Carsten Krebs
Professor of Chemistry, Professor of Biochemistry and Molecular Biology
- PA 16802
- cdk10@psu.edu
- 814-865-6089
Research Summary
Bioinorganic Chemistry - spectroscopic and kinetic studies on the mechanisms of iron-containing enzymes
Links
Most Recent Publications
Biochemical Studies of a Cyanobacterial Halogenase Support the Involvement of a Dimetal Cofactor
Michelle L. Wang, Nathaniel R. Glasser, Mrutyunjay A. Nair, Carsten Krebs, J. Martin Bollinger, Emily P. Balskus, 2025, Biochemistry on p. 2173-2180
Steric Perturbation of the Grob-like Final Step of Ethylene-Forming Enzyme Enables 3-Hydroxypropionate and Propylene Production
Evan Burke, Rachelle Copeland, Yash Dixit, Carsten Krebs, J. Martin Bollinger, 2024, Journal of the American Chemical Society on p. 1977-1983
An Unusual Ferryl Intermediate and Its Implications for the Mechanism of Oxacyclization by the Loline-Producing Iron(II)- and 2-Oxoglutarate-Dependent Oxygenase, LolO
Juan Pan, E Wnger, Eliott S. Wenger, Chi Yun Lin, B Zhange, Bo Zhang, Debangsu Sil, Irene Schaperdoth, Setareh Saryazdi, Robert B. Grossman, Carsten Krebs, J. Martin Bollinger, 2024, Biochemistry on p. 1674-1683
Optimized Substrate Positioning Enables Switches in the C−H Cleavage Site and Reaction Outcome in the Hydroxylation−Epoxidation Sequence Catalyzed by Hyoscyamine 6β-Hydroxylase
Eliott Wenger, Ryan Martinie, Richiro Ushimary, Richiro Ushimaru, Christopher Pollock, D Sil, Aaron Li, Nhi Hoang, Gavin Palowitch, Brandt Graham, Irene Schaperdoth, Evan Burke, A Maggiolo, Wei Chang, B Allen, Carsten Krebs, Alexey Silakov, Amie Kathleen Boal, Joseph Bollinger, 2024, Journal of the American Chemical Society on p. 24271-24287
Synergistic Binding of the Halide and Cationic Prime Substrate of l-Lysine 4-Chlorinase, BesD, in Both Ferrous and Ferryl States
Jeffrey Slater, Chi Lin, M Neugebauer, Monica Neugebauer, M McBride, D Sil, Molly McBride, C Lin, D Sil, Mrutyunjay Nair, B Katch, Amie Boal, Bryce Katch, M Chang, Michelle Chang, A Silakov, C Krebs, Alexey Silakov, J Bollinger Jr., Joseph Bollinger, Carsten Krebs, 2023, Biochemistry on p. 2480-2491
Capturing a bis-Fe(IV) State in Methylosinus trichosporium OB3b MbnH
Anastasia C. Manesis, Jeffrey W. Slater, Kenny Cantave, Joseph Bollinger, Carsten Krebs, Amy C. Rosenzweig, 2023, Biochemistry on p. 1082-1092
Methods for Biophysical Characterization of SznF, a Member of the Heme-Oxygenase-Like Diiron Oxidase/Oxygenase Superfamily
Molly McBride, Sarah Pope, Mrutyunjay Nair, D Sil, Xavier Salas-Solá, Carsten Krebs, J. Martin Bollinger, Amie K. Boal, 2023, on p. 123-154
An iron–sulfur cluster in the zinc-binding domain of the SARS-CoV-2 helicase modulates its RNA-binding and -unwinding activities
Nunziata Maio, Md Kausar Raza, Yan Li, De Liang Zhang, J. Martin Bollinger, Carsten Krebs, Tracey A. Rouault, 2023, Proceedings of the National Academy of Sciences of the United States of America
What Is the Right Level of Activation of a High-Spin {FeNO}<sup>7</sup>Complex to Enable Direct N-N Coupling? Mechanistic Insight into Flavodiiron NO Reductases
Hai T. Dong, Stephanie Camarena, Debangsu Sil, Michael O. Lengel, Jiyong Zhao, Michael Y. Hu, E. Ercan Alp, Carsten Krebs, Nicolai Lehnert, 2022, Journal of the American Chemical Society on p. 16395-16409
Characterization of LipS1 and LipS2 from Thermococcus kodakarensis: Proteins Annotated as Biotin Synthases, which Together Catalyze Formation of the Lipoyl Cofactor
Syam Sundar Neti, Debangsu Sil, Douglas M. Warui, Olga A. Esakova, Amy E. Solinski, Dante A. Serrano, Carsten Krebs, Squire J. Booker, 2022, ACS Bio and Med Chem Au on p. 509-520
Most-Cited Papers
Human calprotectin is an iron-sequestering host-defense protein
Toshiki G. Nakashige, Bo Zhang, Carsten Krebs, Elizabeth M. Nolan, 2015, Nature Chemical Biology on p. 765-771
Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers
Franklin D. Fuller, Sheraz Gul, Ruchira Chatterjee, E. Sethe Burgie, Iris D. Young, Hugo Lebrette, Vivek Srinivas, Aaron S. Brewster, Tara Michels-Clark, Jonathan A. Clinger, Babak Andi, Mohamed Ibrahim, Ernest Pastor, Casper De Lichtenberg, Rana Hussein, Christopher J. Pollock, Miao Zhang, Claudiu A. Stan, Thomas Kroll, Thomas Fransson, Clemens Weninger, Markus Kubin, Pierre Aller, Louise Lassalle, Philipp Bräuer, Mitchell D. Miller, Muhamed Amin, Sergey Koroidov, Christian G. Roessler, Marc Allaire, Raymond G. Sierra, Peter T. Docker, James M. Glownia, Silke Nelson, Jason E. Koglin, Diling Zhu, Matthieu Chollet, Sanghoon Song, Henrik Lemke, Mengning Liang, Dimosthenis Sokaras, Roberto Alonso-Mori, Athina Zouni, Johannes Messinger, Uwe Bergmann, Amie K. Boal, J. Martin Bollinger, Carsten Krebs, Martin Högbom, George N. Phillips, Richard D. Vierstra, Nicholas K. Sauter, Allen M. Orville, Jan Kern, Vittal K. Yachandra, Junko Yano, 2017, Nature Methods on p. 443-449
