Deb Kelly

Director of the Center for Structural Oncology; Huck Chair in Molecular Biophysics; Professor of Biomedical Engineering

Deb Kelly

Research Summary

Engineering new molecular paradigms to create a world without cancer.

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Liquids Nanoparticles Proteins Electron Microscopy Cells Imaging Techniques Macromolecules Glioblastoma Stem Cells Visualization Electron Microscopes Electrons Vacuum Protein Liquid Cryo Electron Microscopy Tomography Viruses Microfluidics Electron Particle Neoplasms Transmission Electron Microscopy Tumors Messenger Rna Genes

Most Recent Papers

Microchip-based structure determination of low-molecular weight proteins using cryo-electron microscopy

Michael A. Casasanta, G. M. Jonaid, Liam Kaylor, William Y. Luqiu, Maria J. Solares, Mariah L. Schroen, William J. Dearnaley, Jarad Wilson, Madeline J. Dukes, Deborah F. Kelly, 2021, Nanoscale on p. 7285-7293

Isolation of Disease-relevant p53 for Cryo-Electron Microscopy Analysis

Deborah Kelly, 2020, Nature Protocol Exchange

Liquid cell TEM imaging techniques and optimization for biological samples

Madeline Dukes, Deborah Kelly, Cameron Varano, 2020, Microscopy and Microanalysis

Microchip-Based Structure Determination of Disease-Relevant p53

Maria J. Solares, G. M. Jonaid, William Y. Luqiu, Yanping Liang, Madison C. Evans, William J. Dearnaley, Zhi Sheng, Deborah F. Kelly, 2020, Analytical Chemistry

Liquid-Cell Electron Tomography of Biological Systems

William J. Dearnaley, Beatrice Schleupner, A. Cameron Varano, Nick A. Alden, Floricel Gonzalez, Michael A. Casasanta, Birgit E. Scharf, Madeline J. Dukes, Deborah F. Kelly, 2019, Nano Letters on p. 6734-6741

Cryo-EM-On-a-Chip

Nick A. Alden, A. Cameron Varano, William J. Dearnaley, Maria J. Solares, William Y. Luqiu, Yanping Liang, Zhi Sheng, Sarah M. McDonald, John Damiano, Jennifer McConnell, Madeline J. Dukes, Deborah F. Kelly, 2019, Small on p. 1970109

Cryo-EM Reveals Architectural Diversity in Active Rotavirus Particles

Mary Hauser, William J. Dearnaley, A. Cameron Varano, Michael Casasanta, Sarah M. McDonald, Deborah F. Kelly, 2019, Computational and Structural Biotechnology Journal on p. 1178-1183

Customizable Cryo-EM Chips Improve 3D Analysis of Macromolecules

Varano, A Cameron, Nick Alden, W Dearnaley, Michael Casasanta, John Damiano, Jennifer McConnell, Madeline Dukes, Deborah Kelly, 2019, Microscopy and Microanalysis on p. 1310--1311

Correcting errors in the BRCA1 warning system

Yanping Liang, William J. Dearnaley, Nick A. Alden, Maria J. Solares, Brian L. Gilmore, Kevin J. Pridham, Cameron Varano, Zhi Sheng, Elizabeth Alli, Deb Kelly, 2019, DNA Repair on p. 120-128

Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival

Robin T. Varghese, Sarah Young, Lily Pham, Yanping Liang, Kevin J. Pridham, Sujuan Guo, Susan Murphy, Deborah F. Kelly, Zhi Sheng, 2018, Scientific Reports

Most-Cited Papers

A rapid and high content assay that measures cyto-ID-stained autophagic compartments and estimates autophagy flux with potential clinical applications

Sujuan Guo, Yanping Liang, Susan F. Murphy, Angela Huang, Haihong Shen, Deborah F. Kelly, Pablo Sobrado, Zhi Sheng, 2015, Autophagy on p. 560-572

Toward design of magnetic nanoparticle clusters stabilized by biocompatible diblock copolymers for T <sub>2</sub>-weighted MRI contrast

Sharavanan Balasubramaniam, Sanem Kayandan, Yin Nian Lin, Deborah F. Kelly, Michael J. House, Robert C. Woodward, Timothy G. St. Pierre, Judy S. Riffle, Richey M. Davis, 2014, Langmuir on p. 1580-1587

Real-Time Visualization of Nanoparticles Interacting with Glioblastoma Stem Cells

Elliot S. Pohlmann, Kaya Patel, Sujuan Guo, Madeline J. Dukes, Zhi Sheng, Deb Kelly, 2015, Nano Letters on p. 2329-2335

Visualizing viral assemblies in a nanoscale biosphere

Brian L. Gilmore, Shannon P. Showalter, Madeline J. Dukes, Justin R. Tanner, Andrew C. Demmert, Sarah M. McDonald, Deborah F. Kelly, 2013, Lab on a Chip - Miniaturisation for Chemistry and Biology on p. 216-219

