Aimin Liu
Associate Professor of Biology
-
Life Sciences Bldg
University Park, - axl25@psu.edu
- 814-865-7043
Research Summary
Biogenesis and function of cilia in mammalian embryonic development.
Huck Affiliations
- Molecular, Cellular, and Integrative Biosciences
- Neuroscience
- Neuroscience Institute
- Center for Molecular Investigation of Neurological Disorders
- Center for Cellular Dynamics
Links
Publication Tags
Proteins Genes Hedgehogs Cilia Brain Protein Transcription Factors Genome Transfer Rna Cell Polarity Guide Rna Clustered Regularly Interspaced Short Palindromic Repeats Drosophila Melanogaster Cells Ablation Neuroglia Rna Signal Transduction Mice Cell Proliferation Morphogenesis Polarity Length Stromal Cells MicrocephalyMost Recent Publications
Hedgehog signaling pathway in development and cancer
Steven Cheng, Matthias Lauth, Aimin Liu, Frontiers in cell and developmental biology
Differential expression of the Tmem132 family genes in the developing mouse nervous system
Yuan Wang, Graham Herzig, Cassandra Molano, Aimin Liu, 2022, Gene Expression Patterns
Erratum: Efficient multiplexed genome engineering with a polycistronic tRNA and CRISPR guide-RNA reveals an important role of detonator in reproduction of Drosophila melanogaster (PLoS ONE (2021) 16:1 (e0245454) DOI: 10.1371/journal.pone.0245454)
Cristin Chon, Grace Chon, Yurika Matsui, Huiqing Zeng, Zhi Chun Lai, Aimin Liu, 2021, PLoS One
Efficient multiplexed genome engineering with a polycistronic tRNA and CRISPR guide-RNA reveals an important role of detonator in reproduction of Drosophila melanogaster
Cristin Chon, G Chon, Yurika Matsui, Huiqing Zeng, Zhi Chun Lai, Aimin Liu, 2021, PLoS One on p. e0245454
Animal models of human birth defects
Aimin Liu, 2020, on p. 244
Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development
Abilasha Rao-Bhatia, Min Zhu, Wen Chi Yin, Sabrina Coquenlorge, Xiaoyun Zhang, Janghee Woo, Yu Sun, Charlotte H. Dean, Aimin Liu, Chi chung Hui, Ramesh A. Shivdasani, Helen McNeill, Sevan Hopyan, Tae Hee Kim, 2020, Developmental Cell on p. 647-658.e6
Fat4-Dchs1 and planar cell polarity pathways activated by Hedgehog signaling mediate mesenchymal clustering and villification during mammalian intestinal development
Rao-Bhatia, Zhu, Yin, Coquenlorge-Gallon, Zhang, Woo, Sun, Dean, Aimin Liu, Hui, Shivdasani, McNeill, Hopyan, Kim, 2020, Developmental Cell on p. 647-658
Immunohistochemistry and RNA In Situ Hybridization in Mouse Brain Development
Jinling Liu, Aimin Liu, 2020, on p. 475-489
Modeling microcephaly with cerebral organoids reveals a WDR62–CEP170–KIF2A pathway promoting cilium disassembly in neural progenitors
Wei Zhang, Si Lu Yang, Mei Yang, Stephanie Herrlinger, Qiang Shao, John L. Collar, Edgar Fierro, Yanhong Shi, Aimin Liu, Hui Lu, Bruce E. Herring, Ming Lei Guo, Shilpa Buch, Zhen Zhao, Jian Xu, Zhipeng Lu, Jian Fu Chen, 2019, Nature Communications
Proteostasis in the Hedgehog signaling pathway
Aimin Liu, 2019, Seminars in Cell and Developmental Biology on p. 153-163
Most-Cited Papers
C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals
Xuan Ye, Huiqing Zeng, Gang Ning, Jeremy F. Reiter, Aimin Liu, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 2164-2169
Modeling microcephaly with cerebral organoids reveals a WDR62–CEP170–KIF2A pathway promoting cilium disassembly in neural progenitors
Wei Zhang, Si Lu Yang, Mei Yang, Stephanie Herrlinger, Qiang Shao, John L. Collar, Edgar Fierro, Yanhong Shi, Aimin Liu, Hui Lu, Bruce E. Herring, Ming Lei Guo, Shilpa Buch, Zhen Zhao, Jian Xu, Zhipeng Lu, Jian Fu Chen, 2019, Nature Communications
Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling
Hongchen Cai, Aimin Liu, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 14751-14756
Centrosomal protein DZIP1 regulates hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis
Chengbing Wang, Wee Chuang Low, Aimin Liu, Baolin Wang, 2013, Journal of Biological Chemistry on p. 29518-29529
Dual function of suppressor of fused in Hh pathway activation and mouse spinal cord patterning
Jinling Liu, Westley Heydeck, Huiqing Zeng, Aimin Liu, 2012, Developmental Biology on p. 141-153
Proteostasis in the Hedgehog signaling pathway
Aimin Liu, 2019, Seminars in Cell and Developmental Biology on p. 153-163
Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development
Abilasha Rao-Bhatia, Min Zhu, Wen Chi Yin, Sabrina Coquenlorge, Xiaoyun Zhang, Janghee Woo, Yu Sun, Charlotte H. Dean, Aimin Liu, Chi chung Hui, Ramesh A. Shivdasani, Helen McNeill, Sevan Hopyan, Tae Hee Kim, 2020, Developmental Cell on p. 647-658.e6
Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia
D. Dai, L. Li, A. Huebner, H. Zeng, E. Guevara, D. J. Claypool, A. Liu, J. Chen, 2013, Cell Death and Differentiation on p. 130-138
The small GTPase RSG1 controls a final step in primary cilia initiation
Stephanie O. Agbu, Yinwen Liang, Aimin Liu, Kathryn V. Anderson, 2018, Journal of Cell Biology on p. 413-427
Spop regulates Gli3 activity and Shh signaling in dorsoventral patterning of the mouse spinal cord
Hongchen Cai, Aimin Liu, 2017, Developmental Biology on p. 72-85