Aimin Liu

Associate Professor of Biology

Aimin Liu

Research Summary

Biogenesis and function of cilia in mammalian embryonic development.

Huck Affiliations

Links

Publication Tags

Proteins Cilia Genes Hedgehogs Brain Cells Transcription Factors Ablation Neuroglia Mice Cell Proliferation Genome Neural Tube Clustered Regularly Interspaced Short Palindromic Repeats Guide Rna Drosophila Melanogaster Microcephaly Cell Polarity Rna Organoids Stat1 Transcription Factor Transfer Rna Gene Encoding Basal Bodies Kidneys

Most Recent Papers

Efficient multiplexed genome engineering with a polycistronic tRNA and CRISPR guide-RNA reveals an important role of detonator in reproduction of Drosophila melanogaster

Cristin Chon, Grace Chon, Yurika Matsui, Huiqing Zeng, Zhi Chun Lai, Aimin Liu, 2021, PLoS One

Animal models of human birth defects

Aimin Liu, 2020, on p. 244

Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development

Abilasha Rao-Bhatia, Min Zhu, Wen Chi Yin, Sabrina Coquenlorge, Xiaoyun Zhang, Janghee Woo, Yu Sun, Charlotte H. Dean, Aimin Liu, Chi chung Hui, Ramesh A. Shivdasani, Helen McNeill, Sevan Hopyan, Tae Hee Kim, 2020, Developmental Cell on p. 647-658.e6

Fat4-Dchs1 and planar cell polarity pathways activated by Hedgehog signaling mediate mesenchymal clustering and villification during mammalian intestinal development

Rao-Bhatia, Zhu, Yin, Coquenlorge-Gallon, Zhang, Woo, Sun, Dean, Aimin Liu, Hui, Shivdasani, McNeill, Hopyan, Kim, 2020, Developmental Cell on p. 647-658

Immunohistochemistry and RNA In Situ Hybridization in Mouse Brain Development

Jinling Liu, Aimin Liu, 2020, on p. 475-489

Preface

Aimin Liu, 2020, Advances in Experimental Medicine and Biology on p. v-vi

Modeling microcephaly with cerebral organoids reveals a WDR62–CEP170–KIF2A pathway promoting cilium disassembly in neural progenitors

Wei Zhang, Si Lu Yang, Mei Yang, Stephanie Herrlinger, Qiang Shao, John L. Collar, Edgar Fierro, Yanhong Shi, Aimin Liu, Hui Lu, Bruce E. Herring, Ming Lei Guo, Shilpa Buch, Zhen Zhao, Jian Xu, Zhipeng Lu, Jian Fu Chen, 2019, Nature Communications

Proteostasis in the Hedgehog signaling pathway

Aimin Liu, 2019, Seminars in Cell and Developmental Biology on p. 153-163

Distinct activities of Gli1 and Gli2 in the absence of Ift88 and the primary cilia

Yuan Wang, Huiqing Zeng, Aimin Liu, 2019, Journal of Developmental Biology

The CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation

Shixuan Wang, Aimin Liu, Guangyu Wu, Han Fei Ding, Shuang Huang, Stanley Nahman, Zheng Dong, 2018, Nature Communications

Most-Cited Papers

Grainyhead-like 2 regulates neural tube closure and adhesion molecule expression during neural fold fusion

Christina Pyrgaki, Aimin Liu, Lee Niswander, 2011, Developmental Biology on p. 38-49

C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals

Xuan Ye, Huiqing Zeng, Gang Ning, Jeremy F. Reiter, Aimin Liu, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 2164-2169

Centrosomal protein DZIP1 regulates hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis

Chengbing Wang, Wee Chuang Low, Aimin Liu, Baolin Wang, 2013, Journal of Biological Chemistry on p. 29518-29529

Modeling microcephaly with cerebral organoids reveals a WDR62–CEP170–KIF2A pathway promoting cilium disassembly in neural progenitors

Wei Zhang, Si Lu Yang, Mei Yang, Stephanie Herrlinger, Qiang Shao, John L. Collar, Edgar Fierro, Yanhong Shi, Aimin Liu, Hui Lu, Bruce E. Herring, Ming Lei Guo, Shilpa Buch, Zhen Zhao, Jian Xu, Zhipeng Lu, Jian Fu Chen, 2019, Nature Communications

Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling

Hongchen Cai, Aimin Liu, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 14751-14756

Dual function of suppressor of fused in Hh pathway activation and mouse spinal cord patterning

Jinling Liu, Westley Heydeck, Huiqing Zeng, Aimin Liu, 2012, Developmental Biology on p. 141-153

PCP effector proteins inturned and fuzzy play nonredundant roles in the patterning but not convergent extension of mammalian neural tube

Westley Heydeck, Aimin Liu, 2011, Developmental Dynamics on p. 1938-1948

Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia

D. Dai, L. Li, A. Huebner, H. Zeng, E. Guevara, D. J. Claypool, A. Liu, J. Chen, 2013, Cell Death and Differentiation on p. 130-138

The loss of Hh responsiveness by a non-ciliary Gli2 variant

Jinling Liu, Huiqing Zeng, Aimin Liu, 2015, Development (Cambridge) on p. 1651-1660

INTU is essential for oncogenic Hh signaling through regulating primary cilia formation in basal cell carcinoma

N. Yang, E. L.H. Leung, C. Liu, L. Li, T. Eguether, X. J. Jun Yao, E. C. Jones, D. A. Norris, Aimin Liu, R. A. Clark, D. R. Roop, G. J. Pazour, K. R. Shroyer, J. Chen, 2017, Oncogene on p. 4997-5005