Aimin Liu

Associate Professor of Biology

Aimin Liu

Research Summary

Biogenesis and function of cilia in mammalian embryonic development.

Huck Affiliations

Links

Publication Tags

Proteins Cilia Hedgehogs Genes Transcription Factors Mammals Homeostasis Neural Tube Cell Polarity Stat1 Transcription Factor Cyclic Amp Dependent Protein Kinases Spinal Cord Cells Zinc Finger Protein Gli1 Centrioles Ablation Brain Hedgehog Proteins Embryonic Structures Mice Mutant Proteins Embryonic Development Transducers Fibroblasts Cell Proliferation

Most Recent Papers

Fat4-Dchs1 and planar cell polarity pathways activated by Hedgehog signaling mediate mesenchymal clustering and villification during mammalian intestinal development

Rao-Bhatia, Zhu, Yin, Coquenlorge-Gallon, Zhang, Woo, Sun, Dean, Aimin Liu, Hui, Shivdasani, McNeill, Hopyan, Kim, 2020, Developmental Cell on p. 647-658

Modeling microcephaly with cerebral organoids reveals a WDR62–CEP170–KIF2A pathway promoting cilium disassembly in neural progenitors

Wei Zhang, Si Lu Yang, Mei Yang, Stephanie Herrlinger, Qiang Shao, John L. Collar, Edgar Fierro, Yanhong Shi, Aimin Liu, Hui Lu, Bruce E. Herring, Ming Lei Guo, Shilpa Buch, Zhen Zhao, Jian Xu, Zhipeng Lu, Jian Fu Chen, 2019, Nature communications

Proteostasis in the Hedgehog signaling pathway

Aimin Liu, 2019, Seminars in Cell and Developmental Biology on p. 153-163

Distinct activities of Gli1 and Gli2 in the absence of Ift88 and the primary cilia

Yuan Wang, Huiqing Zeng, Aimin Liu, 2019, Journal of Developmental Biology

The CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation

Shixuan Wang, Aimin Liu, Guangyu Wu, Han Fei Ding, Shuang Huang, Stanley Nahman, Zheng Dong, 2018, Nature communications

The small GTPase RSG1 controls a final step in primary cilia initiation

Stephanie O. Agbu, Yinwen Liang, Aimin Liu, Kathryn V. Anderson, 2018, Journal of Cell Biology on p. 413-427

Proteostasis in the Hedgehog signaling pathway

Aimin Liu, 2018, Seminars in Cell and Developmental Biology

Spop regulates Gli3 activity and Shh signaling in dorsoventral patterning of the mouse spinal cord

Hongchen Cai, Aimin Liu, 2017, Developmental biology on p. 72-85

INTU is essential for oncogenic Hh signaling through regulating primary cilia formation in basal cell carcinoma

N. Yang, E. L.H. Leung, C. Liu, L. Li, T. Eguether, X. J. Jun Yao, E. C. Jones, D. A. Norris, Aimin Liu, R. A. Clark, D. R. Roop, G. J. Pazour, K. R. Shroyer, J. Chen, 2017, Oncogene on p. 4997-5005

Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling

Hongchen Cai, Aimin Liu, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 14751-14756

Most-Cited Papers

Grainyhead-like 2 regulates neural tube closure and adhesion molecule expression during neural fold fusion

Christina Pyrgaki, Aimin Liu, Lee Niswander, 2011, Developmental biology on p. 38-49

PCP effector gene Inturned is an important regulator of cilia formation and embryonic development in mammals

Huiqing Zeng, Amber N. Hoover, Aimin Liu, 2010, Developmental biology on p. 418-428

C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals

Xuan Ye, Huiqing Zeng, Gang Ning, Jeremy F. Reiter, Aimin Liu, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 2164-2169

Coordinated translocation of mammalian gli proteins and suppressor of fused to the primary cilium

Huiqing Zeng, Jinping Jia, Aimin Liu, 2010, PLoS One

Dual function of suppressor of fused in Hh pathway activation and mouse spinal cord patterning

Jinling Liu, Westley Heydeck, Huiqing Zeng, Aimin Liu, 2012, Developmental biology on p. 141-153

Centrosomal protein DZIP1 regulates hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis

Chengbing Wang, Wee Chuang Low, Aimin Liu, Baolin Wang, 2013, Journal of Biological Chemistry on p. 29518-29529

PCP effector proteins inturned and fuzzy play nonredundant roles in the patterning but not convergent extension of mammalian neural tube

Westley Heydeck, Aimin Liu, 2011, Developmental Dynamics on p. 1938-1948

Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling

Hongchen Cai, Aimin Liu, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 14751-14756

Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia

D. Dai, L. Li, A. Huebner, H. Zeng, E. Guevara, D. J. Claypool, A. Liu, J. Chen, 2013, Cell Death and Differentiation on p. 130-138

The loss of Hh responsiveness by a non-ciliary Gli2 variant

Jinling Liu, Huiqing Zeng, Aimin Liu, 2015, Development (Cambridge) on p. 1651-1660