Daniel Hayes

Director, Center of Excellence in Industrial Biotechnology; Huck Chair in Nanotherapeutics and Regenerative Medicine; Professor of Biomedical Engineering

Daniel Hayes

Research Summary

Biomaterials engineering for applications ranging from regenerative medicine to lab-on-a-chip technologies. An emphasis on nanomaterials, macromolecules and composite structures. Ongoing efforts include development of optically and magnetically modulated drug delivery systems, quasi 3D cell sheet culture systems, cell encapsulation and delivery materials and hybrid in situ polymerizing grafts/augments.

Huck Affiliations

Links

Publication Tags

Stem Cells Bone Nanoparticles Scaffolds Hydrogels Tissue Silver Hydrogel Genes Osteogenic Oligonucleotides Collagen Defects Gene Expression Polycaprolactone Tissue Engineering Proteins Micrornas Microrna Silver Nanoparticles Rats Modulation Scaffolds (Biology) Cellulose Nanocomposites

Most Recent Publications

miRNA induced 3D bioprinted-heterotypic osteochondral interface

Nazmiye Celik, Myoung Hwan Kim, Miji Yeo, Fadia Kamal, Daniel J. Hayes, Ibrahim T. Ozbolat, 2022, Biofabrication

Ultrasound-Induced Drug Release from Stimuli-Responsive Hydrogels

Tyus J. Yeingst, Julien H. Arrizabalaga, Daniel J. Hayes, 2022, Gels

Delivery of Therapeutic miR-148b Mimic via Poly(β Amino Ester) Polyplexes for Post-transcriptional Gene Regulation and Apoptosis of A549 Cells

Nick A. Alden, Julien H. Arrizabalaga, Yiming Liu, Shantu Amin, Krishne Gowda, Shun Yao, Marco Archetti, Adam B. Glick, Daniel J. Hayes, 2022, Langmuir on p. 9833-9843

Developing a clinical grade human adipose decellularized biomaterial

Daniel J. Hayes, Jeffrey M. Gimble, 2022, Biomaterials and Biosystems

Ultrasound-Responsive Hydrogels for On-Demand Protein Release

Julien H. Arrizabalaga, Molly Smallcomb, Mohammad Abu-Laban, Yiming Liu, Tyus J. Yeingst, Aman Dhawan, Julianna C. Simon, Daniel J. Hayes, 2022, ACS Applied Bio Materials on p. 3212-3218

Mesenchymal Stem Cell Sheets for Engineering of the Tendon-Bone Interface

Lisa Berntsen, Anoosha Forghani, Daniel J. Hayes, 2022, Tissue Engineering - Part A. on p. 341-352

Development of Magnetic Nanoparticles for the Intracellular Delivery of miR-148b in Non-Small Cell Lung Cancer

Julien Arrizabalaga, Jonathan Casey, Jeffrey Becca, Yiming Liu, L Jensen, Daniel Hayes, 2022, Biomedical Engineering Advances on p. 100031

Hybrid adipose graft materials synthesized from chemically modified adipose extracellular matrix

Shue Li, Yiming Liu, Jacob McCann, Dino J. Ravnic, Jeffrey M. Gimble, Daniel J. Hayes, 2022, Journal of Biomedical Materials Research - Part A on p. 156-163

Comparison of thermoresponsive Diels-Alder linkers for the release of payloads from magnetic nanoparticles via hysteretic heating

Julien H. Arrizabalaga, Jonathan S. Casey, Jeffrey C. Becca, Lasse Jensen, Daniel J. Hayes, 2021, JCIS Open

Breast Cancer Reconstruction: Design Criteria for a Humanized Microphysiological System

Trivia Frazier, Christopher Williams, Michael Henderson, Tamika Duplessis, Emma Rogers, Xiying Wu, Katie Hamel, Elizabeth C. Martin, Omair Mohiuddin, Shahensha Shaik, Ram Devireddy, Brian G. Rowan, Daniel J. Hayes, Jeffrey M. Gimble, 2021, Tissue Engineering - Part A. on p. 479-488

Most-Cited Papers

Electrospun bio-nanocomposite scaffolds for bone tissue engineering by cellulose nanocrystals reinforcing maleic anhydride grafted PLA

Chengjun Zhou, Qingfeng Shi, Weihong Guo, Lekeith Terrell, Ammar T. Qureshi, Daniel J. Hayes, Qinglin Wu, 2013, ACS applied materials & interfaces on p. 3847-3854

Silver nanoscale antisense drug delivery system for photoactivated gene silencing

Paige K. Brown, Ammar T. Qureshi, Alyson N. Moll, Daniel J. Hayes, W. Todd Monroe, 2013, ACS Nano on p. 2948-2959

MiR-148b-Nanoparticle conjugates for light mediated osteogenesis ofhuman adipose stromal/stem cells

Ammar T. Qureshi, William T. Monroe, Vinod Dasa, Jeffrey M. Gimble, Daniel J. Hayes, 2013, Biomaterials on p. 7799-7810

Human adipose-derived stem cells and three-dimensional scaffold constructs: A review of the biomaterials and models currently used for bone regeneration

Andrea S. Zanetti, Cristina Sabliov, Jeffrey M. Gimble, Daniel J. Hayes, 2013, Journal of Biomedical Materials Research - Part B Applied Biomaterials on p. 187-199

Thermoreversible and Injectable ABC Polypeptoid Hydrogels: Controlling the Hydrogel Properties through Molecular Design

Sunting Xuan, Chang Uk Lee, Cong Chen, Andrew B. Doyle, Yueheng Zhang, Li Guo, Vijay T. John, Daniel Hayes, Donghui Zhang, 2016, Chemistry of Materials on p. 727-737

Photoactivated miR-148b-nanoparticle conjugates improve closure of critical size mouse calvarial defects

Ammar T. Qureshi, Andrew Doyle, Cong Chen, Diana Coulon, Vinod Dasa, Fabio DelPiero, Benjamin Levi, W. Todd Monroe, Jeffrey M. Gimble, Daniel J. Hayes, 2015, Acta Biomaterialia on p. 166-173

Evaluation of bone regeneration potential of dental follicle stem cells for treatment of craniofacial defects

Maryam Rezai-Rad, Jonathan F. Bova, Mahdi Orooji, Jennifer Pepping, Ammar Qureshi, Fabio Del Piero, Daniel Hayes, Shaomian Yao, 2015, Cytotherapy on p. 1572-1581

Targeting Calcium Magnesium Silicates for Polycaprolactone/Ceramic Composite Scaffolds

Cong Chen, Pilanda Watkins-Curry, Mollie Smoak, Katie Hogan, Steve Deese, Gregory T. McCandless, Julia Y. Chan, Daniel J. Hayes, 2015, ACS Biomaterials Science and Engineering on p. 94-102

Collagen-infilled 3D printed scaffolds loaded with miR-148b-transfected bone marrow stem cells improve calvarial bone regeneration in rats

Kazim K. Moncal, R. Seda Tigli Aydin, Mohammad Abu-Laban, Dong N. Heo, Elias Rizk, Scott M. Tucker, Gregory S. Lewis, Daniel Hayes, Ibrahim T. Ozbolat, 2019, Materials Science and Engineering C

Decellularized Adipose Tissue Hydrogel Promotes Bone Regeneration in Critical-Sized Mouse Femoral Defect Model

Omair A. Mohiuddin, Brett Campbell, J. Nick Poche, Michelle Ma, Emma Rogers, Dina Gaupp, Mark A.A. Harrison, Bruce A. Bunnell, Daniel J. Hayes, Jeffrey M. Gimble, 2019, Frontiers in Bioengineering and Biotechnology

News Articles Featuring Daniel Hayes

Oct 28, 2022

Tiny magnetic particles fight lung cancer cells on command in lab test

Traditional treatments for lung cancers can have serious side effects throughout the body, but newly developed, highly targeted treatments could reduce damage, according to Penn State researchers. A team led by Dan Hayes developed a method that could lead to one such treatment with magnetic nanoparticles.

Full Article

Jun 22, 2022

Alumnus and professor named new head of biomedical engineering

When Dan Hayes graduated from the Penn State Eberly College of Science with a bachelor’s degree in science in 1997, the Department of Biomedical Engineering was still three years away from forming. Now, Hayes will lead the Department of Biomedical Engineering. His tenure as department head begins July 1.

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Aug 23, 2021

Here and Now: Hayes Ready to Lead Center of Excellence in Industrial Biotechnology into the Next Phase of Impact

Dan Hayes, Ph.D., replaced Andrew Zydney, Ph.D., as the Center of Excellence in Industrial Biotechnology's Director.

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Feb 10, 2021

Researchers awarded $1.5M to create stem cell predictive model

Stem cells are the building blocks of the body, according to Penn State researchers. Though similar to one another at their origins, stem cells take on unique characteristics as they mature, becoming specialized cells throughout the body — such as bone, muscle, ligament, tissue or other organ cells.

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Jul 07, 2020

Custom nanoparticle regresses tumors when exposed to light

A unique nanoparticle to deliver a localized cancer treatment inhibits tumor growth in mice, according to a team of Penn State researchers.

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Feb 07, 2020

$2.8M grant to fund bioprinting for reconstruction of face, mouth, skull tissues

Seamlessly correcting defects in the face, mouth and skull is highly challenging because it requires precise stacking of a variety of tissues including bone, muscle, fat and skin. Now, Penn State researchers are investigating methods to 3D bioprint and grow the appropriate tissues for craniomaxillofacial reconstruction.

Full Article