Deb Kelly

Professor of Biomedical Engineering

Deb Kelly

Research Summary

Engineering new molecular paradigms to create a world without cancer.

Graduate Students

Huck Affiliations

Links

Most Recent Papers

Cryo-EM-On-a-Chip

Nick A. Alden, Cameron Varano, William J. Dearnaley, Maria J. Solares, William Y. Luqiu, Yanping Liang, Zhi Sheng, Sarah M. McDonald, John Damiano, Jennifer McConnell, Madeline J. Dukes, Deb Kelly, 2019, Small

Correcting errors in the BRCA1 warning system

Yanping Liang, William J. Dearnaley, Nick A. Alden, Maria J. Solares, Brian L. Gilmore, Kevin J. Pridham, Cameron Varano, Zhi Sheng, Elizabeth Alli, Deb Kelly, 2019, DNA Repair on p. 120-128

Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival

Robin T. Varghese, Sarah Young, Lily Pham, Yanping Liang, Kevin J. Pridham, Sujuan Guo, Susan Murphy, Deb Kelly, Zhi Sheng, 2018, Scientific reports

PIK3CB/p110β is a selective survival factor for glioblastoma

Kevin J. Pridham, Lamvy Le, Sujuan Guo, Robin T. Varghese, Sarah Algino, Yanping Liang, Renee Fajardin, Cara M. Rodgers, Gary R. Simonds, Deb Kelly, Zhi Sheng, 2018, Neuro-Oncology on p. 494-505

Molecular Analysis of BRCA1 in Human Breast Cancer Cells under Oxidative Stress

Brian L. Gilmore, Yanping Liang, Carly E. Winton, Kaya Patel, Vasilea Karageorge, Cameron Varano, William Dearnaley, Zhi Sheng, Deb Kelly, 2017, Scientific reports

Real-time observation of protein aggregates in pharmaceutical formulations using liquid cell electron microscopy

Lynn M. DiMemmo, A. Cameron Varano, Jonathan Haulenbeek, Yanping Liang, Kaya Patel, Madeline J. Dukes, Songyan Zheng, Mario Hubert, Steven P. Piccoli, Deb Kelly, 2017, Lab on a Chip on p. 315-322

Structural analysis of BRCA1 reveals modification hotspot

Yanping Liang, William J. Dearnaley, A. Cameron Varano, Carly E. Winton, Brian L. Gilmore, Nick A. Alden, Zhi Sheng, Deb Kelly, 2017, Science Advances

A microchip platform for structural oncology applications

Carly E. Winton, Brian L. Gilmore, Andrew C. Demmert, Vasilea Karageorge, Zhi Sheng, Deb Kelly, 2016, npj Breast Cancer

Prolonged particulate hexavalent chromium exposure suppresses homologous recombination repair in human lung cells

Cynthia L. Browning, Qin Qin, Deb Kelly, Rohit Prakash, Fabio Vanoli, Maria Jasin, John Pierce Wise, 2016, Toxicological Sciences on p. 70-78

Survival kinase genes present prognostic significance in glioblastoma

Robin T. Varghese, Yanping Liang, Ting Guan, Christopher T. Franck, Deb Kelly, Zhi Sheng, 2016, Oncotarget on p. 20140-20151

High-Impact Papers

A rapid and high content assay that measures cyto-ID-stained autophagic compartments and estimates autophagy flux with potential clinical applications

Sujuan Guo, Yanping Liang, Susan F. Murphy, Angela Huang, Haihong Shen, Deb Kelly, Pablo Sobrado, Zhi Sheng, 2015, Autophagy on p. 560-572

Toward design of magnetic nanoparticle clusters stabilized by biocompatible diblock copolymers for T 2-weighted MRI contrast

Sharavanan Balasubramaniam, Sanem Kayandan, Yin Nian Lin, Deb Kelly, Michael J. House, Robert C. Woodward, Timothy G. St. Pierre, Judy S. Riffle, Richey M. Davis, 2014, Langmuir on p. 1580-1587

