Deb Kelly

Huck Chair in Molecular Biophysics; Professor of Biomedical Engineering

Deb Kelly

Research Summary

Engineering new molecular paradigms to create a world without cancer.

Graduate Students

Huck Affiliations

Links

Publication Tags

Proteins Liquids Neoplasms Electrons Electron Microscopes Microfluidics Electron Microscopy Rotavirus Macromolecules Cells Vacuum Brca1 Protein Breast Neoplasms Glioblastoma Transmission Electron Microscopy Dna Tomography Nanoparticles Rna Imaging Techniques Messenger Rna Mutation Survival Silicon Nitride Microscopy

Most Recent Papers

Liquid-Cell Electron Tomography of Biological Systems

William Dearnaley, Beatrice Schleupner, Cameron Varano, Nick A. Alden, Floricel Gonzalez, Michael A. Casasanta, Birgit E. Scharf, Madeline J. Dukes, Deb Kelly, 2019, Nano letters on p. 6734-6741

Cryo-EM-On-a-Chip

Nick A. Alden, A. Cameron Varano, William J. Dearnaley, Maria J. Solares, William Y. Luqiu, Yanping Liang, Zhi Sheng, Sarah M. McDonald, John Damiano, Jennifer McConnell, Madeline J. Dukes, Deborah F. Kelly, 2019, Small

Correcting errors in the BRCA1 warning system

Yanping Liang, William J. Dearnaley, Nick A. Alden, Maria J. Solares, Brian L. Gilmore, Kevin J. Pridham, Cameron Varano, Zhi Sheng, Elizabeth Alli, Deb Kelly, 2019, DNA Repair on p. 120-128

Cryo-EM Reveals Architectural Diversity in Active Rotavirus Particles

Mary Hauser, William Dearnaley, Cameron Varano, Michael Casasanta, Sarah M. McDonald, Deb Kelly, 2019, Computational and Structural Biotechnology Journal on p. 1178-1183

Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival

Robin T. Varghese, Sarah Young, Lily Pham, Yanping Liang, Kevin J. Pridham, Sujuan Guo, Susan Murphy, Deborah F. Kelly, Zhi Sheng, 2018, Scientific reports

PIK3CB/p110β is a selective survival factor for glioblastoma

Kevin J. Pridham, Lamvy Le, Sujuan Guo, Robin T. Varghese, Sarah Algino, Yanping Liang, Renee Fajardin, Cara M. Rodgers, Gary R. Simonds, Deb Kelly, Zhi Sheng, 2018, Neuro-oncology on p. 494-505

Molecular Analysis of BRCA1 in Human Breast Cancer Cells under Oxidative Stress

Brian L. Gilmore, Yanping Liang, Carly E. Winton, Kaya Patel, Vasilea Karageorge, A. Cameron Varano, William Dearnaley, Zhi Sheng, Deborah F. Kelly, 2017, Scientific reports

Structural analysis of BRCA1 reveals modification hotspot

Yanping Liang, William J. Dearnaley, A. Cameron Varano, Carly E. Winton, Brian L. Gilmore, Nick A. Alden, Zhi Sheng, Deborah F. Kelly, 2017, Science Advances

A microchip platform for structural oncology applications

Carly E. Winton, Brian L. Gilmore, Andrew C. Demmert, Vasilea Karageorge, Zhi Sheng, Deb Kelly, 2016, npj Breast Cancer

A Molecular Toolkit to Visualize Native Protein Assemblies in the Context of Human Disease

Brian L. Gilmore, Carly E. Winton, Andrew C. Demmert, Justin R. Tanner, Sam Bowman, Vasilea Karageorge, Kaya Patel, Zhi Sheng, Deborah F. Kelly, 2015, Scientific reports

Most-Cited Papers

Toward design of magnetic nanoparticle clusters stabilized by biocompatible diblock copolymers for T <sub>2</sub>-weighted MRI contrast

