Colin Barnstable

Professor and Chair of Neural Behavioral Sciences

Colin Barnstable

Research Summary

How interacting networks of transcription factors and signal transduction molecules guide the development of precursor/stem cells into mature neurons. Role of these networks in neurodegenerative diseases. Factors that can act as neuroprotective agents.

Huck Affiliations

Links

Publication Tags

Retina Histones Genes Uncoupling Protein 2 Retinal Ganglion Cells Retinal Rod Photoreceptor Cells Cell Death Reactive Oxygen Species Neuroprotection Gene Expression Neuroglia Glaucoma Histone Rod Like Crystal Therapeutics Astrocytes Oxidative Stress Proteins Mitophagy Pigment Epithelium Derived Factor Histone Deacetylase 1 Acetylation Lysine Mitochondrial Degradation Cell Survival

Most Recent Papers

Novel Regulators of Retina Neovascularization

Manhong Xu, Yilin Jiang, Lin Su, Xin Chen, Xianfeng Shao, Vicki Ea, Zhenying Shang, Xiaomin Zhang, Colin J. Barnstable, Xiaorong Li, Joyce Tombran-Tink, 2022, Journal of Proteome Research on p. 101-117

Neuroprotection of retinal cells by Caffeic Acid Phenylethyl Ester（CAPE) is mediated by mitochondrial uncoupling protein UCP2

Mingliang Zhang, Liming Wang, Dejia Wen, Changjie Ren, Shuang Chen, Zhihui Zhang, Lanlan Hu, Zihao Yu, Joyce Tombran-Tink, Xiaomin Zhang, Xiaorong Li, Colin J. Barnstable, 2021, Neurochemistry International

PEDF is an endogenous inhibitor of VEGF-R2 angiogenesis signaling in endothelial cells

Mingliang Zhang, Joyce Tombran-Tink, Songyang Yang, Xiaomin Zhang, Xiaorong Li, Colin J. Barnstable, 2021, Experimental Eye Research

Uncoupling proteins in the mitochondrial defense against oxidative stress

Daniel T. Hass, Colin J. Barnstable, 2021, Progress in Retinal Research

Pluripotent Stem Cells as Models of Retina Development

Amy Q. Lu, Colin J. Barnstable, 2019, Molecular Neurobiology on p. 6056-6070

Mitochondrial uncoupling protein 2 knock-out promotes mitophagy to decrease retinal ganglion cell death in a mouse model of glaucoma

Daniel T. Hass, Colin J. Barnstable, 2019, Journal of Neuroscience on p. 3582-3596

Cell Autonomous Neuroprotection by the Mitochondrial Uncoupling Protein 2 in a Mouse Model of Glaucoma

Daniel T. Hass, Colin J. Barnstable, 2019, Frontiers in Neuroscience

The 3-phosphoinositide-dependent protein kinase 1 inhibits rod photoreceptor development

Tiaosi Xing, Daniel T. Hass, Samuel S. Zhang, Colin J. Barnstable, 2018, Frontiers in Cell and Developmental Biology

Perineuronal nets labeled by monoclonal antibody VC1.1 ensheath interneurons expressing parvalbumin and calbindin in the rat amygdala

Alexander J. McDonald, Patricia G. Hamilton, Colin J. Barnstable, 2018, Brain Structure and Function on p. 1133-1148

Generation of Photoreceptor Precursors from Mouse Embryonic Stem Cells

Amy Q. Lu, Colin J. Barnstable, 2018, Stem Cell Reviews on p. 247-261

Most-Cited Papers

Pigment epithelium-derived factor (PEDF) peptide eye drops reduce inflammation, cell death and vascular leakage in diabetic retinopathy in Ins2(Akita) mice.

Yanling Liu, Lan Franco Leo, Corban McGregor, Anzor Grivitishvili, Colin J. Barnstable, Joyce Tombran-Tink, 2012, [No source information available] on p. 1387-1401

Stage and Gene Specific Signatures Defined by Histones H3K4me2 and H3K27me3 Accompany Mammalian Retina Maturation In Vivo

Evgenya Y. Popova, Xuming Xu, Andrew T. DeWan, Anna C. Salzberg, Arthur Berg, Josephine Hoh, Samuel S. Zhang, Colin J. Barnstable, 2012, PLoS One

Developmentally regulated linker histone H1c promotes heterochromatin condensation and mediates structural integrity of rod photoreceptors in mouse retina

Evgenya Y. Popova, Sergei A. Grigoryev, Yuhong Fan, Arthur I. Skoultchi, Samuel S. Zhang, Colin J. Barnstable, 2013, Journal of Biological Chemistry on p. 17895-17907

Stat3 mediates LIF-induced protection of astrocytes against toxic ROS by upregulating the UPC2 mRNA pool

Daniel W. Lapp, Samuel S. Zhang, Colin J. Barnstable, 2014, GLIA on p. 159-170

Uncoupling protein 2 in the glial response to stress

Daniel T. Hass, Colin J. Barnstable, 2016, Neural Regeneration Research on p. 1197-1200

Mitochondrial uncoupling protein 2 knock-out promotes mitophagy to decrease retinal ganglion cell death in a mouse model of glaucoma

Daniel T. Hass, Colin J. Barnstable, 2019, Journal of Neuroscience on p. 3582-3596

LSD1-Mediated Demethylation of H3K4me2 Is Required for the Transition from Late Progenitor to Differentiated Mouse Rod Photoreceptor

Evgenya Y. Popova, Carolina Pinzon-Guzman, Anna C. Salzberg, Samuel Shao Min Zhang, Colin J. Barnstable, 2016, Molecular Neurobiology on p. 4563-4581

Histone deacetylase 1 is essential for rod photoreceptor differentiation by regulating acetylation at histone H3 lysine 9 and histone H4 lysine 12 in the mouse retina

Renata C. Ferreira, Evgenya Y. Popova, Jessica James, Marcelo R.S. Briones, Samuel S. Zhang, Colin J. Barnstable, 2017, Journal of Biological Chemistry on p. 2422-2440

Therapeutic Retrobulbar Inhibition of STAT3 Protects Ischemic Retina Ganglion Cells

Mansin Wong, Ying Li, Shang Li, Shaodan Zhang, Weiyi Li, Pei Zhang, Chaoran Chen, Colin J. Barnstable, Samuel S. Zhang, Chun Zhang, Ping Huang, 2015, Molecular Neurobiology on p. 1364-1377

Mitochondrial Uncoupling Protein 2 (UCP2) Regulates Retinal Ganglion Cell Number and Survival

Colin J. Barnstable, Rajini Reddy, Hong Li, Tamas L. Horvath, 2016, Molecular and Chemical Neuropathology on p. 461-469