Ashley Shay

Director, Metabolomics Core Facility

323 Huck Life Sciences
University Park, PA
She/Her
aes5254@psu.edu
814-863-2274

Research Summary

The implementation and expansion of liquid chromatography tandem mass spectrometry for the structural elucidation of novel lipid mediators and metabolites in various inflammatory diseases coupled with diverse cellular and in vivo approaches to determine functionality.

Huck Affiliations

Metabolomics Core Facility

Publication Tags

Macrophages Inflammation Regeneration Tandem Mass Spectrometry Protectin D1 Cd59 Antigens Leukocytes Selenoproteins Chromatography Pneumonia Resolvin Antiinflammatory Stem Cells Docosahexaenoic Acids Virus Diseases Wounds And Injuries Neutrophils Acid Viral Load Fragmentation Docosahexaenoic Acid Resolvin D3 Respiratory Syncytial Virus Infections Skin Neuroprotective

Most Recent Publications

Transcellular biosynthesis of leukotriene B<sub>4</sub> orchestrates neutrophil swarming to fungi

Alex Hopke, Tian Lin, Allison K. Scherer, Ashley E. Shay, Kyle D. Timmer, Brittany Wilson-Mifsud, Michael K. Mansour, Charles N. Serhan, Daniel Irimia, Bryan P. Hurley, 2022, iScience

A newly synthesized 17-epi-NeuroProtectin D1/17-epi-Protectin D1: Authentication and functional regulation of Inflammation-Resolution

Kajal Hamidzadeh, Jodi Westcott, Nicholas Wourms, Ashley E. Shay, Anand Panigrahy, Michael J. Martin, Robert Nshimiyimana, Charles N. Serhan, 2022, Biochemical Pharmacology

Periodontal Stem Cells Synthesize Maresin Conjugate in Tissue Regeneration 3

A. Rakian, R. Rakian, A. E. Shay, C. N. Serhan, T. E. Van Dyke, 2022, Journal of Dental Research on p. 1205-1213

Cysteinyl Maresins Reprogram Macrophages to Protect Mice from Streptococcus pneumoniae after Influenza A Virus Infection

Luciana P. Tavares, Thayse R. Brüggemann, Rafael M. Rezende, Marina G. Machado, R. Elaine Cagnina, Ashley E. Shay, Cristiana C. Garcia, Julie Nijmeh, Mauro M. Teixeira, Bruce D. Levy, 2022, mBio

Human leukocytes selectively convert 4S,5S-epoxy-resolvin to resolvin D3, resolvin D4, and a cys-resolvin isomer

Ashley E. Shay, Robert Nshimiyimana, Bengt Samuelsson, Nicos A. Petasis, Jesper Z. Haeggstrom, Charles N. Serhan, 2021, Proceedings of the National Academy of Sciences of the United States of America

Protectins PCTR1 and PD1 Reduce Viral Load and Lung Inflammation During Respiratory Syncytial Virus Infection in Mice

Katherine H. Walker, Nandini Krishnamoorthy, Thayse R. Brüggemann, Ashley E. Shay, Charles N. Serhan, Bruce D. Levy, 2021, Frontiers in Immunology

PCTR1 Enhances Repair and Bacterial Clearance in Skin Wounds

Brian E. Sansbury, Xiaofeng Li, Blenda Wong, Colin O. Riley, Ashley E. Shay, Robert Nshimiyimana, Nicos A. Petasis, Charles N. Serhan, Matthew Spite, 2021, American Journal of Pathology on p. 1049-1063

Stereoselective Synthesis and Structural Confirmation of the Specialized Pro-Resolving Mediator Resolvin E4

Amalie Føreid Reinertsen, Karoline Gangestad Primdahl, Ashley Elizabeth Shay, Charles Nicholas Serhan, Trond Vidar Hansen, Marius Aursnes, 2021, Journal of Organic Chemistry on p. 3535-3545

A New E-Series Resolvin: RvE4 Stereochemistry and Function in Efferocytosis of Inflammation-Resolution

Stephania Libreros, Ashley E. Shay, Robert Nshimiyimana, David Fichtner, Michael J. Martin, Nicholas Wourms, Charles N. Serhan, 2021, Frontiers in Immunology

Biosynthetic metabolomes of cysteinyl-containing immunoresolvents

Charlotte C. Jouvene, Ashley E. Shay, Mieke A. Soens, Paul C. Norris, Jesper Z. Haeggström, Charles N. Serhan, 2019, FASEB Journal on p. 13794-13807

Most-Cited Papers