Kumble Sandeep Prabhu

Professor of Immunology and Molecular Toxicology

Kumble Sandeep Prabhu

Research Summary

Molecular mechanisms by which bioactives such as selenium, omega-3 fatty acids, and other products of natural origin alter the host response and immune function in inflammation and cancer

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Selenium Selenoproteins Macrophages Inflammation Selenocysteine Neoplasms Proteins Genes Pharmacological Metabolism Protein Inflammatory Bowel Diseases Citrobacter Rodentium Lipopolysaccharide Terminology Acetylation Leukemia Neoplasm Metastasis Immunity Erythropoietin Receptors Oxidation Reduction Histones Therapeutics Growth Prostaglandins Acute Myeloid Leukemia

Most Recent Publications

Selenoprotein W Ameliorates Experimental Colitis and Promotes Intestinal Epithelial Repair

Shaneice K. Nettleford, Chang Liao, Sarah P. Short, Randall M. Rossi, Vishal Singh, K. Sandeep Prabhu, 2023, Antioxidants

Loss of selenoprotein W in murine macrophages alters the hierarchy of selenoprotein expression, redox tone, and mitochondrial functions during inflammation

Sougat Misra, Tai-Jung Lee, Molly Hall, Aswathy Sebastian, John McGuigan, Chang Liao, Imhoi Koo, A Patterson, Randall Rossi, Molly Hall, Istvan Albert, others, K Prabhu, 2023, Redox Biology on p. 102571

The role of selenoproteins in neutrophils during inflammation

Tai Jung Lee, Shaneice K. Nettleford, Allison McGlynn, Bradley A. Carlson, Girish S. Kirimanjeswara, K. Sandeep Prabhu, 2022, Archives of Biochemistry and Biophysics

Correlation of Serum Selenium in Asthma Patients with Severity of the Disorder

Nidhi Girdhar, Heena Kansal, Kranti Garg, Siddharth Sharma, K. Sandeep Prabhu, Vishal Chopra, Alexey A. Tinkov, Anatoly V. Skalny, N. Tejo Prakash, 2022, Biological Trace Element Research on p. 4949-4954

Interleukin-4 treatment reduces leukemia burden in acute myeloid leukemia

F Qian, B Arner, Kathleen M. Kelly, C Annageldiyev, Arati Sharma, David F. Claxton, Robert F. Paulson, K Prabhu, 2022, FASEB Journal on p. e22328

Macrophage Selenoproteins Restrict Intracellular Replication of Francisella tularensis and Are Essential for Host Immunity

Rachel Markley, Katherine Restori, Bhuvana Katkere, Sarah Sumner, McKayla Nicol, Anastasia Tyryshkina, Shaneice Nettleford, David Williamson, David Place, Kalyan Dewan, Ashley Shay, others, Bradley Carlson, Santhosh Girirajan, K. Sandeep Prabhu, Girish S. Kirimanjeswara, 2021, Frontiers in Immunology on p. 701341

Selenium-dependent metabolic reprogramming during inflammation and resolution

A Korwar, A Hossain, T Lee, Ashley Shay, V Basrur, K Conlon, Philip B. Smith, B Carlson, Howard M. Salis, Andrew D. Patterson, K. Sandeep Prabhu, 2021, Journal of Biological Chemistry on p. 100410

A novel clinically relevant graft-versus-leukemia model in humanized mice

B Jia, C Zhao, Michael Bayerl, Hiroko Shike, David F. Claxton, W Ehmann, Shin Mineishi, Todd D. Schell, P Zheng, Y Zhang, L Shultz, K. Sandeep Prabhu, Robert Paulson, Hong Zheng, 2021, Journal of Leukocyte Biology on p. 427-437

Epo receptor signaling in macrophages alters the splenic niche to promote erythroid differentiation

Y Chen, J Xiang, F Qian, B Diwakar, B Ruan, S Hao, K Prabhu, K. Sandeep Prabhu, Robert F. Paulson, 2020, Blood on p. 235-246

The Essential Role of Selenoproteins in the Resolution of Citrobacter rodentium-Induced Intestinal Inflammation

S Nettleford, L Zhao, F Qian, M Herold, B Arner, Dhimant Desai, Shantu Amin, N Xiong, Vishal Singh, B Carlson, K. Sandeep Prabhu, 2020, Frontiers in Nutrition on p. 96

Most-Cited Papers

Selenoprotein gene nomenclature

Brigelius Flohé Regina, Vadim N. Gladyshev, Elias S. Arnér, Marla J. Berry, Elspeth A. Bruford, Raymond F. Burk, Bradley A. Carlson, Sergi Castellano, Laurent Chavatte, Marcus Conrad, Paul R. Copeland, Alan M. Diamond, Donna M. Driscoll, Ana Ferreiro, Leopold Flohé, Fiona R. Green, Roderic Guigó, Diane E. Handy, Dolph L. Hatfield, John Hesketh, Peter R. Hoffmann, Arne Holmgren, Robert J. Hondal, Michael T. