Colin Barnstable

Professor and Chair of Neural Behavioral Sciences

Colin Barnstable

Research Summary

How interacting networks of transcription factors and signal transduction molecules guide the development of precursor/stem cells into mature neurons. Role of these networks in neurodegenerative diseases. Factors that can act as neuroprotective agents.

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Oxidative Stress Reactive Oxygen Species Retina Therapeutics Retinal Diseases Genes Histones Proteins Retinal Rod Photoreceptor Cells Uncoupling Protein 2 Retinal Ganglion Cells Esters Neuroprotection Caffeic Acid Mitochondrial Uncoupling Proteins Histone Deacetylase 1 Lysine Neurodegenerative Diseases Gene Expression Epigenomics Cell Death Retinal Astrocytes Chromatin Neuroglia

Most Recent Publications

Molecular Mechanisms of Oxidative Stress Relief by CAPE in ARPE−19 Cells

Changjie Ren, Peiran Zhou, Mingliang Zhang, Zihao Yu, Xiaomin Zhang, Joyce Tombran-Tink, Colin J. Barnstable, Xiaorong Li, 2023, International Journal of Molecular Sciences

Deletion of the Pedf gene leads to inflammation, photoreceptor loss and vascular disturbances in the retina

Xin Chen, Manhong Xu, Xiaomin Zhang, Colin J. Barnstable, Xiaorong Li, Joyce Tombran-Tink, 2022, Experimental Eye Research

Epigenetics and Degenerative Retinal Diseases: Prospects for New Therapeutic Approaches

Colin J. Barnstable, 2022, Asia-Pacific Journal of Ophthalmology on p. 328-334

Regenerative Medicine, Advanced Stem Cell, and Gene Therapies for Eye Diseases

Colin J. Barnstable, Jost B. Jonas, Kang Zhang, 2022, Asia-Pacific Journal of Ophthalmology on p. 299-301

Uncoupling Proteins as Therapeutic Targets for Neurodegenerative Diseases

Colin J. Barnstable, Mingliang Zhang, Joyce Tombran-Tink, 2022, International Journal of Molecular Sciences

Novel Regulators of Retina Neovascularization: A Proteomics Approach

Manhong Xu, Yilin Jiang, Lin Su, Xin Chen, Xianfeng Shao, Vicki Ea, Zhenying Shang, Xiaomin Zhang, Colin J. Barnstable, Xiaorong Li, Joyce Tombran-Tink, 2022, Journal of Proteome Research on p. 101-117

Neuroprotection of retinal cells by Caffeic Acid Phenylethyl Ester（CAPE) is mediated by mitochondrial uncoupling protein UCP2

Mingliang Zhang, Liming Wang, Dejia Wen, Changjie Ren, Shuang Chen, Zhihui Zhang, Lanlan Hu, Zihao Yu, Joyce Tombran-Tink, Xiaomin Zhang, Xiaorong Li, Colin J. Barnstable, 2021, Neurochemistry International

PEDF is an endogenous inhibitor of VEGF-R2 angiogenesis signaling in endothelial cells

Mingliang Zhang, Joyce Tombran-Tink, Songyang Yang, Xiaomin Zhang, Xiaorong Li, Colin J. Barnstable, 2021, Experimental Eye Research

Inhibition of epigenetic modifiers LSD1 and HDAC1 blocks rod photoreceptor death in mouse models of retinitis pigmentosa

Evgenya Y. Popova, Yuka Imamura Kawasawa, Samuel Shao Min Zhang, Colin J. Barnstable, 2021, Journal of Neuroscience on p. 6775-6792

Uncoupling proteins in the mitochondrial defense against oxidative stress

Daniel T. Hass, Colin J. Barnstable, 2021, Progress in Retinal Research

Most-Cited Papers

Developmentally regulated linker histone H1c promotes heterochromatin condensation and mediates structural integrity of rod photoreceptors in mouse retina

Evgenya Y. Popova, Sergei A. Grigoryev, Yuhong Fan, Arthur I. Skoultchi, Samuel S. Zhang, Colin J. Barnstable, 2013, Journal of Biological Chemistry on p. 17895-17907

Uncoupling proteins in the mitochondrial defense against oxidative stress

Daniel T. Hass, Colin J. Barnstable, 2021, Progress in Retinal Research

Mitochondrial uncoupling protein 2 knock-out promotes mitophagy to decrease retinal ganglion cell death in a mouse model of glaucoma

Daniel T. Hass, Colin J. Barnstable, 2019, Journal of Neuroscience on p. 3582-3596

Stat3 mediates LIF-induced protection of astrocytes against toxic ROS by upregulating the UPC2 mRNA pool

Daniel W. Lapp, Samuel S. Zhang, Colin J. Barnstable, 2014, GLIA on p. 159-170

Histone deacetylase 1 is essential for rod photoreceptor differentiation by regulating acetylation at histone H3 lysine 9 and histone H4 lysine 12 in the mouse retina

Renata C. Ferreira, Evgenya Y. Popova, Jessica James, Marcelo R.S. Briones, Samuel S. Zhang, Colin J. Barnstable, 2017, Journal of Biological Chemistry on p. 2422-2440

LSD1-Mediated Demethylation of H3K4me2 Is Required for the Transition from Late Progenitor to Differentiated Mouse Rod Photoreceptor

Evgenya Y. Popova, Carolina Pinzon-Guzman, Anna C. Salzberg, Samuel Shao Min Zhang, Colin J. Barnstable, 2016, Molecular Neurobiology on p. 4563-4581

Uncoupling protein 2 in the glial response to stress: Implications for neuroprotection

Daniel T. Hass, Colin J. Barnstable, 2016, Neural Regeneration Research on p. 1197-1200

Therapeutic Retrobulbar Inhibition of STAT3 Protects Ischemic Retina Ganglion Cells

Mansin Wong, Ying Li, Shang Li, Shaodan Zhang, Weiyi Li, Pei Zhang, Chaoran Chen, Colin J. Barnstable, Samuel S. Zhang, Chun Zhang, Ping Huang, 2015, Molecular Neurobiology on p. 1364-1377

Tetrandrine protects mouse retinal ganglion cells from ischemic injury

Weiyi Li, Chen Yang, Jing Lu, Ping Huang, Colin J. Barnstable, Chun Zhang, Samuel S. Zhang, 2014, Drug Design, Development and Therapy on p. 327-339

Mitochondrial Uncoupling Protein 2 (UCP2) Regulates Retinal Ganglion Cell Number and Survival

Colin J. Barnstable, Rajini Reddy, Hong Li, Tamas L. Horvath, 2016, Molecular and Chemical Neuropathology on p. 461-469