David Kennedy

Assistant Professor of Biology

David Kennedy

Research Summary

Ecology and evolution of infectious diseases, with particular interest in how disease dynamics influence pathogen emergence, virulence evolution, and drug or vaccine resistance.

Graduate Students

Huck Affiliations

Links

Publication Tags

Principal Component Analysis Malaria Virulence Pathogens Genetic Drift Marek Disease Markov Chain Monte Carlo Chickens Observational Studies Efficacy Plasmodium Chabaudi Pathogen Effect Parallel Computing Parasites Testing Epidemiology Farms Viruses Immune System Test Immunity Metropolis Hastings Immunosuppression Line Search

Most Recent Papers

Why the evolution of vaccine resistance is less of a concern than the evolution of drug resistance.

David Kennedy, Andrew Read, 2018, Proceedings of the National Academy of Sciences of the United States of America on p. 12878-12886

Effects of multiple sources of genetic drift on pathogen variation within hosts

David A. Kennedy, Greg Dwyer, 2018, PLoS biology

DNA from dust: Comparative genomics of large DNA viruses in field surveillance samples

Utsav Pandey, Andrew Bell, Daniel Renner, David Kennedy, Jacob Shreve, Chris Cairns, Matthew Jones, Patricia Dunn, Andrew Read, Moriah Szpara, 2016, mSphere on p. e00132--16

DNA from dust: the first field-isolated genomes of MDV-1, from virions in poultry dust and chicken feather follicles

U. Pandey, Andrew Bell, D. Renner, David Kennedy, J. Shreve, C. Cairns, Matthew Jones, Patricia Dunn, Andrew Read, Moriah Szpara, 2016,

An observational study of the temporal and spatial patterns of Marek's-disease-associated leukosis condemnation of young chickens in the United States of America

David A. Kennedy, John R. Dunn, Patricia A. Dunn, Andrew F. Read, 2015, Preventive Veterinary Medicine on p. 328-335

Combining principal component analysis with parameter line-searches to improve the efficacy of Metropolis–Hastings MCMC

David A. Kennedy, Vanja Dukic, Greg Dwyer, 2015, Environmental and Ecological Statistics on p. 247-274

Pathogen growth in insect hosts

David A. Kennedy, Vanja Dukic, Greg Dwyer, 2014, American Naturalist on p. 407-423

The effect of immunodeficiency on the evolution of virulence

Victoria C. Barclay, David A. Kennedy, Veronika C. Weaver, Derek Sim, James O. Lloyd-Smith, Andrew F. Read, 2014, American Naturalist on p. S47-S57

Using quantitative disease dynamics as a tool for guiding response to avian influenza in poultry in the United States of America

KM Pepin, E Spackman, JD Brown, KL Pabilonia, LP Garber, JT Weaver, David Kennedy, KA Patyk, KP Huyvaert, RS Miller, others, 2014, Preventive veterinary medicine on p. 376--397

Ahead of the curve: next generation estimators of drug resistance in malaria infections

Nicole Mideo, David Kennedy, Jane Carlton, Jeffrey Bailey, Jonathan Juliano, Andrew Read, 2013, Trends in parasitology on p. 321--328

Most-Cited Papers

The effect of immunodeficiency on the evolution of virulence

Victoria C. Barclay, David A. Kennedy, Veronika C. Weaver, Derek Sim, James O. Lloyd-Smith, Andrew F. Read, 2014, American Naturalist on p. S47-S57

Pathogen growth in insect hosts

David A. Kennedy, Vanja Dukic, Greg Dwyer, 2014, American Naturalist on p. 407-423

Combining principal component analysis with parameter line-searches to improve the efficacy of Metropolis–Hastings MCMC

David A. Kennedy, Vanja Dukic, Greg Dwyer, 2015, Environmental and Ecological Statistics on p. 247-274

An observational study of the temporal and spatial patterns of Marek's-disease-associated leukosis condemnation of young chickens in the United States of America

David A. Kennedy, John R. Dunn, Patricia A. Dunn, Andrew F. Read, 2015, Preventive Veterinary Medicine on p. 328-335

Effects of multiple sources of genetic drift on pathogen variation within hosts

David A. Kennedy, Greg Dwyer, 2018, PLoS biology

Ahead of the curve: next generation estimators of drug resistance in malaria infections

Nicole Mideo, David Kennedy, Jane Carlton, Jeffrey Bailey, Jonathan Juliano, Andrew Read, 2013, Trends in parasitology on p. 321--328

DNA from dust: Comparative genomics of large DNA viruses in field surveillance samples

Utsav Pandey, Andrew Bell, Daniel Renner, David Kennedy, Jacob Shreve, Chris Cairns, Matthew Jones, Patricia Dunn, Andrew Read, Moriah Szpara, 2016, mSphere on p. e00132--16

Why the evolution of vaccine resistance is less of a concern than the evolution of drug resistance.

David Kennedy, Andrew Read, 2018, Proceedings of the National Academy of Sciences of the United States of America on p. 12878-12886

In vitro effects of anthocyanidins on sinonasal epithelial nitric oxide production and bacterial physiology

Benjamin Hariri, Sakeena Payne, Bei Chen, Corrine Mansfield, Laurel Doghramji, Nithin Adappa, James Palmer, David Kennedy, Masha Niv, Robert Lee, 2016, AMERICAN JOURNAL OF RHINOLOGY & ALLERGY on p. 261-268

Epidural Steroid Injections are Safe and Effective: Multisociety Letter in Support of the Safety and Effectiveness of Epidural Steroid Injections

David Kennedy, Joshua Levin, Richard Rosenquist, Virtaj Singh, Clark Smith, Milan Stojanovic, Yakov Vorobeychik, 2015, PAIN MEDICINE on p. 833-838

News Articles Featuring David Kennedy

Virus evolution could undermine a COVID-19 vaccine – but this can be stopped

The first drug against HIV brought dying patients back from the brink. But as excited doctors raced to get the miracle drug to new patients, the miracle melted away. In each and every patient, the drug only worked only for a while.

Mutant coronaviruses found in mink spark massive culls and doom a Danish group’s research

Jens Malmkvist’s life’s work came to a dramatic end this week. An ethologist at Aarhus University, Malmkvist studies the behavior and welfare of farmed mink, with the aim of giving them a better life as they are raised for fur. But on Monday and Tuesday, all 6350 minks at the Aarhus facility were gassed as part of a nationwide cull ordered on 4 November by the Danish government.

Vaccines will not be a 'silver bullet' to end Covid-19 immediately

A coronavirus vaccine won't immediately bring the pandemic to an end and scientists and officials must be honest about how long it will take to roll one out and get life back to normal, experts say.

Could SARS-CoV-2 evolve resistance to COVID-19 vaccines?

Similar to bacteria evolving resistance to antibiotics, viruses can evolve resistance to vaccines, and the evolution of SARS-CoV-2 could undermine the effectiveness of vaccines that are currently under development, according to a paper published Nov. 9 in the open-access journal PLOS Biology by David Kennedy and Andrew Read from Penn State.