Arun Sharma

Associate Professor of Pharmacology

Arun Sharma

Huck Affiliations

Publication Tags

Apoptosis Cells Neoplasms Selenium Therapeutics Cell Death Cytotoxicity Selenium Compounds Dna Cell Line In Vitro Techniques Cancer Colorectal Neoplasms Cell Viability Solubility Aspirin Chemical Activation Melanoma Growth Cyclodextrins Pharmaceutical Preparations Degradation Molecule Peroxisome Proliferator Activated Receptor Agonist Caspase 8

Most Recent Papers

Diminished Hepatocarcinogenesis by a Potent, High-Affinity Human PPARα Agonist in PPARA-Humanized Mice

Jennifer E. Foreman, Takayuki Koga, Oksana Kosyk, Boo Hyon Kang, Xiaoyang Zhu, Samuel M. Cohen, Laura J. Billy, Arun K. Sharma, Shantu Amin, Frank J. Gonzalez, Ivan Rusyn, Jeffrey M. Peters, 2021, Toxicological Sciences on p. 70-80

Species Differences between Mouse and Human PPARα in Modulating the Hepatocarcinogenic Effects of Perinatal Exposure to a High-Affinity Human PPARα Agonist in Mice

Jennifer E. Foreman, Takayuki Koga, Oksana Kosyk, Boo Hyon Kang, Xiaoyang Zhu, Samuel M. Cohen, Laura J. Billy, Arun K. Sharma, Shantu Amin, Frank J. Gonzalez, Ivan Rusyn, Jeffrey M. Peters, 2021, Toxicological Sciences on p. 81-92

Activating Sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibiting cancer metastasis

Yu Chi Chen, Saketh S. Dinavahi, Qilong Feng, Raghavendra Gowda, Srinivasa Ramisetti, Xinghai Xia, Kyle B. LaPenna, Venkat R. Chirasani, Sung Hyun Cho, Susan L. Hafenstein, Madhu Babu Battu, Arthur Berg, Arun K. Sharma, Tom Kirchhausen, Nikolay V. Dokholyan, Shantu Amin, Pingnian He, Gavin P. Robertson, 2021, Cancer Letters on p. 107-119

Novel seleno-aspirinyl compound as-10 induces apoptosis, g1 arrest of pancreatic ductal adenocarcinoma cells, inhibits their nf-κb signaling, and synergizes with gemcitabine cytotoxicity

Deepkamal N. Karelia, Sangyub Kim, Manoj K. Pandey, Daniel Plano, Shantu Amin, Junxuan Lu, Arun K. Sharma, 2021, International Journal of Molecular Sciences

Biological activity of a thiobarbituric acid compound in neuroblastomas

Sang Y. Lee, Becky Slagle-Webb, Arun K. Sharma, James R. Connor, 2021, Anticancer Research on p. 1171-1181

In vitro cytotoxicity of trastuzumab (Tz) and se-trastuzumab (se-tz) against the her/2 breast cancer cell lines jimt-1 and bt-474

Priyanka Bapat, Debalina Goswami Sewell, Mallory Boylan, Arun K. Sharma, Julian E. Spallholz, 2021, International Journal of Molecular Sciences

Elective Cancer Surgery in COVID-19-Free Surgical Pathways during the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study

James C. Glasbey, Dmitri Nepogodiev, Joana F.F. Simoes, Omar Omar, Elizabeth Li, Mary L. Venn, Mohammad K.Abou Chaar, Vita Capizzi, Daoud Chaudhry, Anant Desai, Jonathan G. Edwards, Jonathan P. Evans, Marco Fiore, Jose Flavio Videria, Samuel J. Ford, Ian Ganly, Ewen A. Griffiths, Rohan R. Gujjuri, Angelos G. Kolias, Haytham M.A. Kaafarani, Ana Minaya-Bravo, Siobhan C. McKay, Helen M. Mohan, Keith J. Roberts, Carlos San Miguel-Méndez, Peter Pockney, Richard Shaw, Neil J. Smart, Grant D. Stewart, Sudha Sundar, Raghavan Vidya, Aneel A. Bhangu, C. Allemand, L. Boccalatte, M. Figari, M. Lamm, J. Larrañaga, C. Marchitelli, F. Noll, D. Odetto, M. Perrotta, J. Saadi, L. Zamora, C. Alurralde, E. L. Caram, D. Eskinazi, J. P. Mendoza, M. Usandivaras, R. Badra, A. Esteban, 2021, Journal of Clinical Oncology on p. 66-78

Small molecule inhibitor of Igf2bp1 represses Kras and a pro-oncogenic phenotype in cancer cells

Nadav Wallis, Froma Oberman, Khriesto Shurrush, Nicolas Germain, Gila Greenwald, Tehila Gershon, Talia Pearl, Giancarlo Abis, Vikash Singh, Amandeep Singh, Arun Sharma, Haim M. Barr, Andres Ramos, Vladimir S. Spiegelman, Joel K. Yisraeli, 2021, RNA Biology

New formulation of a methylseleno-aspirin analog with anticancer activity towards colon cancer

