Francesca Chiaromonte
Director of the Genome Sciences Institute; Huck Chair in Statistics for the Life Sciences; Professor of Statistics
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0325 Thomas
University Park, PA - fxc11@psu.edu
- 814-865-7075
Research Summary
Developing methods for the analysis of large, high-dimensional and complex data.
Huck Affiliations
Links
Most Recent Publications
Venture capital investments through the lens of network and functional data analysis
Christian Esposito, Marco Gortan, Lorenzo Testa, Francesca Chiaromonte, Giorgio Fagiolo, Andrea Mina, Giulio Rossetti, 2022, Applied Network Science
Honey bee colony loss linked to parasites, pesticides and extreme weather across the United States
Luca Insolia, Roberto Molinari, Stephanie R. Rogers, Geoffrey R. Williams, Francesca Chiaromonte, Martina Calovi, 2022, Scientific Reports
An explainable model of host genetic interactions linked to COVID-19 severity
Anthony Onoja, Nicola Picchiotti, Chiara Fallerini, Margherita Baldassarri, Francesca Fava, Francesca Mari, Sergio Daga, Elisa Benetti, Mirella Bruttini, Maria Palmieri, Susanna Croci, Sara Amitrano, Ilaria Meloni, Elisa Frullanti, Gabriella Doddato, Mirjam Lista, Giada Beligni, Floriana Valentino, Kristina Zguro, Rossella Tita, Annarita Giliberti, Maria Antonietta Mencarelli, Caterina Lo Rizzo, Anna Maria Pinto, Francesca Ariani, Laura Di Sarno, Francesca Montagnani, Mario Tumbarello, Ilaria Rancan, Massimiliano Fabbiani, Barbara Rossetti, Laura Bergantini, Miriana D’Alessandro, Paolo Cameli, David Bennett, Federico Anedda, Simona Marcantonio, Sabino Scolletta, Federico Franchi, Maria Antonietta Mazzei, Susanna Guerrini, Edoardo Conticini, Luca Cantarini, Bruno Frediani, Danilo Tacconi, Chiara Spertilli Raffaelli, Marco Feri, Alice Donati, Raffaele Scala, Francesca Chiaromonte, 2022, Communications Biology
Automated and distributed statistical analysis of economic agent-based models
Andrea Vandin, Daniele Giachini, Francesco Lamperti, Francesca Chiaromonte, 2022, Journal of Economic Dynamics and Control
Can You Always Reap What You Sow? Network and Functional Data Analysis of Venture Capital Investments in Health-Tech Companies
Christian Esposito, Marco Gortan, Lorenzo Testa, Francesca Chiaromonte, Giorgio Fagiolo, Andrea Mina, Giulio Rossetti, 2022, on p. 744-755
MultiVeStA: Statistical Analysis of Economic Agent-Based Models by Statistical Model Checking
Andrea Vandin, Daniele Giachini, Francesco Lamperti, Francesca Chiaromonte, 2022, on p. 3-6
Advanced age increases frequencies of de novo mitochondrial mutations in macaque oocytes and somatic tissues
Barbara Arbeithuber, Mazia Cremona, James Hester, Alison Barrett, Bonnie Higgins, Kate Anthony, Francesca Chiaromonte, Francisco J. Diaz, Kateryna D. Makova, 2022, Proceedings of the National Academy of Sciences of the United States of America on p. e2118740119
Functional data analysis characterizes the shapes of the first COVID-19 epidemic wave in Italy
Tobia Boschi, Jacopo Di Iorio, Lorenzo Testa, Marzia A. Cremona, Francesca Chiaromonte, 2021, Scientific Reports
Covariate Information Number for Feature Screening in Ultrahigh-Dimensional Supervised Problems
Debmalya Nandy, Francesca Chiaromonte, Runze Li, 2021, Journal of the American Statistical Association
Can you always reap what you sow? Network and functional data analysis of VC investments in health-tech companies
Christian Esposito, Marco Gortan, Lorenzo Testa, Francesca Chiaromonte, Giorgio Fagiolo, Andrea Mina, Giulio Rossetti, 2021,
Most-Cited Papers
