Arun Sharma

Associate Professor of Pharmacology

Arun Sharma

Huck Affiliations

Publication Tags

Apoptosis Neoplasms Selenium Cells Therapeutics Selenium Compounds Colorectal Neoplasms Pharmaceutical Preparations Cell Death Dna Dibenzo(A,L)Pyrene Growth Solubility Cell Line Phosphorylation Cyclodextrins Aspirin Cancer Dna Adducts Death Domain Receptor Signaling Adaptor Proteins Tubulin Modulators Indole Environmental Carcinogens Ucon 50 Hb 5100 Acids

Most Recent Papers

Activating Sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibiting cancer metastasis

Yu Chi Chen, Saketh S. Dinavahi, Qilong Feng, Raghavendra Gowda, Srinivasa Ramisetti, Xinghai Xia, Kyle B. LaPenna, Venkat R. Chirasani, Sung Hyun Cho, Susan L. Hafenstein, Madhu Babu Battu, Arthur Berg, Arun K. Sharma, Tom Kirchhausen, Nikolay V. Dokholyan, Shantu Amin, Pingnian He, Gavin P. Robertson, 2021, Cancer Letters on p. 107-119

New formulation of a methylseleno-aspirin analog with anticancer activity towards colon cancer

Ana Carolina Ruberte, Gustavo González-Gaitano, Arun K. Sharma, Carlos Aydillo, Ignacio Encío, Carmen Sanmartín, Daniel Plano, 2020, International Journal of Molecular Sciences on p. 1-17

ASR490, a small molecule, overrides aberrant expression of notch1 in colorectal cancer

Ashish Tyagi, Balaji Chandrasekaran, Venkatesh Kolluru, Becca V. Baby, Cibi A. Sripathi, Murali K. Ankem, Srinivasa R. Ramisetti, Venkat R. Chirasani, Nikolay V. Dokholyan, Arun K. Sharma, Chendil Damodaran, 2020, Molecular Cancer Therapeutics on p. 2422-2431

Synthesis of indole-tethered [1,3,4]thiadiazolo and [1,3,4]oxadiazolo[3,2-a]pyrimidin-5-one hybrids as anti-pancreatic cancer agents

Lalitha Gummidi, Nagaraju Kerru, Paul Awolade, Asif Raza, Arun K. Sharma, Parvesh Singh, 2020, Bioorganic and Medicinal Chemistry Letters

Characterization of a novel barbituric acid and two thiobarbituric acid compounds for lung cancer treatment

Sang Lee, Becky Slagle-Webb, Arun Sharma, James R. Connor, 2020, Anticancer Research on p. 6039-6049

Vilsmeier reagent, NaHSe and diclofenac acid chloride

Ana Carolina Ruberte, Carlos Aydillo, Arun K. Sharma, Carmen Sanmartín, Daniel Plano, 2020, RSC Advances on p. 38404-38408

Breakthroughs in medicinal chemistry

Michael Gütschow, Jean Jacques Vanden Eynde, Josef Jampilek, Cong Bao Kang, Arduino A. Mangoni, Paola Fossa, Rafik Karaman, Andrea Trabocchi, Peter J.H. Scott, Jóhannes Reynisson, Simona Rapposelli, Stefania Galdier, Jean Yves Winum, Chiara Brullo, Katalin Prokai-Tatrai, Arun K. Sharma, Matthieu Schapira, Yasu Taka Azuma, Laura Cerchia, Mariana Spete, Giangiacomo Torri, Simona Collina, Athina Geronikaki, Alfonso T. García-Sosa, M. Helena Vasconcelos, Maria Emília Sousa, Ivan Kosalec, Tiziano Tuccinardi, Iola F. Duarte, Jorge A.R. Salvador, Massimo Bertinaria, Maurizio Pellecchia, Jussara Amato, Giulio Rastelli, Paula A.C. Gomes, Rita C. Guedes, Jean Marc Sabatier, Ana Estévez-Braun, Bruno Pagano, Stefano Mangani, Rino Ragno, George Kokotos, Margherita Brindisi, Florenci V. González, Fernanda Borges, Mariarosaria Miloso, Jarkko Rautio, Diego Muñoz-Torrero, 2020, Molecules

ASR488, a novel small molecule, activates an mRNA binding protein, CPEB1, and inhibits the growth of bladder cancer

