Costas Maranas
Donald B. Broughton Professor of Chemical Engineering

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126 Land and Water Research
University Park, PA - cdm8@psu.edu
- 814-863-9958
Research Summary
Computational studies of metabolism and gene regulation.
Huck Affiliations
Links
Publication Tags
Escherichia Coli Metabolic Fluxes Genome Metabolism Biomass Enzymes Metabolites Genes Fatty Acids Kinetics Metabolic Networks And Pathways Metabolite Ethanol Uncertainty Strain Pharmacological Metabolism Clostridium Thermocellum Metabolic Engineering Glucose Enzyme Kinetics Genomics Reaction Yield Application PyrophosphatasesMost Recent Papers
Metabolic engineering of Rhodotorula toruloides IFO0880 improves C16 and C18 fatty alcohol production from synthetic media
J. Carl Schultz, Shekhar Mishra, Emily Gaither, Andrea Mejia, Hoang Dinh, Costas Maranas, Huimin Zhao, 2022, Microbial Cell Factories
Developmental changes in lignin composition are driven by both monolignol supply and laccase specificity
Chunliu Zhuo, Xin Wang, Maite Docampo-Palacios, Brian C. Sanders, Nancy L. Engle, Timothy J. Tschaplinski, John I. Hendry, Costas D. Maranas, Fang Chen, Richard A. Dixon, 2022, Science advances
Toward low-cost biological and hybrid biological/catalytic conversion of cellulosic biomass to fuels†
Lee R. Lynd, Gregg T. Beckham, Adam M. Guss, Lahiru N. Jayakody, Eric M. Karp, Costas Maranas, Robert L. McCormick, Daniel Amador-Noguez, Yannick J. Bomble, Brian H. Davison, Charles Foster, Michael E. Himmel, Evert K. Holwerda, Mark S. Laser, Chiam Yu Ng, Daniel G. Olson, Yuriy Román-Leshkov, Cong T. Trinh, Gerald A. Tuskan, Vikas Upadhayay, Derek R. Vardon, Lin Wang, Charles E. Wyman, 2022, Energy and Environmental Science on p. 938-990
Multiple spillovers from humans and onward transmission of SARS-CoV-2 in white-tailed deer
Suresh V. Kuchipudi, Meera Surendran-Nair, Rachel M. Ruden, Michele Yon, Ruth H. Nissly, Kurt J. Vandegrift, Rahul K. Nelli, Lingling Li, Bhushan M. Jayarao, Costas D. Maranas, Nicole Levine, Katriina Willgert, Andrew J.K. Conlan, Randall J. Olsen, James J. Davis, James M. Musser, Peter John Hudson, Vivek Kapur, 2022, Proceedings of the National Academy of Sciences of the United States of America
Functional Analysis of H<sup>+</sup>-Pumping Membrane-Bound Pyrophosphatase, ADP-Glucose Synthase, and Pyruvate Phosphate Dikinase as Pyrophosphate Sources in Clostridium thermocellum
Teun Kuil, Shuen Hon, Johannes Yayo, Charles Foster, Giulia Ravagnan, Costas D. Maranas, Lee R. Lynd, Daniel G. Olson, Antonius J.A. van Maris, 2022, Applied and Environmental Microbiology
Quantifying the propagation of parametric uncertainty on flux balance analysis
Hoang V. Dinh, Debolina Sarkar, Costas D. Maranas, 2022, Metabolic Engineering on p. 26-39
Dissecting the metabolic reprogramming of maize root under nitrogen-deficient stress conditions
Niaz Chowdhury, Wheaton Schroeder, Debolina Sarkar, Nardjis Amiour, Isabelle Quillere, Bertrand Hirel, Costas Maranas, Rajib Saha, 2022, JOURNAL OF EXPERIMENTAL BOTANY on p. 275-291
Assessing the impact of substrate-level enzyme regulations limiting ethanol titer in Clostridium thermocellum using a core kinetic model
Charles Foster, Veda Sheersh Boorla, Satyakam Dash, Saratram Gopalakrishnan, Tyler B. Jacobson, Daniel G. Olson, Daniel Amador-Noguez, Lee R. Lynd, Costas D. Maranas, 2022, Metabolic Engineering on p. 286-301
EnZymClass
Deepro Banerjee, Michael A. Jindra, Alec J. Linot, Brian F. Pfleger, Costas D. Maranas, 2022, Current Research in Biotechnology on p. 1-9
