Carsten Krebs

Professor of Chemistry, Professor of Biochemistry and Molecular Biology

Research Summary

Bioinorganic Chemistry - spectroscopic and kinetic studies on the mechanisms of iron-containing enzymes

Links

Publication Tags

Iron Enzymes Oxygenases Substrates Hydrogen Oxygen Carbon Proteins S Adenosylmethionine Tyrosine Electrons Ligands Hydroxylation Fatty Aldehyde Aldehyde Decarbonylase Formic Acid Oxidation Reduction Aldehydes Decarboxylation Fatty Acids Oxidoreductases Glutarates Alpha Ketoglutaric Acid Carbon Monoxide Electronic Structure

Most Recent Papers

High-resolution iron X-ray absorption spectroscopic and computational studies of non-heme diiron peroxo intermediates

George E. Cutsail, Elizabeth J. Blaesi, Christopher J. Pollock, J. Martin Bollinger, Carsten Krebs, Serena DeBeer, 2020, Journal of Inorganic Biochemistry

The Fe<sub>2</sub>(NO)<sub>2</sub> Diamond Core

Hai T. Dong, Amy L. Speelman, Claire E. Kozemchak, Debangsu Sil, Carsten Krebs, Nicolai Lehnert, 2019, Angewandte Chemie - International Edition on p. 17695-17699

Structure of a Ferryl Mimic in the Archetypal Iron(II)- And 2-(Oxo)-glutarate-Dependent Dioxygenase, TauD

Katherine M. Davis, Madison Altmyer, Ryan J. Martinie, Irene Schaperdoth, Carsten Krebs, J. Martin Bollinger, Amie K. Boal, 2019, Biochemistry on p. 4218-4223

Evidence for Modulation of Oxygen Rebound Rate in Control of Outcome by Iron(II)- And 2-Oxoglutarate-Dependent Oxygenases

Juan Pan, Eliott S. Wenger, Megan L. Matthews, Christopher J. Pollock, Minakshi Bhardwaj, Amelia J. Kim, Benjamin D. Allen, Robert B. Grossman, Carsten Krebs, J. Martin Bollinger, 2019, Journal of the American Chemical Society on p. 15153-15165

Substrate-Triggered Formation of a Peroxo-Fe<sub>2</sub>(III/III) Intermediate during Fatty Acid Decarboxylation by UndA

Bo Zhang, Lauren J. Rajakovich, Devon Van Cura, Elizabeth J. Blaesi, Andrew J. Mitchell, Christina R. Tysoe, Xuejun Zhu, Bennett R. Streit, Zhe Rui, Wenjun Zhang, Amie K. Boal, Carsten Krebs, J. Martin Bollinger, 2019, Journal of the American Chemical Society on p. 14510-14514

Analysis of RNA Methylation by Phylogenetically Diverse Cfr Radical S-Adenosylmethionine Enzymes Reveals an Iron-Binding Accessory Domain in a Clostridial Enzyme

James D. Gumkowski, Ryan J. Martinie, Patrick S. Corrigan, Juan Pan, Matthew R. Bauerle, Mohamed Almarei, Squire J. Booker, Alexey Silakov, Carsten Krebs, Amie Kathleen Boal, 2019, Biochemistry on p. 3169-3184

Hydrogen Donation but not Abstraction by a Tyrosine (Y68) during Endoperoxide Installation by Verruculogen Synthase (FtmOx1)

Noah P. Dunham, José M. Del Río Pantoja, Bo Zhang, Lauren J. Rajakovich, Benjamin D. Allen, Carsten Krebs, Amie K. Boal, J. Martin Bollinger, 2019, Journal of the American Chemical Society on p. 9964-9979

A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases

Lauren J. Rajakovich, Maria Eirini Pandelia, Andrew J. Mitchell, Wei Chen Chang, Bo Zhang, Amie K. Boal, Carsten Krebs, J. Martin Bollinger, 2019, Biochemistry on p. 1627-1647

Synthetic Model Complex of the Key Intermediate in Cytochrome P450 Nitric Oxide Reductase

Ashley B. McQuarters, Elizabeth J. Blaesi, Jeff W. Kampf, E. Ercan Alp, Jiyong Zhao, Michael Hu, Carsten Krebs, Nicolai Lehnert, 2019, Inorganic Chemistry on p. 1398-1413

Steric Enforcement of cis-Epoxide Formation in the Radical C-O-Coupling Reaction by Which (S)-2-Hydroxypropylphosphonate Epoxidase (HppE) Produces Fosfomycin

Shengbin Zhou, Juan Pan, Katherine M. Davis, Irene Schaperdoth, Bo Wang, Amie K. Boal, Carsten Krebs, J. Martin Bollinger, 2019, Journal of the American Chemical Society

Most-Cited Papers

A radically different mechanism for S-adenosylmethionine-dependent methyltransferases

Tyler L. Grove, Jack S. Benner, Matthew I. Radle, Jessica H. Ahlum, Bradley J. Landgraf, Carsten Krebs, Squire J. Booker, 2011, Science on p. 604-607

Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme

Yang Zhang, Xuling Zhu, Andrew T. Torelli, Michael Lee, Boris Dzikovski, Rachel M. Koralewski, Eileen Wang, Jack Freed, Carsten Krebs, Steven E. Ealick, Hening Lin, 2010, Nature on p. 891-896

Elucidation of the Fe(iv)=O intermediate in the catalytic cycle of the halogenase SyrB2

Shaun D. Wong, Martin Srnec, Megan L. Matthews, Lei V. Liu, Yeonju Kwak, Kiyoung Park, Caleb B. Bell, E. Ercan Alp, Jiyong Zhao, Yoshitaka Yoda, Shinji Kitao, Makoto Seto, Carsten Krebs, Joseph M. Bollinger, Jr., Edward I. Solomon, 2013, Nature on p. 320-323

Detection of formate, rather than carbon monoxide, as the stoichiometric coproduct in conversion of fatty aldehydes to alkanes by a cyanobacterial aldehyde decarbonylase

Douglas M. Warui, Ning Li, Hanne Nørgaard, Carsten Krebs, J. Martin Bollinger, Squire J. Booker, 2011, Journal of the American Chemical Society on p. 3316-3319

Conversion of fatty aldehydes to alka(e)nes and formate by a cyanobacterial aldehyde decarbonylase

Ning Li, Hanne Nørgaard, Douglas M. Warui, Squire J. Booker, Carsten Krebs, J. Martin Bollinger, 2011, Journal of the American Chemical Society on p. 6158-6161

Mechanism of the C5 stereoinversion reaction in the biosynthesis of carbapenem antibiotics

Wei Chen Chang, Yisong Guo, Chen Wang, Susan E. Butch, Amy C. Rosenzweig, Amie K. Boal, Carsten Krebs, J. Martin Bollinger, 2014, Science on p. 1140-1144

Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase

Megan L. Matthews, Wei Chen Chang, Andrew P. Layne, Linde A. Miles, Carsten Krebs, J. Martin Bollinger, 2014, Nature Chemical Biology on p. 209-215

Evidence for a high-Spin Fe(IV) species in the catalytic cycle of a bacterial phenylalanine hydroxylase

Aram Joel Panay, Michael Lee, Carsten Krebs, Joseph M. Bollinger, Jr., Paul F. Fitzpatrick, 2011, Biochemistry on p. 1928-1933

Electronic structure analysis of the oxygen-activation mechanism by Fe <sup>II</sup>- and α-ketoglutarate (αKG)-dependent dioxygenases

Shengfa Ye, Christoph Riplinger, Andreas Hansen, Carsten Krebs, J. Martin Bollinger, Frank Neese, 2012, Chemistry - A European Journal on p. 6555-6567

A consensus mechanism for radical SAM-dependent dehydrogenation? BtrN contains two [4Fe-4S] clusters

Tyler L. Grove, Jessica H. Ahlum, Priya Sharma, Carsten Krebs, Squire J. Booker, 2010, Biochemistry on p. 3783-3785