Edward O’Brien

Professor of Chemistry

Edward O’Brien

Research Summary

Developing and applying Physical Bioinformatic techniques to measure rates of translation transcriptome-wide and their molecular origins as relates to fundamental biology and disease.

Huck Graduate Students

Huck Affiliations

Publication Tags

Proteins Protein Folding Protein Ribosomes Kinetics Messenger Rna Codon Simulation Force Molecules Proteome Experiments Molecular Dynamics Peptides Tunnels Genes Molecule Antibodies Biochemistry Enzymes Electrostatic Force Folding Genome Static Electricity Thermodynamics

Most Recent Publications

Daniel A. Nissley, Yang Jiang, Fabio Trovato, Ian Sitarik, Karthik B. Narayan, Philip To, Yingzi Xia, Stephen D. Fried, Edward P. O’Brien, 2022, Nature Communications

Boyang Zhao, Yiyun Rao, Scott Leighow, Edward P. O’Brien, Luke Gilbert, Justin R. Pritchard, 2022, Nature Communications

Mang Zhu, Erich R. Kuechler, Ryan W.K. Wong, Gaetano Calabrese, Ian M. Sitarik, Viraj Rana, Nikolay Stoynov, Edward P. O'Brien, Jörg Gsponer, Thibault Mayor, 2022, Cell Reports

Hung Nguyen, Pham Dang Lan, Daniel A. Nissley, Edward P. O'Brien, Mai Suan Li, 2022, Journal of Physical Chemistry B on p. 2812-2823

Erratum: Ribosome Elongation Kinetics of Consecutively Charged Residues Are Coupled to Electrostatic Force (Biochemistry (2021) 60:43 (3223−3235) DOI:10.1021/acs.biochem.1c00507)

Sarah E. Leininger, Judith Rodriguez, Quyen V. Vu, Yang Jiang, Mai Suan Li, Carol Deutsch, Edward P. O’Brien, 2022, Biochemistry on p. 125

Ajeet K. Sharma, Johannes Venezian, Ayala Shiber, Günter Kramer, Bernd Bukau, Edward P. O’Brien, 2021, Proceedings of the National Academy of Sciences of the United States of America

Danying Shao, Nabeel Ahmed, Nishant Soni, Edward P. O’Brien, 2021, BMC Bioinformatics

Haider Inam, Ivan Sokirniy, Yiyun Rao, Anushka Shah, Farnaz Naeemikia, Edward O'Brien, Cheng Dong, David M. McCandlish, Justin R. Pritchard, 2021, iScience

Sarah E. Leininger, Judith Rodriguez, Quyen V. Vu, Yang Jiang, Mai Suan Li, Carol Deutsch, Edward P. O'Brien, 2021, Biochemistry on p. 3223-3235

Quyen V. Vu, Yang Jiang, Mai Suan Li, Edward P. O'Brien, 2021, Chemical Science on p. 11851-11857

Most-Cited Papers

Ola B. Nilsson, Rickard Hedman, Jacopo Marino, Stephan Wickles, Lukas Bischoff, Magnus Johansson, Annika Müller-Lucks, Fabio Trovato, Joseph D. Puglisi, Edward P. O'Brien, Roland Beckmann, Gunnar von Heijne, 2015, Cell Reports on p. 1533-1540

Kristina Döring, Nabeel Ahmed, Trine Riemer, Harsha Garadi Suresh, Yevhen Vainshtein, Markus Habich, Jan Riemer, Matthias P. Mayer, Edward P. O'Brien, Günter Kramer, Bernd Bukau, 2017, Cell on p. 298-311.e20

Edward P. O'Brien, Michele Vendruscolo, Christopher M. Dobson, 2012, Nature Communications

Hoang Linh Nguyen, Pham Dang Lan, Nguyen Quoc Thai, Daniel A. Nissley, Edward P. O'Brien, Mai Suan Li, 2020, Journal of Physical Chemistry B on p. 7336-7347

Understanding the influence of codon translation rates on cotranslational protein folding

Edward P. O'Brien, Prajwal Ciryam, Michele Vendruscolo, Christopher M. Dobson, 2014, Accounts of Chemical Research on p. 1536-1544

Edward P. O'Brien, Bernard R. Brooks, D. Thirumalai, 2012, Journal of the American Chemical Society on p. 979-987

Trigger factor slows Co-translational folding through kinetic trapping while sterically protecting the nascent chain from aberrant cytosolic interactions

Edward P. O'Brien, John Christodoulou, Michele Vendruscolo, Christopher M. Dobson, 2012, Journal of the American Chemical Society on p. 10920-10932

Edward P. O'brien, Michele Vendruscolo, Christopher M. Dobson, 2014, Nature Communications

Protein folding: From theory to practice

D. Thirumalai, Zhenxing Liu, Edward P. O'Brien, Govardhan Reddy, 2013, Current Opinion in Structural Biology on p. 22-29

Timing is everything: Unifying Codon translation rates and nascent proteome behavior

Daniel A. Nissley, Edward P. Obrien, 2014, Journal of the American Chemical Society on p. 17892-17898