Carsten Krebs
Professor of Chemistry, Professor of Biochemistry and Molecular Biology
- PA 16802
- cdk10@psu.edu
- 814-865-6089
Research Summary
Bioinorganic Chemistry - spectroscopic and kinetic studies on the mechanisms of iron-containing enzymes
Links
Publication Tags
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Iron Enzymes Proteins Oxygenases Hydrogen Carbon Nitric Oxide Protein Oxidoreductases Glutarates Oxygen X Rays Electrons Beta Lactams Substrates Hydroxylation Molecular Cluster Carbon Atom Arginine Ligands Sulfur Mixed Function Oxygenases Spectrum Analysis Vanadium CofactorMost Recent Publications
Capturing a bis-Fe(IV) State in Methylosinus trichosporium OB3b MbnH
Anastasia C. Manesis, Jeffrey W. Slater, Kenny Cantave, J. Martin Bollinger, Carsten Krebs, Amy C. Rosenzweig, 2023, Biochemistry on p. 1082-1092
Methods for Biophysical Characterization of SznF, a Member of the Heme-Oxygenase-Like Diiron Oxidase/Oxygenase Superfamily
Molly J. McBride, Sarah R. Pope, Mrutyunjay A. Nair, Debangsu Sil, Xavier E. Salas-Solá, Carsten Krebs, J. Martin Bollinger, Amie K. Boal, 2023, on p. 123-154
What Is the Right Level of Activation of a High-Spin {FeNO}<sup>7</sup>Complex to Enable Direct N-N Coupling? Mechanistic Insight into Flavodiiron NO Reductases
Hai T. Dong, Stephanie Camarena, Debangsu Sil, Michael O. Lengel, Jiyong Zhao, Michael Y. Hu, E. Ercan Alp, Carsten Krebs, Nicolai Lehnert, 2022, Journal of the American Chemical Society on p. 16395-16409
Characterization of LipS1 and LipS2 from Thermococcus kodakarensis: Proteins Annotated as Biotin Synthases, which Together Catalyze Formation of the Lipoyl Cofactor
Syam Sundar Neti, Debangsu Sil, Douglas M. Warui, Olga A. Esakova, Amy E. Solinski, Dante A. Serrano, Carsten Krebs, Squire J. Booker, 2022, ACS Bio and Med Chem Au on p. 509-520
Progress Toward Understanding Protein Control of Reaction Outcome in the Diverse Reactivity of Iron(II)- and 2-Oxoglutarate-dependent Oxygenases
J. M. Bollinger, Carsten Krebs, Amie K. Boal, Alexey Silakov, John C. Price, Megan L. Matthews, Wei Chen Chang, Ryan J. Martinie, Juan Pan, Noah P. Dunham, Eliott S. Wenger, Rachelle A. Copeland, Chi Yun Lin, 2022, FASEB Journal
Synthesis and characterization of a model complex for flavodiiron NO reductases that stabilizes a diiron mononitrosyl complex
Hai T. Dong, Yu Zong, Abigail J. Bracken, Michael O. Lengel, Jeff W. Kampf, Debangsu Sil, Carsten Krebs, Nicolai Lehnert, 2022, Journal of Inorganic Biochemistry
Substrate-Triggered μ-Peroxodiiron(III) Intermediate in the 4-Chloro- l -Lysine-Fragmenting Heme-Oxygenase-like Diiron Oxidase (HDO) BesC: Substrate Dissociation from, and C4 Targeting by, the Intermediate
Molly J. McBride, Mrutyunjay A. Nair, Debangsu Sil, M Neugebauer, Jeffrey W. Slater, Monica E. Neugebauer, M Chng, A Boal, Michelle C.Y. Chang, C Krebs, Amie Boal, Carsten Krebs, J. Martin Bollinger, 2022, Biochemistry on p. 689-702
A mixed-valent Fe(II)Fe(III) species converts cysteine to an oxazolone/thioamide pair in methanobactin biosynthesis
Yun Ji Park, Richard J. Jodts, Jeffrey W. Slater, Reyvin M. Reyes, Valerie J. Winton, Rana A. Montaser, Paul M. Thomas, William B. Dowdle, Anahi Ruiz, Neil L. Kelleher, Joseph Bollinger, Carsten Krebs, Brian M. Hoffman, Amy C. Rosenzweig, 2022, Proceedings of the National Academy of Sciences of the United States of America on p. e2123566119
Synthesis of 6,6- and 7,7-Difluoro-1-acetamidopyrrolizidines and Their Oxidation Catalyzed by the Nonheme Fe Oxygenase LolO
Nabin Panth, Eliott S. Wenger, Carsten Krebs, Joseph Bollinger, Robert B. Grossman, 2022, ChemBioChem on p. e202200081
In Vitro Demonstration of Human Lipoyl Synthase Catalytic Activity in the Presence of NFU1
Douglas M. Warui, Debangsu Sil, Kyung Hoon Lee, Syam Sundar Neti, Olga A. Esakova, Hayley L. Knox, Carsten Krebs, Squire J. Booker, 2022, ACS Bio and Med Chem Au on p. 456-468
Most-Cited Papers
Human calprotectin is an iron-sequestering host-defense protein
Toshiki G. Nakashige, Bo Zhang, Carsten Krebs, Elizabeth M. Nolan, 2015, Nature Chemical Biology on p. 765-771
Elucidation of the Fe(iv)=O intermediate in the catalytic cycle of the halogenase SyrB2
Shaun D. Wong, Martin Srnec, Megan L. Matthews, Lei V. Liu, Yeonju Kwak, Kiyoung Park, Caleb B. Bell, E. Ercan Alp, Jiyong Zhao, Yoshitaka Yoda, Shinji Kitao, Makoto Seto, Carsten Krebs, J. Martin Bollinger, Edward I. Solomon, 2013, Nature on p. 320-323
Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers
Franklin D. Fuller, Sheraz Gul, Ruchira Chatterjee, E. Sethe Burgie, Iris D. Young, Hugo Lebrette, Vivek Srinivas, Aaron S. Brewster, Tara Michels-Clark, Jonathan A. Clinger, Babak Andi, Mohamed Ibrahim, Ernest Pastor, Casper De Lichtenberg, Rana Hussein, Christopher J. Pollock, Miao Zhang, Claudiu A. Stan, Thomas Kroll, Thomas Fransson, Clemens Weninger, Markus Kubin, Pierre Aller, Louise Lassalle, Philipp Bräuer, Mitchell D. Miller, Muhamed Amin, Sergey Koroidov, Christian G. Roessler, Marc Allaire, Raymond G. Sierra, Peter T. Docker, James M. Glownia, Silke Nelson, Jason E. Koglin, Diling Zhu, Matthieu Chollet, Sanghoon Song, Henrik Lemke, Mengning Liang, Dimosthenis Sokaras, Roberto Alonso-Mori, Athina Zouni, Johannes Messinger, Uwe Bergmann, Amie K. Boal, J. Martin Bollinger, Carsten Krebs, Martin Högbom, George N. Phillips, Richard D. Vierstra, Nicholas K. Sauter, Allen M. Orville, Jan Kern, Vittal K. Yachandra, Junko Yano, 2017, Nature Methods on p. 443-449
Mechanism of the C5 stereoinversion reaction in the biosynthesis of carbapenem antibiotics
Wei Chen Chang, Yisong Guo, Chen Wang, Susan E. Butch, Amy C. Rosenzweig, Amie K. Boal, Carsten Krebs, J. Martin Bollinger, 2014, Science on p. 1140-1144
Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase
Megan L. Matthews, Wei Chen Chang, Andrew P. Layne, Linde A. Miles, Carsten Krebs, J. Martin Bollinger, 2014, Nature Chemical Biology on p. 209-215
Spectroscopic Evidence for the Two C-H-Cleaving Intermediates of Aspergillus nidulans Isopenicillin N Synthase
Esta Tamanaha, Bo Zhang, Yisong Guo, Wei Chen Chang, Eric W. Barr, Gang Xing, Jennifer St Clair, Shengfa Ye, Frank Neese, J. Martin Bollinger, Carsten Krebs, 2016, Journal of the American Chemical Society on p. 8862-8874
Mössbauer spectroscopy of Fe/S proteins
Maria-Eirini Pandelia, Nicholas Lanz, Squire Booker, Carsten Krebs, 2015, Biochimica et Biophysica Acta - Molecular Cell Research on p. 1395-1405
Visualizing the reaction cycle in an Iron(II)- and 2-(Oxo)-glutarate-dependent hydroxylase
Andrew J. Mitchell, Noah P. Dunham, Ryan J. Martinie, Jonathan A. Bergman, Christopher J. Pollock, Kai Hu, Benjamin D. Allen, Wei Chen Chang, Alexey Silakov, J. Martin Bollinger, Carsten Krebs, Amie K. Boal, 2017, Journal of the American Chemical Society on p. 13830-13836
The biosynthesis of methanobactin
Grace E. Kenney, Laura M.K. Dassama, Maria Eirini Pandelia, Anthony S. Gizzi, Ryan J. Martinie, Peng Gao, Caroline J. DeHart, Luis F. Schachner, Owen S. Skinner, Soo Y. Ro, Xiao Zhu, Monica Sadek, Paul M. Thomas, Steven C. Almo, J. Martin Bollinger, Carsten Krebs, Neil L. Kelleher, Amy C. Rosenzweig, 2018, Science on p. 1411-1416
Two Distinct Mechanisms for C-C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of α-Heteroatom Assistance
Noah P. Dunham, Wei Chen Chang, Andrew J. Mitchell, Ryan J. Martinie, Bo Zhang, Jonathan A. Bergman, Lauren J. Rajakovich, Bo Wang, Alexey Silakov, Carsten Krebs, Amie K. Boal, J. Martin Bollinger, 2018, Journal of the American Chemical Society on p. 7116-7126
News Articles Featuring Carsten Krebs
Jun 03, 2021
A potential new antiviral drug for COVID-19
The experimental drug TEMPOL may be a promising oral antiviral treatment for COVID-19, according to a new study of cell cultures by a team of researchers that includes Penn State scientists. TEMPOL can limit SARS-CoV-2 infection by impairing the activity of a viral enzyme called “RNA replicase.”
Full Article
Nov 26, 2019
Fourteen Penn State faculty recognized with lifetime honor
Fourteen Penn State faculty members in areas ranging from physics and engineering to entomology and plant science have been named fellows of the American Association for the Advancement of Science (AAAS), the world’s largest general scientific society. A lifetime honor bestowed upon members by their peers, a total of 443 individuals are being recognized for their extraordinary achievements in advancing science.
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Oct 29, 2018
Germs Dodge Immune Defenses With DNA-Building Enzymes
Some bacteria, including those that cause strep throat and pneumonia, use a certain type of enzyme to replicate their DNA without the usually required metal ions, according to new research.
Full Article