Costas Maranas
Donald B. Broughton Professor of Chemical Engineering
-
126 Land and Water Research
University Park, PA - cdm8@psu.edu
- 814-863-9958
Research Summary
Computational studies of metabolism and gene regulation.
Huck Graduate Students
Huck Affiliations
- Bioinformatics and Genomics
- Molecular, Cellular, and Integrative Biosciences
- Center for Biorenewables
Links
Publication Tags
These publication tags are generated from the output of this researcher. Click any tag below to view other Huck researchers working on the same topic.
Escherichia Coli Genome Genes Metabolic Metabolism Phenotype Lipid Metabolism Fluxes Liver Kinetics Genomics Methane Biofuels Enzymes Metabolomics Obesity Pharmacological Metabolism Metabolites Enzyme Kinetics Strain Metabolite Fermentation Gastrointestinal Microbiome Metabolic Engineering CoronavirusMost Recent Publications
Genome streamlining to improve performance of a fast-growing cyanobacterium <i>Synechococcus elongatus</i> UTEX 2973
Annesha Sengupta, Anindita Bandyopadhyay, Debolina Sarkar, John Hendry, Max Schubert, Deng Liu, George Church, Costas Maranas, Himadri Pakrasi, mBio
Data-driven and physics informed modeling of Chinese Hamster Ovary cell bioreactors
Tianqi Cui, Tom Bertalan, Nelson Ndahiro, Pratik Khare, Michael Betenbaugh, Costas Maranas, Ioannis G. Kevrekidis, 2024, Computers and Chemical Engineering
Proteome efficiency of bioenergetic pathways
Yihui Shen, Hoang Dinh, Edward Cruz, Zihong Chen, Caroline Bartman, Yasuo Yoshikuni, Huimin Zhao, Costas Maranas, Martin Wühr, Joshua Rabinowitz, 2024, Biophysical Journal on p. 248a
A multi-organ maize metabolic model connects temperature stress with energy production and reducing power generation
Niaz Bahar Chowdhury, Margaret Simons-Senftle, Berengere Decouard, Isabelle Quillere, Martine Rigault, Karuna Anna Sajeevan, Bibek Acharya, Ratul Chowdhury, Bertrand Hirel, Alia Dellagi, Costas Maranas, Rajib Saha, 2023, iScience
Deuterated water as a substrate-agnostic isotope tracer for investigating reversibility and thermodynamics of reactions in central carbon metabolism
Melanie M. Callaghan, Eashant Thusoo, Bishal D. Sharma, Fitsum Getahun, David M. Stevenson, Costas Maranas, Daniel G. Olson, Lee R. Lynd, Daniel Amador-Noguez, 2023, Metabolic Engineering on p. 254-266
A single amino acid change led to structural and functional differentiation of PvHd1 to control flowering in switchgrass
Soyeon Choi, Pradeep K. Prabhakar, Ratul Chowdhury, Thomas H. Pendergast, Breeanna R. Urbanowicz, Costas Maranas, Katrien M. Devos, 2023, Journal of Experimental Botany on p. 5532-5546
Rank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neural network
Vikas Upadhyay, Veda Sheersh Boorla, Costas D. Maranas, 2023, Metabolic Engineering on p. 171-182
Metabolic engineering of low-pH-tolerant non-model yeast, Issatchenkia orientalis, for production of citramalate
Zong-Yen Wu, Wan Sun, Yihui Shen, Jimmy Pratas, P Suthers, Ping-Hung Hsieh, Sudharsan Dwaraknath, Joshua Rabinowitz, Costas Maranas, Zengyi Shao, Yasuo Yoshikuni, 2023, Metabolic Engineering Communications on p. e00220
Evaluating proteome allocation of Saccharomyces cerevisiae phenotypes with resource balance analysis
Hoang V. Dinh, Costas D. Maranas, 2023, Metabolic Engineering on p. 242-255
Little Brown Bats (Myotis lucifugus) Support the Binding of SARS-CoV-2 Spike and Are Likely Susceptible to SARS-CoV-2 Infection
Shubhada K. Chothe, Padmaja Jakka, Veda Sheersh Boorla, Santhamani Ramasamy, Abhinay Gontu, Ruth H. Nissly, Justin Brown, Gregory Turner, Brent J. Sewall, Dee Ann M. Reeder, Kenneth A. Field, Julie B. Engiles, Saranya Amirthalingam, Abirami Ravichandran, Lindsey LaBella, Meera Surendran Nair, Costas D. Maranas, Suresh V. Kuchipudi, 2023, Viruses
Most-Cited Papers
Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v.3.0
