Colin Barnstable
Professor and Chair of Neural Behavioral Sciences

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H109 Neural & Behavioral Sciences
Hershey, PA - cjb30@psu.edu
- 717-531-3631
Research Summary
How interacting networks of transcription factors and signal transduction molecules guide the development of precursor/stem cells into mature neurons. Role of these networks in neurodegenerative diseases. Factors that can act as neuroprotective agents.
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Oxidative Stress Reactive Oxygen Species Retina Therapeutics Retinal Diseases Genes Histones Proteins Retinal Rod Photoreceptor Cells Uncoupling Protein 2 Retinal Ganglion Cells Esters Neuroprotection Caffeic Acid Mitochondrial Uncoupling Proteins Histone Deacetylase 1 Lysine Neurodegenerative Diseases Gene Expression Epigenomics Cell Death Retinal Astrocytes Chromatin NeurogliaMost Recent Publications
Molecular Mechanisms of Oxidative Stress Relief by CAPE in ARPE−19 Cells
Changjie Ren, Peiran Zhou, Mingliang Zhang, Zihao Yu, Xiaomin Zhang, Joyce Tombran-Tink, Colin J. Barnstable, Xiaorong Li, 2023, International Journal of Molecular Sciences
Deletion of the Pedf gene leads to inflammation, photoreceptor loss and vascular disturbances in the retina
Xin Chen, Manhong Xu, Xiaomin Zhang, Colin J. Barnstable, Xiaorong Li, Joyce Tombran-Tink, 2022, Experimental Eye Research
Epigenetics and Degenerative Retinal Diseases: Prospects for New Therapeutic Approaches
Colin J. Barnstable, 2022, Asia-Pacific Journal of Ophthalmology on p. 328-334
Regenerative Medicine, Advanced Stem Cell, and Gene Therapies for Eye Diseases
Colin J. Barnstable, Jost B. Jonas, Kang Zhang, 2022, Asia-Pacific Journal of Ophthalmology on p. 299-301
Uncoupling Proteins as Therapeutic Targets for Neurodegenerative Diseases
Colin J. Barnstable, Mingliang Zhang, Joyce Tombran-Tink, 2022, International Journal of Molecular Sciences
Novel Regulators of Retina Neovascularization: A Proteomics Approach
Manhong Xu, Yilin Jiang, Lin Su, Xin Chen, Xianfeng Shao, Vicki Ea, Zhenying Shang, Xiaomin Zhang, Colin J. Barnstable, Xiaorong Li, Joyce Tombran-Tink, 2022, Journal of Proteome Research on p. 101-117
Neuroprotection of retinal cells by Caffeic Acid Phenylethyl Ester(CAPE) is mediated by mitochondrial uncoupling protein UCP2
Mingliang Zhang, Liming Wang, Dejia Wen, Changjie Ren, Shuang Chen, Zhihui Zhang, Lanlan Hu, Zihao Yu, Joyce Tombran-Tink, Xiaomin Zhang, Xiaorong Li, Colin J. Barnstable, 2021, Neurochemistry International
PEDF is an endogenous inhibitor of VEGF-R2 angiogenesis signaling in endothelial cells
Mingliang Zhang, Joyce Tombran-Tink, Songyang Yang, Xiaomin Zhang, Xiaorong Li, Colin J. Barnstable, 2021, Experimental Eye Research
Inhibition of epigenetic modifiers LSD1 and HDAC1 blocks rod photoreceptor death in mouse models of retinitis pigmentosa
Evgenya Y. Popova, Yuka Imamura Kawasawa, Samuel Shao Min Zhang, Colin J. Barnstable, 2021, Journal of Neuroscience on p. 6775-6792
Uncoupling proteins in the mitochondrial defense against oxidative stress
Daniel T. Hass, Colin J. Barnstable, 2021, Progress in Retinal Research
Most-Cited Papers
Developmentally regulated linker histone H1c promotes heterochromatin condensation and mediates structural integrity of rod photoreceptors in mouse retina
Evgenya Y. Popova, Sergei A. Grigoryev, Yuhong Fan, Arthur I. Skoultchi, Samuel S. Zhang, Colin J. Barnstable, 2013, Journal of Biological Chemistry on p. 17895-17907
Uncoupling proteins in the mitochondrial defense against oxidative stress
Daniel T. Hass, Colin J. Barnstable, 2021, Progress in Retinal Research
Mitochondrial uncoupling protein 2 knock-out promotes mitophagy to decrease retinal ganglion cell death in a mouse model of glaucoma
Daniel T. Hass, Colin J. Barnstable, 2019, Journal of Neuroscience on p. 3582-3596
Stat3 mediates LIF-induced protection of astrocytes against toxic ROS by upregulating the UPC2 mRNA pool
Daniel W. Lapp, Samuel S. Zhang, Colin J. Barnstable, 2014, GLIA on p. 159-170
Histone deacetylase 1 is essential for rod photoreceptor differentiation by regulating acetylation at histone H3 lysine 9 and histone H4 lysine 12 in the mouse retina
Renata C. Ferreira, Evgenya Y. Popova, Jessica James, Marcelo R.S. Briones, Samuel S. Zhang, Colin J. Barnstable, 2017, Journal of Biological Chemistry on p. 2422-2440
LSD1-Mediated Demethylation of H3K4me2 Is Required for the Transition from Late Progenitor to Differentiated Mouse Rod Photoreceptor
Evgenya Y. Popova, Carolina Pinzon-Guzman, Anna C. Salzberg, Samuel Shao Min Zhang, Colin J. Barnstable, 2016, Molecular Neurobiology on p. 4563-4581
Uncoupling protein 2 in the glial response to stress: Implications for neuroprotection
Daniel T. Hass, Colin J. Barnstable, 2016, Neural Regeneration Research on p. 1197-1200
Therapeutic Retrobulbar Inhibition of STAT3 Protects Ischemic Retina Ganglion Cells
Mansin Wong, Ying Li, Shang Li, Shaodan Zhang, Weiyi Li, Pei Zhang, Chaoran Chen, Colin J. Barnstable, Samuel S. Zhang, Chun Zhang, Ping Huang, 2015, Molecular Neurobiology on p. 1364-1377
Tetrandrine protects mouse retinal ganglion cells from ischemic injury
Weiyi Li, Chen Yang, Jing Lu, Ping Huang, Colin J. Barnstable, Chun Zhang, Samuel S. Zhang, 2014, Drug Design, Development and Therapy on p. 327-339
Mitochondrial Uncoupling Protein 2 (UCP2) Regulates Retinal Ganglion Cell Number and Survival
Colin J. Barnstable, Rajini Reddy, Hong Li, Tamas L. Horvath, 2016, Molecular and Chemical Neuropathology on p. 461-469