Arun Sharma
Associate Professor of Pharmacology
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Hershey Med Ctr
Hershey, - aks14@psu.edu
- 717-531-8285
Huck Affiliations
Publication Tags
Neoplasms Apoptosis Therapeutics Cells Selenium Cell Death Pharmaceutical Preparations Selenium Compounds Dna Molecule Anti Inflammatory Agents Chemical Activation Drug Cell Line Cytotoxicity In Vitro Techniques Proteins Chemistry Membranes Peroxisome Proliferator Activated Receptor Agonist Peroxisome Proliferator Activated Receptors Caspase 8 Urea Honokiol Death Domain Receptor Signaling Adaptor ProteinsMost Recent Papers
Influence of ceramide on lipid domain stability studied with small-angle neutron scattering
Mitchell DiPasquale, Tye G. Deering, Dhimant Desai, Arun K. Sharma, Shantu Amin, Todd E. Fox, Mark Kester, John Katsaras, Drew Marquardt, Frederick A. Heberle, 2022, Chemistry and Physics of Lipids
Therapeutics Targeting p53-MDM2 Interaction to Induce Cancer Cell Death
Nayeong Koo, Arun K. Sharma, Satya Narayan, 2022, International Journal of Molecular Sciences
Recent Advances in the Chemistry and Therapeutic Evaluation of Naturally Occurring and Synthetic Withanolides
Amandeep Singh, Asif Raza, Shantu Amin, Chendil Damodaran, Arun K. Sharma, 2022, Molecules
Small molecule inhibitor of Igf2bp1 represses Kras and a pro-oncogenic phenotype in cancer cells
Nadav Wallis, Froma Oberman, Khriesto Shurrush, Nicolas Germain, Gila Greenwald, Tehila Gershon, Talia Pearl, Giancarlo Abis, Vikash Singh, Amandeep Singh, Arun K. Sharma, Haim M. Barr, Andres Ramos, Vladimir S. Spiegelman, Joel K. Yisraeli, 2022, RNA Biology on p. 26-43
NSAIDs
Sandra Ramos-Inza, Ana Carolina Ruberte, Carmen Sanmartín, Arun K. Sharma, Daniel Plano, 2021, Journal of Medicinal Chemistry on p. 16380-16421
Diminished Hepatocarcinogenesis by a Potent, High-Affinity Human PPARα Agonist in PPARA-Humanized Mice
Jennifer E. Foreman, Takayuki Koga, Oksana Kosyk, Boo Hyon Kang, Xiaoyang Zhu, Samuel M. Cohen, Laura J. Billy, Arun K. Sharma, Shantu Amin, Frank J. Gonzalez, Ivan Rusyn, Jeffrey M. Peters, 2021, Toxicological Sciences on p. 70-80
Species Differences between Mouse and Human PPARα in Modulating the Hepatocarcinogenic Effects of Perinatal Exposure to a High-Affinity Human PPARα Agonist in Mice
Jennifer E. Foreman, Takayuki Koga, Oksana Kosyk, Boo Hyon Kang, Xiaoyang Zhu, Samuel M. Cohen, Laura J. Billy, Arun K. Sharma, Shantu Amin, Frank J. Gonzalez, Ivan Rusyn, Jeffrey M. Peters, 2021, Toxicological Sciences on p. 81-92
Activating Sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibiting cancer metastasis
Yu Chi Chen, Saketh S. Dinavahi, Qilong Feng, Raghavendra Gowda, Srinivasa Ramisetti, Xinghai Xia, Kyle B. LaPenna, Venkat R. Chirasani, Sung Hyun Cho, Susan L. Hafenstein, Madhu Babu Battu, Arthur Berg, Arun K. Sharma, Tom Kirchhausen, Nikolay V. Dokholyan, Shantu Amin, Pingnian He, Gavin P. Robertson, 2021, Cancer Letters on p. 107-119
Novel seleno-aspirinyl compound as-10 induces apoptosis, g1 arrest of pancreatic ductal adenocarcinoma cells, inhibits their nf-κb signaling, and synergizes with gemcitabine cytotoxicity
Deepkamal N. Karelia, Sangyub Kim, Manoj K. Pandey, Daniel Plano, Shantu Amin, Junxuan Lu, Arun K. Sharma, 2021, International Journal of Molecular Sciences
Biological activity of a thiobarbituric acid compound in neuroblastomas
