Amie Boal

Professor of Chemistry and of Biochemistry and Molecular Biology

Amie Boal

Research Summary

The structural differences between members of large metalloenzyme superfamilies that share common features but promote different reactions or use distinct cofactors.

Huck Affiliations

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Publication Tags

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Enzymes Iron Oxygenases Proteins Hydrogen Carbon Mixed Function Oxygenases Glutarates X Rays Protein Hydroxylation Halogenation Carbon Atom Substrates Oxygen Ketoglutaric Acids Arginine Chemical Transformation Catalytic Domain Ligands Hydrogen Atom Alkenes Vanadium Sensors S Adenosylmethionine

Most Recent Publications

Methods for Biophysical Characterization of SznF, a Member of the Heme-Oxygenase-Like Diiron Oxidase/Oxygenase Superfamily

Molly McBride, Sarah Pope, Mrutyunjay Nair, D Sil, Xavier Salas-Solá, Carsten Krebs, J. Martin Bollinger, Amie K. Boal, 2023, on p. 123-154

Enhanced rare-earth separation with a metal-sensitive lanmodulin dimer

Joseph A. Mattocks, Jonathan J. Jung, Chi Yun Lin, Ziye Dong, Neela H. Yennawar, E Featherson, Emily R. Featherston, Christina S. Kang-Yun, Timothy A. Hamilton, Dan M. Park, Amie Boal, Joseph A. Cotruvo, J Cotruvo Jr., 2023, Nature on p. 87-93

Synergistic Binding of the Halide and Cationic Prime Substrate of l-Lysine 4-Chlorinase, BesD, in Both Ferrous and Ferryl States

Jeffrey Slater, Chi Lin, M Neugebauer, Monica Neugebauer, M McBride, D Sil, Molly McBride, C Lin, D Sil, Mrutyunjay Nair, B Katch, Amie Boal, Bryce Katch, M Chang, Michelle Chang, A Silakov, C Krebs, Alexey Silakov, J Bollinger Jr., Joseph Bollinger, Carsten Krebs, 2023, Biochemistry on p. 2480-2491

Discovery, structure and mechanism of a tetraether lipid synthase

Cody T. Lloyd, David F. Iwig, Bo Wang, Matteo Cossu, William W. Metcalf, Amie K. Boal, Squire J. Booker, 2022, Nature on p. 197-203

Structural insights into auxiliary cofactor usage by radical S-adenosylmethionine enzymes

Vivian Robert Jeyachandran, Amie K. Boal, 2022, Current Opinion in Chemical Biology

Progress Toward Understanding Protein Control of Reaction Outcome in the Diverse Reactivity of Iron(II)- and 2-Oxoglutarate-dependent Oxygenases

J. M. Bollinger, Carsten Krebs, Amie K. Boal, Alexey Silakov, John C. Price, Megan L. Matthews, Wei Chen Chang, Ryan J. Martinie, Juan Pan, Noah P. Dunham, Eliott S. Wenger, Rachelle A. Copeland, Chi Yun Lin, 2022, FASEB Journal

Structure of a B<sub>12</sub>-dependent radical SAM enzyme in carbapenem biosynthesis

Hayley L. Knox, Erica K. Sinner, Craig A. Townsend, Amie K. Boal, Squire J. Booker, 2022, Nature on p. 343-348

Structural Basis for an Unprecedented Enzymatic Alkylation in Cylindrocyclophane Biosynthesis

Nathaniel R. Braffman, Terry B. Ruskoski, Katherine M. Davis, Nathaniel R. Glasser, Cassidy Johnson, C. Denise Okafor, Amie K. Boal, Emily P. Balskus, 2022, eLife

Substrate-Triggered μ-Peroxodiiron(III) Intermediate in the 4-Chloro- l -Lysine-Fragmenting Heme-Oxygenase-like Diiron Oxidase (HDO) BesC: Substrate Dissociation from, and C4 Targeting by, the Intermediate

Molly J. McBride, Mrutyunjay A. Nair, Debangsu Sil, M Neugebauer, Jeffrey W. Slater, Monica E. Neugebauer, M Chng, A Boal, Michelle C.Y. Chang, C Krebs, Amie Boal, Carsten Krebs, J. Martin Bollinger, 2022, Biochemistry on p. 689-702

Use of Noncanonical Tyrosine Analogues to Probe Control of Radical Intermediates during Endoperoxide Installation by Verruculogen Synthase (FtmOx1)

Chi-Yun Lin, Angel L. Muñoz Hernández, Angel Hernández, Tatiana N. Laremore, Alexey Silakov, Carsten Krebs, Amie K. Boal, Joseph Bollinger, 2022, ACS Catalysis on p. 6968-6979