Laurent Heirendt, Sylvain Arreckx, Thomas Pfau, Sebastián N. Mendoza, Anne Richelle, Almut Heinken, Hulda S. Haraldsdóttir, Jacek Wachowiak, Sarah M. Keating, Vanja Vlasov, Stefania Magnusdóttir, Chiam Yu Ng, German Preciat, Alise Žagare, Siu H.J. Chan, Maike K. Aurich, Catherine M. Clancy, Jennifer Modamio, John T. Sauls, Alberto Noronha, Aarash Bordbar, Benjamin Cousins, Diana C. El Assal, Luis V. Valcarcel, Iñigo Apaolaza, Susan Ghaderi, Masoud Ahookhosh, Marouen Ben Guebila, Andrejs Kostromins, Nicolas Sompairac, Hoai M. Le, Ding Ma, Yuekai Sun, Lin Wang, James T. Yurkovich, Miguel A.P. Oliveira, Phan T. Vuong, Lemmer P. El Assal, Inna Kuperstein, Andrei Zinovyev, H. Scott Hinton, William A. Bryant, Francisco J. Aragón Artacho, Francisco J. Planes, Egils Stalidzans, Alejandro Maass, Santosh Vempala, Michael Hucka, Michael A. Saunders, Costas D. Maranas, Nathan E. Lewis, Thomas Sauter, Bernhard Palsson, Ines Thiele, Ronan M.T. Fleming, 2019, Nature Protocols on p. 639-702
A genome-scale Escherichia coli kinetic metabolic model k-ecoli457 satisfying flux data for multiple mutant strains
Ali Khodayari, Costas D. Maranas, 2016, Nature Communications
D-OptCom: Dynamic Multi-level and Multi-objective Metabolic Modeling of Microbial Communities
Ali R. Zomorrodi, Mohammad Mazharul Islam, Costas D. Maranas, 2014, ACS Synthetic Biology on p. 247-257
A kinetic model of Escherichia coli core metabolism satisfying multiple sets of mutant flux data
Ali Khodayari, Ali R. Zomorrodi, James C. Liao, Costas D. Maranas, 2014, Metabolic Engineering on p. 50-62
Rational design of a synthetic Entner-Doudoroff pathway for improved and controllable NADPH regeneration
Chiam Yu Ng, Iman Farasat, Costas D. Maranas, Howard M. Salis, 2015, Metabolic Engineering on p. 86-96
SteadyCom: Predicting microbial abundances while ensuring community stability
Siu Hung Joshua Chan, Margaret N. Simons, Costas D. Maranas, 2017, PLoS Computational Biology
Multiple spillovers from humans and onward transmission of SARS-CoV-2 in white-tailed deer
Suresh V. Kuchipudi, Meera Surendran-Nair, R Ruden, M Yon, R Nissly, Kurt J. Vandegrift, R Nelli, Lingling Li, Bhushan Jayarao, Costas D. Maranas, N Levine, K Willgert, Andrew J.K. Conlan, Conlan AJK, R Olsen, J Davis, J Musser, Peter John Hudson, Vivek Kapur, 2022, Proceedings of the National Academy of Sciences of the United States of America
Reversing methanogenesis to capture methane for liquid biofuel precursors
Valerie W.C. Soo, Michael J. McAnulty, Arti Tripathi, Fayin Zhu, Limin Zhang, Emmanuel Hatzakis, Philip B. Smith, Saumya Agrawal, Hadi Nazem-Bokaee, Saratram Gopalakrishnan, Howard M. Salis, James G. Ferry, Costas D. Maranas, Andrew D. Patterson, Thomas K. Wood, 2016, Microbial Cell Factories on p. 11
Farnesoid X receptor signaling shapes the gut microbiota and controls hepatic lipid metabolism
Limin Zhang, Cen Xie, Robert G. Nichols, Siu H.J. Chan, Changtao Jiang, Ruixin Hao, Philip B. Smith, Jingwei Cai, Margaret N. Simons, Emmanuel Hatzakis, Costas D. Maranas, Frank J. Gonzalez, Andrew D. Patterson, 2016, mSystems on p. e00070-16
Recent advances in the reconstruction of metabolic models and integration of omics data
Rajib Saha, Anupam Chowdhury, Costas D. Maranas, 2014, Current Opinion in Biotechnology on p. 39-45
News Articles Featuring Costas Maranas
Nov 03, 2021
Deer may be reservoir for SARS-CoV-2, study finds
The findings of a study by Penn State and Iowa researchers suggest that white-tailed deer may be a reservoir for the SARS-CoV-2 virus to continually circulate, and raises concerns of emergence of new strains that may prove a threat to wildlife and, possibly, to humans.
Full Article
Sep 29, 2021
New tool predicts changes that may make COVID variants more infectious
The first key step in SARS-CoV-2 infection is when the virus’ spike protein binds to the ACE2 receptor on human cells. Researchers at Penn State have created a novel framework that can predict with reasonable accuracy the amino-acid changes in the virus’ spike protein that may improve its binding to human cells and confer increased infectivity to the virus.
Full Article