Ashley Shay
Director, Metabolomics Core Facility

-
323 Huck Life Sciences
University Park, PA - She/Her
- aes5254@psu.edu
- 814-863-2274
Research Summary
The implementation and expansion of liquid chromatography tandem mass spectrometry for the structural elucidation of novel lipid mediators and metabolites in various inflammatory diseases coupled with diverse cellular and in vivo approaches to determine functionality.
Huck Affiliations
Publication Tags
Macrophages Inflammation Regeneration Tandem Mass Spectrometry Protectin D1 Cd59 Antigens Leukocytes Selenoproteins Chromatography Pneumonia Resolvin Antiinflammatory Stem Cells Docosahexaenoic Acids Virus Diseases Wounds And Injuries Neutrophils Acid Viral Load Fragmentation Docosahexaenoic Acid Resolvin D3 Respiratory Syncytial Virus Infections Skin NeuroprotectiveMost Recent Publications
Transcellular biosynthesis of leukotriene B<sub>4</sub> orchestrates neutrophil swarming to fungi
Alex Hopke, Tian Lin, Allison K. Scherer, Ashley E. Shay, Kyle D. Timmer, Brittany Wilson-Mifsud, Michael K. Mansour, Charles N. Serhan, Daniel Irimia, Bryan P. Hurley, 2022, iScience
A newly synthesized 17-epi-NeuroProtectin D1/17-epi-Protectin D1: Authentication and functional regulation of Inflammation-Resolution
Kajal Hamidzadeh, Jodi Westcott, Nicholas Wourms, Ashley E. Shay, Anand Panigrahy, Michael J. Martin, Robert Nshimiyimana, Charles N. Serhan, 2022, Biochemical Pharmacology
Periodontal Stem Cells Synthesize Maresin Conjugate in Tissue Regeneration 3
A. Rakian, R. Rakian, A. E. Shay, C. N. Serhan, T. E. Van Dyke, 2022, Journal of Dental Research on p. 1205-1213
Cysteinyl Maresins Reprogram Macrophages to Protect Mice from Streptococcus pneumoniae after Influenza A Virus Infection
Luciana P. Tavares, Thayse R. Brüggemann, Rafael M. Rezende, Marina G. Machado, R. Elaine Cagnina, Ashley E. Shay, Cristiana C. Garcia, Julie Nijmeh, Mauro M. Teixeira, Bruce D. Levy, 2022, mBio
Human leukocytes selectively convert 4S,5S-epoxy-resolvin to resolvin D3, resolvin D4, and a cys-resolvin isomer
Ashley E. Shay, Robert Nshimiyimana, Bengt Samuelsson, Nicos A. Petasis, Jesper Z. Haeggstrom, Charles N. Serhan, 2021, Proceedings of the National Academy of Sciences of the United States of America
Protectins PCTR1 and PD1 Reduce Viral Load and Lung Inflammation During Respiratory Syncytial Virus Infection in Mice
Katherine H. Walker, Nandini Krishnamoorthy, Thayse R. Brüggemann, Ashley E. Shay, Charles N. Serhan, Bruce D. Levy, 2021, Frontiers in Immunology
PCTR1 Enhances Repair and Bacterial Clearance in Skin Wounds
Brian E. Sansbury, Xiaofeng Li, Blenda Wong, Colin O. Riley, Ashley E. Shay, Robert Nshimiyimana, Nicos A. Petasis, Charles N. Serhan, Matthew Spite, 2021, American Journal of Pathology on p. 1049-1063
Stereoselective Synthesis and Structural Confirmation of the Specialized Pro-Resolving Mediator Resolvin E4
Amalie Føreid Reinertsen, Karoline Gangestad Primdahl, Ashley Elizabeth Shay, Charles Nicholas Serhan, Trond Vidar Hansen, Marius Aursnes, 2021, Journal of Organic Chemistry on p. 3535-3545