Sharavanan Balasubramaniam, Sanem Kayandan, Yin Nian Lin, Deborah F. Kelly, Michael J. House, Robert C. Woodward, Timothy G. St. Pierre, Judy S. Riffle, Richey M. Davis, 2014, Langmuir on p. 1580-1587

Visualizing viral assemblies in a nanoscale biosphere

Brian L. Gilmore, Shannon P. Showalter, Madeline J. Dukes, Justin R. Tanner, Andrew C. Demmert, Sarah M. McDonald, Deb Kelly, 2013, Lab on a Chip on p. 216-219

The development of affinity capture devices - A nanoscale purification platform for biological in situ transmission electron microscopy

Katherine Degen, Madeline Dukes, Justin R. Tanner, Deb Kelly, 2012, RSC Advances on p. 2408-2412

PIK3CB/p110β is a selective survival factor for glioblastoma

Kevin J. Pridham, Lamvy Le, Sujuan Guo, Robin T. Varghese, Sarah Algino, Yanping Liang, Renee Fajardin, Cara M. Rodgers, Gary R. Simonds, Deb Kelly, Zhi Sheng, 2018, Neuro-oncology on p. 494-505

Rotavirus core shell subdomains involved in polymerase encapsidation into virus-like particles

Crystal E. Boudreaux, Donald C. Vile, Brian L. Gilmore, Justin R. Tanner, Deborah F. Kelly, Sarah M. McDonald, 2013, Journal of General Virology on p. 1818-1826

Electron microscopic analysis of rotavirus assembly-replication intermediates

Crystal E. Boudreaux, Deb Kelly, Sarah M. McDonald, 2015, Virology on p. 32-41

Molecular Analysis of BRCA1 in Human Breast Cancer Cells under Oxidative Stress

Brian L. Gilmore, Yanping Liang, Carly E. Winton, Kaya Patel, Vasilea Karageorge, A. Cameron Varano, William Dearnaley, Zhi Sheng, Deborah F. Kelly, 2017, Scientific reports

A Molecular Toolkit to Visualize Native Protein Assemblies in the Context of Human Disease

Brian L. Gilmore, Carly E. Winton, Andrew C. Demmert, Justin R. Tanner, Sam Bowman, Vasilea Karageorge, Kaya Patel, Zhi Sheng, Deborah F. Kelly, 2015, Scientific reports

A microchip platform for structural oncology applications

Carly E. Winton, Brian L. Gilmore, Andrew C. Demmert, Vasilea Karageorge, Zhi Sheng, Deb Kelly, 2016, npj Breast Cancer

In situ TEM of biological assemblies in liquid.

Madeline J. Dukes, Brian L. Gilmore, Justin R. Tanner, Sarah M. McDonald, Deb Kelly, 2013, Journal of visualized experiments : JoVE

News Articles Featuring Deb Kelly

Aspiring neurosurgeon mapping cancer-suppressing protein

Madison Evans is a Penn State biomedical engineering major who would like to become a neurosurgeon. Before she heads off to medical school, though, the Schreyer Honors Scholar is part of a research project that could change the way her future patients receive treatment.

Discovering the Secret Life of Cancer Cells (pg. 14)

Penn State's Center for Structural Oncology seeks to understand molecular culprits of breast cancer

Professor of Biomedical Engineering Deb Kelly hopes to 'outsmart breast cancer'

October is National Breast Cancer Awareness Month. One of the pioneering researchers in the fight against breast cancer is Deb Kelly, professor of biomedical engineering and director of the Center for Structural Oncology at Penn State.

Scientists have first 3D view of life's processes in liquid

A new liquid-cell technology allows scientists to see living biological materials and systems in three dimensions under an electron microscope, according to researchers at Penn State, Virginia Tech and Protochips Inc.

New liquid-cell technology provides first 3D view of life’s processes

A new liquid-cell technology allows scientists to see biological materials and systems in three dimensions under an electron microscope (EM), according to researchers at Penn State, Virginia Tech and Protochips Inc.