Daniel Hayes

Director, Center of Excellence in Industrial Biotechnology; Huck Chair in Nanotherapeutics and Regenerative Medicine; Professor of Biomedical Engineering

Daniel Hayes

Research Summary

Biomaterials engineering for applications ranging from regenerative medicine to lab-on-a-chip technologies. An emphasis on nanomaterials, macromolecules and composite structures. Ongoing efforts include development of optically and magnetically modulated drug delivery systems, quasi 3D cell sheet culture systems, cell encapsulation and delivery materials and hybrid in situ polymerizing grafts/augments.

Huck Affiliations


Publication Tags

Stem Cells Hydrogels Nanoparticles Silver Scaffolds Bone Tissue Oligonucleotides Cellulose Hydrogel Polycaprolactone Micrornas Osteogenic Genes Silver Nanoparticles Tissue Engineering Nanocomposites Proteomics Regenerative Medicine Gene Expression Modulation Stromal Cells Composite Materials Adipose Tissue Biomaterial

Most Recent Papers

Mesenchymal Stem Cell Sheets for Engineering of the Tendon-Bone Interface

Lisa Berntsen, Anoosha Forghani, Daniel J. Hayes, 2022, Tissue Engineering - Part A. on p. 341-352

Development of Magnetic Nanoparticles for the Intracellular Delivery of miR-148b in Non-Small Cell Lung Cancer

Julien Arrizabalaga, Jonathan Casey, Jeffrey Becca, Yiming Liu, L Jensen, Daniel Hayes, 2022, Biomedical Engineering Advances on p. 100031

Hybrid adipose graft materials synthesized from chemically modified adipose extracellular matrix

Shue Li, Yiming Liu, Jacob McCann, Dino J. Ravnic, Jeffrey M. Gimble, Daniel J. Hayes, 2022, Journal of Biomedical Materials Research - Part A on p. 156-163

Comparison of thermoresponsive Diels-Alder linkers for the release of payloads from magnetic nanoparticles via hysteretic heating

Julien H. Arrizabalaga, Jonathan S. Casey, Jeffrey C. Becca, Lasse Jensen, Daniel J. Hayes, 2021, JCIS Open

MiRNA induced co-differentiation and cross-talk of adipose tissue-derived progenitor cells for 3D heterotypic pre-vascularized bone formation

Nazmiye Celik, Myoung Hwan Kim, Daniel J. Hayes, Ibrahim T. Ozbolat, 2021, Biofabrication

Breast Cancer Reconstruction: Design Criteria for a Humanized Microphysiological System

Trivia Frazier, Christopher Williams, Michael Henderson, Tamika Duplessis, Emma Rogers, Xiying Wu, Katie Hamel, Elizabeth C. Martin, Omair Mohiuddin, Shahensha Shaik, Ram Devireddy, Brian G. Rowan, Daniel J. Hayes, Jeffrey M. Gimble, 2021, Tissue Engineering - Part A. on p. 479-488

MicroRNA sequencing of CD34+ sorted adipose stem cells undergoing endotheliogenesis

Shahensha Shaik, Elizabeth Martin, Daniel Hayes, Jeffrey Gimble, Ram Devireddy, 2021, Stem Cells and Development on p. 265-288

Detection of cellular mineralization using the Doppler ultrasound twinkling artifact

Lucas Ruge-Jones, Lisa Berntsen, Daniel Hayes, J Simon, 2021, The Journal of the Acoustical Society of America on p. A89--A89

Clinical translational potential in skin wound regeneration for adipose‐derived, blood‐derived, and cellulose materials: Cells, exosomes, and hydrogels

Trivia Frazier, Andrea Alarcon, Xiying Wu, Omair A. Mohiuddin, Jessica M. Motherwell, Anders H. Carlsson, Robert J. Christy, Judson V. Edwards, Robert T. Mackin, Nicolette Prevost, Elena Gloster, Qiang Zhang, Guangdi Wang, Daniel J. Hayes, Jeffrey M. Gimble, 2020, Biomolecules on p. 1-21

Characterization and Proteomic Analysis of Decellularized Adipose Tissue Hydrogels Derived from Lean and Overweight/Obese Human Donors

Omair A. Mohiuddin, Jessica M. Motherwell, Emma Rogers, Melyssa R. Bratton, Qiang Zhang, Guangdi Wang, Bruce Bunnell, Daniel J. Hayes, Jeffrey M. Gimble, 2020, Advanced Biology

Most-Cited Papers

Electrospun bio-nanocomposite scaffolds for bone tissue engineering by cellulose nanocrystals reinforcing maleic anhydride grafted PLA