Mössbauer spectroscopy of Fe/S proteins
Maria-Eirini Pandelia, Nicholas Lanz, Squire Booker, Carsten Krebs, 2015, Biochimica et Biophysica Acta - Molecular Cell Research on p. 1395-1405
Visualizing the reaction cycle in an Iron(II)- and 2-(Oxo)-glutarate-dependent hydroxylase
Andrew J. Mitchell, Noah P. Dunham, Ryan J. Martinie, Jonathan A. Bergman, Christopher J. Pollock, Kai Hu, Benjamin D. Allen, Wei Chen Chang, Alexey Silakov, J. Martin Bollinger, Carsten Krebs, Amie K. Boal, 2017, Journal of the American Chemical Society on p. 13830-13836
The biosynthesis of methanobactin
Grace E. Kenney, Laura M.K. Dassama, Maria Eirini Pandelia, Anthony S. Gizzi, Ryan J. Martinie, Peng Gao, Caroline J. DeHart, Luis F. Schachner, Owen S. Skinner, Soo Y. Ro, Xiao Zhu, Monica Sadek, Paul M. Thomas, Steven C. Almo, J. Martin Bollinger, Carsten Krebs, Neil L. Kelleher, Amy C. Rosenzweig, 2018, Science on p. 1411-1416
Spectroscopic Evidence for the Two C-H-Cleaving Intermediates of Aspergillus nidulans Isopenicillin N Synthase
Esta Tamanaha, Bo Zhang, Yisong Guo, Wei Chen Chang, Eric W. Barr, Gang Xing, Jennifer St Clair, Shengfa Ye, Frank Neese, J. Martin Bollinger, Carsten Krebs, 2016, Journal of the American Chemical Society on p. 8862-8874
Two Distinct Mechanisms for C-C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of α-Heteroatom Assistance
Noah P. Dunham, Wei Chen Chang, Andrew J. Mitchell, Ryan J. Martinie, Bo Zhang, Jonathan A. Bergman, Lauren J. Rajakovich, Bo Wang, Alexey Silakov, Carsten Krebs, Amie K. Boal, J. Martin Bollinger, 2018, Journal of the American Chemical Society on p. 7116-7126
Fe-S cofactors in the SARS-CoV-2 RNA-dependent RNA polymerase are potential antiviral targets
N Maio, Bernard A.P. Lafont, A Lafont, D Sil, Y Li, J. Martin Bollinger, Joseph Bollinger, Carsten Krebs, T Pierson, W. Marston Linehan, M Linehan, Tracey A. Rouault, 2021, Science on p. 236-241
Experimental correlation of substrate position with reaction outcome in the aliphatic halogenase, SyrB2
Ryan J. Martinie, Jovan Livada, Wei Chen Chang, Michael T. Green, Carsten Krebs, J. Martin Bollinger, Alexey Silakov, 2015, Journal of the American Chemical Society on p. 6912-6919
Electronic Structure of the Ferryl Intermediate in the α-Ketoglutarate Dependent Non-Heme Iron Halogenase SyrB2: Contributions to H Atom Abstraction Reactivity
Martin Srnec, Shaun D. Wong, Megan L. Matthews, Carsten Krebs, J. Martin Bollinger, Edward I. Solomon, 2016, Journal of the American Chemical Society on p. 5110-5122
News Articles Featuring Carsten Krebs
Feb 14, 2024
Penn State biochemist Carsten Krebs named distinguished professor
Carsten Krebs, professor of chemistry and of biochemistry and molecular biology at Penn State, has been selected to receive the title of Distinguished Professor of Chemistry and Biochemistry and Molecular Biology
Full Article
Jun 03, 2021
A potential new antiviral drug for COVID-19
The experimental drug TEMPOL may be a promising oral antiviral treatment for COVID-19, according to a new study of cell cultures by a team of researchers that includes Penn State scientists. TEMPOL can limit SARS-CoV-2 infection by impairing the activity of a viral enzyme called “RNA replicase.”
Full Article
Nov 26, 2019
Fourteen Penn State faculty recognized with lifetime honor
Fourteen Penn State faculty members in areas ranging from physics and engineering to entomology and plant science have been named fellows of the American Association for the Advancement of Science (AAAS), the world’s largest general scientific society. A lifetime honor bestowed upon members by their peers, a total of 443 individuals are being recognized for their extraordinary achievements in advancing science.
Full Article
Oct 29, 2018
Germs Dodge Immune Defenses With DNA-Building Enzymes
Some bacteria, including those that cause strep throat and pneumonia, use a certain type of enzyme to replicate their DNA without the usually required metal ions, according to new research.
Full Article