Colin Barnstable
Co-Chair, Intercollege Graduate Degree Program in Neuroscience; Professor and Chair of Neural Behavioral Sciences
- H109 Neural & Behavioral Sciences
Hershey, PA - cjb30@psu.edu
- 717-531-3631
Research Summary
How interacting networks of transcription factors and signal transduction molecules guide the development of precursor/stem cells into mature neurons. Role of these networks in neurodegenerative diseases. Factors that can act as neuroprotective agents.
Huck Institutes Affiliations
Most Recent Papers
Perineuronal nets labeled by monoclonal antibody VC1.1 ensheath interneurons expressing parvalbumin and calbindin in the rat amygdala
Alexander J. McDonald, Patricia G. Hamilton, Colin J. Barnstable, 2018, Brain Structure and Function on p. 1133-1148
Generation of Photoreceptor Precursors from Mouse Embryonic Stem Cells
Amy Q. Lu, Colin J. Barnstable, 2018, Stem Cell Reviews and Reports on p. 247-261
Activin Signals through SMAD2/3 to Increase Photoreceptor Precursor Yield during Embryonic Stem Cell Differentiation
Amy Q. Lu, Evgenya Y. Popova, Colin J. Barnstable, 2017, Stem Cell Reports on p. 838-852
Identification and prediction of alternative transcription start sites that generate rod photoreceptor-specific transcripts from ubiquitously expressed genes
Evgenya Y. Popova, Anna C. Salzberg, Chen Yang, Samuel Shao Min Zhang, Colin J. Barnstable, 2017, PloS one
Histone deacetylase 1 is essential for rod photoreceptor differentiation by regulating acetylation at histone H3 lysine 9 and histone H4 lysine 12 in the mouse retina
Renata C. Ferreira, Evgenya Y. Popova, Jessica James, Marcelo R.S. Briones, Samuel S. Zhang, Colin J. Barnstable, 2017, Journal of Biological Chemistry on p. 2422-2440
High pressure-induced mtDNA alterations in retinal ganglion cells and subsequent apoptosis
Sheng Hai Zhang, Feng Juan Gao, Zhong Mou Sun, Ping Xu, Jun Yi Chen, Xing Huai Sun, Ji Hong Wu, Hansen Wang, Stephanie C. Joachim, Colin Barnstable, 2016, Frontiers in Cellular Neuroscience
LSD1-Mediated Demethylation of H3K4me2 Is Required for the Transition from Late Progenitor to Differentiated Mouse Rod Photoreceptor
Evgenya Y. Popova, Carolina Pinzon-Guzman, Anna C. Salzberg, Samuel Shao Min Zhang, Colin J. Barnstable, 2016, Molecular Neurobiology on p. 4563-4581
Mitochondrial Uncoupling Protein 2 (UCP2) Regulates Retinal Ganglion Cell Number and Survival
Colin J. Barnstable, Rajini Reddy, Hong Li, Tamas L. Horvath, 2016, Journal of Molecular Neuroscience on p. 461-469
Therapeutic Retrobulbar Inhibition of STAT3 Protects Ischemic Retina Ganglion Cells
Mansin Wong, Ying Li, Shang Li, Shaodan Zhang, Weiyi Li, Pei Zhang, Chaoran Chen, Colin J. Barnstable, Samuel S. Zhang, Chun Zhang, Ping Huang, 2015, Molecular Neurobiology on p. 1364-1377
Tetrandrine protects mouse retinal ganglion cells from ischemic injury
Weiyi Li, Chen Yang, Jing Lu, Ping Huang, Colin J. Barnstable, Chun Zhang, Samuel S. Zhang, 2014, Drug Design, Development and Therapy on p. 327-339
High-Impact Papers
Bacterial endotoxin activates retinal pigment epithelial cells and induces their degeneration through IL-6 and IL-8 autocrine signaling
Kar Wah Leung, Colin J. Barnstable, Joyce Tombran-Tink, 2009, Molecular Immunology on p. 1374-1386
Pigment epithelium-derived factor (PEDF) peptide eye drops reduce inflammation, cell death and vascular leakage in diabetic retinopathy in Ins2(Akita) mice.
Yanling Liu, Lan Franco Leo, Corban McGregor, Anzor Grivitishvili, Colin J. Barnstable, Joyce Tombran-Tink, 2012, Molecular Medicine on p. 1387-1401
Stage and Gene Specific Signatures Defined by Histones H3K4me2 and H3K27me3 Accompany Mammalian Retina Maturation In Vivo
Evgenya Y. Popova, Xuming Xu, Andrew T. DeWan, Anna C. Salzberg, Arthur Berg, Josephine Hoh, Samuel S. Zhang, Colin J. Barnstable, 2012, PLoS One
Developmentally regulated linker histone H1c promotes heterochromatin condensation and mediates structural integrity of rod photoreceptors in mouse retina
Evgenya Y. Popova, Sergei A. Grigoryev, Yuhong Fan, Arthur I. Skoultchi, Samuel S. Zhang, Colin J. Barnstable, 2013, Journal of Biological Chemistry on p. 17895-17907
PEDF and GDNF are key regulators of photoreceptor development and retinal neurogenesis in reaggregates from chick embryonic retina
Katja N. Volpert, Joyce Tombran-Tink, Colin Barnstable, Paul G. Layer, 2009, Journal of Ocular Biology, Diseases, and Informatics on p. 1-11
Stat3 mediates LIF-induced protection of astrocytes against toxic ROS by upregulating the UPC2 mRNA pool
Daniel W. Lapp, Samuel S. Zhang, Colin J. Barnstable, 2014, GLIA on p. 159-170
Specific protein kinase C isoforms are required for rod photoreceptor differentiation
Carolina Pinzon-Guzman, Samuel Shao Min Zhang, Colin J. Barnstable, 2011, Journal of Neuroscience on p. 18606-18617
LSD1-Mediated Demethylation of H3K4me2 Is Required for the Transition from Late Progenitor to Differentiated Mouse Rod Photoreceptor
Evgenya Y. Popova, Carolina Pinzon-Guzman, Anna C. Salzberg, Samuel Shao Min Zhang, Colin J. Barnstable, 2016, Molecular Neurobiology on p. 4563-4581
Tetrandrine protects mouse retinal ganglion cells from ischemic injury
Weiyi Li, Chen Yang, Jing Lu, Ping Huang, Colin J. Barnstable, Chun Zhang, Samuel S. Zhang, 2014, Drug Design, Development and Therapy on p. 327-339
Therapeutic Retrobulbar Inhibition of STAT3 Protects Ischemic Retina Ganglion Cells
Mansin Wong, Ying Li, Shang Li, Shaodan Zhang, Weiyi Li, Pei Zhang, Chaoran Chen, Colin J. Barnstable, Samuel S. Zhang, Chun Zhang, Ping Huang, 2015, Molecular Neurobiology on p. 1364-1377