Douglas Cavener

Professor of Biology; Former Dean, Eberly College of Science

Douglas Cavener

Research Summary

Regulation of protein synthesis and control of translation initiation of mRNAs in higher eukaryotes and the evolution of tissue specific transcriptional regulation.

Graduate Students

Huck Affiliations

Links

Publication Tags

Proteins Phosphotransferases Genes Insulin Endoplasmic Reticulum Perk Kinase Phosphorylation Glucose Mammals Alzheimer Disease Depression Endoplasmic Reticulum Stress Giraffes Protein Kinases Proinsulin Brain Genome Cells Homeostasis Gene Dosage 25 Hydroxycholesterol Fever Macrophages Physiology Giraffa Camelopardalis

Most Recent Papers

Seeing spots

Derek E. Lee, Douglas R. Cavener, Monica L. Bond, 2018, PeerJ

The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones

Carrie R. Sowers, Rong Wang, Rebecca A. Bourne, Barbara C. McGrath, Jingjie Hu, Sarah C. Bevilacqua, James C. Paton, Adrienne W. Paton, Sophie Collardeau-Frachon, Marc Nicolino, Douglas R. Cavener, 2018, Journal of Biological Chemistry on p. 5134-5149

The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration

Guangyan Xiong, Sajedah M. Hindi, Aman K. Mann, Yann S. Gallot, Kyle R. Bohnert, Douglas R. Cavener, Scott R. Whittemore, Ashok Kumar, 2017, eLife

Evolutionary analysis of vision genes identifies potential drivers of visual differences between giraffe and okapi

Edson Ishengoma, Morris Agaba, Douglas R. Cavener, 2017, PeerJ

Ablation of Perk in schwann cells improves myelination in the S63del charcot-marie-tooth 1B mouse

Mariapaola Sidoli, Nicolò Musner, Nicholas Silvestri, Daniela Ungaro, Maurizio D’Antonio, Douglas R. Cavener, M. Laura Feltri, Lawrence Wrabetz, 2016, Journal of Neuroscience on p. 11350-11361

PERK regulates G<sub>q</sub> protein-coupled intracellular Ca<sup>2+</sup> dynamics in primary cortical neurons

Siying Zhu, Barbara C. McGrath, Yuting Bai, Xin Tang, Douglas R. Cavener, 2016, Molecular Brain on p. 1-11

PERK Regulates working memory and protein synthesis-dependent memory flexibility

Siying Zhu, Keely Henninger, Barbara C. McGrath, Douglas R. Cavener, 2016, PloS one on p. e0162766

Giraffe genome sequence reveals clues to its unique morphology and physiology

Morris Agaba, Edson Ishengoma, Webb C. Miller, Barbara C. McGrath, Chelsea N. Hudson, Oscar C. Bedoya Reina, Aakrosh Ratan, Rico Burhans, Rayan Chikhi, Paul Medvedev, Craig A. Praul, Lan Wu-Cavener, Brendan Wood, Heather Robertson, Linda Penfold, Douglas R. Cavener, 2016, Nature communications

Repression of the eIF2α kinase PERK alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease

Wenzhong Yang, Xueyan Zhou, Helena R. Zimmermann, Douglas R. Cavener, Eric Klann, Tao Ma, 2016, Neurobiology of Aging on p. 19-24

Perk gene dosage regulates glucose homeostasis by modulating pancreatic β-cell functions

Rong Wang, Elyse E. Munoz, Siying Zhu, Barbara Claire McGrath, Douglas R. Cavener, 2014, PLoS One

Most-Cited Papers

Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits

Tao Ma, Mimi A. Trinh, Alyse J. Wexler, Clarisse Bourbon, Evelina Gatti, Philippe Pierre, Douglas R. Cavener, Eric Klann, 2013, Nature Neuroscience on p. 1299-1305

Endoplasmic reticulum stress response mediated by the PERK-eIF2α-ATF4 pathway is involved in osteoblast differentiation induced by BMP2

Atsushi Saito, Kimiko Ochiai, Shinichi Kondo, Kenji Tsumagari, Tomohiko Murakami, Douglas R. Cavener, Kazunori Imaizumi, 2011, Journal of Biological Chemistry on p. 4809-4818

PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway

Sounak Gupta, Barbara McGrath, Douglas R. Cavener, 2010, Diabetes on p. 1937-1947

Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility

Mimi A. Trinh, Hanoch Kaphzan, Ronald C. Wek, Philippe Pierre, Douglas R. Cavener, Eric Klann, 2012, Cell Reports on p. 676-688

Insulin secretion and Ca<sup>2+</sup> dynamics in β-cells are regulated by PERK (EIF2AK3) in concert with calcineurin

Rong Wang, Barbara Claire McGrath, Richard F. Kopp, Michael W. Roe, Xin Tang, Gong Chen, Douglas R. Cavener, 2013, Journal of Biological Chemistry on p. 33824-33836

The eIF2α kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression

Mimi A. Trinh, Tao Ma, Hanoch Kaphzan, Aditi Bhattacharya, Marcia D. Antion, Douglas R. Cavener, Charles A. Hoeffer, Eric Klann, 2014, Learning and Memory on p. 298-304

Endoplasmic reticulum stress sensor protein kinase R-like endoplasmic reticulum kinase (PERK) protects against pressure overload-induced heart failure and lung remodeling

Xiaoyu Liu, Dongmin Kwak, Zhongbing Lu, Xin Xu, John Fassett, Huan Wang, Yidong Wei, Douglas R. Cavener, Xinli Hu, Jennifer Hall, Robert J. Bache, Yingjie Chen, 2014, Hypertension on p. 738-744

25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages

Norihito Shibata, Aaron F. Carlin, Nathanael J. Spann, Kaoru Saijo, Christopher S. Morello, Jeffrey G. McDonald, Casey E. Romanoski, Mano R. Maurya, Minna U. Kaikkonen, Michael T. Lam, Andrea Crotti, Donna Reichart, Jesse N. Fox, Oswald Quehenberger, Christian R.H. Raetz, M. Cameron Sullards, Robert C. Murphy, Alfred H. Merrill, H. Alex Brown, Edward A. Dennis, Eoin Fahy, Shankar Subramaniam, Douglas R. Cavener, Deborah H. Spector, David W. Russell, Christopher K. Glassa, 2013, Journal of Biological Chemistry on p. 35812-35823

Hyperthermia induces the ER stress pathway

Xu Xu, Sounak Gupta, Wenli Hu, Barbara Claire McGrath, Douglas R. Cavener, 2011, PloS one

Repression of the eIF2α kinase PERK alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease

Wenzhong Yang, Xueyan Zhou, Helena R. Zimmermann, Douglas R. Cavener, Eric Klann, Tao Ma, 2016, Neurobiology of Aging on p. 19-24