Arthur Lesk
Professor of Biology and of Biochemistry & Molecular Biology
-
Wartik
University Park, - aml25@psu.edu
Most Recent Publications
PhiSiCal-Checkup: A Bayesian framework to validate amino acid conformations within experimental protein structures
Piyumi R. Amarasinghe, Lloyd Allison, Craig J. Morton, Peter J. Stuckey, Maria Garcia de la Banda, Arthur M. Lesk, Arun S. Konagurthu, 2025, Proceedings of the National Academy of Sciences of the United States of America
Editorial: Computational and experimental protein variant interpretation in the era of precision medicine
Tiziana Sanavia, Paola Turina, Silvia Morante, Valerio Consalvi, Arthur M. Lesk, Constantina Bakolitsa, Daniele Dell'Orco, 2024, Frontiers in Molecular Biosciences
Getting ‘ϕψxal’ with proteins: minimum message length inference of joint distributions of backbone and sidechain dihedral angles
Piyumi R. Amarasinghe, Lloyd Allison, Peter J. Stuckey, Maria Garcia de la Banda, Arthur M. Lesk, Arun S. Konagurthu, 2023, Bioinformatics on p. I357-I367
Sequence and structure alignments in post-AlphaFold era
Sandun Rajapaksa, Arun S. Konagurthu, Arthur M. Lesk, 2023, Current Opinion in Structural Biology
Protein structure prediction improves the quality of amino-acid sequence alignment
Arthur M. Lesk, Arun S. Konagurthu, 2022, Proteins: Structure, Function and Genetics on p. 2144-2147
On the reliability and the limits of inference of amino acid sequence alignments
Sandun Rajapaksa, Dinithi Sumanaweera, Arthur M. Lesk, Lloyd Allison, Peter J. Stuckey, Maria Garcia De La Banda, David Abramson, Arun S. Konagurthu, 2022, Bioinformatics on p. I255-I263
Editorial: A Journey Through 50 Years of Structural Bioinformatics in Memoriam of Cyrus Chothia
Alfredo Iacoangeli, Paolo Marcatili, Charlotte Deane, Arthur M. Lesk, Annalisa Pastore, Sarah A. Teichmann, 2022, Frontiers in Molecular Biosciences
Three-dimensional Structure Databases of Biological Macromolecules
Vaishali P. Waman, Christine Orengo, Gerard J. Kleywegt, Arthur M. Lesk, 2022, on p. 43-91
Paths Through the Yeast Regulatory Network in Different Physiological States
Arthur M. Lesk, Arun S. Konagurthu, 2021, Journal of Molecular Biology
Universal Architectural Concepts Underlying Protein Folding Patterns
Arun S. Konagurthu, Ramanan Subramanian, Lloyd Allison, David Abramson, Peter J. Stuckey, Maria Garcia de la Banda, Arthur M. Lesk, 2021, Frontiers in Molecular Biosciences
Most-Cited Papers
Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation
Andrija Sente, Raphael Peer, Ashish Srivastava, Mithu Baidya, Arthur M. Lesk, Santhanam Balaji, Arun K. Shukla, M. Madan Babu, Tilman Flock, 2018, Nature Structural Biology on p. 538-545
Statistical inference of protein structural alignments using information and compression
James H. Collier, Lloyd Allison, Arthur M. Lesk, Peter J. Stuckey, Maria Garcia De La Banda, Arun S. Konagurthu, 2017, Bioinformatics on p. 1005-1013
Invisible leashes: The tethering VAPs from infectious diseases to neurodegeneration
Erika F. Dudás, Martijn A. Huynen, Arthur M. Lesk, Annalisa Pastore, 2021, Journal of Biological Chemistry
On the reliability and the limits of inference of amino acid sequence alignments
Sandun Rajapaksa, Dinithi Sumanaweera, Arthur M. Lesk, Lloyd Allison, Peter J. Stuckey, Maria Garcia De La Banda, David Abramson, Arun S. Konagurthu, 2022, Bioinformatics on p. I255-I263
Universal Architectural Concepts Underlying Protein Folding Patterns
Arun S. Konagurthu, Ramanan Subramanian, Lloyd Allison, David Abramson, Peter J. Stuckey, Maria Garcia de la Banda, Arthur M. Lesk, 2021, Frontiers in Molecular Biosciences
Statistical Compression of Protein Folding Patterns for Inference of Recurrent Substructural Themes
Ramanan Subramanian, Lloyd Allison, Peter J. Stuckey, Maria Garcia De La Banda, David Abramson, Arthur M. Lesk, Arun S. Konagurthu, 2017, on p. 340-349
Information-Theoretic Inference of an Optimal Dictionary of Protein Supersecondary Structures
Arun S. Konagurthu, Ramanan Subramanian, Lloyd Allison, David Abramson, Maria Garcia de la Banda, Peter J. Stuckey, Arthur Lesk, 2019, on p. 123-131
Sequence and structure alignments in post-AlphaFold era
Sandun Rajapaksa, Arun S. Konagurthu, Arthur M. Lesk, 2023, Current Opinion in Structural Biology
Protein structure prediction improves the quality of amino-acid sequence alignment
Arthur M. Lesk, Arun S. Konagurthu, 2022, Proteins: Structure, Function and Genetics on p. 2144-2147
Three-dimensional Structure Databases of Biological Macromolecules
Vaishali P. Waman, Christine Orengo, Gerard J. Kleywegt, Arthur M. Lesk, 2022, on p. 43-91