Sang Y. Lee, Becky Slagle-Webb, Arun K. Sharma, James R. Connor, 2021, Anticancer Research on p. 1171-1181
Most-Cited Papers
Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis
Megan M. Young, Yoshinori Takahashi, Osman Khan, Sungman Park, Tsukasa Hori, Jong Yun, Arun K. Sharma, Shantu Amin, Chang Deng Hu, Jianke Zhang, Mark Kester, Hong Gang Wang, 2012, Journal of Biological Chemistry on p. 12455-12468
Selenium compounds, apoptosis and other types of cell death
Carmen Sanmartín, Daniel Plano, Arun K. Sharma, Juan Antonio Palop, 2012, International Journal of Molecular Sciences on p. 9649-9672
Design, Synthesis, and Biological Evaluation of Novel Selenium (Se-NSAID) Molecules as Anticancer Agents
Daniel Plano, Deepkamal N. Karelia, Manoj K. Pandey, Julian E. Spallholz, Shantu Amin, Arun K. Sharma, 2016, Journal of Medicinal Chemistry on p. 1946-1959
Elective Cancer Surgery in COVID-19-Free Surgical Pathways during the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study
James C. Glasbey, Dmitri Nepogodiev, Joana F.F. Simoes, Omar Omar, Elizabeth Li, Mary L. Venn, Mohammad K.Abou Chaar, Vita Capizzi, Daoud Chaudhry, Anant Desai, Jonathan G. Edwards, Jonathan P. Evans, Marco Fiore, Jose Flavio Videria, Samuel J. Ford, Ian Ganly, Ewen A. Griffiths, Rohan R. Gujjuri, Angelos G. Kolias, Haytham M.A. Kaafarani, Ana Minaya-Bravo, Siobhan C. McKay, Helen M. Mohan, Keith J. Roberts, Carlos San Miguel-Méndez, Peter Pockney, Richard Shaw, Neil J. Smart, Grant D. Stewart, Sudha Sundar, Raghavan Vidya, Aneel A. Bhangu, C. Allemand, L. Boccalatte, M. Figari, M. Lamm, J. Larrañaga, C. Marchitelli, F. Noll, D. Odetto, M. Perrotta, J. Saadi, L. Zamora, C. Alurralde, E. L. Caram, D. Eskinazi, J. P. Mendoza, M. Usandivaras, R. Badra, A. Esteban, 2021, Journal of Clinical Oncology on p. 66-78
Importance of sphingosine kinase (SphK) as a target in developing cancer therapeutics and recent developments in the synthesis of novel SphK inhibitors
Daniel Plano, Shantu Amin, Arun Sharma, 2014, Journal of Medicinal Chemistry on p. 5509-5524
Synthesis and biological evaluation of some 2-(3,5-dimethyl-1H-pyrazol-1- yl)-1-arylethanones
Vinod Kumar, Kamalneet Kaur, Deepkamal N. Karelia, Vikas Beniwal, Girish Kumar Gupta, Arun K. Sharma, Akhilesh Kumar Gupta, 2014, CHIM.THER. on p. 267-276
Mutagenesis and carcinogenesis induced by dibenzo[a,l]pyrene in the mouse oral cavity
Joseph B. Guttenplan, Wieslawa Kosinska, Zhong Lin Zhao, Kun Ming Chen, Cesar Aliaga, Joseph Deltondo, Timothy Cooper, Yuan Wan Sun, Shang Min Zhang, Kun Jiang, Richard Bruggeman, Arun K. Sharma, Shantu Amin, Kwangmi Ahn, Karam El-Bayoumy, 2012, International Journal of Cancer on p. 2783-2790
Development and Therapeutic Potential of Selenazo Compounds
Ana Carolina Ruberte, Carmen Sanmartin, Carlos Aydillo, Arun K. Sharma, Daniel Plano, 2020, Journal of Medicinal Chemistry on p. 1473-1489
Novel seleno- and thio-urea derivatives with potent in vitro activities against several cancer cell lines
Verónica Alcolea, Daniel Plano, Deepkamal N. Karelia, Juan Antonio Palop, Shantu Amin, Carmen Sanmartín, Arun Sharma, 2016, CHIM.THER. on p. 134-144
In vitro growth inhibition of human cancer cells by novel honokiol analogs
Jyh ming Lin, A. S. Prakasha Gowda, Arun Sharma, Shantu Amin, 2012, Bioorganic and Medicinal Chemistry on p. 3202-3211