Deb Kelly

Director of the Center for Structural Oncology; Huck Chair in Molecular Biophysics; Professor of Biomedical Engineering

Deb Kelly

Research Summary

Engineering new molecular paradigms to create a world without cancer.

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Electron Microscopy Liquids Nanoparticles Viruses Imaging Techniques Proteins Liquid Stem Cells Visualization Glioblastoma Vacuum Electron Microscopes Microfluidics Protein Macromolecules Therapeutics Virus Assembly Neoplasms Block Copolymers Ice Electron Particle Magnetic Resonance Imaging Phosphatidylinositol 3 Kinase Chromium Hexavalent Ion Molecular Weight

Most Recent Publications

Microchip-based structure determination of low-molecular weight proteins using Cryo-Electron Microscopy

Deborah Kelly, Nanoscale on p. 7285-7293

High-resolution imaging of human viruses in liquid droplets

Deborah Kelly, Advanced Materials on p. 2103221

Automated Tools to Advance High-Resolution Imaging in Liquid

Deborah Kelly,

Kevin J. Pridham, Farah Shah, Kasen R. Hutchings, Kevin L. Sheng, Sujuan Guo, Min Liu, Pratik Kanabur, Samy Lamouille, Gabrielle Lewis, Marc Morales, Jane Jourdan, Christina L. Grek, Gautam G. Ghatnekar, Robin Varghese, Deborah F. Kelly, Robert G. Gourdie, Zhi Sheng, 2022, Oncogenesis

High-Resolution Imaging of Human Cancer Proteins Using Microprocessor Materials

Maria J. Solares, G. M. Jonaid, William Y. Luqiu, Samantha Berry, Janki Khadela, Yanping Liang, Madison C. Evans, Kevin J. Pridham, William J. Dearnaley, Zhi Sheng, Deborah F. Kelly, 2022, ChemBioChem

Liquid-EM goes viral – visualizing structure and dynamics

Deborah F. Kelly, Liza Anastasia DiCecco, G. M. Jonaid, William J. Dearnaley, Michael S. Spilman, Jennifer L. Gray, Madeline J. Dressel-Dukes, 2022, Current Opinion in Structural Biology

Advancing High-Resolution Imaging of Virus Assemblies in Liquid and Ice

Liza Anastasia Dicecco, Samantha Berry, G. M. Jonaid, Maria J. Solares, Liam Kaylor, Jennifer L. Gray, Carol Bator, William J. Dearnaley, Michael Spilman, Madeline J. Dressel-Dukes, Kathryn Grandfield, Sarah M. McDonald Esstman, Deborah F. Kelly, 2022, Journal of Visualized Experiments

G. M. Jonaid, Michael A. Casasanta, William J. Dearnaley, Samantha Berry, Liam Kaylor, Madeline J. Dressel-Dukes, Michael S. Spilman, Jennifer L. Gray, Deborah F. Kelly, 2022, Microscopy and Microanalysis on p. 361-370

G. M. Jonaid, William J. Dearnaley, Michael A. Casasanta, Liam Kaylor, Samantha Berry, Madeline J. Dukes, Michael S. Spilman, Jennifer L. Gray, Deborah F. Kelly, 2021, Advanced Materials

Michael A. Casasanta, G. M. Jonaid, Liam Kaylor, William Y. Luqiu, Maria J. Solares, Mariah L. Schroen, William J. Dearnaley, Jarad Wilson, Madeline J. Dukes, Deborah F. Kelly, 2021, Nanoscale on p. 7285-7293

Most-Cited Papers

Sujuan Guo, Yanping Liang, Susan Murphy, Angela Huang, Haihong Shen, Deborah F. Kelly, Pablo Sobrado, Zhi Sheng, 2015, Autophagy on p. 560-572

Toward design of magnetic nanoparticle clusters stabilized by biocompatible diblock copolymers for T <sub>2</sub>-weighted MRI contrast

Sharavanan Balasubramaniam, Sanem Kayandan, Yin Nian Lin, Deborah F. Kelly, Michael J. House, Robert C. Woodward, Timothy G. St. Pierre, Judy S. Riffle, Richey M. Davis, 2014, Langmuir on p. 1580-1587

Real-Time Visualization of Nanoparticles Interacting with Glioblastoma Stem Cells

Elliot S. Pohlmann, Kaya Patel, Sujuan Guo, Madeline J. Dukes, Zhi Sheng, Deb Kelly, 2015, Nano Letters on p. 2329-2335

Robin T. Varghese, Yanping Liang, Ting Guan, Christopher T. Franck, Deborah F. Kelly, Zhi Sheng, 2016, Oncotarget on p. 20140-20151

