Darrell Cockburn

Assistant Professor of Food Science

Darrell Cockburn

Huck Affiliations

Publication Tags

Enzymes Starch Carbohydrates Cellulose Binding Sites Polysaccharides Ruminococcus Glycoside Hydrolases Oligosaccharides Glucans Surface Plasmon Resonance Mutation Proteins Rumen Assays Milk Proteins Sporulation Bacterial Proteins Amylases Bacteria Temperature Electrophoresis Eubacterium Phylogeny Enzyme

Most Recent Papers

Characterization of microbial dynamics and volatile metabolome changes during fermentation of Chambourcin hybrid grapes from two Pennsylvania regions

Hung Wang, Helene Hopfer, Darrell Cockburn, Josephine Wee, 2020, Frontiers in Microbiology on p. 3454

The structures of the GH13_36 amylases from Eubacterium rectale and Ruminococcus bromii reveal subsite architectures that favor maltose production

Darrell Cockburn, Filipe Cerqueira, Constance Bahr, Nicole Koropatkin, 2020, Amylase on p. 24-44

Structural basis for the flexible recognition of α-glucan substrates by Bacteroides thetaiotaomicron SusG

Gregory Arnal, Darrell W. Cockburn, Harry Brumer, Nicole M. Koropatkin, 2018, Protein Science on p. 1093-1101

Novel carbohydrate binding modules in the surface anchored α-amylase of Eubacterium rectale provide a molecular rationale for the range of starches used by this organism in the human gut

Darrell Cockburn, Carolyn Suh, Krizia Perez Medina, Rebecca M. Duvall, Zdzislaw Wawrzak, Bernard Henrissat, Nicole M. Koropatkin, 2018, Molecular Microbiology on p. 249-264

Sporulation capability and amylosome conservation among diverse human colonic and rumen isolates of the keystone starch-degrader Ruminococcus bromii

Indrani Mukhopadhya, Sarah Moraïs, Jenny Laverde-Gomez, Paul O. Sheridan, Alan W. Walker, William Kelly, Athol V. Klieve, Diane Ouwerkerk, Sylvia H. Duncan, Petra Louis, Nicole Koropatkin, Darrell Cockburn, Ryan Kibler, Philip J. Cooper, Carlos Sandoval, Emmanuelle Crost, Nathalie Juge, Edward A. Bayer, Harry J. Flint, 2018, Environmental microbiology on p. 324-336

Sporulation capability and amylosome conservation among diverse human colonic and rumen isolates of the keystone starch-degrader Ruminococcus bromii.

I Mukhopadhya, S Moraïs, J Laverde-Gomez, P Sheridan, A Walker, W Kelly, A Klieve, D Ouwerkerk, S Duncan, P Louis, N Koropatkin, Darrell Cockburn, R Kibler, P Cooper, C Sandoval, E Crost, N Juge, E Bayer, H Flint, 2017, Environmental microbiology

Novel carbohydrate binding modules in the surface anchored α-amylase of Eubacterium rectale provide a molecular rationale for the range of starches used by this organism in the human gut.

Darrell Cockburn, C Suh, K Medina, R Duvall, Z Wawrzak, B Henrissat, N Koropatkin, 2017, Molecular microbiology

Affinity electrophoresis for analysis of catalytic module-carbohydrate interactions

Darrell Cockburn, Casper Wilkens, Birte Svensson, 2017, Methods in Molecular Biology on p. 119–127

Lysozyme activity of the Ruminococcus champanellensis cellulosome

Sarah Moraïs, Darrell W. Cockburn, Yonit Ben-David, Nicole M. Koropatkin, Eric C. Martens, Sylvia H. Duncan, Harry J. Flint, Itzhak Mizrahi, Edward A. Bayer, 2016, Environmental microbiology on p. 5112-5122

Using carbohydrate interaction assays to reveal novel binding sites in carbohydrate active enzymes

Darrell Cockburn, Casper Wilkens, Adiphol Dilokpimol, Hiroyuki Nakai, Anna Lewińska, Maher Abou Hachem, Birte Svensson, 2016, PloS one on p. e0160112

