Carsten Krebs
Professor of Chemistry, Professor of Biochemistry and Molecular Biology
- PA 16802
- cdk10@psu.edu
- 814-865-6089
Research Summary
Bioinorganic Chemistry - spectroscopic and kinetic studies on the mechanisms of iron-containing enzymes
Links
Publication Tags
Iron Enzymes Oxygenases Hydrogen Proteins Sulfur Substrates Biosynthesis Arginine Electrons X Rays Carbon Hydroxylation Atoms Ethylene Catalysis Dioxygenases Beta Lactams Oxidoreductases Decarboxylation Spectrum Analysis Mixed Function Oxygenases Glutarates Ferryl Iron AldehydesMost Recent Papers
Hybrid radical-polar pathway for excision of ethylene from 2-oxoglutarate by an iron oxygenase
Rachelle A. Copeland, Shengbin Zhou, Irene Schaperdoth, Tokufu Kent C. Shoda, J. Martin Bollinger, Carsten Krebs, 2021, Science on p. 1489-1493
Fe-S cofactors in the SARS-CoV-2 RNA-dependent RNA polymerase are potential antiviral targets
Nunziata Maio, Bernard A.P. Lafont, Debangsu Sil, Yan Li, J. Martin Bollinger, Carsten Krebs, Theodore C. Pierson, W. Marston Linehan, Tracey A. Rouault, 2021, Science on p. 236-241
An Iron(IV)-Oxo Intermediate Initiating l -Arginine Oxidation but Not Ethylene Production by the 2-Oxoglutarate-Dependent Oxygenase, Ethylene-Forming Enzyme
Rachelle Copeland, Katherine Davis, Tokufu Shoda, Elizabeth Blaesi, A Boal, Carsten Krebs, J. Bollinger, 2021, Journal of the American Chemical Society on p. 2293-2303
Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase
Gang Liu, Debangsu Sil, Nunziata Maio, Wing Hang Tong, J. Martin Bollinger, Carsten Krebs, Tracey Ann Rouault, 2020, Nature Communications
Nuclear Resonance Vibrational Spectroscopic Definition of the Facial Triad Fe<sup>IV</sup>═O Intermediate in Taurine Dioxygenase: Evaluation of Structural Contributions to Hydrogen Atom Abstraction.
Martin Srnec, Shyam R. Iyer, Laura M.K. Dassama, Kiyoung Park, Shaun D. Wong, Kyle D. Sutherlin, Yoshitaka Yoda, Yasuhiro Kobayashi, Masayuki Kurokuzu, Makina Saito, Makoto Seto, Carsten Krebs, J. Martin Bollinger, Edward I. Solomon, 2020, Journal of the American Chemical Society on p. 18886-18896
Emerging Functional Diversity Among Non-Heme Diiron Oxidases and Oxygenases
Lauren Rajakovich, Bo Zhang, Molly McBride, Amie Boal, Carsten Krebs, J Bollinger, Jr., 2020, Comprehensive Natural Products III: Chemistry and Biology
Emerging structural and functional diversity in proteins with dioxygen-reactive dinuclear transition metal cofactors
Lauren J. Rajakovich, Bo Zhang, Molly J. McBride, Amie K. Boal, Carsten Krebs, J. Martin Bollinger, 2020, Comprehensive Natural Products III: Chemistry and Biology on p. 215-250
A peroxodiiron(III/III) intermediate mediating both n-hydroxylation steps in biosynthesis of the n-nitrosourea pharmacophore of streptozotocin by the multi-domain metalloenzyme SznF
Molly J. McBride, Debangsu Sil, Tai L. Ng, Anne Marie Crooke, Grace E. Kenney, Christina R. Tysoe, Bo Zhang, Emily P. Balskus, Amie K. Boal, Carsten Krebs, J. Martin Bollinger, 2020, Journal of the American Chemical Society on p. 11818-11828
High-resolution iron X-ray absorption spectroscopic and computational studies of non-heme diiron peroxo intermediates
George E. Cutsail, Elizabeth J. Blaesi, Christopher J. Pollock, J. Martin Bollinger, Carsten Krebs, Serena DeBeer, 2020, Journal of Inorganic Biochemistry
First step in catalysis of the radical s-adenosylmethionine methylthiotransferase MiaB yields an intermediate with a [3Fe-4S]0-like auxiliary cluster
Bo Zhang, Arthur J. Arcinas, Matthew I. Radle, Alexey Silakov, Squire J. Booker, Carsten Krebs, 2020, Journal of the American Chemical Society on p. 1911-1924
Most-Cited Papers
Human calprotectin is an iron-sequestering host-defense protein
Toshiki G. Nakashige, Bo Zhang, Carsten Krebs, Elizabeth M. Nolan, 2015, Nature Chemical Biology on p. 765-771
Elucidation of the Fe(iv)=O intermediate in the catalytic cycle of the halogenase SyrB2
Shaun D. Wong, Martin Srnec, Megan L. Matthews, Lei V. Liu, Yeonju Kwak, Kiyoung Park, Caleb B. Bell, E. Ercan Alp, Jiyong Zhao, Yoshitaka Yoda, Shinji Kitao, Makoto Seto, Carsten Krebs, J. Martin Bollinger, Edward I. Solomon, 2013, Nature on p. 320-323
