Christopher Norbury
Professor of Microbiology

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H107 Microbiology & Immunology
Hershey, PA - ccn1@psu.edu
- 717-531-8253
Huck Affiliations
Publication Tags
Vaccinia Virus Infection Proteins T Lymphocytes Viruses Infections Virus Diseases Dendritic Cells Virion Glycoproteins T Cells Peptides Macrophages Parasites Cross Priming Cells Histocompatibility Antigens Class I Interferon Type I Malaria Protein Molecule Interleukin 4 Immunity Ectromelia Virus AntigensMost Recent Publications
An increase in glycoprotein concentration on extracellular virions dramatically alters vaccinia virus infectivity and pathogenesis without impacting immunogenicity
Stephanie R. Monticelli, Peter Bryk, Matthew G. Brewer, Hector C. Aguilar, Christopher C. Norbury, Brian M. Ward, 2021, PLoS Pathogens
IL-4 treatment mitigates experimental cerebral malaria by reducing parasitemia, dampening inflammation, and lessening the cytotoxicity of T cells
Xianzhu Wu, Ramesh P. Thylur, Kiran K. Dayanand, Kishore Punnath, Christopher C. Norbury, D. Channe Gowda, 2021, Journal of Immunology on p. 118-131
IL-4Rα signaling by CD8α<sup>+</sup> dendritic cells contributes to cerebral malaria by enhancing inflammatory, Th1, and cytotoxic CD8<sup>+</sup> T cell responses
Xianzhu Wu, Frank Brombacher, Zissis C. Chroneos, Christopher C. Norbury, D. Channe Gowda, 2021, Journal of Biological Chemistry
Vaccinia Virus Glycoproteins A33, A34, and B5 Form a Complex for Efficient Endoplasmic Reticulum to trans-Golgi Network Transport
Stephanie R. Monticelli, Amalia K. Earley, Raychel Stone, Christopher C. Norbury, Brian M. Ward, 2020, Journal of Virology
Analysis of MHC Class I Processing Pathways That Generate a Response to Vaccinia Virus Late Proteins
Ting Kuang Niu, Michael F. Princiotta, Janet J. Sei, Christopher C. Norbury, 2019, ImmunoHorizons on p. 559-572
Type I interferon-dependent CCL4 is induced by a cGAS/STING pathway that bypasses viral inhibition and protects infected tissue, independent of viral burden
Nikhil J. Parekh, Tracy E. Krouse, Irene E. Reider, Ryan P. Hobbs, Brian M. Ward, Christopher C. Norbury, 2019, PLoS Pathogens
Small Molecule– based inhibition of MEK1/2 proteins dampens inflammatory responses to malaria, reduces parasite load, and mitigates pathogenic outcomes
Xianzhu Wu, Kiran K. Dayanand, Ramesh P. Thylur, Christopher C. Norbury, D. Channe Gowda, 2017, Journal of Biological Chemistry on p. 13615-13634
A systemic macrophage response is required to contain a peripheral poxvirus infection
Michael L. Davies, Nikhil J. Parekh, Lauren W. Kaminsky, Chetna Soni, Irene E. Reider, Tracy E. Krouse, Matthew A. Fischer, Nico van Rooijen, Ziaur S.M. Rahman, Christopher C. Norbury, 2017, PLoS Pathogens
Editorial overview: Antigen processing
Christopher C. Norbury, Laurence C. Eisenlohr, 2016, Current Opinion in Immunology on p. v-vi
Defining cross presentation for a wider audience
Christopher C. Norbury, 2016, Current Opinion in Immunology on p. 110-116
Most-Cited Papers
Crosstalk between the type 1 interferon and nuclear factor kappa B pathways confers resistance to a lethal virus infection
Daniel Rubio, Ren Huan Xu, Sanda Remakus, Tracy E. Krouse, Mary Ellen Truckenmiller, Roshan J. Thapa, Siddharth Balachandran, Antonio Alcamí, Christopher C. Norbury, Luis J. Sigal, 2013, Cell Host and Microbe on p. 701-710
Peptide-MHC-I from Endogenous Antigen Outnumber Those from Exogenous Antigen, Irrespective of APC Phenotype or Activation
Janet J. Sei, Scott Haskett, Lauren W. Kaminsky, Eugene Lin, Mary E. Truckenmiller, Clifford J. Bellone, R. Mark Buller, Christopher C. Norbury, 2015, PLoS Pathogens
C-Myc regulation by costimulatory signals modulates the generation of CD8<sup>+</sup> memory T cells during viral infection
Jianxun Song, Mohammad Haque, Jianyong Song, Kristin Fino, Youfei Wang, Praneet Sandhu, Xinmeng Song, Christopher Norbury, Bing Ni, Deyu Fang, Shahram Salek-Ardakani, 2016, Open Biology
Prolonged antigen presentation following an acute virus infection requires direct and then cross-presentation
Erica L. Heipertz, Michael L. Davies, Eugene Lin, Christopher C. Norbury, 2014, Journal of Immunology on p. 4169-4177
Defining cross presentation for a wider audience
Christopher C. Norbury, 2016, Current Opinion in Immunology on p. 110-116
MyD88-dependent immunity to a natural model of vaccinia virus infection does not involve toll-like receptor 2
Michael L. Davies, Janet J. Sei, Nicholas A. Siciliano, Ren Huan Xu, Felicia Roscoe, Luis J. Sigal, Laurence C. Eisenlohr, Christopher C. Norbury, 2014, Journal of Virology on p. 3557-3567
Small Molecule– based inhibition of MEK1/2 proteins dampens inflammatory responses to malaria, reduces parasite load, and mitigates pathogenic outcomes
Xianzhu Wu, Kiran K. Dayanand, Ramesh P. Thylur, Christopher C. Norbury, D. Channe Gowda, 2017, Journal of Biological Chemistry on p. 13615-13634
Redundant function of plasmacytoid and conventional dendritic cells is required to survive a natural virus infection
Lauren W. Kaminsky, Janet J. Sei, Nikhil J. Parekh, Michael L. Davies, Irene E. Reider, Tracy E. Krouse, Christopher C. Norbury, 2015, Journal of Virology on p. 9974-9985
A systemic macrophage response is required to contain a peripheral poxvirus infection
Michael L. Davies, Nikhil J. Parekh, Lauren W. Kaminsky, Chetna Soni, Irene E. Reider, Tracy E. Krouse, Matthew A. Fischer, Nico van Rooijen, Ziaur S.M. Rahman, Christopher C. Norbury, 2017, PLoS Pathogens
Type I interferon-dependent CCL4 is induced by a cGAS/STING pathway that bypasses viral inhibition and protects infected tissue, independent of viral burden
Nikhil J. Parekh, Tracy E. Krouse, Irene E. Reider, Ryan P. Hobbs, Brian M. Ward, Christopher C. Norbury, 2019, PLoS Pathogens