Darrell Cockburn

Assistant Professor of Food Science

Darrell Cockburn

Huck Affiliations

Publication Tags

Starch Enzymes Health Carbohydrates Binding Sites Oligosaccharides Polysaccharides Gastrointestinal Microbiome Amylases Microbiota Glycoside Hydrolases Surface Butyrates Fermentation Reconfigurable Hardware Maltose Binding Site Carbohydrate Glucans Escherichia Coli Degradation Ruminococcus Catalytic Domain Genetically Modified Plants Mutation

Most Recent Papers

Additional Resistant Starch from One Potato Side Dish per Day Alters the Gut Microbiota but Not Fecal Short-Chain Fatty Acid Concentrations

Peter Demartino, Emily A. Johnston, Kristina S. Petersen, Penny M. Kris-Etherton, Darrell W. Cockburn, 2022, Nutrients

Structure and substrate recognition by the Ruminococcus bromii amylosome pullulanases

Darrell W. Cockburn, Ryan Kibler, Haley A. Brown, Rebecca Duvall, Sarah Moraïs, Edward Bayer, Nicole M. Koropatkin, 2021, Journal of Structural Biology

In vitro Fermentation Reveals Changes in Butyrate Production Dependent on Resistant Starch Source and Microbiome Composition

June Teichmann, Darrell W. Cockburn, 2021, Frontiers in Microbiology

Characterization of Microbial Dynamics and Volatile Metabolome Changes During Fermentation of Chambourcin Hybrid Grapes From Two Pennsylvania Regions

Hung Li Wang, Helene Hopfer, Darrell W. Cockburn, Josephine Wee, 2021, Frontiers in Microbiology on p. 3454

A Modified Brewing Procedure Informed by the Enzymatic Profiles of Gluten-Free Malts Significantly Improves Fermentable Sugar Generation in Gluten-Free Brewing

Andrew Ledley, R Elias, H Hopfer, Darrell Cockburn, 2021, Beverages on p. 53

Resistant starch

Peter DeMartino, Darrell W. Cockburn, 2020, Current Opinion in Biotechnology on p. 66-71


Darrell Cockburn, 2020, Zippia

The structures of the GH13_36 amylases from Eubacterium rectale and Ruminococcus bromii reveal subsite architectures that favor maltose production

Darrell Cockburn, Filipe Cerqueira, Constance Bahr, Nicole Koropatkin, 2020, Amylase on p. 24-44

5 things you can do to make your microbiome healthier

Darrell Cockburn, C Rogers, 2019, The Conversation

Structural basis for the flexible recognition of α-glucan substrates by Bacteroides thetaiotaomicron SusG

Gregory Arnal, Darrell W. Cockburn, Harry Brumer, Nicole M. Koropatkin, 2018, Protein Science on p. 1093-1101

Most-Cited Papers

Polysaccharide Degradation by the Intestinal Microbiota and Its Influence on Human Health and Disease

Darrell W. Cockburn, Nicole M. Koropatkin, 2016, Journal of Molecular Biology on p. 3230-3252

The Sus operon

Matthew H. Foley, Darrell W. Cockburn, Nicole M. Koropatkin, 2016, Cellular and Molecular Life Sciences on p. 2603-2617

Molecular details of a starch utilization pathway in the human gut symbiont Eubacterium rectale

Darrell W. Cockburn, Nicole I. Orlovsky, Matthew H. Foley, Kurt J. Kwiatkowski, Constance M. Bahr, Mallory Maynard, Borries Demeler, Nicole M. Koropatkin, 2015, Molecular Microbiology on p. 209-230

Resistant starch

Peter DeMartino, Darrell W. Cockburn, 2020, Current Opinion in Biotechnology on p. 66-71

Sporulation capability and amylosome conservation among diverse human colonic and rumen isolates of the keystone starch-degrader Ruminococcus bromii

Indrani Mukhopadhya, Sarah Moraïs, Jenny Laverde-Gomez, Paul O. Sheridan, Alan W. Walker, William Kelly, Athol V. Klieve, Diane Ouwerkerk, Sylvia H. Duncan, Petra Louis, Nicole Koropatkin, Darrell Cockburn, Ryan Kibler, Philip J. Cooper, Carlos Sandoval, Emmanuelle Crost, Nathalie Juge, Edward A. Bayer, Harry J. Flint, 2018, Environmental Microbiology on p. 324-336

Analysis of surface binding sites (SBSs) in carbohydrate active enzymes with focus on glycoside hydrolase families 13 and 77 - a mini-review

Darrell Cockburn, Casper Wilkens, Christian Ruzanski, Susan Andersen, Jonas Willum Nielsen, Alison M. Smith, Robert A. Field, Martin Willemoës, Maher Abou Hachem, Birte Svensson, 2014, Biologia (Poland) on p. 705-712

Surface binding sites in amylase have distinct roles in recognition of starch structure motifs and degradation

Darrell Cockburn, Morten M. Nielsen, Camilla Christiansen, Joakim M. Andersen, Julie B. Rannes, Andreas Blennow, Birte Svensson, 2015, International Journal of Biological Macromolecules on p. 338-345

Novel carbohydrate binding modules in the surface anchored α-amylase of Eubacterium rectale provide a molecular rationale for the range of starches used by this organism in the human gut

Darrell W. Cockburn, Carolyn Suh, Krizia Perez Medina, Rebecca M. Duvall, Zdzislaw Wawrzak, Bernard Henrissat, Nicole M. Koropatkin, 2018, Molecular Microbiology on p. 249-264

A bacterial glucanotransferase can replace the complex maltose metabolism required for starch to sucrose conversion in leaves at night

Christian Ruzanski, Julia Smirnova, Martin Rejzek, Darrell Cockburn, Henriette L. Pedersen, Marilyn Pike, William G.T. Willats, Birte Svensson, Martin Steup, Oliver Ebenhöh, Alison M. Smith, Robert A. Field, 2013, Journal of Biological Chemistry on p. 28581-28598

Surface binding sites in carbohydrate active enzymes

Darrell Cockburn, Birte Svensson, 2013, on p. 204-221