Computational pan-genomics: Status, promises and challenges
Tobias Marschall, Manja Marz, Thomas Abeel, Louis Dijkstra, Bas E. Dutilh, Ali Ghaffaari, Paul Kersey, Wigard P. Kloosterman, Veli Mäkinen, Adam M. Novak, Benedict Paten, David Porubsky, Eric Rivals, Can Alkan, Jasmijn A. Baaijens, Paul I.W. De Bakker, Valentina Boeva, Raoul J.P. Bonnal, Francesca Chiaromonte, Rayan Chikhi, Francesca D. Ciccarelli, Robin Cijvat, Erwin Datema, Cornelia M. Van Duijn, Evan E. Eichler, Corinna Ernst, Eleazar Eskin, Erik Garrison, Mohammed El-Kebir, Gunnar W. Klau, Jan O. Korbel, Eric Wubbo Lameijer, Benjamin Langmead, Marcel Martin, Paul Medvedev, John C. Mu, Pieter Neerincx, Klaasjan Ouwens, Pierre Peterlongo, Nadia Pisanti, Sven Rahmann, Ben Raphael, Knut Reinert, Dick de Ridder, Jeroen de Ridder, Matthias Schlesner, Ole Schulz-Trieglaff, Ashley D. Sanders, Siavash Sheikhizadeh, Carl Shneider, 2018, Briefings in Bioinformatics on p. 118-135
Maternal age effect and severe germ-line bottleneck in the inheritance of human mitochondrial DNA
Boris Rebolledo-Jaramillo, Marcia Su, Nicholas Stoler, Jennifer A. McElhoe, N Stoler, Ben Dickins, D Blankenberg, Thorfinn S. Korneliussen, Francesca Chiaromonte, Rasmus Nielsen, M Holland, Ian M. Paul, Anton Nekrutenko, Kateryna D. Makova, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 15474-15479
Evidence for sharp increase in the economic damages of extreme natural disasters
Matteo Coronese, Francesco Lamperti, Klaus Keller, Francesca Chiaromonte, Andrea Roventini, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 21450-21455
A general theory for nonlinear sufficient dimension reduction: Formulation and estimation
Kuang Yao Lee, Bing Li, Francesca Chiaromonte, 2013, Annals of Statistics on p. 221-249
Distinct mutational behaviors differentiate short tandem repeats from micro satellites in the human genome
Guruprasad Ananda, Erin Walsh, Kimberly D. Jacob, Maria Krasilnikova, Kristin A. Eckert, Francesca Chiaromonte, Kateryna D. Makova, 2013, Genome Biology and Evolution on p. 606-620
Non-B DNA: A major contributor to small-and large-scale variation in nucleotide substitution frequencies across the genome
Wilfried Guiblet, Marzia Cremona, Robert Harris, Di Chen, Kristin A. Eckert, Francesca Chiaromonte, Yi Fei Huang, Kateryna D. Makova, 2021, Nucleic Acids Research on p. 1497--1516
Child Weight Gain Trajectories Linked To Oral Microbiota Composition
Sarah J.C. Craig, Daniel Blankenberg, Alice Carla Luisa Parodi, Ian M. Paul, Leann L. Birch, Jennifer S. Savage, Michele E. Marini, Jennifer L. Stokes, Anton Nekrutenko, Matthew Reimherr, Francesca Chiaromonte, Kateryna D. Makova, 2018, Scientific Reports
Long-read sequencing technology indicates genome-wide effects of non-B DNA on polymerization speed and error rate
Wilfried M. Guiblet, Marzia A. Cremona, Monika Cechova, Robert S. Harris, Iva Kejnovská, Eduard Kejnovsky, Kristin Eckert, Francesca Chiaromonte, Kateryna D. Makova, 2018, Genome Research on p. 1767-1778
Integration and Fixation Preferences of Human and Mouse Endogenous Retroviruses Uncovered with Functional Data Analysis
Rebeca Campos-Sánchez, Marzia A. Cremona, Alessia Pini, Francesca Chiaromonte, Kateryna D. Makova, 2016, PLoS Computational Biology
Age-related accumulation of de novo mitochondrial mutations in mammalian oocytes and somatic tissues
Barbara Arbeithuber, James Hester, Marzia A. Cremona, Nicholas Stoler, Arslan Zaidi, Bonnie Higgins, Kate Anthony, Francesca Chiaromonte, Francisco J. Diaz, Kateryna D. Makova, 2020, PLoS Biology
News Articles Featuring Francesca Chiaromonte
