David Kennedy

Assistant Professor of Biology

David Kennedy

Research Summary

Ecology and evolution of infectious diseases, with particular interest in how disease dynamics influence pathogen emergence, virulence evolution, and drug or vaccine resistance.

Huck Graduate Students

Huck Affiliations

Links

Publication Tags

Vaccines Viruses Poultry Pathogens Farms Drug Resistance Marek Disease Industry Clinical Trials Virulence Mardivirus Aquaculture Principal Component Analysis Resistance Vaccination Pharmaceutical Preparations Pathogen Dust Monitoring Efficacy Genetic Drift Markov Chain Monte Carlo Parallel Computing Sampling Dna

Most Recent Papers

What the reproductive number R<sub>0</sub> can and cannot tell us about COVID-19 dynamics

Clara L. Shaw, David A. Kennedy, 2021, Theoretical Population Biology on p. 2-9

Why it matters that the coronavirus is changing -- and what this means for vaccine effectiveness

David Kennedy, 2020,

Virus evolution could undermine a COVID-19 vaccine -- but this can be stopped

A Read, David Kennedy, 2020,

Monitor for COVID-19 vaccine resistance evolution during clinical trials

David A. Kennedy, Andrew F. Read, David A. Kennedy, 2020, PLoS Biology

Molecular epidemiology of Marek’s disease virus in central Pennsylvania, USA

Andrew Bell, David Kennedy, Matthew Jones, Christopher Cairns, Utsav Pandey, Patricia Dunn, Moriah Szpara, Andrew Read, 2019, Virus Evolution

Molecular epidemiology of Marek’s disease virus in central Pennsylvania, USA

Andrew S. Bell, David A. Kennedy, Matthew J. Jones, Christopher L. Cairns, Utsav Pandey, Patricia A. Dunn, Moriah L. Szpara, Andrew F. Read, 2019, Virus Evolution

Why the evolution of vaccine resistance is less of a concern than the evolution of drug resistance

David A. Kennedy, Andrew F. Read, 2018, Proceedings of the National Academy of Sciences of the United States of America on p. 12878-12886

Modeling Marek's disease virus transmission: A framework for evaluating the impact of farming practices and evolution

David A. Kennedy, Patricia A. Dunn, Andrew F. Read, 2018, Epidemics on p. 85-95

Effects of multiple sources of genetic drift on pathogen variation within hosts

David A. Kennedy, Greg Dwyer, 2018, PLoS Biology

Industry-wide surveillance of Marek’s disease virus on commercial poultry farms.

David A. Kennedy, Christopher Cairns, Matthew J. Jones, Andrew S. Bell, Rahel M. Salathé, Susan J. Baigent, Venugopal K. Nair, Patricia A. Dunn, Andrew F. Read, 2017, Avian Diseases on p. 153-164

Most-Cited Papers

Imperfect vaccination can enhance the transmission of highly virulent pathogens

Andrew F. Read, Susan J. Baigent, Claire Powers, Lydia B. Kgosana, Luke Blackwell, Lorraine P. Smith, David A. Kennedy, Stephen W. Walkden-Brown, Venugopal K. Nair, 2015, PLoS Biology on p. e1002198

Why does drug resistance readily evolve but vaccine resistance does not?

David A. Kennedy, Andrew F. Read, 2017, Proceedings of the Royal Society B: Biological Sciences

Potential drivers of virulence evolution in aquaculture

David A. Kennedy, Gael Kurath, Ilana L. Brito, Maureen K. Purcell, Andrew F. Read, James R. Winton, Andrew R. Wargo, 2016, Evolutionary Applications on p. 344-354

Why the evolution of vaccine resistance is less of a concern than the evolution of drug resistance

David A. Kennedy, Andrew F. Read, 2018, Proceedings of the National Academy of Sciences of the United States of America on p. 12878-12886

Monitor for COVID-19 vaccine resistance evolution during clinical trials

David A. Kennedy, Andrew F. Read, David A. Kennedy, 2020, PLoS Biology

Industry-wide surveillance of Marek’s disease virus on commercial poultry farms.

