Deb Kelly

Director of the Center for Structural Oncology; Huck Chair in Molecular Biophysics; Professor of Biomedical Engineering

Deb Kelly

Research Summary

Engineering new molecular paradigms to create a world without cancer.

Graduate Students

Huck Affiliations


Publication Tags

Nanoparticles Electron Microscopy Liquids Proteins Transmission Electron Microscopy Cells Visualization Electrons Macromolecules Vacuum Neoplasms Glioblastoma Stem Cells Imaging Techniques Tomography Electron Microscopes Microfluidics Tumors Messenger Rna Dna Brca1 Protein Silicon Nitride Magnetic Resonance Imaging Rna Fluidics

Most Recent Papers

Liquid-Cell Electron Tomography of Biological Systems

William Dearnaley, Beatrice Schleupner, Cameron Varano, Nick A. Alden, Floricel Gonzalez, Michael A. Casasanta, Birgit E. Scharf, Madeline J. Dukes, Deb Kelly, 2019, Nano letters on p. 6734-6741


Nick A. Alden, A. Cameron Varano, William J. Dearnaley, Maria J. Solares, William Y. Luqiu, Yanping Liang, Zhi Sheng, Sarah M. McDonald, John Damiano, Jennifer McConnell, Madeline J. Dukes, Deborah F. Kelly, 2019, Small on p. 1970109

Customizable Cryo-EM Chips Improve 3D Analysis of Macromolecules

Varano, A Cameron, Nick Alden, William Dearnaley, Michael Casasanta, John Damiano, Jennifer McConnell, Madeline Dukes, Deborah Kelly, 2019, Microscopy and Microanalysis on p. 1310--1311

Cryo-EM Reveals Architectural Diversity in Active Rotavirus Particles

Mary Hauser, William Dearnaley, Cameron Varano, Michael Casasanta, Sarah M. McDonald, Deb Kelly, 2019, Computational and Structural Biotechnology Journal on p. 1178-1183

Correcting errors in the BRCA1 warning system

Yanping Liang, William J. Dearnaley, Nick A. Alden, Maria J. Solares, Brian L. Gilmore, Kevin J. Pridham, Cameron Varano, Zhi Sheng, Elizabeth Alli, Deb Kelly, 2019, DNA Repair on p. 120-128

Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival

Robin T. Varghese, Sarah Young, Lily Pham, Yanping Liang, Kevin J. Pridham, Sujuan Guo, Susan Murphy, Deborah F. Kelly, Zhi Sheng, 2018, Scientific reports

PIK3CB/p110β is a selective survival factor for glioblastoma

Kevin J. Pridham, Lamvy Le, Sujuan Guo, Robin T. Varghese, Sarah Algino, Yanping Liang, Renee Fajardin, Cara M. Rodgers, Gary R. Simonds, Deb Kelly, Zhi Sheng, 2018, Neuro-oncology on p. 494-505

Preparation of Tunable Microchips to Visualize Native Protein Complexes for Single-Particle Electron Microscopy

B Gilmore, A Varano, W Dearnaley, Y Liang, B Marcinkowski, M Dukes, Deborah Kelly, 2018, Methods in molecular biology on p. -

Tunable substrates improve imaging of viruses and cancer proteins.

C Winton, B Gilmore, J Tanner, M Dukes, Z Sheng, Deborah Kelly, 2017, Microscopy Today on p. 22-27

Molecular analysis of BRCA1 in human breast cancer cells under oxidative stress

Brian L. Gilmore, Yanping Liang, Carly E. Winton, Kaya Patel, Vasilea Karageorge, A. Cameron Varano, William Dearnaley, Zhi Sheng, Deborah F. Kelly, 2017, Scientific reports

Most-Cited Papers

A rapid and high content assay that measures cyto-ID-stained autophagic compartments and estimates autophagy flux with potential clinical applications

Sujuan Guo, Yanping Liang, Susan F. Murphy, Angela Huang, Haihong Shen, Deb Kelly, Pablo Sobrado, Zhi Sheng, 2015, Autophagy on p. 560-572

