Aimin Liu

Associate Professor of Biology

Aimin Liu

Research Summary

Biogenesis and function of cilia in mammalian embryonic development.

Huck Affiliations

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Most Recent Publications

CPLANE protein INTU regulates growth and patterning of the mouse lungs through cilia-dependent Hh signaling

Huiqing Zeng, Shimaa Ali, Aswathy Sebastian, Adriana Ramos-Medero, Istvan Albert, Charlotte Dean, Aimin Liu, 2024, Developmental Biology on p. 92--101

TMEM132A regulates mouse hindgut morphogenesis and caudal development

Huiqing Zeng, Aimin Liu, 2023, Journal of Embryology and Experimental Morphology

Deficiency of the Planar Cell Polarity Protein Intu Delays Kidney Repair and Suppresses Renal Fibrosis after Acute Kidney Injury

Shixuan Wang, Aimin Liu, Yunchao Su, Zheng Dong, 2023, American Journal of Pathology on p. 275-285

Differential expression of the Tmem132 family genes in the developing mouse nervous system

Yuan Wang, Graham Herzig, Cassandra Molano, Aimin Liu, 2022, Gene Expression Patterns

Editorial: Hedgehog signaling pathway in development and cancer

Steven Y. Cheng, Matthias Lauth, Aimin Liu, 2022, Frontiers in Cell and Developmental Biology

Hedgehog signaling pathway in development and cancer

Steven Cheng, Matthias Lauth, Aimin Liu, 2022, Frontiers in cell and developmental biology

Erratum: Efficient multiplexed genome engineering with a polycistronic tRNA and CRISPR guide-RNA reveals an important role of detonator in reproduction of Drosophila melanogaster (PLoS ONE (2021) 16:1 (e0245454) DOI: 10.1371/journal.pone.0245454)

Cristin Chon, Grace Chon, Yurika Matsui, Huiqing Zeng, Zhi Chun Lai, Aimin Liu, 2021, PLoS One

Efficient multiplexed genome engineering with a polycistronic tRNA and CRISPR guide-RNA reveals an important role of detonator in reproduction of Drosophila melanogaster

Cristin Chon, G Chon, Yurika Matsui, Huiqing Zeng, Zhi Chun Lai, Aimin Liu, 2021, PLoS One on p. e0245454

Animal models of human birth defects

Aimin Liu, 2020, on p. 244

Fat4-Dchs1 and planar cell polarity pathways activated by Hedgehog signaling mediate mesenchymal clustering and villification during mammalian intestinal development

Rao-Bhatia, Zhu, Yin, Coquenlorge-Gallon, Zhang, Woo, Sun, Dean, Aimin Liu, Hui, Shivdasani, McNeill, Hopyan, Kim, 2020, Developmental Cell on p. 647-658

Most-Cited Papers

Modeling microcephaly with cerebral organoids reveals a WDR62–CEP170–KIF2A pathway promoting cilium disassembly in neural progenitors

Wei Zhang, Si Lu Yang, Mei Yang, Stephanie Herrlinger, Qiang Shao, John L. Collar, Edgar Fierro, Yanhong Shi, Aimin Liu, Hui Lu, Bruce E. Herring, Ming Lei Guo, Shilpa Buch, Zhen Zhao, Jian Xu, Zhipeng Lu, Jian Fu Chen, 2019, Nature Communications

Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling

Hongchen Cai, Aimin Liu, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 14751-14756

Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development

Abilasha Rao-Bhatia, Min Zhu, Wen Chi Yin, Sabrina Coquenlorge, Xiaoyun Zhang, Janghee Woo, Yu Sun, Charlotte H. Dean, Aimin Liu, Chi chung Hui, Ramesh A. Shivdasani, Helen McNeill, Sevan Hopyan, Tae Hee Kim, 2020, Developmental Cell on p. 647-658.e6

Proteostasis in the Hedgehog signaling pathway

Aimin Liu, 2019, Seminars in Cell and Developmental Biology on p. 153-163

The small GTPase RSG1 controls a final step in primary cilia initiation

Stephanie O. Agbu, Yinwen Liang, Aimin Liu, Kathryn V. Anderson, 2018, Journal of Cell Biology on p. 413-427

INTU is essential for oncogenic Hh signaling through regulating primary cilia formation in basal cell carcinoma

N. Yang, E. L.H. Leung, C. Liu, L. Li, T. Eguether, X. J. Jun Yao, E. C. Jones, D. A. Norris, A. Liu, R. A. Clark, D. R. Roop, G. J. Pazour, K. R. Shroyer, J. Chen, 2017, Oncogene on p. 4997-5005

Spop regulates Gli3 activity and Shh signaling in dorsoventral patterning of the mouse spinal cord

Hongchen Cai, Aimin Liu, 2017, Developmental Biology on p. 72-85

The CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation

Shixuan Wang, Aimin Liu, Guangyu Wu, Han Fei Ding, Shuang Huang, Stanley Nahman, Zheng Dong, 2018, Nature Communications

The loss of Hh responsiveness by a non-ciliary Gli2 variant

Jinling Liu, Huiqing Zeng, Aimin Liu, 2015, Journal of Embryology and Experimental Morphology on p. 1651-1660

A hypomorphic allele reveals an important role of inturned in mouse skeletal development

Rachel Chang, Juliette R. Petersen, Lee A. Niswander, Aimin Liu, 2015, American Journal of Anatomy on p. 736-747