Amie Boal
Professor of Chemistry and of Biochemistry and Molecular Biology

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326 Chemistry
University Park, PA - akb20@psu.edu
- 814-867-2863
Research Summary
The structural differences between members of large metalloenzyme superfamilies that share common features but promote different reactions or use distinct cofactors.
Huck Affiliations
Links
Publication Tags
Enzymes Oxygenases Iron Proteins Hydrogen Carbon Arginine X Rays Glutarates Protein Hydroxylation Ketoglutaric Acids Mixed Function Oxygenases Ligands Catalytic Domain Carbon Atom S Adenosylmethionine Hydrogen Atom Chemical Transformation Oxygen Ferryl Iron Halogenation Cofactor Alkenes SubstratesMost Recent Publications
Discovery, structure and mechanism of a tetraether lipid synthase
Cody T. Lloyd, David F. Iwig, Bo Wang, Matteo Cossu, William W. Metcalf, Amie K. Boal, Squire J. Booker, 2022, Nature on p. 197-203
Use of Noncanonical Tyrosine Analogues to Probe Control of Radical Intermediates during Endoperoxide Installation by Verruculogen Synthase (FtmOx1)
Chi Yun Lin, Angel L. Muñoz Hernández, Tatiana N. Laremore, Alexey Silakov, Carsten Krebs, Amie K. Boal, J. Martin Bollinger, 2022, ACS Catalysis on p. 6968-6979
Structural insights into auxiliary cofactor usage by radical S-adenosylmethionine enzymes
Vivian Robert Jeyachandran, Amie K. Boal, 2022, Current Opinion in Chemical Biology
Progress Toward Understanding Protein Control of Reaction Outcome in the Diverse Reactivity of Iron(II)- and 2-Oxoglutarate-dependent Oxygenases
J. M. Bollinger, Carsten Krebs, Amie K. Boal, Alexey Silakov, John C. Price, Megan L. Matthews, Wei Chen Chang, Ryan J. Martinie, Juan Pan, Noah P. Dunham, Eliott S. Wenger, Rachelle A. Copeland, Chi Yun Lin, 2022, FASEB Journal
Substrate-Triggered μ-Peroxodiiron(III) Intermediate in the 4-Chloro- l -Lysine-Fragmenting Heme-Oxygenase-like Diiron Oxidase (HDO) BesC: Substrate Dissociation from, and C4 Targeting by, the Intermediate
Molly J. McBride, Mrutyunjay A. Nair, Debangsu Sil, Jeffrey W. Slater, Monica E. Neugebauer, Michelle C.Y. Chang, Amie K. Boal, Carsten Krebs, J. Martin Bollinger, 2022, Biochemistry on p. 689-702
Structure of a B<sub>12</sub>-dependent radical SAM enzyme in carbapenem biosynthesis
Hayley L. Knox, Erica K. Sinner, Craig A. Townsend, Amie K. Boal, Squire J. Booker, 2022, Nature on p. 343-348
Structural Basis for an Unprecedented Enzymatic Alkylation in Cylindrocyclophane Biosynthesis
Nathaniel R. Braffman, Terry B. Ruskoski, Katherine M. Davis, Nathaniel R. Glasser, Cassidy Johnson, C. Denise Okafor, Amie K. Boal, Emily P. Balskus, 2022, eLife
The periodic table of ribonucleotide reductases
Terry B. Ruskoski, Amie K. Boal, 2021, Journal of Biological Chemistry
An Iron(IV)-Oxo Intermediate Initiating l -Arginine Oxidation but Not Ethylene Production by the 2-Oxoglutarate-Dependent Oxygenase, Ethylene-Forming Enzyme
Rachelle Copeland, Katherine Davis, Tokufu Shoda, Elizabeth Blaesi, A Boal, Carsten Krebs, J. Bollinger, 2021, Journal of the American Chemical Society on p. 2293-2303
Structure and assembly of the diiron cofactor in the heme-oxygenase–like domain of the N-nitrosourea–producing enzyme SznF
M McBride, S Pope, K Hu, C. Denise Okafor, C Denise Okafor, E Balskus, J Bollinger, J. Martin Bollinger, Amie K. Boal, 2021, Proceedings of the National Academy of Sciences of the United States of America
Most-Cited Papers
Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers
Franklin D. Fuller, Sheraz Gul, Ruchira Chatterjee, E. Sethe Burgie, Iris D. Young, Hugo Lebrette, Vivek Srinivas, Aaron S. Brewster, Tara Michels-Clark, Jonathan A. Clinger, Babak Andi, Mohamed Ibrahim, Ernest Pastor, Casper De Lichtenberg, Rana Hussein, Christopher J. Pollock, Miao Zhang, Claudiu A. Stan, Thomas Kroll, Thomas Fransson, Clemens Weninger, Markus Kubin, Pierre Aller, Louise Lassalle, Philipp Bräuer, Mitchell D. Miller, Muhamed Amin, Sergey Koroidov, Christian G. Roessler, Marc Allaire, Raymond G. Sierra, Peter T. Docker, James M. Glownia, Silke Nelson, Jason E. Koglin, Diling Zhu, Matthieu Chollet, Sanghoon Song, Henrik Lemke, Mengning Liang, Dimosthenis Sokaras, Roberto Alonso-Mori, Athina Zouni, Johannes Messinger, Uwe Bergmann, Amie K. Boal, J. Martin Bollinger, Carsten Krebs, Martin Högbom, George N. Phillips, Richard D. Vierstra, Nicholas K. Sauter, Allen M. Orville, Jan Kern, Vittal K. Yachandra, Junko Yano, 2017, Nature Methods on p. 443-449
Mechanism of the C5 stereoinversion reaction in the biosynthesis of carbapenem antibiotics
Wei Chen Chang, Yisong Guo, Chen Wang, Susan E. Butch, Amy C. Rosenzweig, Amie K. Boal, Carsten Krebs, J. Martin Bollinger, 2014, Science on p. 1140-1144
Structural basis for halogenation by iron-and 2-oxo-glutarate-dependent enzyme WelO5
Andrew J. Mitchell, Qin Zhu, Ailiena O. Maggiolo, Nikhil R. Ananth, Matthew L. Hillwig, Xinyu Liu, Amie K. Boal, 2016, Nature Chemical Biology on p. 636-640
Visualizing the reaction cycle in an Iron(II)- and 2-(Oxo)-glutarate-dependent hydroxylase
Andrew J. Mitchell, Noah P. Dunham, Ryan J. Martinie, Jonathan A. Bergman, Christopher J. Pollock, Kai Hu, Benjamin D. Allen, Wei Chen Chang, Alexey Silakov, J. Martin Bollinger, Carsten Krebs, Amie K. Boal, 2017, Journal of the American Chemical Society on p. 13830-13836
Two Distinct Mechanisms for C-C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of α-Heteroatom Assistance
Noah P. Dunham, Wei Chen Chang, Andrew J. Mitchell, Ryan J. Martinie, Bo Zhang, Jonathan A. Bergman, Lauren J. Rajakovich, Bo Wang, Alexey Silakov, Carsten Krebs, Amie K. Boal, J. Martin Bollinger, 2018, Journal of the American Chemical Society on p. 7116-7126
An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin
Tai L. Ng, Roman Rohac, Andrew J. Mitchell, Amie K. Boal, Emily P. Balskus, 2019, Nature on p. 94-99
AgHalo: A Facile Fluorogenic Sensor to Detect Drug-Induced Proteome Stress
Yu Liu, Matthew Fares, Noah P. Dunham, Zi Gao, Kun Miao, Xueyuan Jiang, Samuel S. Bollinger, Amie K. Boal, Xin Zhang, 2017, Angewandte Chemie - International Edition on p. 8672-8676
Mechanisms of 2-oxoglutarate-dependent oxygenases: The hydroxylation paradigm and beyond
J. Martin Bollinger, Wei Chen Chang, Megan L. Matthews, Ryan J. Martinie, Amie K. Boal, Carsten Krebs, 2015, on p. 95-122
The Cation−π Interaction Enables a Halo-Tag Fluorogenic Probe for Fast No-Wash Live Cell Imaging and Gel-Free Protein Quantification
Yu Liu, Kun Miao, Noah P. Dunham, Hongbin Liu, Matthew Fares, Amie K. Boal, Xiaosong Li, Xin Zhang, 2017, Biochemistry on p. 1585-1595
Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA
Erica L. Schwalm, Tyler L. Grove, Squire J. Booker, Amie K. Boal, 2016, Science on p. 309-312
News Articles Featuring Amie Boal
Aug 31, 2022
Boal recieves Early Career Award from Society of Biological Inorganic Chemistry
Amie Boal, professor of chemistry and of biochemistry and molecular biology, has been named a recipient of the 2022 Early Career Award from the International Society for Biological Inorganic Chemistry (SBIC), an organization dedicated to advancing research and promoting understanding of biological inorganic chemistry within academia, industry, and the general public
Full Article
Aug 22, 2022
Revealed missing step in lipid formation could enable detection of past climate
The missing step in the formation of a lipid molecule that allows certain single-celled organisms to survive the most extreme environments on Earth has now been deciphered.
Full Article