Feb 01, 2023
Penn State study shows many causes of Honey bee colony loss
For years, honey bee colonies have been dying off at alarming rates. According to one study, between April 2019 and April 2020, there was a 43% colony loss across the United States. When you consider that one-third of the food we eat comes from crops pollinated by honey bees, “alarming” really is the right word for the situation.
Full Article
Jan 30, 2023
Parasites, pesticides, climate change linked to loss of honey bee colonies
About 43% of honey bee colonies were lost in the span of one year, according to a new study that considered multiple factors that put a crucial part of the ecosystem at risk.
Full Article
Jan 30, 2023
Honey bee colony loss in the U.S. linked to mites, extreme weather, pesticides
About one-third of the food eaten by Americans comes from crops pollinated by honey bees, yet the insect is dying off at alarming rates.
Full Article
Aug 30, 2021
Staying home, primary care, and limiting contagion hubs may curb COVID-19 deaths
Staying home and limiting local travel, supporting access to primary care, and limiting contacts in contagion hubs — including hospitals, schools, and workplaces — are strategies that might help reduce COVID-19-related deaths, according to new research.
Full Article
Feb 04, 2021
Unusual DNA folding increases the rates of mutations
DNA sequences that can fold into shapes other than the classic double helix tend to have higher mutation rates than other regions in the human genome. New research by a team of Penn State scientists shows that the elevated mutation rate in these sequences plays a major role in determining regional variation in mutation rates across the genome.
Full Article
Sep 29, 2020
Scientists take a step toward understanding 'jumping genes' effect on the genome
Using state-of-the-art statistical methods, a team of researchers said they may have taken a leap closer to understanding a class of jumping genes, sequences that move to different locations in the human genome, which is the body’s complete set of DNA.
Full Article
Dec 12, 2019
Hurricanes Wreak Greater Havoc as Temperatures Soar
Devastation caused by the most powerful hurricanes has increased by up to twentyfold, according to a newly-identified pattern in natural disasters.
Full Article
Oct 08, 2019
Cost of natural disasters like hurricanes Katrina, Maria are increasing at high end
According to an international team of researchers, The costs of major disasters like hurricanes Katrina, Maria and Dorian or the massive tornado swarms in the Midwest have increased to a disproportionately larger extent than those of lesser events, and these major disasters have become far more expensive.
Full Article
Oct 07, 2019
Data scientists put a staggering price tag on climate change's effects
Hurricanes, floods, and other natural disasters can destroy and displace communities. Beyond the human cost, this damage is unimaginably expensive for many who are affected. New research out Monday puts a price tag on how bad things might get.
Full Article
Oct 07, 2019
Costs of natural disasters are increasing at the high end
While the economic cost of natural disasters has not increased much on average, averages can be deceptive. The costs of major disasters like hurricanes Katrina, Maria and Dorian or the massive tornado swarms in the Midwest have increased to a disproportionately larger extent than those of lesser events, and these major disasters have become far more expensive, according to an international team of researchers.
Full Article