Edward O’Brien
Professor of Chemistry
-
0104 Chemistry
University Park, PA - He/His
- epo2@psu.edu
- 814-867-5100
Research Summary
Developing and applying Physical Bioinformatic techniques to measure rates of translation transcriptome-wide and their molecular origins as relates to fundamental biology and disease.
Huck Graduate Students
Huck Affiliations
Publication Tags
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Proteins Protein Folding Protein Kinetics Ribosomes Codon Enzymes Simulation Proteome Elongation Reaction Kinetics Molecular Dynamics Antibodies Folding Messenger Rna Proteostasis Molecules Experiments Viruses Tunnels Physics Force Stem Cells Peptides SubstratesMost Recent Publications
Synonymous Mutations Can Alter Protein Dimerization Through Localized Interface Misfolding Involving Self-entanglements.
P Lan, D Nissley, I Sitarik, Q Vu, Y Jiang, P To, Y Xia, S Fried, M Li, Edward O'Brien, 2024, Journal of molecular biology on p. 168487
Deciphering the free energy landscapes of SARS-CoV-2 wild type and Omicron variant interacting with human ACE2.
P Lan, D Nissley, Edward O'Brien, T Nguyen, M Li, 2024, The Journal of chemical physics
Non-covalent Lasso Entanglements in Folded Proteins: Prevalence, Functional Implications, and Evolutionary Significance.
V Rana, I Sitarik, J Petucci, Y Jiang, H Song, Edward O'Brien, 2024, Journal of molecular biology on p. 168459
How soluble misfolded proteins bypass chaperones at the molecular level
Ritaban Halder, Daniel A. Nissley, Ian Sitarik, Yang Jiang, Yiyun Rao, Quyen V. Vu, Mai Suan Li, Justin Pritchard, Edward P. O’Brien, 2023, Nature Communications
Incorporating mutational heterogeneity to identify genes that are enriched for synonymous mutations in cancer
Yiyun Rao, Nabeel Ahmed, Justin Pritchard, Edward P. O’Brien, 2023, BMC Bioinformatics
Is Posttranslational Folding More Efficient Than Refolding from a Denatured State: A Computational Study
Quyen V. Vu, Daniel A. Nissley, Yang Jiang, Edward P. O’Brien, Mai Suan Li, 2023, Journal of Physical Chemistry B on p. 4761-4774
Universal protein misfolding intermediates can bypass the proteostasis network and remain soluble and less functional
Daniel A. Nissley, Yang Jiang, Fabio Trovato, Ian Sitarik, Karthik B. Narayan, Philip To, Yingzi Xia, Stephen D. Fried, Edward P. O’Brien, 2022, Nature Communications
Modeling Ensembles of Enzyme Reaction Pathways with Hi-MSM Reveals the Importance of Accounting for Pathway Diversity
Joseph R. Persichetti, Yang Jiang, Phillip S. Hudson, Edward P. O'Brien, 2022, Journal of Physical Chemistry B on p. 9748-9758
Pulse labeling reveals the tail end of protein folding by proteome profiling
Mang Zhu, Erich R. Kuechler, Ryan W.K. Wong, Gaetano Calabrese, Ian M. Sitarik, Viraj Rana, Nikolay Stoynov, Edward P. O'Brien, Jörg Gsponer, Thibault Mayor, 2022, Cell Reports
Cocktail of REGN Antibodies Binds More Strongly to SARS-CoV-2 Than Its Components, but the Omicron Variant Reduces Its Neutralizing Ability
Hung Nguyen, Pham Dang Lan, Daniel A. Nissley, Edward P. O'Brien, Mai Suan Li, 2022, Journal of Physical Chemistry B on p. 2812-2823
Most-Cited Papers
Cotranslational Protein Folding inside the Ribosome Exit Tunnel
Ola B. Nilsson, Rickard Hedman, Jacopo Marino, Stephan Wickles, Lukas Bischoff, Magnus Johansson, Annika Müller-Lucks, Fabio Trovato, Joseph D. Puglisi, Edward P. O'Brien, Roland Beckmann, Gunnar von Heijne, 2015, Cell Reports on p. 1533-1540
Profiling Ssb-Nascent Chain Interactions Reveals Principles of Hsp70-Assisted Folding
Kristina Döring, Nabeel Ahmed, Trine Riemer, Harsha Garadi Suresh, Yevhen Vainshtein, Markus Habich, Jan Riemer, Matthias P. Mayer, Edward P. O'Brien, Günter Kramer, Bernd Bukau, 2017, Cell on p. 298-311.e20
Does SARS-CoV-2 bind to human ACE2 more strongly than does SARS-CoV?
Hoang Linh Nguyen, Pham Dang Lan, Nguyen Quoc Thai, Daniel A. Nissley, Edward P. O'Brien, Mai Suan Li, 2020, Journal of Physical Chemistry B on p. 7336-7347
Understanding the influence of codon translation rates on cotranslational protein folding
Edward P. O'Brien, Prajwal Ciryam, Michele Vendruscolo, Christopher M. Dobson, 2014, Accounts of Chemical Research on p. 1536-1544
Kinetic modelling indicates that fast-translating codons can coordinate cotranslational protein folding by avoiding misfolded intermediates
Edward P. O'brien, Michele Vendruscolo, Christopher M. Dobson, 2014, Nature Communications
Non-equilibrium coupling of protein structure and function to translation–elongation kinetics
Ajeet K. Sharma, Edward P. O'Brien, 2018, Current Opinion in Structural Biology on p. 94-103
Timing is everything: Unifying Codon translation rates and nascent proteome behavior
Daniel A. Nissley, Edward P. Obrien, 2014, Journal of the American Chemical Society on p. 17892-17898
A chemical kinetic basis for measuring translation initiation and elongation rates from ribosome profiling data
Ajeet K. Sharma, Pietro Sormanni, Nabeel Ahmed, Prajwal Ciryam, Ulrike A. Friedrich, Günter Kramer, Edward P. O'Brien, 2019, PLoS Computational Biology
Accurate prediction of cellular co-translational folding indicates proteins can switch from post- to co-translational folding
Daniel A. Nissley, Ajeet K. Sharma, Nabeel Ahmed, Ulrike A. Friedrich, Günter Kramer, Bernd Bukau, Edward P. O'Brien, 2016, Nature Communications
Kinetic and structural comparison of a protein’s cotranslational folding and refolding pathways
Avi J. Samelson, Eric Bolin, Shawn M. Costello, Ajeet K. Sharma, Edward P. O’Brien, Susan Marqusee, 2018, Science advances