A New E-Series Resolvin: RvE4 Stereochemistry and Function in Efferocytosis of Inflammation-Resolution
Stephania Libreros, Ashley E. Shay, Robert Nshimiyimana, David Fichtner, Michael J. Martin, Nicholas Wourms, Charles N. Serhan, 2021, Frontiers in Immunology
Biosynthetic metabolomes of cysteinyl-containing immunoresolvents
Charlotte C. Jouvene, Ashley E. Shay, Mieke A. Soens, Paul C. Norris, Jesper Z. Haeggström, Charles N. Serhan, 2019, FASEB Journal on p. 13794-13807
Most-Cited Papers
A New E-Series Resolvin: RvE4 Stereochemistry and Function in Efferocytosis of Inflammation-Resolution
Stephania Libreros, Ashley E. Shay, Robert Nshimiyimana, David Fichtner, Michael J. Martin, Nicholas Wourms, Charles N. Serhan, 2021, Frontiers in Immunology
Biosynthetic metabolomes of cysteinyl-containing immunoresolvents
Charlotte C. Jouvene, Ashley E. Shay, Mieke A. Soens, Paul C. Norris, Jesper Z. Haeggström, Charles N. Serhan, 2019, FASEB Journal on p. 13794-13807
PCTR1 Enhances Repair and Bacterial Clearance in Skin Wounds
Brian E. Sansbury, Xiaofeng Li, Blenda Wong, Colin O. Riley, Ashley E. Shay, Robert Nshimiyimana, Nicos A. Petasis, Charles N. Serhan, Matthew Spite, 2021, American Journal of Pathology on p. 1049-1063
Protectins PCTR1 and PD1 Reduce Viral Load and Lung Inflammation During Respiratory Syncytial Virus Infection in Mice
Katherine H. Walker, Nandini Krishnamoorthy, Thayse R. Brüggemann, Ashley E. Shay, Charles N. Serhan, Bruce D. Levy, 2021, Frontiers in Immunology
Stereoselective Synthesis and Structural Confirmation of the Specialized Pro-Resolving Mediator Resolvin E4
Amalie Føreid Reinertsen, Karoline Gangestad Primdahl, Ashley Elizabeth Shay, Charles Nicholas Serhan, Trond Vidar Hansen, Marius Aursnes, 2021, Journal of Organic Chemistry on p. 3535-3545
The role of selenoproteins in resolution of inflammation
Bastihalli T. Diwakar, Emily R. Finch, Chang Liao, Ashley E. Shay, K. Sandeep Prabhu, 2016, on p. 499-510
Human leukocytes selectively convert 4S,5S-epoxy-resolvin to resolvin D3, resolvin D4, and a cys-resolvin isomer
Ashley E. Shay, Robert Nshimiyimana, Bengt Samuelsson, Nicos A. Petasis, Jesper Z. Haeggstrom, Charles N. Serhan, 2021, Proceedings of the National Academy of Sciences of the United States of America
A newly synthesized 17-epi-NeuroProtectin D1/17-epi-Protectin D1: Authentication and functional regulation of Inflammation-Resolution
Kajal Hamidzadeh, Jodi Westcott, Nicholas Wourms, Ashley E. Shay, Anand Panigrahy, Michael J. Martin, Robert Nshimiyimana, Charles N. Serhan, 2022, Biochemical Pharmacology
Cysteinyl Maresins Reprogram Macrophages to Protect Mice from Streptococcus pneumoniae after Influenza A Virus Infection
Luciana P. Tavares, Thayse R. Brüggemann, Rafael M. Rezende, Marina G. Machado, R. Elaine Cagnina, Ashley E. Shay, Cristiana C. Garcia, Julie Nijmeh, Mauro M. Teixeira, Bruce D. Levy, 2022, mBio
Periodontal Stem Cells Synthesize Maresin Conjugate in Tissue Regeneration 3
A. Rakian, R. Rakian, A. E. Shay, C. N. Serhan, T. E. Van Dyke, 2022, Journal of Dental Research on p. 1205-1213