Colin Barnstable
Professor and Chair of Neural Behavioral Sciences

-
H109 Neural & Behavioral Sciences
Hershey, PA - cjb30@psu.edu
- 717-531-3631
Research Summary
How interacting networks of transcription factors and signal transduction molecules guide the development of precursor/stem cells into mature neurons. Role of these networks in neurodegenerative diseases. Factors that can act as neuroprotective agents.
Huck Affiliations
Links
Publication Tags
Genes Retina Histones Retinal Rod Photoreceptor Cells Retinal Ganglion Cells Gene Expression Histone Deacetylase 1 Acetylation Lysine Uncoupling Protein 2 Stem Cells Histone Deacetylases Cell Death Chromatin Cell Survival Epigenomics Transcription Initiation Site Activins Cell Count Astrocytes Transcription Factors Therapeutics Activin A Embryonic Stem Cells PharmacologyMost Recent Papers
Mitochondrial uncoupling protein 2 knock-out promotes mitophagy to decrease retinal ganglion cell death in a mouse model of glaucoma
Daniel T. Hass, Colin J. Barnstable, 2019, Journal of Neuroscience on p. 3582-3596
The 3-phosphoinositide-dependent protein kinase 1 inhibits rod photoreceptor development
Tiaosi Xing, Daniel T. Hass, Samuel S. Zhang, Colin J. Barnstable, 2018, Frontiers in Cell and Developmental Biology
Generation of Photoreceptor Precursors from Mouse Embryonic Stem Cells
Amy Q. Lu, Colin J. Barnstable, 2018, Stem Cell Reviews and Reports on p. 247-261
Perineuronal nets labeled by monoclonal antibody VC1.1 ensheath interneurons expressing parvalbumin and calbindin in the rat amygdala
Alexander J. McDonald, Patricia G. Hamilton, Colin J. Barnstable, 2018, Brain Structure and Function on p. 1133-1148
Activin Signals through SMAD2/3 to Increase Photoreceptor Precursor Yield during Embryonic Stem Cell Differentiation
Amy Q. Lu, Evgenya Y. Popova, Colin J. Barnstable, 2017, Stem Cell Reports on p. 838-852
Identification and prediction of alternative transcription start sites that generate rod photoreceptor-specific transcripts from ubiquitously expressed genes
Evgenya Y. Popova, Anna C. Salzberg, Chen Yang, Samuel Shao Min Zhang, Colin J. Barnstable, 2017, PloS one
Histone deacetylase 1 is essential for rod photoreceptor differentiation by regulating acetylation at histone H3 lysine 9 and histone H4 lysine 12 in the mouse retina
Renata C. Ferreira, Evgenya Y. Popova, Jessica James, Marcelo R.S. Briones, Samuel S. Zhang, Colin J. Barnstable, 2017, Journal of Biological Chemistry on p. 2422-2440
High pressure-induced mtDNA alterations in retinal ganglion cells and subsequent apoptosis
Sheng Hai Zhang, Feng Juan Gao, Zhong Mou Sun, Ping Xu, Jun Yi Chen, Xing Huai Sun, Ji Hong Wu, Hansen Wang, Stephanie C. Joachim, Colin Barnstable, 2016, Frontiers in Cellular Neuroscience
LSD1-Mediated Demethylation of H3K4me2 Is Required for the Transition from Late Progenitor to Differentiated Mouse Rod Photoreceptor
Evgenya Y. Popova, Carolina Pinzon-Guzman, Anna C. Salzberg, Samuel Shao Min Zhang, Colin J. Barnstable, 2016, Molecular Neurobiology on p. 4563-4581
Mitochondrial Uncoupling Protein 2 (UCP2) Regulates Retinal Ganglion Cell Number and Survival
Colin J. Barnstable, Rajini Reddy, Hong Li, Tamas L. Horvath, 2016, Journal of Molecular Neuroscience on p. 461-469
Most-Cited Papers
Pigment epithelium-derived factor (PEDF) peptide eye drops reduce inflammation, cell death and vascular leakage in diabetic retinopathy in Ins2(Akita) mice.
Yanling Liu, Lan Franco Leo, Corban McGregor, Anzor Grivitishvili, Colin J. Barnstable, Joyce Tombran-Tink, 2012, Unknown Journal on p. 1387-1401
Stage and Gene Specific Signatures Defined by Histones H3K4me2 and H3K27me3 Accompany Mammalian Retina Maturation In Vivo
Evgenya Y. Popova, Xuming Xu, Andrew T. DeWan, Anna C. Salzberg, Arthur Berg, Josephine Hoh, Samuel S. Zhang, Colin J. Barnstable, 2012, PloS one
Developmentally regulated linker histone H1c promotes heterochromatin condensation and mediates structural integrity of rod photoreceptors in mouse retina
Evgenya Y. Popova, Sergei A. Grigoryev, Yuhong Fan, Arthur I. Skoultchi, Samuel S. Zhang, Colin J. Barnstable, 2013, Journal of Biological Chemistry on p. 17895-17907
Stat3 mediates LIF-induced protection of astrocytes against toxic ROS by upregulating the UPC2 mRNA pool
Daniel W. Lapp, Samuel S. Zhang, Colin J. Barnstable, 2014, Glia on p. 159-170
Specific protein kinase C isoforms are required for rod photoreceptor differentiation
Carolina Pinzon-Guzman, Samuel Shao Min Zhang, Colin J. Barnstable, 2011, Journal of Neuroscience on p. 18606-18617
LSD1-Mediated Demethylation of H3K4me2 Is Required for the Transition from Late Progenitor to Differentiated Mouse Rod Photoreceptor
Evgenya Y. Popova, Carolina Pinzon-Guzman, Anna C. Salzberg, Samuel Shao Min Zhang, Colin J. Barnstable, 2016, Molecular Neurobiology on p. 4563-4581
Histone deacetylase 1 is essential for rod photoreceptor differentiation by regulating acetylation at histone H3 lysine 9 and histone H4 lysine 12 in the mouse retina
Renata C. Ferreira, Evgenya Y. Popova, Jessica James, Marcelo R.S. Briones, Samuel S. Zhang, Colin J. Barnstable, 2017, Journal of Biological Chemistry on p. 2422-2440
Therapeutic Retrobulbar Inhibition of STAT3 Protects Ischemic Retina Ganglion Cells
Mansin Wong, Ying Li, Shang Li, Shaodan Zhang, Weiyi Li, Pei Zhang, Chaoran Chen, Colin J. Barnstable, Samuel S. Zhang, Chun Zhang, Ping Huang, 2015, Molecular Neurobiology on p. 1364-1377
Tetrandrine protects mouse retinal ganglion cells from ischemic injury
Weiyi Li, Chen Yang, Jing Lu, Ping Huang, Colin J. Barnstable, Chun Zhang, Samuel S. Zhang, 2014, Drug Design, Development and Therapy on p. 327-339
Mitochondrial Uncoupling Protein 2 (UCP2) Regulates Retinal Ganglion Cell Number and Survival
Colin J. Barnstable, Rajini Reddy, Hong Li, Tamas L. Horvath, 2016, Journal of Molecular Neuroscience on p. 461-469