Curtis Omiecinski

Professor of Veterinary & Biomedical Sciences; H. Thomas and Dorothy Willits Hallowell Chair; Emphasis Area Representative, Molecular Toxicology

Curtis Omiecinski

Research Summary

Nuclear receptor biology and genomics. Xenobiotic Receptor systems that regulate biotransformation, detoxication, cancer predisposition, lipid and energy homeostasis.

Huck Institutes Affiliations

Links

Most Recent Papers

Activation of the Constitutive Androstane Receptor by Monophthalates

Elizabeth M. Laurenzana, Denise M. Coslo, M. Veronica Vigilar, Anthony M. Roman, Curtis J. Omiecinski, 2016, Chemical Research in Toxicology on p. 1651-1661

Bioinformatic analysis of microRNA networks following the activation of the constitutive androstane receptor (CAR) in mouse liver

Ruixin Hao, Shengzhong Su, Yinan Wan, Frank Shen, Ben Niu, Denise M. Coslo, Istvan Albert, Xing Han, Curtis J. Omiecinski, 2016, Biochimica et Biophysica Acta - Gene Regulatory Mechanisms on p. 1228-1237

Hepatic aryl hydrocarbon receptor attenuates fibroblast growth factor 21 expression

Nathaniel G. Girer, Iain A. Murray, Curtis J. Omiecinski, Gary H. Perdew, 2016, Journal of Biological Chemistry on p. 15378-15387

δ<sup>9</sup>-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression

Shuso Takeda, Eriko Ikeda, Shengzhong Su, Mari Harada, Hiroyuki Okazaki, Yasushi Yoshioka, Hajime Nishimura, Hiroyuki Ishii, Kazuhiro Kakizoe, Aya Taniguchi, Miki Tokuyasu, Taichi Himeno, Kazuhito Watanabe, Curtis J. Omiecinski, Hironori Aramaki, 2014, Toxicology on p. 18-24

Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture

Banrida Wahlang, K. Cameron Falkner, Heather B. Clair, Laila Al-Eryani, Russell A. Prough, J. Christopher States, Denise M. Coslo, Curtis J. Omiecinski, Matthew C. Cave, 2014, Toxicological Sciences on p. 283-297

Phenobarbital and propiconazole toxicogenomic profiles in mice show major similarities consistent with the key role that constitutive androstane receptor (CAR) activation plays in their mode of action

Richard A. Currie, Richard C. Peffer, Amber K. Goetz, Curtis J. Omiecinski, Jay I. Goodman, 2014, Toxicology on p. 80-88

Sp1 and Sp3 transcription factors regulate the basal expression of human microsomal epoxide hydrolase (EPHX1) through interaction with the E1b far upstream promoter

Shengzhong Su, Curtis J. Omiecinski, 2014, Gene on p. 135-144

Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor

Tao Chen, Elizabeth M. Laurenzana, Denise M. Coslo, Fengming Chen, Curtis J. Omiecinski, 2014, Biochemical Journal on p. 95-107

Intronic DNA elements regulate Nrf2 chemical responsiveness of the human microsomal epoxide hydrolase gene (EPHX1) through a far upstream alternative promoter

Shengzhong Su, Xi Yang, Curtis J. Omiecinski, 2014, Biochimica et Biophysica Acta - Gene Regulatory Mechanisms on p. 493-505

The human constitutive androstane receptor promotes the differentiation and maturation of hepatic-like cells

Fengming Chen, Stephanie M. Zamule, Denise M. Coslo, Tao Chen, Curtis J. Omiecinski, 2013, Developmental biology on p. 155-165

High-Impact Papers

Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling

Brett C. DiNatale, Iain A. Murray, Jennifer C. Schroeder, Colin A. Flaveny, Tejas S. Lahoti, Elizabeth M. Laurenzana, Curtis J. Omiecinski, Gary H. Perdew, 2010, Toxicological Sciences on p. 89-97

The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor

Jennifer C. Schroeder, Brett C. DiNatale, Iain A. Murray, Colin A. Flaveny, Qiang Liu, Elizabeth M. Laurenzana, Jyh Ming Lin, Stephen C. Strom, Curtis J. Omiecinski, Shantu Amin, Gary H. Perdew, 2010, Biochemistry on p. 393-400

Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor

Joshua G. Dekeyser, Elizabeth M. Laurenzana, Eric C. Peterson, Tao Chen, Curtis J. Omiecinski, 2011, Toxicological Sciences on p. 381-391

Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2

Joshua G. DeKeyser, Michael C. Stagliano, Scott S. Auerbach, K. Sandeep Prabhu, A. Daniel Jones, Curtis J. Omiecinski, 2009, Molecular Pharmacology on p. 1005-1012

Multi-species analyses of direct activators of the constitutive androstane receptor

Curtis J. Omiecinski, Denise M. Coslo, Tao Chen, Elizabeth M. Laurenzana, Richard C. Peffer, 2011, Toxicological Sciences on p. 550-562

Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration

Shuso Takeda, Shunsuke Okajima, Hiroko Miyoshi, Kazutaka Yoshida, Yoshiko Okamoto, Tomoko Okada, Toshiaki Amamoto, Kazuhito Watanabe, Curtis J. Omiecinski, Hironori Aramaki, 2012, Toxicology Letters on p. 314-319

(-)-Xanthatin selectively induces GADD45γ and stimulates caspase-independent cell death in human breast cancer MDA-MB-231 cells

Shuso Takeda, Kazumasa Matsuo, Kentaro Yaji, Shunsuke Okajima-Miyazaki, Mari Harada, Hiroko Miyoshi, Yoshiko Okamoto, Toshiaki Amamoto, Mitsuru Shindo, Curtis J. Omiecinski, Hironori Aramaki, 2011, Chemical Research in Toxicology on p. 855-865

Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture

Banrida Wahlang, K. Cameron Falkner, Heather B. Clair, Laila Al-Eryani, Russell A. Prough, J. Christopher States, Denise M. Coslo, Curtis J. Omiecinski, Matthew C. Cave, 2014, Toxicological Sciences on p. 283-297

Differentiation of human embryonic stem cells along a hepatic lineage

Stephanie M. Zamule, Denise M. Coslo, Fengming Chen, Curtis J. Omiecinski, 2011, Chemico-Biological Interactions on p. 62-72

Phenobarbital and propiconazole toxicogenomic profiles in mice show major similarities consistent with the key role that constitutive androstane receptor (CAR) activation plays in their mode of action

Richard A. Currie, Richard C. Peffer, Amber K. Goetz, Curtis J. Omiecinski, Jay I. Goodman, 2014, Toxicology on p. 80-88