Arun Sharma

Associate Professor of Pharmacology

Arun Sharma

Huck Affiliations

Publication Tags

Neoplasms Therapeutics Apoptosis Cell Death Selenium Selenium Compounds Pharmaceutical Preparations Molecule Drug Cells Anti Inflammatory Agents Cancer Colorectal Neoplasms Dna Membranes Cell Line Caspase 8 Urea Ligand Peroxisome Proliferator Activated Receptor Agonist Death Domain Receptor Signaling Adaptor Proteins Death Peroxisome Proliferator Activated Receptors Chemistry Chemical Activation

Most Recent Publications

Identification and biotin receptor-mediated activity of a novel seleno-biotin compound that inhibits viability of and induces apoptosis in ovarian cancer cells

Asif Raza, Amandeep Singh, Shantu Amin, Julian E. Spallholz, Arun K. Sharma, 2022, Chemico-Biological Interactions

Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A

Satya Narayan, Asif Raza, Iqbal Mahmud, Nayeong Koo, Timothy J. Garrett, Mary E. Law, Brian K. Law, Arun K. Sharma, 2022, iScience

Influence of ceramide on lipid domain stability studied with small-angle neutron scattering

Mitchell DiPasquale, Tye G. Deering, Dhimant Desai, Arun K. Sharma, Shantu Amin, Todd E. Fox, Mark Kester, John Katsaras, Drew Marquardt, Frederick A. Heberle, 2022, Chemistry and Physics of Lipids

Therapeutics Targeting p53-MDM2 Interaction to Induce Cancer Cell Death

Nayeong Koo, Arun K. Sharma, Satya Narayan, 2022, International Journal of Molecular Sciences

Recent Advances in the Chemistry and Therapeutic Evaluation of Naturally Occurring and Synthetic Withanolides

Amandeep Singh, Asif Raza, Shantu Amin, Chendil Damodaran, Arun K. Sharma, 2022, Molecules

Seleno-aspirin compound AS-10 promotes histone acetylation ahead of suppressing androgen receptor transcription, G1 arrest, and apoptosis of prostate cancer cells

Deepkamal N. Karelia, Sangyub Kim, Daniel Plano, Arun K. Sharma, Cheng Jiang, Junxuan Lu, 2022, Prostate

Small molecule inhibitor of Igf2bp1 represses Kras and a pro-oncogenic phenotype in cancer cells

Nadav Wallis, Froma Oberman, Khriesto Shurrush, Nicolas Germain, Gila Greenwald, Tehila Gershon, Talia Pearl, Giancarlo Abis, Vikash Singh, Amandeep Singh, Arun K. Sharma, Haim M. Barr, Andres Ramos, Vladimir S. Spiegelman, Joel K. Yisraeli, 2022, RNA Biology on p. 26-43

NSAIDs: Old Acquaintance in the Pipeline for Cancer Treatment and Prevention-Structural Modulation, Mechanisms of Action, and Bright Future

Sandra Ramos-Inza, Ana Carolina Ruberte, Carmen Sanmartín, Arun K. Sharma, Daniel Plano, 2021, Journal of Medicinal Chemistry on p. 16380-16421

Diminished Hepatocarcinogenesis by a Potent, High-Affinity Human PPARα Agonist in PPARA-Humanized Mice

Jennifer E. Foreman, Takayuki Koga, Oksana Kosyk, Boo Hyon Kang, Xiaoyang Zhu, Samuel M. Cohen, Laura J. Billy, Arun K. Sharma, Shantu Amin, Frank J. Gonzalez, Ivan Rusyn, Jeffrey M. Peters, 2021, Toxicological Sciences on p. 70-80

Species Differences between Mouse and Human PPARα in Modulating the Hepatocarcinogenic Effects of Perinatal Exposure to a High-Affinity Human PPARα Agonist in Mice

Jennifer E. Foreman, Takayuki Koga, Oksana Kosyk, Boo Hyon Kang, Xiaoyang Zhu, Samuel M. Cohen, Laura J. Billy, Arun K. Sharma, Shantu Amin, Frank J. Gonzalez, Ivan Rusyn, Jeffrey M. Peters, 2021, Toxicological Sciences on p. 81-92

