Carsten Krebs

Professor of Chemistry, Professor of Biochemistry and Molecular Biology

Research Summary

Bioinorganic Chemistry - spectroscopic and kinetic studies on the mechanisms of iron-containing enzymes

Publication Tags

Iron Enzymes Oxygenases Hydrogen Proteins Substrates Formic Acid Sulfur Aldehyde Decarbonylase Aldehydes Decarboxylation Oxidoreductases Dioxygenases Hydroxylation Biosynthesis Fatty Aldehyde Fatty Acids Oxidation Reduction Taurine Electrons Atoms Carbon Monoxide Carbon Ethylene Catalysis

Most Recent Papers

An Iron(IV)-Oxo Intermediate Initiating l -Arginine Oxidation but Not Ethylene Production by the 2-Oxoglutarate-Dependent Oxygenase, Ethylene-Forming Enzyme

Rachelle A. Copeland, Katherine M. Davis, Tokufu Kent C. Shoda, Elizabeth J. Blaesi, Amie K. Boal, Carsten Krebs, J. Martin Bollinger, 2021, Journal of the American Chemical Society

Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase

Gang Liu, Debangsu Sil, Nunziata Maio, Wing Hang Tong, J. Martin Bollinger, Carsten Krebs, Tracey Ann Rouault, 2020, Nature Communications

Nuclear Resonance Vibrational Spectroscopic Definition of the Facial Triad FeIV═O Intermediate in Taurine Dioxygenase: Evaluation of Structural Contributions to Hydrogen Atom Abstraction.

M Srnec, S Iyer, Dassama LMK, K Park, Terrie Wong, K Sutherlin, Y Yoda, Y Kobayashi, M Kurokuzu, M Saito, M Seto, Carsten Krebs, Joseph Bollinger, E Solomon, 2020, Journal of the American Chemical Society on p. 18886-18896

Emerging Functional Diversity Among Non-Heme Diiron Oxidases and Oxygenases

Lauren Rajakovich, Bo Zhang, Molly McBride, Amie Boal, Carsten Krebs, J Bollinger, Jr., 2020, Comprehensive Natural Products III: Chemistry and Biology

A peroxodiiron(III/III) intermediate mediating both n-hydroxylation steps in biosynthesis of the n-nitrosourea pharmacophore of streptozotocin by the multi-domain metalloenzyme SznF

Molly J. McBride, Debangsu Sil, Tai L. Ng, Anne Marie Crooke, Grace E. Kenney, Christina R. Tysoe, Bo Zhang, Emily P. Balskus, Amie K. Boal, Carsten Krebs, J. Martin Bollinger, 2020, Journal of the American Chemical Society on p. 11818-11828

High-resolution iron X-ray absorption spectroscopic and computational studies of non-heme diiron peroxo intermediates

George E. Cutsail, Elizabeth J. Blaesi, Christopher J. Pollock, J. Martin Bollinger, Carsten Krebs, Serena DeBeer, 2020, Journal of Inorganic Biochemistry

First step in catalysis of the radical s-adenosylmethionine methylthiotransferase MiaB yields an intermediate with a [3Fe-4S]0-like auxiliary cluster

Bo Zhang, Arthur J. Arcinas, Matthew I. Radle, Alexey Silakov, Squire J. Booker, Carsten Krebs, 2020, Journal of the American Chemical Society on p. 1911-1924

The Fe2(NO)2 Diamond Core

Hai T. Dong, Amy L. Speelman, Claire E. Kozemchak, Debangsu Sil, Carsten Krebs, Nicolai Lehnert, 2019, Angewandte Chemie - International Edition on p. 17695-17699

Structure of a Ferryl Mimic in the Archetypal Iron(II)- And 2-(Oxo)-glutarate-Dependent Dioxygenase, TauD

Katherine M. Davis, Madison Altmyer, Ryan J. Martinie, Irene Schaperdoth, Carsten Krebs, J. Martin Bollinger, Amie K. Boal, 2019, Biochemistry on p. 4218-4223

Substrate-triggered formation of a peroxo-Fe2(III/III) intermediate during fatty acid decarboxylation by UndA

Bo Zhang, Lauren J. Rajakovich, Devon Van Cura, Elizabeth J. Blaesi, Andrew J. Mitchell, Christina R. Tysoe, Xuejun Zhu, Bennett R. Streit, Zhe Rui, Wenjun Zhang, Amie K. Boal, Carsten Krebs, J. Martin Bollinger, 2019, Journal of the American Chemical Society on p. 14510-14514

Most-Cited Papers

A radically different mechanism for S-adenosylmethionine-dependent methyltransferases

Tyler L. Grove, Jack S. Benner, Matthew I. Radle, Jessica H. Ahlum, Bradley J. Landgraf, Carsten Krebs, Squire J. Booker, 2011, Science on p. 604-607

