Francesca Chiaromonte

Director of the Genome Sciences Institute; Huck Chair in Statistics for the Life Sciences; Professor of Statistics

Francesca Chiaromonte

Research Summary

Developing methods for the analysis of large, high-dimensional and complex data.

Huck Affiliations

Links

Most Recent Publications

Author Correction: Honey bee colony loss linked to parasites, pesticides and extreme weather across the United States (Scientific Reports, (2022), 12, 1, (20787), 10.1038/s41598-022-24946-4)

Luca Insolia, Roberto Molinari, Stephanie R. Rogers, Geoffrey R. Williams, Francesca Chiaromonte, Martina Calovi, 2023, Scientific Reports

Towards Novel Statistical Methods for Anomaly Detection in Industrial Processes

Simone Tonini, Fernando Barsacchi, Francesca Chiaromonte, Daniele Licari, Andrea Vandin, 2023, on p. 147-153

Probabilistic K-means with Local Alignment for Clustering and Motif Discovery in Functional Data

Marzia Cremona, Francesca Chiaromonte, 2023, Journal of Computational and Graphical Statistics

An explainable model of host genetic interactions linked to COVID-19 severity

Anthony Onoja, Nicola Picchiotti, Chiara Fallerini, Margherita Baldassarri, Francesca Fava, Francesca Mari, Sergio Daga, Elisa Benetti, Mirella Bruttini, Maria Palmieri, Susanna Croci, Sara Amitrano, Ilaria Meloni, Elisa Frullanti, Gabriella Doddato, Mirjam Lista, Giada Beligni, Floriana Valentino, Kristina Zguro, Rossella Tita, Annarita Giliberti, Maria Antonietta Mencarelli, Caterina Lo Rizzo, Anna Maria Pinto, Francesca Ariani, Laura Di Sarno, Francesca Montagnani, Mario Tumbarello, Ilaria Rancan, Massimiliano Fabbiani, Barbara Rossetti, Laura Bergantini, Miriana D’Alessandro, Paolo Cameli, David Bennett, Federico Anedda, Simona Marcantonio, Sabino Scolletta, Federico Franchi, Maria Antonietta Mazzei, Susanna Guerrini, Edoardo Conticini, Luca Cantarini, Bruno Frediani, Danilo Tacconi, Chiara Spertilli Raffaelli, Marco Feri, Alice Donati, Raffaele Scala, Francesca Chiaromonte, 2022, Communications Biology

Venture capital investments through the lens of network and functional data analysis

Christian Esposito, Marco Gortan, Lorenzo Testa, Francesca Chiaromonte, Giorgio Fagiolo, Andrea Mina, Giulio Rossetti, 2022, Applied Network Science

Honey bee colony loss linked to parasites, pesticides and extreme weather across the United States

Luca Insolia, Roberto Molinari, Stephanie R. Rogers, Geoffrey R. Williams, Francesca Chiaromonte, Martina Calovi, 2022, Scientific Reports

Automated and distributed statistical analysis of economic agent-based models

Andrea Vandin, Daniele Giachini, Francesco Lamperti, Francesca Chiaromonte, 2022, Journal of Economic Dynamics and Control

MultiVeStA: Statistical Analysis of Economic Agent-Based Models by Statistical Model Checking

Andrea Vandin, Daniele Giachini, Francesco Lamperti, Francesca Chiaromonte, 2022, on p. 3-6

Can You Always Reap What You Sow? Network and Functional Data Analysis of Venture Capital Investments in Health-Tech Companies

Christian Esposito, Marco Gortan, Lorenzo Testa, Francesca Chiaromonte, Giorgio Fagiolo, Andrea Mina, Giulio Rossetti, 2022, on p. 744-755

Advanced age increases frequencies of de novo mitochondrial mutations in macaque oocytes and somatic tissues

Barbara Arbeithuber, Mazia Cremona, James Hester, Alison Barrett, Bonnie Higgins, Kate Anthony, Francesca Chiaromonte, Francisco J. Diaz, Kateryna Makova, 2022, Proceedings of the National Academy of Sciences of the United States of America on p. e2118740119

Most-Cited Papers

Computational pan-genomics: Status, promises and challenges

Tobias Marschall, Manja Marz, Thomas Abeel, Louis Dijkstra, Bas E. Dutilh, Ali Ghaffaari, Paul Kersey, Wigard P. Kloosterman, Veli Mäkinen, Adam M. Novak, Benedict Paten, David Porubsky, Eric Rivals, Can Alkan, Jasmijn A. Baaijens, Paul I.W. De Bakker, Valentina Boeva, Raoul J.P. Bonnal, Francesca Chiaromonte, Rayan Chikhi, Francesca D. Ciccarelli, Robin Cijvat, Erwin Datema, Cornelia M. Van Duijn, Evan E. Eichler, Corinna Ernst, Eleazar Eskin, Erik Garrison, Mohammed El-Kebir, Gunnar W. Klau, Jan O. Korbel, Eric Wubbo Lameijer, Benjamin Langmead, Marcel Martin, Paul Medvedev, John C. Mu, Pieter Neerincx, Klaasjan Ouwens, Pierre Peterlongo, Nadia Pisanti, Sven Rahmann, Ben Raphael, Knut Reinert, Dick de Ridder, Jeroen de Ridder, Matthias Schlesner, Ole Schulz-Trieglaff, Ashley D. Sanders, Siavash Sheikhizadeh, Carl Shneider, 2018, Briefings in Bioinformatics on p. 118-135

Maternal age effect and severe germ-line bottleneck in the inheritance of human mitochondrial DNA

