Colin Barnstable

Co-Chair, Intercollege Graduate Degree Program in Neuroscience; Professor and Chair of Neural Behavioral Sciences

Colin Barnstable

Research Summary

How interacting networks of transcription factors and signal transduction molecules guide the development of precursor/stem cells into mature neurons. Role of these networks in neurodegenerative diseases. Factors that can act as neuroprotective agents.

Huck Institutes Affiliations

Publication Tags

Genes Retina Histones Retinal Rod Photoreceptor Cells Retinal Ganglion Cells Gene Expression Stem Cells Chromatin Nerve Growth Factors Cell Death Transcription Initiation Site Activins Neurons Epigenomics Neuroglia Acetylation Astrocytes Lysine Histone Deacetylase 1 Ganglia Uncoupling Protein 2 Transcription Factors Ischemia Cell Survival Cell Differentiation

Most Recent Papers

Perineuronal nets labeled by monoclonal antibody VC1.1 ensheath interneurons expressing parvalbumin and calbindin in the rat amygdala

Alexander J. McDonald, Patricia G. Hamilton, Colin J. Barnstable, 2018, Brain Structure and Function on p. 1133-1148

Generation of Photoreceptor Precursors from Mouse Embryonic Stem Cells

Amy Q. Lu, Colin J. Barnstable, 2018, Stem Cell Reviews and Reports on p. 247-261

Activin Signals through SMAD2/3 to Increase Photoreceptor Precursor Yield during Embryonic Stem Cell Differentiation

Amy Q. Lu, Evgenya Y. Popova, Colin J. Barnstable, 2017, Stem Cell Reports on p. 838-852

Identification and prediction of alternative transcription start sites that generate rod photoreceptor-specific transcripts from ubiquitously expressed genes

Evgenya Y. Popova, Anna C. Salzberg, Chen Yang, Samuel Shao Min Zhang, Colin J. Barnstable, 2017, PloS one

Histone deacetylase 1 is essential for rod photoreceptor differentiation by regulating acetylation at histone H3 lysine 9 and histone H4 lysine 12 in the mouse retina

Renata C. Ferreira, Evgenya Y. Popova, Jessica James, Marcelo R.S. Briones, Samuel S. Zhang, Colin J. Barnstable, 2017, Journal of Biological Chemistry on p. 2422-2440

High pressure-induced mtDNA alterations in retinal ganglion cells and subsequent apoptosis

Sheng Hai Zhang, Feng Juan Gao, Zhong Mou Sun, Ping Xu, Jun Yi Chen, Xing Huai Sun, Ji Hong Wu, Hansen Wang, Stephanie C. Joachim, Colin Barnstable, 2016, Frontiers in Cellular Neuroscience

LSD1-Mediated Demethylation of H3K4me2 Is Required for the Transition from Late Progenitor to Differentiated Mouse Rod Photoreceptor

Evgenya Y. Popova, Carolina Pinzon-Guzman, Anna C. Salzberg, Samuel Shao Min Zhang, Colin J. Barnstable, 2016, Molecular Neurobiology on p. 4563-4581

Mitochondrial Uncoupling Protein 2 (UCP2) Regulates Retinal Ganglion Cell Number and Survival

Colin J. Barnstable, Rajini Reddy, Hong Li, Tamas L. Horvath, 2016, Journal of Molecular Neuroscience on p. 461-469

Therapeutic Retrobulbar Inhibition of STAT3 Protects Ischemic Retina Ganglion Cells

Mansin Wong, Ying Li, Shang Li, Shaodan Zhang, Weiyi Li, Pei Zhang, Chaoran Chen, Colin J. Barnstable, Samuel S. Zhang, Chun Zhang, Ping Huang, 2015, Molecular Neurobiology on p. 1364-1377

Tetrandrine protects mouse retinal ganglion cells from ischemic injury

Weiyi Li, Chen Yang, Jing Lu, Ping Huang, Colin J. Barnstable, Chun Zhang, Samuel S. Zhang, 2014, Drug Design, Development and Therapy on p. 327-339

High-Impact Papers

Bacterial endotoxin activates retinal pigment epithelial cells and induces their degeneration through IL-6 and IL-8 autocrine signaling

Kar Wah Leung, Colin J. Barnstable, Joyce Tombran-Tink, 2009, Molecular Immunology on p. 1374-1386

Pigment epithelium-derived factor (PEDF) peptide eye drops reduce inflammation, cell death and vascular leakage in diabetic retinopathy in Ins2(Akita) mice.

Yanling Liu, Lan Franco Leo, Corban McGregor, Anzor Grivitishvili, Colin J. Barnstable, Joyce Tombran-Tink, 2012, Molecular Medicine on p. 1387-1401

Expression of ZnT and ZIP zinc transporters in the human RPE and their regulation by neurotrophic factors

Kar Wah Leung, Mugen Liu, Ming Xu, Magdalene J. Seiler, Colin J. Barnstable, Joyce Tombran-Tink, 2008, Investigative Ophthalmology and Visual Science on p. 1221-1231

STAT3 activation protects retinal ganglion cell layer neurons in response to stress

Chun Zhang, Hong Li, Mu Gen Liu, Atsushi Kawasaki, Xin Yuan Fu, Colin J. Barnstable, Samuel Shao-Min Zhang, 2008, Experimental Eye Research on p. 991-997

Stage and Gene Specific Signatures Defined by Histones H3K4me2 and H3K27me3 Accompany Mammalian Retina Maturation In Vivo

Evgenya Y. Popova, Xuming Xu, Andrew T. DeWan, Anna C. Salzberg, Arthur Berg, Josephine Hoh, Samuel S. Zhang, Colin J. Barnstable, 2012, PLoS One

Developmentally regulated linker histone H1c promotes heterochromatin condensation and mediates structural integrity of rod photoreceptors in mouse retina

Evgenya Y. Popova, Sergei A. Grigoryev, Yuhong Fan, Arthur I. Skoultchi, Samuel S. Zhang, Colin J. Barnstable, 2013, Journal of Biological Chemistry on p. 17895-17907

PEDF and GDNF are key regulators of photoreceptor development and retinal neurogenesis in reaggregates from chick embryonic retina

Katja N. Volpert, Joyce Tombran-Tink, Colin Barnstable, Paul G. Layer, 2009, Journal of Ocular Biology, Diseases, and Informatics on p. 1-11

Stat3 mediates LIF-induced protection of astrocytes against toxic ROS by upregulating the UPC2 mRNA pool

Daniel W. Lapp, Samuel S. Zhang, Colin J. Barnstable, 2014, GLIA on p. 159-170

Specific protein kinase C isoforms are required for rod photoreceptor differentiation

Carolina Pinzon-Guzman, Samuel Shao Min Zhang, Colin J. Barnstable, 2011, Journal of Neuroscience on p. 18606-18617

LSD1-Mediated Demethylation of H3K4me2 Is Required for the Transition from Late Progenitor to Differentiated Mouse Rod Photoreceptor

Evgenya Y. Popova, Carolina Pinzon-Guzman, Anna C. Salzberg, Samuel Shao Min Zhang, Colin J. Barnstable, 2016, Molecular Neurobiology on p. 4563-4581