Elucidation of the Fe(iv)=O intermediate in the catalytic cycle of the halogenase SyrB2

Shaun D. Wong, Martin Srnec, Megan L. Matthews, Lei V. Liu, Yeonju Kwak, Kiyoung Park, Caleb B. Bell, E. Ercan Alp, Jiyong Zhao, Yoshitaka Yoda, Shinji Kitao, Makoto Seto, Carsten Krebs, Joseph M. Bollinger, Jr., Edward I. Solomon, 2013, Nature on p. 320-323

Human calprotectin is an iron-sequestering host-defense protein

Toshiki G. Nakashige, Bo Zhang, Carsten Krebs, Elizabeth M. Nolan, 2015, Nature Chemical Biology on p. 765-771

Evidence for only oxygenative cleavage of aldehydes to alk(a/e)nes and formate by cyanobacterial aldehyde decarbonylases

Ning Li, Wei Chen Chang, Douglas Warui, Squire J. Booker, Carsten Krebs, Joseph M. Bollinger, Jr., 2012, Biochemistry on p. 7908-7916

Detection of formate, rather than carbon monoxide, as the stoichiometric coproduct in conversion of fatty aldehydes to alkanes by a cyanobacterial aldehyde decarbonylase

Douglas M. Warui, Ning Li, Hanne Nørgaard, Carsten Krebs, J. Martin Bollinger, Squire J. Booker, 2011, Journal of the American Chemical Society on p. 3316-3319

Conversion of fatty aldehydes to alka(e)nes and formate by a cyanobacterial aldehyde decarbonylase: Cryptic redox by an unusual dimetal oxygenase

Ning Li, Hanne Nørgaard, Douglas M. Warui, Squire J. Booker, Carsten Krebs, J. Martin Bollinger, 2011, Journal of the American Chemical Society on p. 6158-6161

Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers

Franklin D. Fuller, Sheraz Gul, Ruchira Chatterjee, E. Sethe Burgie, Iris D. Young, Hugo Lebrette, Vivek Srinivas, Aaron S. Brewster, Tara Michels-Clark, Jonathan A. Clinger, Babak Andi, Mohamed Ibrahim, Ernest Pastor, Casper De Lichtenberg, Rana Hussein, Christopher J. Pollock, Miao Zhang, Claudiu A. Stan, Thomas Kroll, Thomas Fransson, Clemens Weninger, Markus Kubin, Pierre Aller, Louise Lassalle, Philipp Bräuer, Mitchell D. Miller, Muhamed Amin, Sergey Koroidov, Christian G. Roessler, Marc Allaire, Raymond G. Sierra, Peter T. Docker, James M. Glownia, Silke Nelson, Jason E. Koglin, Diling Zhu, Matthieu Chollet, Sanghoon Song, Henrik Lemke, Mengning Liang, Dimosthenis Sokaras, Roberto Alonso-Mori, Athina Zouni, Johannes Messinger, Uwe Bergmann, Amie K. Boal, J. Martin Bollinger, Carsten Krebs, Martin Högbom, George N. Phillips, Richard D. Vierstra, Nicholas K. Sauter, Allen M. Orville, Jan Kern, Vittal K. Yachandra, Junko Yano, 2017, Nature Methods on p. 443-449

Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase

Megan L. Matthews, Wei Chen Chang, Andrew P. Layne, Linde A. Miles, Carsten Krebs, J. Martin Bollinger, 2014, Nature Chemical Biology on p. 209-215

Electronic structure analysis of the oxygen-activation mechanism by Fe II- and α-ketoglutarate (αKG)-dependent dioxygenases

Shengfa Ye, Christoph Riplinger, Andreas Hansen, Carsten Krebs, J. Martin Bollinger, Frank Neese, 2012, Chemistry - A European Journal on p. 6555-6567

Mechanism of the C5 stereoinversion reaction in the biosynthesis of carbapenem antibiotics

Wei Chen Chang, Yisong Guo, Chen Wang, Susan E. Butch, Amy C. Rosenzweig, Amie K. Boal, Carsten Krebs, J. Martin Bollinger, 2014, Science on p. 1140-1144

News Articles Featuring Carsten Krebs

Nov 26, 2019

Fourteen Penn State faculty recognized with lifetime honor

Fourteen Penn State faculty members in areas ranging from physics and engineering to entomology and plant science have been named fellows of the American Association for the Advancement of Science (AAAS), the world’s largest general scientific society. A lifetime honor bestowed upon members by their peers, a total of 443 individuals are being recognized for their extraordinary achievements in advancing science.

Full Article

Oct 29, 2018

Germs Dodge Immune Defenses With DNA-Building Enzymes

Some bacteria, including those that cause strep throat and pneumonia, use a certain type of enzyme to replicate their DNA without the usually required metal ions, according to new research.