Boris Rebolledo-Jaramillo, Marcia Su, Nicholas Stoler, Jennifer A. McElhoe, N Stoler, Ben Dickins, D Blankenberg, Thorfinn S. Korneliussen, Francesca Chiaromonte, Rasmus Nielsen, M Holland, Ian M. Paul, Anton Nekrutenko, Kateryna D. Makova, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 15474-15479

Evidence for sharp increase in the economic damages of extreme natural disasters

Matteo Coronese, Francesco Lamperti, Klaus Keller, Francesca Chiaromonte, Andrea Roventini, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 21450-21455

A general theory for nonlinear sufficient dimension reduction: Formulation and estimation

Kuang Yao Lee, Bing Li, Francesca Chiaromonte, 2013, Annals of Statistics on p. 221-249

Distinct mutational behaviors differentiate short tandem repeats from micro satellites in the human genome

Guruprasad Ananda, Erin Walsh, Kimberly D. Jacob, Maria Krasilnikova, Kristin A. Eckert, Francesca Chiaromonte, Kateryna D. Makova, 2013, Genome Biology and Evolution on p. 606-620

Non-B DNA: A major contributor to small-and large-scale variation in nucleotide substitution frequencies across the genome

Wilfried Guiblet, Marzia Cremona, Robert Harris, Di Chen, Kristin A. Eckert, Francesca Chiaromonte, Yi Fei Huang, Kateryna D. Makova, 2021, Nucleic Acids Research on p. 1497--1516

Child Weight Gain Trajectories Linked To Oral Microbiota Composition

Sarah J.C. Craig, Daniel Blankenberg, Alice Carla Luisa Parodi, Ian M. Paul, Leann L. Birch, Jennifer S. Savage, Michele E. Marini, Jennifer L. Stokes, Anton Nekrutenko, Matthew Reimherr, Francesca Chiaromonte, Kateryna D. Makova, 2018, Scientific Reports

Long-read sequencing technology indicates genome-wide effects of non-B DNA on polymerization speed and error rate

Wilfried M. Guiblet, Marzia A. Cremona, Monika Cechova, Robert S. Harris, Iva Kejnovská, Eduard Kejnovsky, Kristin Eckert, Francesca Chiaromonte, Kateryna D. Makova, 2018, Genome Research on p. 1767-1778

Integration and Fixation Preferences of Human and Mouse Endogenous Retroviruses Uncovered with Functional Data Analysis

Rebeca Campos-Sánchez, Marzia A. Cremona, Alessia Pini, Francesca Chiaromonte, Kateryna D. Makova, 2016, PLoS Computational Biology

Age-related accumulation of de novo mitochondrial mutations in mammalian oocytes and somatic tissues

Barbara Arbeithuber, James Hester, Marzia A. Cremona, Nicholas Stoler, Arslan Zaidi, Bonnie Higgins, Kate Anthony, Francesca Chiaromonte, Francisco J. Diaz, Kateryna D. Makova, 2020, PLoS Biology

News Articles Featuring Francesca Chiaromonte

Feb 17, 2023

For a best friend to Florida bees, each rescue is personal

Melissa Sorokin sees herself as "a bee advocate," deeply passionate about helping to rescue the at-risk creatures that play such a critical role in biodiversity.

Full Article

Feb 01, 2023

Penn State study shows many causes of Honey bee colony loss

For years, honey bee colonies have been dying off at alarming rates. According to one study, between April 2019 and April 2020, there was a 43% colony loss across the United States. When you consider that one-third of the food we eat comes from crops pollinated by honey bees, “alarming” really is the right word for the situation.

Full Article

Jan 30, 2023

Parasites, pesticides, climate change linked to loss of honey bee colonies

About 43% of honey bee colonies were lost in the span of one year, according to a new study that considered multiple factors that put a crucial part of the ecosystem at risk.

Full Article

Jan 30, 2023

Honey bee colony loss in the U.S. linked to mites, extreme weather, pesticides

About one-third of the food eaten by Americans comes from crops pollinated by honey bees, yet the insect is dying off at alarming rates.

Full Article

Aug 30, 2021

Staying home, primary care, and limiting contagion hubs may curb COVID-19 deaths

Staying home and limiting local travel, supporting access to primary care, and limiting contacts in contagion hubs — including hospitals, schools, and workplaces — are strategies that might help reduce COVID-19-related deaths, according to new research.

Full Article

Feb 04, 2021

Unusual DNA folding increases the rates of mutations

DNA sequences that can fold into shapes other than the classic double helix tend to have higher mutation rates than other regions in the human genome. New research by a team of Penn State scientists shows that the elevated mutation rate in these sequences plays a major role in determining regional variation in mutation rates across the genome.

Full Article

Sep 29, 2020

Scientists take a step toward understanding 'jumping genes' effect on the genome

Using state-of-the-art statistical methods, a team of researchers said they may have taken a leap closer to understanding a class of jumping genes, sequences that move to different locations in the human genome, which is the body’s complete set of DNA.

Full Article

Dec 12, 2019

Hurricanes Wreak Greater Havoc as Temperatures Soar

Devastation caused by the most powerful hurricanes has increased by up to twentyfold, according to a newly-identified pattern in natural disasters.

Full Article

Oct 08, 2019

Cost of natural disasters like hurricanes Katrina, Maria are increasing at high end

According to an international team of researchers, The costs of major disasters like hurricanes Katrina, Maria and Dorian or the massive tornado swarms in the Midwest have increased to a disproportionately larger extent than those of lesser events, and these major disasters have become far more expensive.

Full Article

Oct 07, 2019

Data scientists put a staggering price tag on climate change's effects

Hurricanes, floods, and other natural disasters can destroy and displace communities. Beyond the human cost, this damage is unimaginably expensive for many who are affected. New research out Monday puts a price tag on how bad things might get.

Full Article