Most-Cited Papers

Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers

Franklin D. Fuller, Sheraz Gul, Ruchira Chatterjee, E. Sethe Burgie, Iris D. Young, Hugo Lebrette, Vivek Srinivas, Aaron S. Brewster, Tara Michels-Clark, Jonathan A. Clinger, Babak Andi, Mohamed Ibrahim, Ernest Pastor, Casper De Lichtenberg, Rana Hussein, Christopher J. Pollock, Miao Zhang, Claudiu A. Stan, Thomas Kroll, Thomas Fransson, Clemens Weninger, Markus Kubin, Pierre Aller, Louise Lassalle, Philipp Bräuer, Mitchell D. Miller, Muhamed Amin, Sergey Koroidov, Christian G. Roessler, Marc Allaire, Raymond G. Sierra, Peter T. Docker, James M. Glownia, Silke Nelson, Jason E. Koglin, Diling Zhu, Matthieu Chollet, Sanghoon Song, Henrik Lemke, Mengning Liang, Dimosthenis Sokaras, Roberto Alonso-Mori, Athina Zouni, Johannes Messinger, Uwe Bergmann, Amie K. Boal, J. Martin Bollinger, Carsten Krebs, Martin Högbom, George N. Phillips, Richard D. Vierstra, Nicholas K. Sauter, Allen M. Orville, Jan Kern, Vittal K. Yachandra, Junko Yano, 2017, Nature Methods on p. 443-449

Structural basis for halogenation by iron-and 2-oxo-glutarate-dependent enzyme WelO5

Andrew J. Mitchell, Qin Zhu, Ailiena O. Maggiolo, Nikhil R. Ananth, Matthew L. Hillwig, Xinyu Liu, Amie K. Boal, 2016, Nature Chemical Biology on p. 636-640

Mechanism of the C5 stereoinversion reaction in the biosynthesis of carbapenem antibiotics

Wei Chen Chang, Yisong Guo, Chen Wang, Susan E. Butch, Amy C. Rosenzweig, Amie K. Boal, Carsten Krebs, J. Martin Bollinger, 2014, Science on p. 1140-1144

Visualizing the reaction cycle in an Iron(II)- and 2-(Oxo)-glutarate-dependent hydroxylase

Andrew J. Mitchell, Noah P. Dunham, Ryan J. Martinie, Jonathan A. Bergman, Christopher J. Pollock, Kai Hu, Benjamin D. Allen, Wei Chen Chang, Alexey Silakov, J. Martin Bollinger, Carsten Krebs, Amie K. Boal, 2017, Journal of the American Chemical Society on p. 13830-13836

An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin

Tai L. Ng, Roman Rohac, Andrew J. Mitchell, Amie K. Boal, Emily P. Balskus, 2019, Nature on p. 94-99

Two Distinct Mechanisms for C-C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of α-Heteroatom Assistance

Noah P. Dunham, Wei Chen Chang, Andrew J. Mitchell, Ryan J. Martinie, Bo Zhang, Jonathan A. Bergman, Lauren J. Rajakovich, Bo Wang, Alexey Silakov, Carsten Krebs, Amie K. Boal, J. Martin Bollinger, 2018, Journal of the American Chemical Society on p. 7116-7126

AgHalo: A Facile Fluorogenic Sensor to Detect Drug-Induced Proteome Stress

Yu Liu, Matthew Fares, Noah P. Dunham, Zi Gao, Kun Miao, Xueyuan Jiang, Samuel S. Bollinger, Amie K. Boal, Xin Zhang, 2017, Angewandte Chemie - International Edition on p. 8672-8676

The Cation−π Interaction Enables a Halo-Tag Fluorogenic Probe for Fast No-Wash Live Cell Imaging and Gel-Free Protein Quantification

Yu Liu, Kun Miao, Noah P. Dunham, Hongbin Liu, Matthew Fares, Amie K. Boal, Xiaosong Li, Xin Zhang, 2017, Biochemistry on p. 1585-1595

Mechanisms of 2-oxoglutarate-dependent oxygenases: The hydroxylation paradigm and beyond

J. Martin Bollinger, Wei Chen Chang, Megan L. Matthews, Ryan J. Martinie, Amie K. Boal, Carsten Krebs, 2015, on p. 95-122

Structure-Guided Reprogramming of a Hydroxylase to Halogenate Its Small Molecule Substrate

Andrew J. Mitchell, Noah P. Dunham, Jonathan A. Bergman, Bo Wang, Qin Zhu, Wei Chen Chang, Xinyu Liu, Amie K. Boal, 2017, Biochemistry on p. 441-444