Recombination and lineage-specific mutations linked to the emergence of SARS-CoV-2
Juan Ángel Patiño-Galindo, Ioan Filip, Ratul Chowdhury, Costas D. Maranas, Peter K. Sorger, Mohammed AlQuraishi, Raul Rabadan, 2021, Genome Medicine
Most-Cited Papers
Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v.3.0
Laurent Heirendt, Sylvain Arreckx, Thomas Pfau, Sebastián N. Mendoza, Anne Richelle, Almut Heinken, Hulda S. Haraldsdóttir, Jacek Wachowiak, Sarah M. Keating, Vanja Vlasov, Stefania Magnusdóttir, Chiam Yu Ng, German Preciat, Alise Žagare, Siu H.J. Chan, Maike K. Aurich, Catherine M. Clancy, Jennifer Modamio, John T. Sauls, Alberto Noronha, Aarash Bordbar, Benjamin Cousins, Diana C. El Assal, Luis V. Valcarcel, Iñigo Apaolaza, Susan Ghaderi, Masoud Ahookhosh, Marouen Ben Guebila, Andrejs Kostromins, Nicolas Sompairac, Hoai M. Le, Ding Ma, Yuekai Sun, Lin Wang, James T. Yurkovich, Miguel A.P. Oliveira, Phan T. Vuong, Lemmer P. El Assal, Inna Kuperstein, Andrei Zinovyev, H. Scott Hinton, William A. Bryant, Francisco J. Aragón Artacho, Francisco J. Planes, Egils Stalidzans, Alejandro Maass, Santosh Vempala, Michael Hucka, Michael A. Saunders, Costas D. Maranas, Nathan E. Lewis, Thomas Sauter, Bernhard Palsson, Ines Thiele, Ronan M.T. Fleming, 2019, Nature Protocols on p. 639-702
OptCom
Ali R. Zomorrodi, Costas D. Maranas, 2012, PLoS Computational Biology on p. e1002363
Synthetic biology of cyanobacteria
Bertram M. Berla, Rajib Saha, Cheryl M. Immethun, Costas D. Maranas, Tae Seok Moon, Himadri B. Pakrasi, 2013, Frontiers in Microbiology
D-OptCom
Ali R. Zomorrodi, Mohammad Mazharul Islam, Costas D. Maranas, 2014, ACS Synthetic Biology on p. 247-257
A kinetic model of Escherichia coli core metabolism satisfying multiple sets of mutant flux data
Ali Khodayari, Ali R. Zomorrodi, James C. Liao, Costas D. Maranas, 2014, Metabolic Engineering on p. 50-62
Rational design of a synthetic Entner-Doudoroff pathway for improved and controllable NADPH regeneration
Chiam Yu Ng, Iman Farasat, Costas D. Maranas, Howard M. Salis, 2015, Metabolic Engineering on p. 86-96
A genome-scale Escherichia coli kinetic metabolic model k-ecoli457 satisfying flux data for multiple mutant strains
Ali Khodayari, Costas D. Maranas, 2016, Nature Communications
Mathematical optimization applications in metabolic networks
Ali R. Zomorrodi, Patrick F. Suthers, Sridhar Ranganathan, Costas D. Maranas, 2012, Metabolic Engineering on p. 672-686
MetRxn
Akhil Kumar, Patrick F. Suthers, Costas D. Maranas, 2012, BMC Bioinformatics
An integrated computational and experimental study for overproducing fatty acids in Escherichia coli
Sridhar Ranganathan, Ting Wei Tee, Anupam Chowdhury, Ali R. Zomorrodi, Jong Moon Yoon, Yanfen Fu, Jacqueline V. Shanks, Costas D. Maranas, 2012, Metabolic Engineering on p. 687-704
News Articles Featuring Costas Maranas
Nov 03, 2021
Deer may be reservoir for SARS-CoV-2, study finds
The findings of a study by Penn State and Iowa researchers suggest that white-tailed deer may be a reservoir for the SARS-CoV-2 virus to continually circulate, and raises concerns of emergence of new strains that may prove a threat to wildlife and, possibly, to humans.
Full Article
Sep 29, 2021
New tool predicts changes that may make COVID variants more infectious
The first key step in SARS-CoV-2 infection is when the virus’ spike protein binds to the ACE2 receptor on human cells. Researchers at Penn State have created a novel framework that can predict with reasonable accuracy the amino-acid changes in the virus’ spike protein that may improve its binding to human cells and confer increased infectivity to the virus.
Full Article