Visualizing viral assemblies in a nanoscale biosphere

Brian L. Gilmore, Shannon P. Showalter, Madeline J. Dukes, Justin R. Tanner, Andrew C. Demmert, Sarah M. McDonald, Deb Kelly, 2013, Lab on a Chip on p. 216-219

Molecular structure and dimeric organization of the notch extracellular domain as revealed by electron microscopy

Deb Kelly, Robert J. Lake, Teije C. Middelkoop, Hua Ying Fan, Spyros Artavanis-Tsakonas, Thomas Walz, 2010, PloS one

Strategy for the use of affinity grids to prepare non-his-tagged macromolecular complexes for single-particle electron microscopy

Deb Kelly, Danijela Dukovski, Thomas Walz, 2010, Journal of Molecular Biology on p. 675-681

Real-Time Visualization of Nanoparticles Interacting with Glioblastoma Stem Cells

Elliot S. Pohlmann, Kaya Patel, Sujuan Guo, Madeline J. Dukes, Zhi Sheng, Deb Kelly, 2015, Nano Letters on p. 2329-2335

Affinity grid-based cryo-EM of PKC binding to RACK1 on the ribosome

Gyanesh Sharma, Jesper Pallesen, Sanchaita Das, Robert Grassucci, Robert Langlois, Cheri M. Hampton, Deb Kelly, Amedee des Georges, Joachim Frank, 2013, Journal of Structural Biology on p. 190-194

Survival kinase genes present prognostic significance in glioblastoma

Robin T. Varghese, Yanping Liang, Ting Guan, Christopher T. Franck, Deb Kelly, Zhi Sheng, 2016, Oncotarget on p. 20140-20151

The development of affinity capture devices - A nanoscale purification platform for biological in situ transmission electron microscopy

Katherine Degen, Madeline Dukes, Justin R. Tanner, Deb Kelly, 2012, RSC Advances on p. 2408-2412

Visualizing nanoparticle mobility in liquid at atomic resolution

Madeline J. Dukes, Benjamin W. Jacobs, David G. Morgan, Harshad Hegde, Deb Kelly, 2013, Chemical Communications on p. 3007-3009

News Articles Featuring Deb Kelly

Professor of Biomedical Engineering Deb Kelly hopes to 'outsmart breast cancer'

October is National Breast Cancer Awareness Month. One of the pioneering researchers in the fight against breast cancer is Deb Kelly, professor of biomedical engineering and director of the Center for Structural Oncology at Penn State.

Scientists have first 3D view of life's processes in liquid

A new liquid-cell technology allows scientists to see living biological materials and systems in three dimensions under an electron microscope, according to researchers at Penn State, Virginia Tech and Protochips Inc.

New liquid-cell technology provides first 3D view of life’s processes

A new liquid-cell technology allows scientists to see biological materials and systems in three dimensions under an electron microscope (EM), according to researchers at Penn State, Virginia Tech and Protochips Inc.

Advances In Cryo-EM Materials May Aid Cancer And Biomedical Research

Cryogenic-Electron Microscopy (cryo-EM) has been a game changer in the field of medical research, but the substrate used to freeze and view samples under a microscope hasn’t advanced much in decades. Now, thanks to a collaboration between Penn State researchers and the applied science company Protochips, Inc., this is no longer the case.

Biomedical engineering welcomes pioneering cancer, cryo-electron microscopy researcher

Deborah Kelly, a ground-breaking researcher who developed the new field of structural oncology, will join the University’s Department of Biomedical Engineering as full professor and Lloyd and Dottie Foehr Huck Chair in Molecular Biophysics. Kelly will also hold a joint appointment with the Huck Institutes of Life Sciences and will serve as the director of the new Center for Structural Oncology (CSO) at Penn State.