Arthur Lesk

Professor of Biology and of Biochemistry & Molecular Biology

Wartik
University Park,
aml25@psu.edu

Bio & Links
Publications

Huck Affiliations

Bioinformatics and Genomics

Publication Tags

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Proteins Protein Amino Acid Sequence Sequence Alignment Protein Folding Alignment Amino Acids Protein Structure Glossaries Compression Ephrins Eph Family Receptors Databases Length Molecular Biology Statistics Time Framework Set Theory Protein Domains Superposition Statistical Inference Sufficient Statistics Cell Cycle Reproducibility Of Results

Most Recent Publications

Editorial: Computational and experimental protein variant interpretation in the era of precision medicine

Tiziana Sanavia, Paola Turina, Silvia Morante, Valerio Consalvi, Arthur M. Lesk, Constantina Bakolitsa, Daniele Dell'Orco, 2024, Frontiers in Molecular Biosciences

Getting ‘ϕψxal’ with proteins: minimum message length inference of joint distributions of backbone and sidechain dihedral angles

Piyumi R. Amarasinghe, Lloyd Allison, Peter J. Stuckey, Maria Garcia de la Banda, Arthur M. Lesk, Arun S. Konagurthu, 2023, Bioinformatics on p. I357-I367

Sequence and structure alignments in post-AlphaFold era

Sandun Rajapaksa, Arun S. Konagurthu, Arthur M. Lesk, 2023, Current Opinion in Structural Biology

Protein structure prediction improves the quality of amino-acid sequence alignment

Arthur M. Lesk, Arun S. Konagurthu, 2022, Proteins: Structure, Function and Genetics on p. 2144-2147

On the reliability and the limits of inference of amino acid sequence alignments

Sandun Rajapaksa, Dinithi Sumanaweera, Arthur M. Lesk, Lloyd Allison, Peter J. Stuckey, Maria Garcia De La Banda, David Abramson, Arun S. Konagurthu, 2022, Bioinformatics on p. I255-I263

Editorial: A Journey Through 50 Years of Structural Bioinformatics in Memoriam of Cyrus Chothia

Alfredo Iacoangeli, Paolo Marcatili, Charlotte Deane, Arthur M. Lesk, Annalisa Pastore, Sarah A. Teichmann, 2022, Frontiers in Molecular Biosciences

On identifying statistical redundancy at the level of amino acid subsequences

Sandun Rajapaksa, Dinithi Sumanaweera, Maria Garcia de La Banda, Peter Stuckey, David Abramson, Lloyd Allison, Arthur Lesk, Arun Konagurthu, 2022, on p. 7

Three-dimensional Structure Databases of Biological Macromolecules

Vaishali P. Waman, Christine Orengo, Gerard J. Kleywegt, Arthur M. Lesk, 2022, on p. 43-91

Paths Through the Yeast Regulatory Network in Different Physiological States

Arthur M. Lesk, Arun S. Konagurthu, 2021, Journal of Molecular Biology

Universal Architectural Concepts Underlying Protein Folding Patterns

Arun S. Konagurthu, Ramanan Subramanian, Lloyd Allison, David Abramson, Peter J. Stuckey, Maria Garcia de la Banda, Arthur M. Lesk, 2021, Frontiers in Molecular Biosciences

Most-Cited Papers

Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation

Andrija Sente, Raphael Peer, Ashish Srivastava, Mithu Baidya, Arthur M. Lesk, Santhanam Balaji, Arun K. Shukla, M. Madan Babu, Tilman Flock, 2018, Nature Structural Biology on p. 538-545

Statistical inference of protein structural alignments using information and compression

James H. Collier, Lloyd Allison, Arthur M. Lesk, Peter J. Stuckey, Maria Garcia De La Banda, Arun S. Konagurthu, 2017, Bioinformatics on p. 1005-1013

Invisible leashes: The tethering VAPs from infectious diseases to neurodegeneration

Erika F. Dudás, Martijn A. Huynen, Arthur M. Lesk, Annalisa Pastore, 2021, Journal of Biological Chemistry

Universal Architectural Concepts Underlying Protein Folding Patterns

Arun S. Konagurthu, Ramanan Subramanian, Lloyd Allison, David Abramson, Peter J. Stuckey, Maria Garcia de la Banda, Arthur M. Lesk, 2021, Frontiers in Molecular Biosciences

A new statistical framework to assess structural alignment quality using information compression

James H. Collier, Lloyd Allison, Arthur M. Lesk, Maria Garcia De La Banda, Arun S. Konagurthu, 2014, Bioinformatics on p. i512-i518

Sizes of interface residues account for cross-class binding affinity patterns in Eph receptor-ephrin families

Fei Yi Guo, Arthur M. Lesk, 2014, Proteins: Structure, Function and Genetics on p. 349-353

On sufficient statistics of least-squares superposition of vector sets

Arun S. Konagurthu, Parthan Kasarapu, Lloyd Allison, James H. Collier, Arthur M. Lesk, 2014, on p. 144-159

Statistical Compression of Protein Folding Patterns for Inference of Recurrent Substructural Themes

Ramanan Subramanian, Lloyd Allison, Peter J. Stuckey, Maria Garcia De La Banda, David Abramson, Arthur M. Lesk, Arun S. Konagurthu, 2017, on p. 340-349