Edward Gunther

Professor of Medicine

Edward Gunther

Huck Affiliations

Publication Tags

Neoplasms Breast Neoplasms Breast Carcinogenesis Mutation Oncogenes Genes Human Tert Protein Recurrence Epithelial Cells Renilla Luciferases Human Mammary Glands Therapeutics Clonal Evolution Chromosomes Phosphatidylinositol 3 Kinases Bacterial Artificial Chromosomes Neoplasm Metastasis Carcinogens Transcription Messenger Rna Telomerase Doxycycline Transgenic Mice Morphogenesis

Most Recent Papers

Evolution of Relapse-Proficient Subclones Constrained by Collateral Sensitivity to Oncogene Overdose in Wnt-Driven Mammary Cancer

Ross R. Keller, Edward J. Gunther, 2019, Cell Reports on p. 893-905.e4

Carcinogen-specific mutations in preferred Ras-Raf pathway oncogenes directed by strand bias

Ross R. Keller, Shelley A. Gestl, Amy Q. Lu, Alicia Hoke, David J. Feith, Edward J. Gunther, 2016, Carcinogenesis on p. 810-816

Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers

Allison S. Cleary, Travis L. Leonard, Shelley A. Gestl, Edward J. Gunther, 2014, Nature on p. 113-117

Basal but not luminal mammary epithelial cells require PI3K/mTOR signaling for Ras-driven overgrowth

Kristin A. Plichta, Jessica L. Mathers, Shelley A. Gestl, Adam Bleier Glick, Edward Gunther, 2012, Cancer Research on p. 5856-5866

A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis

Wenwen Jia, Shuwen Wang, James W. Horner, Ning Wang, Huayan Wang, Edward J. Gunther, Ronald A. De Pinho, Jiyue Zhu, 2011, FASEB Journal on p. 979-989

P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis

Peter R. McHenry, James C. Sears, Matthew P. Herrick, Peggy Chang, Brandy M. Heckman-Stoddard, Megan Rybarczyk, Lewis A. Chodosh, Edward J. Gunther, Susan G. Hilsenbeck, Jeffrey M. Rosen, Tracy Vargo-Gogola, 2010, Breast Cancer Research

Targeting the activator protein 1 transcription factor for the prevention of estrogen receptor-negative mammary tumors

Qiang Shen, Ivan P. Uray, Yuxin Li, Yun Zhang, Jamal Hill, Xiao Chun Xu, Matthew R. Young, Edward J. Gunther, Susan G. Hilsenbeck, Nancy H. Colburn, Lewis A. Chodosh, Powel H. Brown, 2008, Cancer Prevention Research on p. 45-55

Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19<sup>Arf</sup>/p53 pathway lesions but not p16<sup>Ink4a</sup> loss

Michael T. Debies, Shelley A. Gestl, Jessica L. Mathers, Oliver R. Mikse, Travis L. Leonard, Susan E. Moody, Lewis A. Chodosh, Robert D. Cardiff, Edward J. Gunther, 2008, Journal of Clinical Investigation on p. 51-63

Transgenic overexpression of IGF-IR disrupts mammary ductal morphogenesis and induces tumor formation

R. A. Jones, C. I. Campbell, Edward Gunther, L. A. Chodosh, J. J. Petrik, R. Khokha, R. A. Moorehead, 2007, Oncogene on p. 1636-1644

Dormant Wnt-initiated mammary cancer can participate in reconstituting functional mammary glands

Shelley A. Gestl, Travis L. Leonard, Jessica L. Biddle, Michael T. Debies, Edward J. Gunther, 2007, Molecular and cellular biology on p. 195-207

Most-Cited Papers

Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers

Allison S. Cleary, Travis L. Leonard, Shelley A. Gestl, Edward J. Gunther, 2014, Nature on p. 113-117

P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis

Peter R. McHenry, James C. Sears, Matthew P. Herrick, Peggy Chang, Brandy M. Heckman-Stoddard, Megan Rybarczyk, Lewis A. Chodosh, Edward J. Gunther, Susan G. Hilsenbeck, Jeffrey M. Rosen, Tracy Vargo-Gogola, 2010, Breast Cancer Research

A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis

Wenwen Jia, Shuwen Wang, James W. Horner, Ning Wang, Huayan Wang, Edward J. Gunther, Ronald A. De Pinho, Jiyue Zhu, 2011, FASEB Journal on p. 979-989

Carcinogen-specific mutations in preferred Ras-Raf pathway oncogenes directed by strand bias

Ross R. Keller, Shelley A. Gestl, Amy Q. Lu, Alicia Hoke, David J. Feith, Edward J. Gunther, 2016, Carcinogenesis on p. 810-816

Basal but not luminal mammary epithelial cells require PI3K/mTOR signaling for Ras-driven overgrowth

Kristin A. Plichta, Jessica L. Mathers, Shelley A. Gestl, Adam Bleier Glick, Edward Gunther, 2012, Cancer Research on p. 5856-5866

Evolution of Relapse-Proficient Subclones Constrained by Collateral Sensitivity to Oncogene Overdose in Wnt-Driven Mammary Cancer

Ross R. Keller, Edward J. Gunther, 2019, Cell Reports on p. 893-905.e4