Colin Barnstable

Professor and Chair of Neural Behavioral Sciences

Colin Barnstable

Research Summary

How interacting networks of transcription factors and signal transduction molecules guide the development of precursor/stem cells into mature neurons. Role of these networks in neurodegenerative diseases. Factors that can act as neuroprotective agents.

Huck Affiliations

Links

Publication Tags

Retina Histones Genes Reactive Oxygen Species Therapeutics Oxidative Stress Proteins Retinal Rod Photoreceptor Cells Retinal Diseases Gene Expression Cell Death Neuroprotection Histone Deacetylase 1 Histone Mitochondrial Uncoupling Proteins Lysine Neurodegenerative Diseases Uncoupling Protein 2 Inflammation Neuroglia Rod Like Crystal Epigenomics Retinal Ganglion Cells Blood Vessels Astrocytes

Most Recent Publications

Deletion of the Pedf gene leads to inflammation, photoreceptor loss and vascular disturbances in the retina

Xin Chen, Manhong Xu, Xiaomin Zhang, Colin J. Barnstable, Xiaorong Li, Joyce Tombran-Tink, 2022, Experimental Eye Research

Epigenetics and Degenerative Retinal Diseases: Prospects for New Therapeutic Approaches

Colin J. Barnstable, 2022, Asia-Pacific Journal of Ophthalmology on p. 328-334

Regenerative Medicine, Advanced Stem Cell, and Gene Therapies for Eye Diseases

Colin J. Barnstable, Jost B. Jonas, Kang Zhang, 2022, Asia-Pacific Journal of Ophthalmology on p. 299-301

Uncoupling Proteins as Therapeutic Targets for Neurodegenerative Diseases

Colin J. Barnstable, Mingliang Zhang, Joyce Tombran-Tink, 2022, International Journal of Molecular Sciences

Novel Regulators of Retina Neovascularization: A Proteomics Approach

Manhong Xu, Yilin Jiang, Lin Su, Xin Chen, Xianfeng Shao, Vicki Ea, Zhenying Shang, Xiaomin Zhang, Colin J. Barnstable, Xiaorong Li, Joyce Tombran-Tink, 2022, Journal of Proteome Research on p. 101-117

Neuroprotection of retinal cells by Caffeic Acid Phenylethyl Ester（CAPE) is mediated by mitochondrial uncoupling protein UCP2

Mingliang Zhang, Liming Wang, Dejia Wen, Changjie Ren, Shuang Chen, Zhihui Zhang, Lanlan Hu, Zihao Yu, Joyce Tombran-Tink, Xiaomin Zhang, Xiaorong Li, Colin J. Barnstable, 2021, Neurochemistry International

PEDF is an endogenous inhibitor of VEGF-R2 angiogenesis signaling in endothelial cells

Mingliang Zhang, Joyce Tombran-Tink, Songyang Yang, Xiaomin Zhang, Xiaorong Li, Colin J. Barnstable, 2021, Experimental Eye Research

Inhibition of epigenetic modifiers LSD1 and HDAC1 blocks rod photoreceptor death in mouse models of retinitis pigmentosa

Evgenya Y. Popova, Yuka Imamura Kawasawa, Samuel Shao Min Zhang, Colin J. Barnstable, 2021, Journal of Neuroscience on p. 6775-6792

Uncoupling proteins in the mitochondrial defense against oxidative stress

Daniel T. Hass, Colin J. Barnstable, 2021, Progress in Retinal Research

PEDF gene deletion disrupts corneal innervation and ocular surface function

Zhenying Shang, Chenxi Li, Xuemei Liu, Manhong Xu, Xiaomin Zhang, Xiaorong Li, Colin J. Barnstable, Shaozhen Zhao, Joyce Tombran-Tink, 2021, Investigative Ophthalmology and Visual Science

Most-Cited Papers

Pigment epithelium-derived factor (PEDF) peptide eye drops reduce inflammation, cell death and vascular leakage in diabetic retinopathy in Ins2(Akita) mice.

Yanling Liu, Lan Franco Leo, Corban McGregor, Anzor Grivitishvili, Colin J. Barnstable, Joyce Tombran-Tink, 2012, [No source information available] on p. 1387-1401

Stage and Gene Specific Signatures Defined by Histones H3K4me2 and H3K27me3 Accompany Mammalian Retina Maturation In Vivo

Evgenya Y. Popova, Xuming Xu, Andrew T. DeWan, Anna C. Salzberg, Arthur Berg, Josephine Hoh, Samuel S. Zhang, Colin J. Barnstable, 2012, PLoS One

Developmentally regulated linker histone H1c promotes heterochromatin condensation and mediates structural integrity of rod photoreceptors in mouse retina

Evgenya Y. Popova, Sergei A. Grigoryev, Yuhong Fan, Arthur I. Skoultchi, Samuel S. Zhang, Colin J. Barnstable, 2013, Journal of Biological Chemistry on p. 17895-17907

Stat3 mediates LIF-induced protection of astrocytes against toxic ROS by upregulating the UPC2 mRNA pool

Daniel W. Lapp, Samuel S. Zhang, Colin J. Barnstable, 2014, GLIA on p. 159-170

Mitochondrial uncoupling protein 2 knock-out promotes mitophagy to decrease retinal ganglion cell death in a mouse model of glaucoma

Daniel T. Hass, Colin J. Barnstable, 2019, Journal of Neuroscience on p. 3582-3596

Uncoupling protein 2 in the glial response to stress: Implications for neuroprotection

Daniel T. Hass, Colin J. Barnstable, 2016, Neural Regeneration Research on p. 1197-1200

LSD1-Mediated Demethylation of H3K4me2 Is Required for the Transition from Late Progenitor to Differentiated Mouse Rod Photoreceptor

Evgenya Y. Popova, Carolina Pinzon-Guzman, Anna C. Salzberg, Samuel Shao Min Zhang, Colin J. Barnstable, 2016, Molecular Neurobiology on p. 4563-4581

Histone deacetylase 1 is essential for rod photoreceptor differentiation by regulating acetylation at histone H3 lysine 9 and histone H4 lysine 12 in the mouse retina

Renata C. Ferreira, Evgenya Y. Popova, Jessica James, Marcelo R.S. Briones, Samuel S. Zhang, Colin J. Barnstable, 2017, Journal of Biological Chemistry on p. 2422-2440

Therapeutic Retrobulbar Inhibition of STAT3 Protects Ischemic Retina Ganglion Cells

Mansin Wong, Ying Li, Shang Li, Shaodan Zhang, Weiyi Li, Pei Zhang, Chaoran Chen, Colin J. Barnstable, Samuel S. Zhang, Chun Zhang, Ping Huang, 2015, Molecular Neurobiology on p. 1364-1377

Uncoupling proteins in the mitochondrial defense against oxidative stress

Daniel T. Hass, Colin J. Barnstable, 2021, Progress in Retinal Research