Deb Kelly

Director of the Center for Structural Oncology; Huck Chair in Molecular Biophysics; Professor of Biomedical Engineering

Deb Kelly

Research Summary

Engineering new molecular paradigms to create a world without cancer.

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

These publication tags are generated from the output of this researcher. Click any tag below to view other Huck researchers working on the same topic.

Nanoparticles Visualization Liquids Stem Cells Glioblastoma Electron Microscopes Vacuum Microfluidics Imaging Techniques Therapeutics Block Copolymers Microscopic Examination Electrons Fluidics Viruses Magnetic Resonance Imaging Liquid Electron Particle Chromium Hexavalent Ion Macromolecules Transmission Electron Microscopy Iron Oxides Proteins Genes Phosphotransferases

Most Recent Publications

Microchip-based structure determination of low-molecular weight proteins using Cryo-Electron Microscopy

Deborah Kelly, Nanoscale on p. 7285-7293

Complete models of p53 better inform the impact of hotspot mutations.

Deborah Kelly, International Journal of Molecular Sciences

High-resolution imaging of human viruses in liquid droplets

Deborah Kelly, Advanced Materials on p. 2103221

Liquid-EM Goes Viral – Visualizing Structure and Dynamics

Deborah Kelly, Current Opinion in Structural Biology

Advancing high-resolution imaging of virus assemblies in liquid and ice

Deborah Kelly, Journal of Visualized Experiments

Automated Tools to Advance High-Resolution Imaging in Liquid

Deborah Kelly,

High-resolution imaging of human cancer proteins using microprocessor materials.

Deborah Kelly,

Harnessing the Power of Structural Oncology

Deborah Kelly, Microscopy Today

Delineating Conformational Variability in Small Protein Structures Using Combinatorial Refinement Strategies

Deb Kelly, G. M. Jonaid, Liam Kaylor, Maria J. Solares, Samantha Berry, Liza Anastasia DiCecco, William Dearnaley, Michael Casasanta, 2023, Micromachines

Comparative Analysis of Cryo-electron Microscopy and Liquid-electron Microscopy Image Processing Workflows

G. M. Jonaid, William J. Dearnaley, Samantha Berry, Jennifer Gray, Michael Spilman, Madeline J. Dukes, Deborah F. Kelly, 2023, Microscopy and Microanalysis on p. 1033

Most-Cited Papers

A rapid and high content assay that measures cyto-ID-stained autophagic compartments and estimates autophagy flux with potential clinical applications

Sujuan Guo, Yanping Liang, Susan Murphy, Angela Huang, Haihong Shen, Deborah F. Kelly, Pablo Sobrado, Zhi Sheng, 2015, Autophagy on p. 560-572

Toward design of magnetic nanoparticle clusters stabilized by biocompatible diblock copolymers for T <sub>2</sub>-weighted MRI contrast

Sharavanan Balasubramaniam, Sanem Kayandan, Yin Nian Lin, Deborah F. Kelly, Michael J. House, Robert C. Woodward, Timothy G. St. Pierre, Judy S. Riffle, Richey M. Davis, 2014, Langmuir on p. 1580-1587

Real-Time Visualization of Nanoparticles Interacting with Glioblastoma Stem Cells

Elliot S. Pohlmann, Kaya Patel, Sujuan Guo, Madeline J. Dukes, Zhi Sheng, Deb Kelly, 2015, Nano Letters on p. 2329-2335

Survival kinase genes present prognostic significance in glioblastoma

Robin T. Varghese, Yanping Liang, Ting Guan, Christopher T. Franck, Deborah F. Kelly, Zhi Sheng, 2016, Oncotarget on p. 20140-20151

Visualizing viral assemblies in a nanoscale biosphere

Brian L. Gilmore, Shannon P. Showalter, Madeline J. Dukes, Justin R. Tanner, Andrew C. Demmert, Sarah M. McDonald, Deborah F. Kelly, 2013, Lab on a Chip - Miniaturisation for Chemistry and Biology on p. 216-219

PIK3CB/p110β is a selective survival factor for glioblastoma

Kevin J. Pridham, Lamvy Le, Sujuan Guo, Robin T. Varghese, Sarah Algino, Yanping Liang, Renee Fajardin, Cara M. Rodgers, Gary R. Simonds, Deborah F. Kelly, Zhi Sheng, 2018, Neuro-Oncology on p. 494-505

Visualizing virus particle mobility in liquid at the nanoscale

A. Cameron Varano, Amina Rahimi, Madeline J. Dukes, Steven Poelzing, Sarah M. McDonald, Deborah F. Kelly, 2015, Chemical Communications on p. 16176-16179