Chengjun Zhou, Qingfeng Shi, Weihong Guo, Lekeith Terrell, Ammar T. Qureshi, Daniel J. Hayes, Qinglin Wu, 2013, ACS applied materials & interfaces on p. 3847-3854

Silver nanoscale antisense drug delivery system for photoactivated gene silencing

Paige K. Brown, Ammar T. Qureshi, Alyson N. Moll, Daniel J. Hayes, W. Todd Monroe, 2013, ACS Nano on p. 2948-2959

MiR-148b-Nanoparticle conjugates for light mediated osteogenesis ofhuman adipose stromal/stem cells

Ammar T. Qureshi, William T. Monroe, Vinod Dasa, Jeffrey M. Gimble, Daniel J. Hayes, 2013, Biomaterials on p. 7799-7810

Human adipose-derived stem cells and three-dimensional scaffold constructs

Andrea S. Zanetti, Cristina Sabliov, Jeffrey M. Gimble, Daniel J. Hayes, 2013, Journal of Biomedical Materials Research - Part B Applied Biomaterials on p. 187-199

Thermoreversible and Injectable ABC Polypeptoid Hydrogels

Sunting Xuan, Chang Uk Lee, Cong Chen, Andrew B. Doyle, Yueheng Zhang, Li Guo, Vijay T. John, Daniel Hayes, Donghui Zhang, 2016, Chemistry of Materials on p. 727-737

A planar microfluidic mixer based on logarithmic spirals

Thomas Scherr, Christian Quitadamo, Preston Tesvich, Daniel Sang Won Park, Terrence Tiersch, Daniel Hayes, Jin Woo Choi, Krishnaswamy Nandakumar, W. Todd Monroe, 2012, Journal of Micromechanics and Microengineering

Evaluation of bone regeneration potential of dental follicle stem cells for treatment of craniofacial defects

Maryam Rezai-Rad, Jonathan F. Bova, Mahdi Orooji, Jennifer Pepping, Ammar Qureshi, Fabio Del Piero, Daniel Hayes, Shaomian Yao, 2015, Cytotherapy on p. 1572-1581

Photoactivated miR-148b-nanoparticle conjugates improve closure of critical size mouse calvarial defects

Ammar T. Qureshi, Andrew Doyle, Cong Chen, Diana Coulon, Vinod Dasa, Fabio DelPiero, Benjamin Levi, W. Todd Monroe, Jeffrey M. Gimble, Daniel J. Hayes, 2015, Acta Biomaterialia on p. 166-173

A novel composite film for detection and molecular weight determination of organic vapors

Bishnu P. Regmi, Joshua Monk, Bilal El-Zahab, Susmita Das, Francisco R. Hung, Daniel J. Hayes, Isiah M. Warner, 2012, Journal of Materials Chemistry on p. 13732-13741

Targeting Calcium Magnesium Silicates for Polycaprolactone/Ceramic Composite Scaffolds

Cong Chen, Pilanda Watkins-Curry, Mollie Smoak, Katie Hogan, Steve Deese, Gregory T. McCandless, Julia Y. Chan, Daniel J. Hayes, 2015, ACS Biomaterials Science and Engineering on p. 94-102

News Articles Featuring Daniel Hayes

Alumnus and professor named new head of biomedical engineering

When Dan Hayes graduated from the Penn State Eberly College of Science with a bachelor’s degree in science in 1997, the Department of Biomedical Engineering was still three years away from forming. Now, Hayes will lead the Department of Biomedical Engineering. His tenure as department head begins July 1.

Here and Now: Hayes Ready to Lead Center of Excellence in Industrial Biotechnology into the Next Phase of Impact

Dan Hayes, Ph.D., replaced Andrew Zydney, Ph.D., as the Center of Excellence in Industrial Biotechnology's Director.

Researchers awarded $1.5M to create stem cell predictive model

Stem cells are the building blocks of the body, according to Penn State researchers. Though similar to one another at their origins, stem cells take on unique characteristics as they mature, becoming specialized cells throughout the body — such as bone, muscle, ligament, tissue or other organ cells.

Custom nanoparticle regresses tumors when exposed to light

A unique nanoparticle to deliver a localized cancer treatment inhibits tumor growth in mice, according to a team of Penn State researchers.

$2.8M grant to fund bioprinting for reconstruction of face, mouth, skull tissues

Seamlessly correcting defects in the face, mouth and skull is highly challenging because it requires precise stacking of a variety of tissues including bone, muscle, fat and skin. Now, Penn State researchers are investigating methods to 3D bioprint and grow the appropriate tissues for craniomaxillofacial reconstruction.