Evidence for only oxygenative cleavage of aldehydes to alk(a/e)nes and formate by cyanobacterial aldehyde decarbonylases
Ning Li, Wei Chen Chang, Douglas Warui, Squire J. Booker, Carsten Krebs, Joseph M. Bollinger, Jr., 2012, Biochemistry on p. 7908-7916
Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers
Franklin D. Fuller, Sheraz Gul, Ruchira Chatterjee, E. Sethe Burgie, Iris D. Young, Hugo Lebrette, Vivek Srinivas, Aaron S. Brewster, Tara Michels-Clark, Jonathan A. Clinger, Babak Andi, Mohamed Ibrahim, Ernest Pastor, Casper De Lichtenberg, Rana Hussein, Christopher J. Pollock, Miao Zhang, Claudiu A. Stan, Thomas Kroll, Thomas Fransson, Clemens Weninger, Markus Kubin, Pierre Aller, Louise Lassalle, Philipp Bräuer, Mitchell D. Miller, Muhamed Amin, Sergey Koroidov, Christian G. Roessler, Marc Allaire, Raymond G. Sierra, Peter T. Docker, James M. Glownia, Silke Nelson, Jason E. Koglin, Diling Zhu, Matthieu Chollet, Sanghoon Song, Henrik Lemke, Mengning Liang, Dimosthenis Sokaras, Roberto Alonso-Mori, Athina Zouni, Johannes Messinger, Uwe Bergmann, Amie K. Boal, J. Martin Bollinger, Carsten Krebs, Martin Högbom, George N. Phillips, Richard D. Vierstra, Nicholas K. Sauter, Allen M. Orville, Jan Kern, Vittal K. Yachandra, Junko Yano, 2017, Nature Methods on p. 443-449
Spectroscopic Evidence for the Two C-H-Cleaving Intermediates of Aspergillus nidulans Isopenicillin N Synthase
Esta Tamanaha, Bo Zhang, Yisong Guo, Wei Chen Chang, Eric W. Barr, Gang Xing, Jennifer St Clair, Shengfa Ye, Frank Neese, J. Martin Bollinger, Carsten Krebs, 2016, Journal of the American Chemical Society on p. 8862-8874
Electronic structure analysis of the oxygen-activation mechanism by Fe <sup>II</sup>- and α-ketoglutarate (αKG)-dependent dioxygenases
Shengfa Ye, Christoph Riplinger, Andreas Hansen, Carsten Krebs, J. Martin Bollinger, Frank Neese, 2012, Chemistry - A European Journal on p. 6555-6567
Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase
Megan L. Matthews, Wei Chen Chang, Andrew P. Layne, Linde A. Miles, Carsten Krebs, J. Martin Bollinger, 2014, Nature Chemical Biology on p. 209-215
Mechanism of the C5 stereoinversion reaction in the biosynthesis of carbapenem antibiotics
Wei Chen Chang, Yisong Guo, Chen Wang, Susan E. Butch, Amy C. Rosenzweig, Amie K. Boal, Carsten Krebs, J. Martin Bollinger, 2014, Science on p. 1140-1144
Mössbauer spectroscopy of Fe/S proteins
Maria Eirini Pandelia, Nicholas D. Lanz, Squire J. Booker, Carsten Krebs, 2015, Biochimica et Biophysica Acta - Molecular Cell Research on p. 1395-1405
Visualizing the reaction cycle in an Iron(II)- and 2-(Oxo)-glutarate-dependent hydroxylase
Andrew J. Mitchell, Noah P. Dunham, Ryan J. Martinie, Jonathan A. Bergman, Christopher J. Pollock, Kai Hu, Benjamin D. Allen, Wei Chen Chang, Alexey Silakov, J. Martin Bollinger, Carsten Krebs, Amie K. Boal, 2017, Journal of the American Chemical Society on p. 13830-13836
News Articles Featuring Carsten Krebs
Jun 03, 2021
A potential new antiviral drug for COVID-19
The experimental drug TEMPOL may be a promising oral antiviral treatment for COVID-19, according to a new study of cell cultures by a team of researchers that includes Penn State scientists. TEMPOL can limit SARS-CoV-2 infection by impairing the activity of a viral enzyme called “RNA replicase.”
Full Article
Nov 26, 2019
Fourteen Penn State faculty recognized with lifetime honor
Fourteen Penn State faculty members in areas ranging from physics and engineering to entomology and plant science have been named fellows of the American Association for the Advancement of Science (AAAS), the world’s largest general scientific society. A lifetime honor bestowed upon members by their peers, a total of 443 individuals are being recognized for their extraordinary achievements in advancing science.
Full Article
Oct 29, 2018
Germs Dodge Immune Defenses With DNA-Building Enzymes
Some bacteria, including those that cause strep throat and pneumonia, use a certain type of enzyme to replicate their DNA without the usually required metal ions, according to new research.
Full Article