Survival kinase genes present prognostic significance in glioblastoma

Robin T. Varghese, Yanping Liang, Ting Guan, Christopher T. Franck, Deborah F. Kelly, Zhi Sheng, 2016, Oncotarget on p. 20140-20151

Affinity grid-based cryo-EM of PKC binding to RACK1 on the ribosome

Gyanesh Sharma, Jesper Pallesen, Sanchaita Das, Robert Grassucci, Robert Langlois, Cheri M. Hampton, Deborah F. Kelly, Amedee des Georges, Joachim Frank, 2013, Journal of Structural Biology on p. 190-194

Patient-derived glioblastoma stem cells respond differentially to targeted therapies

Pratik Kanabur, Sujuan Guo, Gary R. Simonds, Deborah F. Kelly, Robert G. Gourdie, Scott S. Verbridge, Zhi Sheng, 2016, Oncotarget on p. 86406-86419

Visualizing nanoparticle mobility in liquid at atomic resolution

Madeline J. Dukes, Benjamin W. Jacobs, David G. Morgan, Harshad Hegde, Deborah F. Kelly, 2013, Chemical Communications on p. 3007-3009

PIK3CB/p110β is a selective survival factor for glioblastoma

Kevin J. Pridham, Lamvy Le, Sujuan Guo, Robin T. Varghese, Sarah Algino, Yanping Liang, Renee Fajardin, Cara M. Rodgers, Gary R. Simonds, Deborah F. Kelly, Zhi Sheng, 2018, Neuro-Oncology on p. 494-505

Visualizing virus particle mobility in liquid at the nanoscale

A. Cameron Varano, Amina Rahimi, Madeline J. Dukes, Steven Poelzing, Sarah M. McDonald, Deborah F. Kelly, 2015, Chemical Communications on p. 16176-16179

News Articles Featuring Deb Kelly

Researchers Film Human Viruses in Liquid Droplets at Near-atomic Detail

A pond in summer can reveal more about a fish than a pond in winter. The fish living in icy conditions might remain still enough to study its scales, but to understand how the fish swims and behaves, it needs to freely move in three dimensions. The same holds true for analyzing how biological items, such as viruses, move in the human body, according to a research team led by Deb Kelly, Huck Chair in Molecular Biophysics and professor of biomedical engineering at Penn State, who has used advanced electron microscopy (EM) technology to see how human viruses move in high resolution in a near-native environment. The visualization technique could lead to improved understanding of how vaccine candidates and treatments behave and function as they interact with target cells, Kelly said.

Researchers film human viruses in liquid droplets at near-atomic detail

A research team led by Deb Kelly, Huck Chair in Molecular Biophysics and professor of biomedical engineering at Penn State, has used advanced electron microscopy (EM) technology to see how human viruses move in high resolution in a near-native environment. The visualization technique could lead to improved understanding of how vaccine candidates and treatments behave and function as they interact with target cells, Kelly said.

Antibody binding-site conserved across COVID-19 virus variants

A tiny protein of SARS-CoV-2, the coronavirus that gives rise to COVID-19, may have big implications for future treatments, according to a team of Penn State researchers.

Engineering professor named Microscopy Society of America president-elect

Deborah Kelly, Huck Chair in Molecular Biophysics and professor of biomedical engineering at Penn State, was elected president of the Microscopy Society of America (MSA). Her three-year commitment as first president-elect, then president, then past president, began in January.

Deb Kelly named chair of NIH study section

Deborah Kelly, Penn State Lloyd & Dottie Foehr Huck Chair in Molecular Biophysics, director of the Penn State Center for Structural Oncology (CSO) and professor of biomedical engineering, has accepted an appointment as chair of the National Institutes of Health’s (NIH) Macromolecular Structure and Function B (MSFB) Study Section, directed by the Center for Scientific Review.

Podcast features three women at the forefront of cryo-EM research

An all-female trio of Penn State research scientists explain how their work on cancer diagnostics and advanced materials science evolves along with improvements in cryo-electron microscopy.

Penn State cancer research center joins pandemic fight

The Penn State Center for Structural Oncology (CSO) is shifting some of its focus from fighting cancer to fighting COVID-19, with three projects. The CSO’s director, Deborah Kelly, believes that the same interdisciplinary research approach and collaborative spirit that drives the CSO’s cancer research can be applied to fighting pandemics.

Aspiring neurosurgeon mapping cancer-suppressing protein

Madison Evans is a Penn State biomedical engineering major who would like to become a neurosurgeon. Before she heads off to medical school, though, the Schreyer Honors Scholar is part of a research project that could change the way her future patients receive treatment.

Discovering the Secret Life of Cancer Cells (pg. 14)

Penn State's Center for Structural Oncology seeks to understand molecular culprits of breast cancer

Professor of Biomedical Engineering Deb Kelly hopes to 'outsmart breast cancer'

October is National Breast Cancer Awareness Month. One of the pioneering researchers in the fight against breast cancer is Deb Kelly, professor of biomedical engineering and director of the Center for Structural Oncology at Penn State.