Ashish Tyagi, Venkatesh Kolluru, Balaji Chandrasekaran, Uttara Saran, Arun K. Sharma, Murali K. Ankem, Chendil Damodaran, 2020, Oncology Letters on p. 850-860

A Review on Notch Signaling and Colorectal Cancer

Ashish Tyagi, Arun K. Sharma, Chendil Damodaran, 2020, Cells

The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia

Charyguly Annageldiyev, Su Fern Tan, Shreya Thakur, Pavan Kumar Dhanyamraju, Srinivasa R. Ramisetti, Preeti Bhadauria, Jacob Schick, Zheng Zeng, Varun Sharma, Wendy Dunton, Sinisa Dovat, Dhimant Desai, Hong Zheng, David J. Feith, Thomas P. Loughran, Shantu Amin, Arun K. Sharma, David Claxton, Arati Sharma, 2020, Frontiers in Oncology

Most-Cited Papers

Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis

Megan M. Young, Yoshinori Takahashi, Osman Khan, Sungman Park, Tsukasa Hori, Jong Yun, Arun K. Sharma, Shantu Amin, Chang Deng Hu, Jianke Zhang, Mark Kester, Hong Gang Wang, 2012, Journal of Biological Chemistry on p. 12455-12468

Selenium compounds, apoptosis and other types of cell death

Carmen Sanmartín, Daniel Plano, Arun K. Sharma, Juan Antonio Palop, 2012, International Journal of Molecular Sciences on p. 9649-9672

Design, Synthesis, and Biological Evaluation of Novel Selenium (Se-NSAID) Molecules as Anticancer Agents

Daniel Plano, Deepkamal N. Karelia, Manoj K. Pandey, Julian E. Spallholz, Shantu Amin, Arun K. Sharma, 2016, Journal of Medicinal Chemistry on p. 1946-1959

Importance of sphingosine kinase (SphK) as a target in developing cancer therapeutics and recent developments in the synthesis of novel SphK inhibitors

Daniel Plano, Shantu Amin, Arun Sharma, 2014, Journal of Medicinal Chemistry on p. 5509-5524

Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway

Krishne Gowda, A. S. Prakasha Gowda, Hephzibah Rani S. Tagaram, Kevin F.Staveley O. Carroll, Rosalyn Irby, Arun Sharma, Shantu Amin, 2011, Bioorganic and Medicinal Chemistry on p. 6006-6014

Melanoma chemoprevention in skin reconstructs and mouse xenografts using isoselenocyanate-4

Natalie Nguyen, Arati Sharma, Nhung Nguyen, Arun K. Sharma, Dhimant Desai, Sung Jin Huh, Shantu Amin, Craig Meyers, Gavin P. Robertson, 2011, Cancer Prevention Research on p. 248-258

Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3′,4′-dimethoxy- α-naphthoflavone

Iain Alexander Murray, Colin A. Flaveny, Christopher R. Chiaro, Arun Sharma, Rachel S. Tanos, Jennifer C. Schroeder, Shantu Amin, William H. Bisson, Siva K. Kolluri, Gary H. Perdew, 2011, Molecular Pharmacology on p. 508-519

Synthesis and biological evaluation of some 2-(3,5-dimethyl-1H-pyrazol-1- yl)-1-arylethanones

Vinod Kumar, Kamalneet Kaur, Deepkamal N. Karelia, Vikas Beniwal, Girish Kumar Gupta, Arun K. Sharma, Akhilesh Kumar Gupta, 2014, European Journal of Medicinal Chemistry on p. 267-276

Mutagenesis and carcinogenesis induced by dibenzo[a,l]pyrene in the mouse oral cavity

Joseph B. Guttenplan, Wieslawa Kosinska, Zhong Lin Zhao, Kun Ming Chen, Cesar Aliaga, Joseph Deltondo, Timothy Cooper, Yuan Wan Sun, Shang Min Zhang, Kun Jiang, Richard Bruggeman, Arun K. Sharma, Shantu Amin, Kwangmi Ahn, Karam El-Bayoumy, 2012, International Journal of Cancer on p. 2783-2790

Identification and quantification of DNA adducts in the oral tissues of mice treated with the environmental carcinogen dibenzo[ a,l ]pyrene by HPLC-MS/MS

Shang Min Zhang, Kun Ming Chen, Cesar Aliaga, Yuan Wan Sun, Jyh Ming Lin, Arun K. Sharma, Shantu Amin, Karam El-Bayoumy, 2011, Chemical Research in Toxicology on p. 1297-1303