Daniel Hayes

Director, Center of Excellence in Industrial Biotechnology; Huck Chair in Nanotherapeutics and Regenerative Medicine; Professor of Biomedical Engineering

Daniel Hayes

Research Summary

Biomaterials engineering for applications ranging from regenerative medicine to lab-on-a-chip technologies. An emphasis on nanomaterials, macromolecules and composite structures. Ongoing efforts include development of optically and magnetically modulated drug delivery systems, quasi 3D cell sheet culture systems, cell encapsulation and delivery materials and hybrid in situ polymerizing grafts/augments.

Huck Affiliations

Links

Most Recent Publications

Posttranscriptional Modification to Modulate Progenitor Differentiation on Heterotypic Spheroids

Nazmiye Celik, Srinivas V. Koduru, Dino J. Ravnic, Ibrahim T. Ozbolat, Daniel J. Hayes, 2024, Tissue Engineering - Part A.

Near-Infrared Induced miR-34a Delivery from Nanoparticles in Esophageal Cancer Treatment

Nick Alden, Tyus Yeingst, Hanna Pfeiffer, Nazmiye Celik, Julien Arrizabalaga, Angelica Helton, Yiming Liu, Douglas B. Stairs, Adam B. Glick, Neerav Goyal, Daniel J. Hayes, 2024, Advanced healthcare materials

Novel fourth generation-like CAR<sup>miR</sup> cells release therapeutic miRNA via exosomes and enhance glioblastoma cell killing activity

Amar Yeware, Angelica Helton, Yicheng Dong, Cheng Dong, Justin Pritchard, Shin Mineishi, Kentaro Minagawa, Todd Schell, Daniel Hayes, 2023, Biochemical Engineering Journal

Controlled Degradation of Polycaprolactone Polymers through Ultrasound Stimulation

Tyus Yeingst, Julien Arrizabalaga, Ferdousi Rawnaque, Lindsay Stone, Amar Yeware, Angelica Helton, Aman Dhawan, Julianna C. Simon, Daniel J. Hayes, 2023, ACS applied materials & interfaces on p. 34607-34616

Photodynamic Therapy for Glioblastoma: Illuminating the Path toward Clinical Applicability

Debarati Bhanja, Hannah Wilding, Angel Baroz, Mara Trifoi, Ganesh Shenoy, Becky Slagle-Webb, Daniel Hayes, Yasaman Soudagar, James Connor, Alireza Mansouri, 2023, Cancers

Ultrasound-Induced Drug Release from Stimuli-Responsive Hydrogels

Tyus J. Yeingst, Julien H. Arrizabalaga, Daniel J. Hayes, 2022, Gels

Delivery of Therapeutic miR-148b Mimic via Poly(β Amino Ester) Polyplexes for Post-transcriptional Gene Regulation and Apoptosis of A549 Cells

N Alden, J Arrizabalaga, Y Liu, Shantu Amin, Krishne Gowda, S Yao, Marco Archetti, Adam Glick, Daniel J. Hayes, 2022, Langmuir on p. 9833-9843

Developing a clinical grade human adipose decellularized biomaterial

Daniel J. Hayes, Jeffrey M. Gimble, 2022, Biomaterials and Biosystems

Ultrasound-Responsive Hydrogels for On-Demand Protein Release

Julien H. Arrizabalaga, Molly Smallcomb, Mohammad Abu-Laban, Yiming Liu, Tyus J. Yeingst, Aman Dhawan, Julianna C. Simon, Daniel J. Hayes, 2022, ACS Applied Bio Materials on p. 3212-3218

Mesenchymal Stem Cell Sheets for Engineering of the Tendon-Bone Interface

Lisa Berntsen, Anoosha Forghani, Daniel J. Hayes, 2022, Tissue Engineering - Part A. on p. 341-352

Most-Cited Papers

Thermoreversible and Injectable ABC Polypeptoid Hydrogels: Controlling the Hydrogel Properties through Molecular Design

Sunting Xuan, Chang Uk Lee, Cong Chen, Andrew B. Doyle, Yueheng Zhang, Li Guo, Vijay T. John, Daniel Hayes, Donghui Zhang, 2016, Chemistry of Materials on p. 727-737

Evaluation of bone regeneration potential of dental follicle stem cells for treatment of craniofacial defects

Maryam Rezai-Rad, Jonathan F. Bova, Mahdi Orooji, Jennifer Pepping, Ammar Qureshi, Fabio Del Piero, Daniel Hayes, Shaomian Yao, 2015, Cytotherapy on p. 1572-1581

Photoactivated miR-148b-nanoparticle conjugates improve closure of critical size mouse calvarial defects

Ammar T. Qureshi, Andrew Doyle, Cong Chen, Diana Coulon, Vinod Dasa, Fabio DelPiero, Benjamin Levi, W. Todd Monroe, Jeffrey M. Gimble, Daniel J. Hayes, 2015, Acta Biomaterialia on p. 166-173

Decellularized Adipose Tissue Hydrogel Promotes Bone Regeneration in Critical-Sized Mouse Femoral Defect Model

Omair A. Mohiuddin, Brett Campbell, J. Nick Poche, Michelle Ma, Emma Rogers, Dina Gaupp, Mark A.A. Harrison, Bruce A. Bunnell, Daniel J. Hayes, Jeffrey M. Gimble, 2019, Frontiers in Bioengineering and Biotechnology

Physical properties of a frozen yogurt fortified with a nano-emulsion containing purple rice bran oil

Luis Alfaro, Daniel Hayes, Charles Boeneke, Zhimin Xu, David Bankston, Peter J. Bechtel, Subramaniam Sathivel, 2015, LWT on p. 1184-1191

Collagen-infilled 3D printed scaffolds loaded with miR-148b-transfected bone marrow stem cells improve calvarial bone regeneration in rats

Kazim K. Moncal, R. Seda Tigli Aydin, Mohammad Abu-Laban, Dong N. Heo, Elias Rizk, Scott M. Tucker, Gregory S. Lewis, Daniel Hayes, Ibrahim T. Ozbolat, 2019, Materials Science and Engineering C

Decellularized Adipose Tissue: Biochemical Composition, in vivo Analysis and Potential Clinical Applications

Omair A. Mohiuddin, Brett Campbell, J. Nicholas Poche, Caasy Thomas-Porch, Daniel A. Hayes, Bruce A. Bunnell, Jeffrey M. Gimble, 2020, on p. 57-70

Targeting Calcium Magnesium Silicates for Polycaprolactone/Ceramic Composite Scaffolds

Cong Chen, Pilanda Watkins-Curry, Mollie Smoak, Katie Hogan, Steve Deese, Gregory T. McCandless, Julia Y. Chan, Daniel J. Hayes, 2015, ACS Biomaterials Science and Engineering on p. 94-102

Comparative proteomic analyses of human adipose extracellular matrices decellularized using alternative procedures

Caasy Thomas-Porch, Jie Li, Fabiana Zanata, Elizabeth C. Martin, Nicholas Pashos, Kaylynn Genemaras, J. Nicholas Poche, Nicholas P. Totaro, Melyssa R. Bratton, Dina Gaupp, Trivia Frazier, Xiying Wu, Lydia Masako Ferreira, Weidong Tian, Guangdi Wang, Bruce A. Bunnell, Lauren Flynn, Daniel Hayes, Jeffrey M. Gimble, 2018, Journal of Biomedical Materials Research - Part A on p. 2481-2493

Characterization of novel akermanite: Poly-ϵ-caprolactone scaffolds for human adipose-derived stem cells bone tissue engineering

A. S. Zanetti, G. T. Mccandless, J. Y. Chan, J. M. Gimble, D. J. Hayes, 2015, Journal of Tissue Engineering and Regenerative Medicine on p. 389-404

News Articles Featuring Daniel Hayes

May 22, 2024

Exhibition showcases art and science collaborations

An art exhibition showcasing recent collaborations in art and science will be on display in the Huck Life Sciences Building on May 30 and May 31 in conjunction with the One Health Microbiome Center Biennial Symposium.

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Jun 26, 2023

Two Arts and Architecture faculty receive Huck Institutes joint projects grants

Penn State College of Arts and Architecture faculty members Aaron Knochel, associate professor of art education, and Cristin Millett, professor of art, have received 2023 Joint Projects in Life/Medical Sciences, Arts and Humanities Grants from Penn State’s Huck Institutes of the Life Sciences.

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May 16, 2023

Millett and White to discuss 'Ex-Utero' project at Paris symposium

Cristin Millett, professor of art in sculpture at Penn State, and Cynthia White, adjunct research associate in the College of Arts and Architecture’s Arts & Design Research Incubator (ADRI), will discuss “Ex-Utero,” their ongoing research project culminating in a sculptural artwork of an artificial uterus, at ISEA2023, the 28th International Symposium on Electronic Art, in Paris, France, May 16-21.

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Oct 28, 2022

Tiny magnetic particles fight lung cancer cells on command in lab test

Traditional treatments for lung cancers can have serious side effects throughout the body, but newly developed, highly targeted treatments could reduce damage, according to Penn State researchers. A team led by Dan Hayes developed a method that could lead to one such treatment with magnetic nanoparticles.

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Jun 22, 2022

Alumnus and professor named new head of biomedical engineering

When Dan Hayes graduated from the Penn State Eberly College of Science with a bachelor’s degree in science in 1997, the Department of Biomedical Engineering was still three years away from forming. Now, Hayes will lead the Department of Biomedical Engineering. His tenure as department head begins July 1.

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Aug 23, 2021

Here and Now: Hayes Ready to Lead Center of Excellence in Industrial Biotechnology into the Next Phase of Impact

Dan Hayes, Ph.D., replaced Andrew Zydney, Ph.D., as the Center of Excellence in Industrial Biotechnology's Director.

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Feb 10, 2021

Researchers awarded $1.5M to create stem cell predictive model

Stem cells are the building blocks of the body, according to Penn State researchers. Though similar to one another at their origins, stem cells take on unique characteristics as they mature, becoming specialized cells throughout the body — such as bone, muscle, ligament, tissue or other organ cells.

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Jul 07, 2020

Custom nanoparticle regresses tumors when exposed to light

A unique nanoparticle to deliver a localized cancer treatment inhibits tumor growth in mice, according to a team of Penn State researchers.

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Feb 07, 2020

$2.8M grant to fund bioprinting for reconstruction of face, mouth, skull tissues

Seamlessly correcting defects in the face, mouth and skull is highly challenging because it requires precise stacking of a variety of tissues including bone, muscle, fat and skin. Now, Penn State researchers are investigating methods to 3D bioprint and grow the appropriate tissues for craniomaxillofacial reconstruction.

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