Arun Sharma

Associate Professor of Pharmacology

Arun Sharma

Huck Affiliations

Publication Tags

Cells Apoptosis Selenium Neoplasms Cell Death Dna Cytotoxicity Therapeutics Selenium Compounds Pharmaceutical Preparations Cell Line Cancer Dibenzo(A,L)Pyrene Colorectal Neoplasms Solubility Aspirin Gemcitabine Chemical Activation Proteins Phosphorylation Cyclodextrins In Vitro Techniques Isatin Environmental Carcinogens Caspase 8

Most Recent Papers

Activating Sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibiting cancer metastasis

Yu Chi Chen, Saketh S. Dinavahi, Qilong Feng, Raghavendra Gowda, Srinivasa Ramisetti, Xinghai Xia, Kyle B. LaPenna, Venkat R. Chirasani, Sung Hyun Cho, Susan L. Hafenstein, Madhu Babu Battu, Arthur Berg, Arun K. Sharma, Tom Kirchhausen, Nikolay V. Dokholyan, Shantu Amin, Pingnian He, Gavin P. Robertson, 2021, Cancer Letters on p. 107-119

Novel seleno-aspirinyl compound as-10 induces apoptosis, g1 arrest of pancreatic ductal adenocarcinoma cells, inhibits their nf-κb signaling, and synergizes with gemcitabine cytotoxicity

Deepkamal N. Karelia, Sangyub Kim, Manoj K. Pandey, Daniel Plano, Shantu Amin, Junxuan Lu, Arun K. Sharma, 2021, International Journal of Molecular Sciences

Biological activity of a thiobarbituric acid compound in neuroblastomas

Sang Lee, Becky Slagle-Webb, Arun K. Sharma, James R. Connor, 2021, Anticancer Research on p. 1171-1181

In vitro cytotoxicity of trastuzumab (Tz) and se-trastuzumab (se-tz) against the her/2 breast cancer cell lines jimt-1 and bt-474

Priyanka Bapat, Debalina Goswami Sewell, Mallory Boylan, Arun K. Sharma, Julian E. Spallholz, 2021, International Journal of Molecular Sciences

ASR490, a small molecule, overrides aberrant expression of notch1 in colorectal cancer

Ashish Tyagi, Balaji Chandrasekaran, Venkatesh Kolluru, Becca V. Baby, Cibi A. Sripathi, Murali K. Ankem, Srinivasa R. Ramisetti, Venkat R. Chirasani, Nikolay V. Dokholyan, Arun K. Sharma, Chendil Damodaran, 2020, Molecular Cancer Therapeutics on p. 2422-2431

New formulation of a methylseleno-aspirin analog with anticancer activity towards colon cancer

Ana Carolina Ruberte, Gustavo González-Gaitano, Arun K. Sharma, Carlos Aydillo, Ignacio Encío, Carmen Sanmartín, Daniel Plano, 2020, International Journal of Molecular Sciences on p. 1-17

Synthesis of indole-tethered [1,3,4]thiadiazolo and [1,3,4]oxadiazolo[3,2-a]pyrimidin-5-one hybrids as anti-pancreatic cancer agents

Lalitha Gummidi, Nagaraju Kerru, Paul Awolade, Asif Raza, Arun K. Sharma, Parvesh Singh, 2020, Bioorganic and Medicinal Chemistry Letters

Characterization of a novel barbituric acid and two thiobarbituric acid compounds for lung cancer treatment

Sang Lee, Becky Slagle-Webb, Arun Sharma, James R. Connor, 2020, Anticancer Research on p. 6039-6049

Vilsmeier reagent, NaHSe and diclofenac acid chloride

Ana Carolina Ruberte, Carlos Aydillo, Arun K. Sharma, Carmen Sanmartín, Daniel Plano, 2020, RSC Advances on p. 38404-38408

