesca Chiaromonte, Andrea Roventini, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 21450-21455

News Articles Featuring Francesca Chiaromonte

Unusual DNA folding increases the rates of mutations

DNA sequences that can fold into shapes other than the classic double helix tend to have higher mutation rates than other regions in the human genome. New research by a team of Penn State scientists shows that the elevated mutation rate in these sequences plays a major role in determining regional variation in mutation rates across the genome.

Scientists take a step toward understanding 'jumping genes' effect on the genome

Using state-of-the-art statistical methods, a team of researchers said they may have taken a leap closer to understanding a class of jumping genes, sequences that move to different locations in the human genome, which is the body’s complete set of DNA.

Hurricanes Wreak Greater Havoc as Temperatures Soar

Devastation caused by the most powerful hurricanes has increased by up to twentyfold, according to a newly-identified pattern in natural disasters.

Cost of natural disasters like hurricanes Katrina, Maria are increasing at high end

According to an international team of researchers, The costs of major disasters like hurricanes Katrina, Maria and Dorian or the massive tornado swarms in the Midwest have increased to a disproportionately larger extent than those of lesser events, and these major disasters have become far more expensive.

Data scientists put a staggering price tag on climate change's effects

Hurricanes, floods, and other natural disasters can destroy and displace communities. Beyond the human cost, this damage is unimaginably expensive for many who are affected. New research out Monday puts a price tag on how bad things might get.

Costs of natural disasters are increasing at the high end

While the economic cost of natural disasters has not increased much on average, averages can be deceptive. The costs of major disasters like hurricanes Katrina, Maria and Dorian or the massive tornado swarms in the Midwest have increased to a disproportionately larger extent than those of lesser events, and these major disasters have become far more expensive, according to an international team of researchers.

Francesca Chiaromonte named Huck Chair in Statistics for the Life Sciences

Francesca Chiaromonte, professor of statistics at Penn State, was recently named Lloyd and Dorothy Foehr Huck Chair in Statistics by the University’s Huck Institutes of the Life Sciences.

Mouth bacteria in toddlers may predict obesity, study says

Bacteria in a toddler's mouth might help predict later obesity, new research suggests. Scientists at Penn State University found the composition of microorganisms in the mouths of 2-year-olds offers clues to the child's future weight.

Swabbing a child’s mouth for bacteria could predict how likely they are to become obese

A swab of a toddler’s mouth may predict their odds of growing into obese children, a new study suggests. Scientists at Pennsylvania State University discovered that the harmless microorganisms living in a two-year-old’s mouth were less diverse if they had gained more weight more quickly than most since birth.

Child Weight Gain Trajectories Linked To Oral Microbiota Composition

Gut and oral microbiota perturbations have been observed in obese adults and adolescents; less is known about their influence on weight gain in young children.