David Kennedy
Assistant Professor of Biology
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W229B Millennium Science Complex
University Park, PA - dak30@psu.edu
- 814-863-5461
Research Summary
Ecology and evolution of infectious diseases, with particular interest in how disease dynamics influence pathogen emergence, virulence evolution, and drug or vaccine resistance.
Graduate Students
Huck Affiliations
Links
Publication Tags
Principal Component Analysis Malaria Virulence Pathogens Genetic Drift Marek Disease Markov Chain Monte Carlo Chickens Observational Studies Efficacy Plasmodium Chabaudi Pathogen Effect Parallel Computing Parasites Testing Epidemiology Farms Viruses Immune System Test Immunity Metropolis Hastings Immunosuppression Line SearchMost Recent Papers
Why the evolution of vaccine resistance is less of a concern than the evolution of drug resistance.
David Kennedy, Andrew Read, 2018, Proceedings of the National Academy of Sciences of the United States of America on p. 12878-12886
Effects of multiple sources of genetic drift on pathogen variation within hosts
David A. Kennedy, Greg Dwyer, 2018, PLoS biology
DNA from dust: Comparative genomics of large DNA viruses in field surveillance samples
Utsav Pandey, Andrew Bell, Daniel Renner, David Kennedy, Jacob Shreve, Chris Cairns, Matthew Jones, Patricia Dunn, Andrew Read, Moriah Szpara, 2016, mSphere on p. e00132--16
DNA from dust: the first field-isolated genomes of MDV-1, from virions in poultry dust and chicken feather follicles
U. Pandey, Andrew Bell, D. Renner, David Kennedy, J. Shreve, C. Cairns, Matthew Jones, Patricia Dunn, Andrew Read, Moriah Szpara, 2016,
An observational study of the temporal and spatial patterns of Marek's-disease-associated leukosis condemnation of young chickens in the United States of America
David A. Kennedy, John R. Dunn, Patricia A. Dunn, Andrew F. Read, 2015, Preventive Veterinary Medicine on p. 328-335
Combining principal component analysis with parameter line-searches to improve the efficacy of Metropolis–Hastings MCMC
David A. Kennedy, Vanja Dukic, Greg Dwyer, 2015, Environmental and Ecological Statistics on p. 247-274
Pathogen growth in insect hosts
David A. Kennedy, Vanja Dukic, Greg Dwyer, 2014, American Naturalist on p. 407-423
The effect of immunodeficiency on the evolution of virulence
Victoria C. Barclay, David A. Kennedy, Veronika C. Weaver, Derek Sim, James O. Lloyd-Smith, Andrew F. Read, 2014, American Naturalist on p. S47-S57
Using quantitative disease dynamics as a tool for guiding response to avian influenza in poultry in the United States of America
KM Pepin, E Spackman, JD Brown, KL Pabilonia, LP Garber, JT Weaver, David Kennedy, KA Patyk, KP Huyvaert, RS Miller, others, 2014, Preventive veterinary medicine on p. 376--397
Ahead of the curve: next generation estimators of drug resistance in malaria infections
Nicole Mideo, David Kennedy, Jane Carlton, Jeffrey Bailey, Jonathan Juliano, Andrew Read, 2013, Trends in parasitology on p. 321--328
Most-Cited Papers
The effect of immunodeficiency on the evolution of virulence
Victoria C. Barclay, David A. Kennedy, Veronika C. Weaver, Derek Sim, James O. Lloyd-Smith, Andrew F. Read, 2014, American Naturalist on p. S47-S57
Pathogen growth in insect hosts
David A. Kennedy, Vanja Dukic, Greg Dwyer, 2014, American Naturalist on p. 407-423
Combining principal component analysis with parameter line-searches to improve the efficacy of Metropolis–Hastings MCMC
David A. Kennedy, Vanja Dukic, Greg Dwyer, 2015, Environmental and Ecological Statistics on p. 247-274
An observational study of the temporal and spatial patterns of Marek's-disease-associated leukosis condemnation of young chickens in the United States of America
David A. Kennedy, John R. Dunn, Patricia A. Dunn, Andrew F. Read, 2015, Preventive Veterinary Medicine on p. 328-335
Effects of multiple sources of genetic drift on pathogen variation within hosts
David A. Kennedy, Greg Dwyer, 2018, PLoS biology
Ahead of the curve: next generation estimators of drug resistance in malaria infections
Nicole Mideo, David Kennedy, Jane Carlton, Jeffrey Bailey, Jonathan Juliano, Andrew Read, 2013, Trends in parasitology on p. 321--328
DNA from dust: Comparative genomics of large DNA viruses in field surveillance samples
Utsav Pandey, Andrew Bell, Daniel Renner, David Kennedy, Jacob Shreve, Chris Cairns, Matthew Jones, Patricia Dunn, Andrew Read, Moriah Szpara, 2016, mSphere on p. e00132--16
Why the evolution of vaccine resistance is less of a concern than the evolution of drug resistance.
David Kennedy, Andrew Read, 2018, Proceedings of the National Academy of Sciences of the United States of America on p. 12878-12886
In vitro effects of anthocyanidins on sinonasal epithelial nitric oxide production and bacterial physiology
Benjamin Hariri, Sakeena Payne, Bei Chen, Corrine Mansfield, Laurel Doghramji, Nithin Adappa, James Palmer, David Kennedy, Masha Niv, Robert Lee, 2016, AMERICAN JOURNAL OF RHINOLOGY & ALLERGY on p. 261-268
Epidural Steroid Injections are Safe and Effective: Multisociety Letter in Support of the Safety and Effectiveness of Epidural Steroid Injections
David Kennedy, Joshua Levin, Richard Rosenquist, Virtaj Singh, Clark Smith, Milan Stojanovic, Yakov Vorobeychik, 2015, PAIN MEDICINE on p. 833-838
News Articles Featuring David Kennedy
Nov 17, 2020
Virus evolution could undermine a COVID-19 vaccine – but this can be stopped
The first drug against HIV brought dying patients back from the brink. But as excited doctors raced to get the miracle drug to new patients, the miracle melted away. In each and every patient, the drug only worked only for a while.
Full Article
Nov 11, 2020
Mutant coronaviruses found in mink spark massive culls and doom a Danish group’s research
Jens Malmkvist’s life’s work came to a dramatic end this week. An ethologist at Aarhus University, Malmkvist studies the behavior and welfare of farmed mink, with the aim of giving them a better life as they are raised for fur. But on Monday and Tuesday, all 6350 minks at the Aarhus facility were gassed as part of a nationwide cull ordered on 4 November by the Danish government.
Full Article
Nov 09, 2020
Vaccines will not be a 'silver bullet' to end Covid-19 immediately
A coronavirus vaccine won't immediately bring the pandemic to an end and scientists and officials must be honest about how long it will take to roll one out and get life back to normal, experts say.
Full Article
Nov 09, 2020
Could SARS-CoV-2 evolve resistance to COVID-19 vaccines?
Similar to bacteria evolving resistance to antibiotics, viruses can evolve resistance to vaccines, and the evolution of SARS-CoV-2 could undermine the effectiveness of vaccines that are currently under development, according to a paper published Nov. 9 in the open-access journal PLOS Biology by David Kennedy and Andrew Read from Penn State.
Full Article