Edward O’Brien

Professor of Chemistry

Edward O’Brien

Research Summary

Developing and applying Physical Bioinformatic techniques to measure rates of translation transcriptome-wide and their molecular origins as relates to fundamental biology and disease.

Huck Graduate Students

Huck Affiliations

Publication Tags

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Proteins Protein Folding Protein Kinetics Ribosomes Codon Enzymes Proteome Simulation Elongation Reaction Kinetics Folding Messenger Rna Proteostasis Molecules Experiments Tunnels Physics Force Stem Cells Peptides Substrates Molecular Dynamics Secondary Structure Quality Control

Most Recent Publications

Pham Dang Lan, Daniel Allen Nissley, Ian Sitarik, Quyen V. Vu, Yang Jiang, Philip To, Yingzi Xia, Stephen D. Fried, Mai Suan Li, Edward P. O'Brien, 2024, Journal of Molecular Biology

Non-covalent Lasso Entanglements in Folded Proteins: Prevalence, Functional Implications, and Evolutionary Significance

Viraj Rana, Ian Sitarik, Justin Petucci, Yang Jiang, Hyebin Song, Edward P. O'Brien, 2024, Journal of Molecular Biology

Yang Jiang, Charlotte M. Deane, Garrett M. Morris, Edward P. O’Brien, 2024, PLoS Computational Biology

Pham Dang Lan, Daniel A. Nissley, Edward P. O’Brien, Toan T. Nguyen, Mai Suan Li, 2024, Journal of Chemical Physics

Ritaban Halder, Daniel A. Nissley, Ian Sitarik, Yang Jiang, Yiyun Rao, Quyen V. Vu, Mai Suan Li, Justin Pritchard, Edward P. O’Brien, 2023, Nature Communications

Yiyun Rao, Nabeel Ahmed, Justin Pritchard, Edward P. O’Brien, 2023, BMC Bioinformatics

Quyen V. Vu, Daniel A. Nissley, Yang Jiang, Edward P. O’Brien, Mai Suan Li, 2023, Journal of Physical Chemistry B on p. 4761-4774

Daniel A. Nissley, Yang Jiang, Fabio Trovato, Ian Sitarik, Karthik B. Narayan, Philip To, Yingzi Xia, Stephen D. Fried, Edward P. O’Brien, 2022, Nature Communications

Modeling Ensembles of Enzyme Reaction Pathways with Hi-MSM Reveals the Importance of Accounting for Pathway Diversity

Joseph R. Persichetti, Yang Jiang, Phillip S. Hudson, Edward P. O'Brien, 2022, Journal of Physical Chemistry B on p. 9748-9758

Mang Zhu, Erich R. Kuechler, Ryan W.K. Wong, Gaetano Calabrese, Ian M. Sitarik, Viraj Rana, Nikolay Stoynov, Edward P. O'Brien, Jörg Gsponer, Thibault Mayor, 2022, Cell Reports

Most-Cited Papers

Ola B. Nilsson, Rickard Hedman, Jacopo Marino, Stephan Wickles, Lukas Bischoff, Magnus Johansson, Annika Müller-Lucks, Fabio Trovato, Joseph D. Puglisi, Edward P. O'Brien, Roland Beckmann, Gunnar von Heijne, 2015, Cell Reports on p. 1533-1540

Kristina Döring, Nabeel Ahmed, Trine Riemer, Harsha Garadi Suresh, Yevhen Vainshtein, Markus Habich, Jan Riemer, Matthias P. Mayer, Edward P. O'Brien, Günter Kramer, Bernd Bukau, 2017, Cell on p. 298-311.e20

Hoang Linh Nguyen, Pham Dang Lan, Nguyen Quoc Thai, Daniel A. Nissley, Edward P. O'Brien, Mai Suan Li, 2020, Journal of Physical Chemistry B on p. 7336-7347

Understanding the influence of codon translation rates on cotranslational protein folding

Edward P. O'Brien, Prajwal Ciryam, Michele Vendruscolo, Christopher M. Dobson, 2014, Accounts of Chemical Research on p. 1536-1544

Edward P. O'brien, Michele Vendruscolo, Christopher M. Dobson, 2014, Nature Communications

Timing is everything: Unifying Codon translation rates and nascent proteome behavior

Daniel A. Nissley, Edward P. Obrien, 2014, Journal of the American Chemical Society on p. 17892-17898

Ajeet K. Sharma, Pietro Sormanni, Nabeel Ahmed, Prajwal Ciryam, Ulrike A. Friedrich, Günter Kramer, Edward P. O'Brien, 2019, PLoS Computational Biology

Ajeet K. Sharma, Edward P. O'Brien, 2018, Current Opinion in Structural Biology on p. 94-103

Daniel A. Nissley, Ajeet K. Sharma, Nabeel Ahmed, Ulrike A. Friedrich, Günter Kramer, Bernd Bukau, Edward P. O'Brien, 2016, Nature Communications

Avi J. Samelson, Eric Bolin, Shawn M. Costello, Ajeet K. Sharma, Edward P. O’Brien, Susan Marqusee, 2018, Science advances