Ana Carolina Ruberte, Gustavo González-Gaitano, Arun K. Sharma, Carlos Aydillo, Ignacio Encío, Carmen Sanmartín, Daniel Plano, 2020, International Journal of Molecular Sciences on p. 1-17

ASR490, a small molecule, overrides aberrant expression of notch1 in colorectal cancer

Ashish Tyagi, Balaji Chandrasekaran, Venkatesh Kolluru, Becca V. Baby, Cibi A. Sripathi, Murali K. Ankem, Srinivasa R. Ramisetti, Venkat R. Chirasani, Nikolay V. Dokholyan, Arun K. Sharma, Chendil Damodaran, 2020, Molecular Cancer Therapeutics on p. 2422-2431

Most-Cited Papers

Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis

Megan M. Young, Yoshinori Takahashi, Osman Khan, Sungman Park, Tsukasa Hori, Jong Yun, Arun K. Sharma, Shantu Amin, Chang Deng Hu, Jianke Zhang, Mark Kester, Hong Gang Wang, 2012, Journal of Biological Chemistry on p. 12455-12468

Selenium compounds, apoptosis and other types of cell death

Carmen Sanmartín, Daniel Plano, Arun K. Sharma, Juan Antonio Palop, 2012, International Journal of Molecular Sciences on p. 9649-9672

Design, Synthesis, and Biological Evaluation of Novel Selenium (Se-NSAID) Molecules as Anticancer Agents

Daniel Plano, Deepkamal N. Karelia, Manoj K. Pandey, Julian E. Spallholz, Shantu Amin, Arun K. Sharma, 2016, Journal of Medicinal Chemistry on p. 1946-1959

Importance of sphingosine kinase (SphK) as a target in developing cancer therapeutics and recent developments in the synthesis of novel SphK inhibitors

Daniel Plano, Shantu Amin, Arun Sharma, 2014, Journal of Medicinal Chemistry on p. 5509-5524

Elective Cancer Surgery in COVID-19-Free Surgical Pathways during the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study

James C. Glasbey, Dmitri Nepogodiev, Joana F.F. Simoes, Omar Omar, Elizabeth Li, Mary L. Venn, Mohammad K.Abou Chaar, Vita Capizzi, Daoud Chaudhry, Anant Desai, Jonathan G. Edwards, Jonathan P. Evans, Marco Fiore, Jose Flavio Videria, Samuel J. Ford, Ian Ganly, Ewen A. Griffiths, Rohan R. Gujjuri, Angelos G. Kolias, Haytham M.A. Kaafarani, Ana Minaya-Bravo, Siobhan C. McKay, Helen M. Mohan, Keith J. Roberts, Carlos San Miguel-Méndez, Peter Pockney, Richard Shaw, Neil J. Smart, Grant D. Stewart, Sudha Sundar, Raghavan Vidya, Aneel A. Bhangu, C. Allemand, L. Boccalatte, M. Figari, M. Lamm, J. Larrañaga, C. Marchitelli, F. Noll, D. Odetto, M. Perrotta, J. Saadi, L. Zamora, C. Alurralde, E. L. Caram, D. Eskinazi, J. P. Mendoza, M. Usandivaras, R. Badra, A. Esteban, 2021, Journal of Clinical Oncology on p. 66-78

Synthesis and biological evaluation of some 2-(3,5-dimethyl-1H-pyrazol-1- yl)-1-arylethanones

Vinod Kumar, Kamalneet Kaur, Deepkamal N. Karelia, Vikas Beniwal, Girish Kumar Gupta, Arun K. Sharma, Akhilesh Kumar Gupta, 2014, CHIM.THER. on p. 267-276

Mutagenesis and carcinogenesis induced by dibenzo[a,l]pyrene in the mouse oral cavity

Joseph B. Guttenplan, Wieslawa Kosinska, Zhong Lin Zhao, Kun Ming Chen, Cesar Aliaga, Joseph Deltondo, Timothy Cooper, Yuan Wan Sun, Shang Min Zhang, Kun Jiang, Richard Bruggeman, Arun K. Sharma, Shantu Amin, Kwangmi Ahn, Karam El-Bayoumy, 2012, International Journal of Cancer on p. 2783-2790

In vitro growth inhibition of human cancer cells by novel honokiol analogs

Jyh ming Lin, A. S. Prakasha Gowda, Arun Sharma, Shantu Amin, 2012, Bioorganic and Medicinal Chemistry on p. 3202-3211

Novel seleno- and thio-urea derivatives with potent in vitro activities against several cancer cell lines

Verónica Alcolea, Daniel Plano, Deepkamal N. Karelia, Juan Antonio Palop, Shantu Amin, Carmen Sanmartín, Arun Sharma, 2016, CHIM.THER. on p. 134-144

Proteasomal Degradation of Mcl-1 by Maritoclax Induces Apoptosis and Enhances the Efficacy of ABT-737 in Melanoma Cells

M Pandey, Krishne Gowda, Kenichiro Doi, A Sharma, H Wang, S Amin, 2013, PLoS One on p. e78570