Visualizing viral assemblies in a nanoscale biosphere

Brian L. Gilmore, Shannon P. Showalter, Madeline J. Dukes, Justin R. Tanner, Andrew C. Demmert, Sarah M. McDonald, Deborah F. Kelly, 2013, Lab on a Chip - Miniaturisation for Chemistry and Biology on p. 216-219

Kevin J. Pridham, Lamvy Le, Sujuan Guo, Robin T. Varghese, Sarah Algino, Yanping Liang, Renee Fajardin, Cara M. Rodgers, Gary R. Simonds, Deborah F. Kelly, Zhi Sheng, 2018, Neuro-Oncology on p. 494-505

Gyanesh Sharma, Jesper Pallesen, Sanchaita Das, Robert Grassucci, Robert Langlois, Cheri M. Hampton, Deborah F. Kelly, Amedee des Georges, Joachim Frank, 2013, Journal of Structural Biology on p. 190-194

Pratik Kanabur, Sujuan Guo, Gary R. Simonds, Deborah F. Kelly, Robert G. Gourdie, Scott S. Verbridge, Zhi Sheng, 2016, Oncotarget on p. 86406-86419

A. Cameron Varano, Amina Rahimi, Madeline J. Dukes, Steven Poelzing, Sarah M. McDonald, Deborah F. Kelly, 2015, Chemical Communications on p. 16176-16179

Cynthia L. Browning, Qin Qin, Deborah F. Kelly, Rohit Prakash, Fabio Vanoli, Maria Jasin, John Pierce Wise, 2016, Toxicological Sciences on p. 70-78

News Articles Featuring Deb Kelly

Researchers Film Human Viruses in Liquid Droplets at Near-atomic Detail

A pond in summer can reveal more about a fish than a pond in winter. The fish living in icy conditions might remain still enough to study its scales, but to understand how the fish swims and behaves, it needs to freely move in three dimensions. The same holds true for analyzing how biological items, such as viruses, move in the human body, according to a research team led by Deb Kelly, Huck Chair in Molecular Biophysics and professor of biomedical engineering at Penn State, who has used advanced electron microscopy (EM) technology to see how human viruses move in high resolution in a near-native environment. The visualization technique could lead to improved understanding of how vaccine candidates and treatments behave and function as they interact with target cells, Kelly said.

Researchers film human viruses in liquid droplets at near-atomic detail

A research team led by Deb Kelly, Huck Chair in Molecular Biophysics and professor of biomedical engineering at Penn State, has used advanced electron microscopy (EM) technology to see how human viruses move in high resolution in a near-native environment. The visualization technique could lead to improved understanding of how vaccine candidates and treatments behave and function as they interact with target cells, Kelly said.

Antibody binding-site conserved across COVID-19 virus variants

A tiny protein of SARS-CoV-2, the coronavirus that gives rise to COVID-19, may have big implications for future treatments, according to a team of Penn State researchers.

Engineering professor named Microscopy Society of America president-elect

Deborah Kelly, Huck Chair in Molecular Biophysics and professor of biomedical engineering at Penn State, was elected president of the Microscopy Society of America (MSA). Her three-year commitment as first president-elect, then president, then past president, began in January.

Deb Kelly named chair of NIH study section

Deborah Kelly, Penn State Lloyd & Dottie Foehr Huck Chair in Molecular Biophysics, director of the Penn State Center for Structural Oncology (CSO) and professor of biomedical engineering, has accepted an appointment as chair of the National Institutes of Health’s (NIH) Macromolecular Structure and Function B (MSFB) Study Section, directed by the Center for Scientific Review.

Podcast features three women at the forefront of cryo-EM research

An all-female trio of Penn State research scientists explain how their work on cancer diagnostics and advanced materials science evolves along with improvements in cryo-electron microscopy.

Penn State cancer research center joins pandemic fight

The Penn State Center for Structural Oncology (CSO) is shifting some of its focus from fighting cancer to fighting COVID-19, with three projects. The CSO’s director, Deborah Kelly, believes that the same interdisciplinary research approach and collaborative spirit that drives the CSO’s cancer research can be applied to fighting pandemics.

Aspiring neurosurgeon mapping cancer-suppressing protein

Madison Evans is a Penn State biomedical engineering major who would like to become a neurosurgeon. Before she heads off to medical school, though, the Schreyer Honors Scholar is part of a research project that could change the way her future patients receive treatment.

Discovering the Secret Life of Cancer Cells (pg. 14)

Penn State's Center for Structural Oncology seeks to understand molecular culprits of breast cancer

Professor of Biomedical Engineering Deb Kelly hopes to 'outsmart breast cancer'

October is National Breast Cancer Awareness Month. One of the pioneering researchers in the fight against breast cancer is Deb Kelly, professor of biomedical engineering and director of the Center for Structural Oncology at Penn State.