Edward Gunther

Professor of Medicine

Edward Gunther

Huck Affiliations

Publication Tags

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Breast Neoplasms Oncogene Neoplasms Carcinogen Breast Mutation 7,12 Dimethylbenz(a)anthracene Mouse Oncogenes Cell Heterogeneity Carcinogenesis Breast Cancer Breast Tumor Recurrence Neoplasm Carcinogens Epithelial Cells Therapeutics Mammary Cancer Genes Strand Bias Drug Collateral Sensitivity Parity Nitrosourea Human Tert Protein

Most Recent Publications

Different Oncogenes and Reproductive Histories Shape the Progression of Distinct Premalignant Clones in Multistage Mouse Breast Cancer Models

Maryknoll P. Linscott, Jerry R. Ren, Shelley A. Gestl, Edward J. Gunther, 2024, American Journal of Pathology on p. 1329-1345

A multistage murine breast cancer model reveals long-lived premalignant clones refractory to parity-induced protection

Shuo Li, Shelley A. Gestl, Edward J. Gunther, 2020, Cancer Prevention Research on p. 173-183

Evolution of Relapse-Proficient Subclones Constrained by Collateral Sensitivity to Oncogene Overdose in Wnt-Driven Mammary Cancer

Ross R. Keller, Edward J. Gunther, 2019, Cell Reports on p. 893-905.e4

Carcinogen-specific mutations in preferred Ras-Raf pathway oncogenes directed by strand bias

Ross R. Keller, Shelley A. Gestl, Amy Q. Lu, Alicia Hoke, David J. Feith, Edward J. Gunther, 2016, Carcinogenesis on p. 810-816

Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers

Allison S. Cleary, Travis L. Leonard, Shelley A. Gestl, Edward J. Gunther, 2014, Nature on p. 113-117

Basal but not luminal mammary epithelial cells require PI3K/mTOR signaling for Ras-driven overgrowth

Kristin A. Plichta, Jessica L. Mathers, Shelley A. Gestl, Adam B. Glick, Edward J. Gunther, 2012, Cancer Research on p. 5856-5866

A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis

Wenwen Jia, Shuwen Wang, James W. Horner, Ning Wang, Huayan Wang, Edward J. Gunther, Ronald A. De Pinho, Jiyue Zhu, 2011, FASEB Journal on p. 979-989

P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis

Peter R. McHenry, James C. Sears, Matthew P. Herrick, Peggy Chang, Brandy M. Heckman-Stoddard, Megan Rybarczyk, Lewis A. Chodosh, Edward J. Gunther, Susan G. Hilsenbeck, Jeffrey M. Rosen, Tracy Vargo-Gogola, 2010, Breast Cancer Research

Targeting the activator protein 1 transcription factor for the prevention of estrogen receptor-negative mammary tumors

Qiang Shen, Ivan P. Uray, Yuxin Li, Yun Zhang, Jamal Hill, Xiao Chun Xu, Matthew R. Young, Edward J. Gunther, Susan G. Hilsenbeck, Nancy H. Colburn, Lewis A. Chodosh, Powel H. Brown, 2008, Cancer Prevention Research on p. 45-55

Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19<sup>Arf</sup>/p53 pathway lesions but not p16<sup>Ink4a</sup> loss

Michael T. Debies, Shelley A. Gestl, Jessica L. Mathers, Oliver R. Mikse, Travis L. Leonard, Susan E. Moody, Lewis A. Chodosh, Robert D. Cardiff, Edward J. Gunther, 2008, Journal of Clinical Investigation on p. 51-63

Most-Cited Papers

Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers

Allison S. Cleary, Travis L. Leonard, Shelley A. Gestl, Edward J. Gunther, 2014, Nature on p. 113-117

Carcinogen-specific mutations in preferred Ras-Raf pathway oncogenes directed by strand bias

Ross R. Keller, Shelley A. Gestl, Amy Q. Lu, Alicia Hoke, David J. Feith, Edward J. Gunther, 2016, Carcinogenesis on p. 810-816

A multistage murine breast cancer model reveals long-lived premalignant clones refractory to parity-induced protection

Shuo Li, Shelley A. Gestl, Edward J. Gunther, 2020, Cancer Prevention Research on p. 173-183

Evolution of Relapse-Proficient Subclones Constrained by Collateral Sensitivity to Oncogene Overdose in Wnt-Driven Mammary Cancer

Ross R. Keller, Edward J. Gunther, 2019, Cell Reports on p. 893-905.e4

Different Oncogenes and Reproductive Histories Shape the Progression of Distinct Premalignant Clones in Multistage Mouse Breast Cancer Models

Maryknoll P. Linscott, Jerry R. Ren, Shelley A. Gestl, Edward J. Gunther, 2024, American Journal of Pathology on p. 1329-1345