Most-Cited Papers

Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis

Megan M. Young, Yoshinori Takahashi, Osman Khan, Sungman Park, Tsukasa Hori, Jong Yun, Arun K. Sharma, Shantu Amin, Chang Deng Hu, Jianke Zhang, Mark Kester, Hong Gang Wang, 2012, Journal of Biological Chemistry on p. 12455-12468

Selenium compounds, apoptosis and other types of cell death

Carmen Sanmartín, Daniel Plano, Arun K. Sharma, Juan Antonio Palop, 2012, International Journal of Molecular Sciences on p. 9649-9672

Design, Synthesis, and Biological Evaluation of Novel Selenium (Se-NSAID) Molecules as Anticancer Agents

Daniel Plano, Deepkamal N. Karelia, Manoj K. Pandey, Julian E. Spallholz, Shantu Amin, Arun K. Sharma, 2016, Journal of Medicinal Chemistry on p. 1946-1959

Elective Cancer Surgery in COVID-19-Free Surgical Pathways during the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study

James C. Glasbey, Dmitri Nepogodiev, Joana F.F. Simoes, Omar Omar, Elizabeth Li, Mary L. Venn, Mohammad K.Abou Chaar, Vita Capizzi, Daoud Chaudhry, Anant Desai, Jonathan G. Edwards, Jonathan P. Evans, Marco Fiore, Jose Flavio Videria, Samuel J. Ford, Ian Ganly, Ewen A. Griffiths, Rohan R. Gujjuri, Angelos G. Kolias, Haytham M.A. Kaafarani, Ana Minaya-Bravo, Siobhan C. McKay, Helen M. Mohan, Keith J. Roberts, Carlos San Miguel-Méndez, Peter Pockney, Richard Shaw, Neil J. Smart, Grant D. Stewart, Sudha Sundar, Raghavan Vidya, Aneel A. Bhangu, C. Allemand, L. Boccalatte, M. Figari, M. Lamm, J. Larrañaga, C. Marchitelli, F. Noll, D. Odetto, M. Perrotta, J. Saadi, L. Zamora, C. Alurralde, E. L. Caram, D. Eskinazi, J. P. Mendoza, M. Usandivaras, R. Badra, A. Esteban, 2021, Journal of Clinical Oncology on p. 66-78

Importance of sphingosine kinase (SphK) as a target in developing cancer therapeutics and recent developments in the synthesis of novel SphK inhibitors

Daniel Plano, Shantu Amin, Arun Sharma, 2014, Journal of Medicinal Chemistry on p. 5509-5524

Synthesis and biological evaluation of some 2-(3,5-dimethyl-1H-pyrazol-1- yl)-1-arylethanones

Vinod Kumar, Kamalneet Kaur, Deepkamal N. Karelia, Vikas Beniwal, Girish Kumar Gupta, Arun K. Sharma, Akhilesh Kumar Gupta, 2014, CHIM.THER. on p. 267-276

Development and Therapeutic Potential of Selenazo Compounds

Ana Carolina Ruberte, Carmen Sanmartin, Carlos Aydillo, Arun K. Sharma, Daniel Plano, 2020, Journal of Medicinal Chemistry on p. 1473-1489

Mutagenesis and carcinogenesis induced by dibenzo[a,l]pyrene in the mouse oral cavity

Joseph B. Guttenplan, Wieslawa Kosinska, Zhong Lin Zhao, Kun Ming Chen, Cesar Aliaga, Joseph Deltondo, Timothy Cooper, Yuan Wan Sun, Shang Min Zhang, Kun Jiang, Richard Bruggeman, Arun K. Sharma, Shantu Amin, Kwangmi Ahn, Karam El-Bayoumy, 2012, International Journal of Cancer on p. 2783-2790

Novel seleno- and thio-urea derivatives with potent in vitro activities against several cancer cell lines

Verónica Alcolea, Daniel Plano, Deepkamal N. Karelia, Juan Antonio Palop, Shantu Amin, Carmen Sanmartín, Arun Sharma, 2016, CHIM.THER. on p. 134-144

A Review on Notch Signaling and Colorectal Cancer

Ashish Tyagi, Arun K. Sharma, Chendil Damodaran, 2020, Cells