Most-Cited Papers

Molecular details of a starch utilization pathway in the human gut symbiont Eubacterium rectale

Darrell W. Cockburn, Nicole I. Orlovsky, Matthew H. Foley, Kurt J. Kwiatkowski, Constance M. Bahr, Mallory Maynard, Borries Demeler, Nicole M. Koropatkin, 2015, Molecular Microbiology on p. 209-230

Surface binding sites in amylase have distinct roles in recognition of starch structure motifs and degradation

Darrell Cockburn, Morten M. Nielsen, Camilla Christiansen, Joakim M. Andersen, Julie B. Rannes, Andreas Blennow, Birte Svensson, 2015, International Journal of Biological Macromolecules on p. 338-345

A bacterial glucanotransferase can replace the complex maltose metabolism required for starch to sucrose conversion in leaves at night

Christian Ruzanski, Julia Smirnova, Martin Rejzek, Darrell Cockburn, Henriette L. Pedersen, Marilyn Pike, William G.T. Willats, Birte Svensson, Martin Steup, Oliver Ebenhöh, Alison M. Smith, Robert A. Field, 2013, Journal of Biological Chemistry on p. 28581-28598

Sporulation capability and amylosome conservation among diverse human colonic and rumen isolates of the keystone starch-degrader Ruminococcus bromii

Indrani Mukhopadhya, Sarah Moraïs, Jenny Laverde-Gomez, Paul O. Sheridan, Alan W. Walker, William Kelly, Athol V. Klieve, Diane Ouwerkerk, Sylvia H. Duncan, Petra Louis, Nicole Koropatkin, Darrell Cockburn, Ryan Kibler, Philip J. Cooper, Carlos Sandoval, Emmanuelle Crost, Nathalie Juge, Edward A. Bayer, Harry J. Flint, 2018, Environmental microbiology on p. 324-336

Novel carbohydrate binding modules in the surface anchored α-amylase of Eubacterium rectale provide a molecular rationale for the range of starches used by this organism in the human gut

Darrell Cockburn, Carolyn Suh, Krizia Perez Medina, Rebecca M. Duvall, Zdzislaw Wawrzak, Bernard Henrissat, Nicole M. Koropatkin, 2018, Molecular Microbiology on p. 249-264

An efficient arabinoxylan-debranching α-l-arabinofuranosidase of family GH62 from Aspergillus nidulans contains a secondary carbohydrate binding site

Casper Wilkens, Susan Andersen, Bent O. Petersen, An Li, Marta Busse-Wicher, Johnny Birch, Darrell Cockburn, Hiroyuki Nakai, Hans E.M. Christensen, Birthe B. Kragelund, Paul Dupree, Barry McCleary, Ole Hindsgaul, Maher Abou Hachem, Birte Svensson, 2016, Applied Microbiology and Biotechnology on p. 6265-6277

Modulating the pH-activity profile of cellulase A from Cellulomonas fimi by replacement of surface residues

Darrell W. Cockburn, Anthony J. Clarke, 2011, Protein Engineering, Design and Selection on p. 429-437

Using carbohydrate interaction assays to reveal novel binding sites in carbohydrate active enzymes

Darrell Cockburn, Casper Wilkens, Adiphol Dilokpimol, Hiroyuki Nakai, Anna Lewińska, Maher Abou Hachem, Birte Svensson, 2016, PloS one on p. e0160112

Binding Interactions Between α-glucans from Lactobacillus reuteri and Milk Proteins Characterised by Surface Plasmon Resonance

Silja K. Diemer, Birte Svensson, Linnéa N. Babol, Darrell Cockburn, Pieter Grijpstra, Lubbert Dijkhuizen, Ditte M. Folkenberg, Christel Garrigues, Richard H. Ipsen, 2012, Food Biophysics on p. 220-226

Lysozyme activity of the Ruminococcus champanellensis cellulosome

Sarah Moraïs, Darrell W. Cockburn, Yonit Ben-David, Nicole M. Koropatkin, Eric C. Martens, Sylvia H. Duncan, Harry J. Flint, Itzhak Mizrahi, Edward A. Bayer, 2016, Environmental microbiology on p. 5112-5122