Prolonged particulate hexavalent chromium exposure suppresses homologous recombination repair in human lung cells

Cynthia L. Browning, Qin Qin, Deborah F. Kelly, Rohit Prakash, Fabio Vanoli, Maria Jasin, John Pierce Wise, 2016, Toxicological Sciences on p. 70-78

Affinity grid-based cryo-EM of PKC binding to RACK1 on the ribosome

Gyanesh Sharma, Jesper Pallesen, Sanchaita Das, Robert Grassucci, Robert Langlois, Cheri M. Hampton, Deborah F. Kelly, Amedee des Georges, Joachim Frank, 2013, Journal of Structural Biology on p. 190-194

Patient-derived glioblastoma stem cells respond differentially to targeted therapies

Pratik Kanabur, Sujuan Guo, Gary R. Simonds, Deborah F. Kelly, Robert G. Gourdie, Scott S. Verbridge, Zhi Sheng, 2016, Oncotarget on p. 86406-86419

News Articles Featuring Deb Kelly

Mar 01, 2023

Guarding the genome: Researchers uncover full 3D structure of p53 protein

The tumor suppressor protein p53, known as "the guardian of the genome," protects the body’s DNA from daily stress or long-term damage by triggering the cells to make repairs or to self-destruct.

Full Article

Aug 02, 2021

Researchers Film Human Viruses in Liquid Droplets at Near-atomic Detail

A pond in summer can reveal more about a fish than a pond in winter. The fish living in icy conditions might remain still enough to study its scales, but to understand how the fish swims and behaves, it needs to freely move in three dimensions. The same holds true for analyzing how biological items, such as viruses, move in the human body, according to a research team led by Deb Kelly, Huck Chair in Molecular Biophysics and professor of biomedical engineering at Penn State, who has used advanced electron microscopy (EM) technology to see how human viruses move in high resolution in a near-native environment. The visualization technique could lead to improved understanding of how vaccine candidates and treatments behave and function as they interact with target cells, Kelly said.

Full Article

Jul 29, 2021

Researchers film human viruses in liquid droplets at near-atomic detail

A research team led by Deb Kelly, Huck Chair in Molecular Biophysics and professor of biomedical engineering at Penn State, has used advanced electron microscopy (EM) technology to see how human viruses move in high resolution in a near-native environment. The visualization technique could lead to improved understanding of how vaccine candidates and treatments behave and function as they interact with target cells, Kelly said.

Full Article

Apr 08, 2021

Antibody binding-site conserved across COVID-19 virus variants

A tiny protein of SARS-CoV-2, the coronavirus that gives rise to COVID-19, may have big implications for future treatments, according to a team of Penn State researchers.

Full Article

Jan 06, 2021

Engineering professor named Microscopy Society of America president-elect

Deborah Kelly, Huck Chair in Molecular Biophysics and professor of biomedical engineering at Penn State, was elected president of the Microscopy Society of America (MSA). Her three-year commitment as first president-elect, then president, then past president, began in January.

Full Article

Nov 16, 2020

Deb Kelly named chair of NIH study section

Deborah Kelly, Penn State Lloyd & Dottie Foehr Huck Chair in Molecular Biophysics, director of the Penn State Center for Structural Oncology (CSO) and professor of biomedical engineering, has accepted an appointment as chair of the National Institutes of Health’s (NIH) Macromolecular Structure and Function B (MSFB) Study Section, directed by the Center for Scientific Review.

Full Article

Jul 24, 2020

Podcast features three women at the forefront of cryo-EM research

An all-female trio of Penn State research scientists explain how their work on cancer diagnostics and advanced materials science evolves along with improvements in cryo-electron microscopy.

Full Article

Apr 23, 2020

Penn State cancer research center joins pandemic fight

The Penn State Center for Structural Oncology (CSO) is shifting some of its focus from fighting cancer to fighting COVID-19, with three projects. The CSO’s director, Deborah Kelly, believes that the same interdisciplinary research approach and collaborative spirit that drives the CSO’s cancer research can be applied to fighting pandemics.

Full Article

Jan 20, 2020

Aspiring neurosurgeon mapping cancer-suppressing protein

Madison Evans is a Penn State biomedical engineering major who would like to become a neurosurgeon. Before she heads off to medical school, though, the Schreyer Honors Scholar is part of a research project that could change the way her future patients receive treatment.

Full Article

Jan 17, 2020

Discovering the Secret Life of Cancer Cells (pg. 14)

Penn State's Center for Structural Oncology seeks to understand molecular culprits of breast cancer

Full Article