Colin Barnstable

Professor and Chair of Neural Behavioral Sciences

Colin Barnstable

Research Summary

How interacting networks of transcription factors and signal transduction molecules guide the development of precursor/stem cells into mature neurons. Role of these networks in neurodegenerative diseases. Factors that can act as neuroprotective agents.

Huck Affiliations

Publication Tags

Genes Retina Retinal Rod Photoreceptor Cells Histones Retinal Ganglion Cells Gene Expression Uncoupling Protein 2 Stem Cells Cell Death Chromatin Cell Survival Transcription Initiation Site Activins Cell Count Epigenomics Histone Deacetylase 1 Acetylation Astrocytes Lysine Transcription Factors Therapeutics Protein Isoforms Activin A Histone Deacetylases Embryonic Stem Cells

Most Recent Papers

Mitochondrial uncoupling protein 2 knock-out promotes mitophagy to decrease retinal ganglion cell death in a mouse model of glaucoma

Daniel T. Hass, Colin J. Barnstable, 2019, Journal of Neuroscience on p. 3582-3596

The 3-phosphoinositide-dependent protein kinase 1 inhibits rod photoreceptor development

Tiaosi Xing, Daniel T. Hass, Samuel S. Zhang, Colin J. Barnstable, 2018, Frontiers in Cell and Developmental Biology

Generation of Photoreceptor Precursors from Mouse Embryonic Stem Cells

Amy Q. Lu, Colin Barnstable, 2018, Stem Cell Reviews and Reports on p. 247-261

Perineuronal nets labeled by monoclonal antibody VC1.1 ensheath interneurons expressing parvalbumin and calbindin in the rat amygdala

Alexander J. McDonald, Patricia G. Hamilton, Colin J. Barnstable, 2018, Brain Structure and Function on p. 1133-1148

Activin Signals through SMAD2/3 to Increase Photoreceptor Precursor Yield during Embryonic Stem Cell Differentiation

Amy Q. Lu, Evgenya Y. Popova, Colin J. Barnstable, 2017, Stem Cell Reports on p. 838-852

Identification and prediction of alternative transcription start sites that generate rod photoreceptor-specific transcripts from ubiquitously expressed genes

Evgenya Y. Popova, Anna C. Salzberg, Chen Yang, Samuel Shao Min Zhang, Colin J. Barnstable, 2017, PloS one

Histone deacetylase 1 is essential for rod photoreceptor differentiation by regulating acetylation at histone H3 lysine 9 and histone H4 lysine 12 in the mouse retina

Renata C. Ferreira, Evgenya Y. Popova, Jessica James, Marcelo R.S. Briones, Samuel S. Zhang, Colin J. Barnstable, 2017, Journal of Biological Chemistry on p. 2422-2440

High pressure-induced mtDNA alterations in retinal ganglion cells and subsequent apoptosis

Sheng Hai Zhang, Feng Juan Gao, Zhong Mou Sun, Ping Xu, Jun Yi Chen, Xing Huai Sun, Ji Hong Wu, Hansen Wang, Stephanie C. Joachim, Colin Barnstable, 2016, Frontiers in Cellular Neuroscience

LSD1-Mediated Demethylation of H3K4me2 Is Required for the Transition from Late Progenitor to Differentiated Mouse Rod Photoreceptor

Evgenya Y. Popova, Carolina Pinzon-Guzman, Anna C. Salzberg, Samuel Shao Min Zhang, Colin J. Barnstable, 2016, Molecular Neurobiology on p. 4563-4581

Mitochondrial Uncoupling Protein 2 (UCP2) Regulates Retinal Ganglion Cell Number and Survival

Colin J. Barnstable, Rajini Reddy, Hong Li, Tamas L. Horvath, 2016, Journal of Molecular Neuroscience on p. 461-469

Most-Cited Papers

Pigment epithelium-derived factor (PEDF) peptide eye drops reduce inflammation, cell death and vascular leakage in diabetic retinopathy in Ins2(Akita) mice.

Yanling Liu, Lan Franco Leo, Corban McGregor, Anzor Grivitishvili, Colin Barnstable, Joyce Tombran-Tink, 2012, Unknown Journal on p. 1387-1401

Stage and Gene Specific Signatures Defined by Histones H3K4me2 and H3K27me3 Accompany Mammalian Retina Maturation In Vivo

Evgenya Y. Popova, Xuming Xu, Andrew T. DeWan, Anna C. Salzberg, Arthur Berg, Josephine Hoh, Samuel S. Zhang, Colin J. Barnstable, 2012, PloS one

Developmentally regulated linker histone H1c promotes heterochromatin condensation and mediates structural integrity of rod photoreceptors in mouse retina

Evgenya Y. Popova, Sergei A. Grigoryev, Yuhong Fan, Arthur I. Skoultchi, Samuel S. Zhang, Colin J. Barnstable, 2013, Journal of Biological Chemistry on p. 17895-17907

Stat3 mediates LIF-induced protection of astrocytes against toxic ROS by upregulating the UPC2 mRNA pool

Daniel W. Lapp, Samuel S. Zhang, Colin Barnstable, 2014, GLIA on p. 159-170

Specific protein kinase C isoforms are required for rod photoreceptor differentiation

Carolina Pinzon-Guzman, Samuel Shao Min Zhang, Colin J. Barnstable, 2011, Journal of Neuroscience on p. 18606-18617

LSD1-Mediated Demethylation of H3K4me2 Is Required for the Transition from Late Progenitor to Differentiated Mouse Rod Photoreceptor

Evgenya Y. Popova, Carolina Pinzon-Guzman, Anna C. Salzberg, Samuel Shao Min Zhang, Colin J. Barnstable, 2016, Molecular Neurobiology on p. 4563-4581

Therapeutic Retrobulbar Inhibition of STAT3 Protects Ischemic Retina Ganglion Cells

Mansin Wong, Ying Li, Shang Li, Shaodan Zhang, Weiyi Li, Pei Zhang, Chaoran Chen, Colin J. Barnstable, Samuel S. Zhang, Chun Zhang, Ping Huang, 2015, Molecular Neurobiology on p. 1364-1377

Tetrandrine protects mouse retinal ganglion cells from ischemic injury

Weiyi Li, Chen Yang, Jing Lu, Ping Huang, Colin J. Barnstable, Chun Zhang, Samuel S. Zhang, 2014, Drug Design, Development and Therapy on p. 327-339

Mitochondrial Uncoupling Protein 2 (UCP2) Regulates Retinal Ganglion Cell Number and Survival

Colin J. Barnstable, Rajini Reddy, Hong Li, Tamas L. Horvath, 2016, Journal of Molecular Neuroscience on p. 461-469

Regulation of Rod Photoreceptor Differentiation by STAT3 Is Controlled by a Tyrosine Phosphatase

Carolina Pinzon-Guzman, Tiaosi Xing, Samuel Shao Min Zhang, Colin Barnstable, 2014, Journal of Molecular Neuroscience on p. 152-159