David A. Kennedy, Christopher Cairns, Matthew J. Jones, Andrew S. Bell, Rahel M. Salathé, Susan J. Baigent, Venugopal K. Nair, Patricia A. Dunn, Andrew F. Read, 2017, Avian Diseases on p. 153-164

Using quantitative disease dynamics as a tool for guiding response to avian influenza in poultry in the United States of America

K. M. Pepin, E. Spackman, J. D. Brown, K. L. Pabilonia, L. P. Garber, J. T. Weaver, D. A. Kennedy, K. A. Patyk, K. P. Huyvaert, R. S. Miller, A. B. Franklin, K. Pedersen, T. L. Bogich, P. Rohani, S. A. Shriner, C. T. Webb, S. Riley, 2014, Preventive Veterinary Medicine on p. 376-397

Pathogen growth in insect hosts

David A. Kennedy, Vanja Dukic, Greg Dwyer, 2014, American Naturalist on p. 407-423

Combining principal component analysis with parameter line-searches to improve the efficacy of Metropolis–Hastings MCMC

David A. Kennedy, Vanja Dukic, Greg Dwyer, 2015, Environmental and Ecological Statistics on p. 247-274

DNA from dust: Comparative genomics of large DNA viruses in field surveillance samples

Utsav Pandey, Andrew S. Bell, Daniel W. Renner, David A. Kennedy, Jacob T. Shreve, Chris L. Cairns, Matthew J. Jones, Patricia A. Dunn, Andrew F. Read, Moriah L. Szpara, 2016, mSphere on p. e00132--16

News Articles Featuring David Kennedy

Vaccine Makers Already Testing Their Shots Against Omicron Variant

As concerns about the new Omicron variant grow, vaccine makers say they're already working on ways to protect people against the potential new threat.

Will Covid variant omicron need a new vaccine? Time and data will tell

The discovery of another coronavirus variant has raised new concerns about the ability of existing vaccines to protect against the mutating virus — and whether they’ll need to be updated.

New tool weighs costs and benefits of managing evolution of pathogens and pests

Spend money now on antibiotic stewardship practices or save the money but run the risk of potentially deadly antibiotic-resistant bacteria emerging later? A new economic tool can help physicians, farmers and other people whose activities may influence the evolution of biological organisms, such as pathogens and insects, decide when they should invest in evolution management strategies.

Are the vaccines effective against mutant Covid variants?

India is undergoing a massive vaccination effort in the midst of a devastating rise in reported daily cases and deaths. While the main cause of the rise in cases is yet to be determined, epidemiological and virological data point to the rise of new variants of concern being a major contributing factor.

How Much Should We Really Worry About the Coronavirus Variants?

Even as things look promising for summer, the coronavirus is still finding new ways to threaten our creep back to normal and our general sense of health and safety.

How devastating could Brazil's 'super-covid' be? Study finds coronavirus overwhelmed the country, killing nearly 40% of hospitalized patients as fears grow its variant could ALREADY be in America

Nearly 40 percent of hospitalized COVID-19 patients in Brazil died of the virus as the nation's health care system was inundated with coronavirus cases last year, a new study estimates.

Why it matters that the coronavirus is changing — and what this means for vaccine effectiveness (Philadelphia Inquirer)

If this new version of the virus is here to stay, as it appears to be, what does that mean? Will this new version of the virus replace the old one? Will it be easier to catch? And, most important, will the current vaccines still be effective?

Why it matters that the coronavirus is changing — and what this means for vaccine effectiveness (The Conversation)

A new variant of SARS-CoV-2 is spreading rapidly in the United Kingdom, with over 1,400 cases since September. SARS-CoV-2, the virus that causes COVID-19, generally accumulates mutations slowly over time, but this new variant had accumulated many mutations quickly.

What happens if you skip the second dose of the COVID-19 vaccine?

As Pfizer’s COVID-19 vaccine begins circulating, there is another big logistical challenge ahead: reminding people to get the second dose.

Virus evolution could undermine a COVID-19 vaccine – but this can be stopped

The first drug against HIV brought dying patients back from the brink. But as excited doctors raced to get the miracle drug to new patients, the miracle melted away. In each and every patient, the drug only worked only for a while.