Toward design of magnetic nanoparticle clusters stabilized by biocompatible diblock copolymers for T <sub>2</sub>-weighted MRI contrast

Sharavanan Balasubramaniam, Sanem Kayandan, Yin Nian Lin, Deborah F. Kelly, Michael J. House, Robert C. Woodward, Timothy G. St. Pierre, Judy S. Riffle, Richey M. Davis, 2014, Langmuir on p. 1580-1587

Visualizing viral assemblies in a nanoscale biosphere

Brian L. Gilmore, Shannon P. Showalter, Madeline J. Dukes, Justin R. Tanner, Andrew C. Demmert, Sarah M. McDonald, Deb Kelly, 2013, Lab on a Chip on p. 216-219

Molecular structure and dimeric organization of the notch extracellular domain as revealed by electron microscopy

Deb Kelly, Robert J. Lake, Teije C. Middelkoop, Hua Ying Fan, Spyros Artavanis-Tsakonas, Thomas Walz, 2010, PloS one

Strategy for the use of affinity grids to prepare non-his-tagged macromolecular complexes for single-particle electron microscopy

Deb Kelly, Danijela Dukovski, Thomas Walz, 2010, Journal of Molecular Biology on p. 675-681

Real-Time Visualization of Nanoparticles Interacting with Glioblastoma Stem Cells

Elliot S. Pohlmann, Kaya Patel, Sujuan Guo, Madeline J. Dukes, Zhi Sheng, Deb Kelly, 2015, Nano Letters on p. 2329-2335

Survival kinase genes present prognostic significance in glioblastoma

Robin T. Varghese, Yanping Liang, Ting Guan, Christopher T. Franck, Deb Kelly, Zhi Sheng, 2016, Oncotarget on p. 20140-20151

Affinity grid-based cryo-EM of PKC binding to RACK1 on the ribosome

Gyanesh Sharma, Jesper Pallesen, Sanchaita Das, Robert Grassucci, Robert Langlois, Cheri M. Hampton, Deb Kelly, Amedee des Georges, Joachim Frank, 2013, Journal of Structural Biology on p. 190-194

Visualizing nanoparticle mobility in liquid at atomic resolution

Madeline J. Dukes, Benjamin W. Jacobs, David G. Morgan, Harshad Hegde, Deb Kelly, 2013, Chemical Communications on p. 3007-3009

The development of affinity capture devices - A nanoscale purification platform for biological in situ transmission electron microscopy

Katherine Degen, Madeline Dukes, Justin R. Tanner, Deb Kelly, 2012, RSC Advances on p. 2408-2412

News Articles Featuring Deb Kelly

Deb Kelly named chair of NIH study section

Deborah Kelly, Penn State Lloyd & Dottie Foehr Huck Chair in Molecular Biophysics, director of the Penn State Center for Structural Oncology (CSO) and professor of biomedical engineering, has accepted an appointment as chair of the National Institutes of Health’s (NIH) Macromolecular Structure and Function B (MSFB) Study Section, directed by the Center for Scientific Review.

Podcast features three women at the forefront of cryo-EM research

An all-female trio of Penn State research scientists explain how their work on cancer diagnostics and advanced materials science evolves along with improvements in cryo-electron microscopy.

Penn State cancer research center joins pandemic fight

The Penn State Center for Structural Oncology (CSO) is shifting some of its focus from fighting cancer to fighting COVID-19, with three projects. The CSO’s director, Deborah Kelly, believes that the same interdisciplinary research approach and collaborative spirit that drives the CSO’s cancer research can be applied to fighting pandemics.

Aspiring neurosurgeon mapping cancer-suppressing protein

Madison Evans is a Penn State biomedical engineering major who would like to become a neurosurgeon. Before she heads off to medical school, though, the Schreyer Honors Scholar is part of a research project that could change the way her future patients receive treatment.

Discovering the Secret Life of Cancer Cells (pg. 14)

Penn State's Center for Structural Oncology seeks to understand molecular culprits of breast cancer