Breakthroughs in medicinal chemistry

Michael Gütschow, Jean Jacques Vanden Eynde, Josef Jampilek, Cong Bao Kang, Arduino A. Mangoni, Paola Fossa, Rafik Karaman, Andrea Trabocchi, Peter J.H. Scott, Jóhannes Reynisson, Simona Rapposelli, Stefania Galdier, Jean Yves Winum, Chiara Brullo, Katalin Prokai-Tatrai, Arun K. Sharma, Matthieu Schapira, Yasu Taka Azuma, Laura Cerchia, Mariana Spete, Giangiacomo Torri, Simona Collina, Athina Geronikaki, Alfonso T. García-Sosa, M. Helena Vasconcelos, Maria Emília Sousa, Ivan Kosalec, Tiziano Tuccinardi, Iola F. Duarte, Jorge A.R. Salvador, Massimo Bertinaria, Maurizio Pellecchia, Jussara Amato, Giulio Rastelli, Paula A.C. Gomes, Rita C. Guedes, Jean Marc Sabatier, Ana Estévez-Braun, Bruno Pagano, Stefano Mangani, Rino Ragno, George Kokotos, Margherita Brindisi, Florenci V. González, Fernanda Borges, Mariarosaria Miloso, Jarkko Rautio, Diego Muñoz-Torrero, 2020, Molecules

Most-Cited Papers

Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis

Megan M. Young, Yoshinori Takahashi, Osman Khan, Sungman Park, Tsukasa Hori, Jong Yun, Arun K. Sharma, Shantu Amin, Chang Deng Hu, Jianke Zhang, Mark Kester, Hong Gang Wang, 2012, Journal of Biological Chemistry on p. 12455-12468

Selenium compounds, apoptosis and other types of cell death

Carmen Sanmartín, Daniel Plano, Arun K. Sharma, Juan Antonio Palop, 2012, International Journal of Molecular Sciences on p. 9649-9672

Design, Synthesis, and Biological Evaluation of Novel Selenium (Se-NSAID) Molecules as Anticancer Agents

Daniel Plano, Deepkamal N. Karelia, Manoj K. Pandey, Julian E. Spallholz, Shantu Amin, Arun K. Sharma, 2016, Journal of Medicinal Chemistry on p. 1946-1959

Importance of sphingosine kinase (SphK) as a target in developing cancer therapeutics and recent developments in the synthesis of novel SphK inhibitors

Daniel Plano, Shantu Amin, Arun Sharma, 2014, Journal of Medicinal Chemistry on p. 5509-5524

Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway

Krishne Gowda, A. S. Prakasha Gowda, Hephzibah Rani S. Tagaram, Kevin F.Staveley O. Carroll, Rosalyn Irby, Arun Sharma, Shantu Amin, 2011, Bioorganic and Medicinal Chemistry on p. 6006-6014

Melanoma chemoprevention in skin reconstructs and mouse xenografts using isoselenocyanate-4

Natalie Nguyen, Arati Sharma, Nhung Nguyen, Arun K. Sharma, Dhimant Desai, Sung Jin Huh, Shantu Amin, Craig Meyers, Gavin P. Robertson, 2011, Cancer Prevention Research on p. 248-258

Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3′,4′-dimethoxy- α-naphthoflavone

Iain Alexander Murray, Colin A. Flaveny, Christopher R. Chiaro, Arun Sharma, Rachel S. Tanos, Jennifer C. Schroeder, Shantu Amin, William H. Bisson, Siva K. Kolluri, Gary H. Perdew, 2011, Molecular Pharmacology on p. 508-519

Synthesis and biological evaluation of some 2-(3,5-dimethyl-1H-pyrazol-1- yl)-1-arylethanones

Vinod Kumar, Kamalneet Kaur, Deepkamal N. Karelia, Vikas Beniwal, Girish Kumar Gupta, Arun K. Sharma, Akhilesh Kumar Gupta, 2014, CHIM.THER. on p. 267-276

Mutagenesis and carcinogenesis induced by dibenzo[a,l]pyrene in the mouse oral cavity

Joseph B. Guttenplan, Wieslawa Kosinska, Zhong Lin Zhao, Kun Ming Chen, Cesar Aliaga, Joseph Deltondo, Timothy Cooper, Yuan Wan Sun, Shang Min Zhang, Kun Jiang, Richard Bruggeman, Arun K. Sharma, Shantu Amin, Kwangmi Ahn, Karam El-Bayoumy, 2012, International Journal of Cancer on p. 2783-2790

Identification and quantification of DNA adducts in the oral tissues of mice treated with the environmental carcinogen dibenzo[ a,l ]pyrene by HPLC-MS/MS

Shang Min Zhang, Kun Ming Chen, Cesar Aliaga, Yuan Wan Sun, Jyh Ming Lin, Arun K. Sharma, Shantu Amin, Karam El-Bayoumy, 2011, Chemical Research in Toxicology on p. 1297-1303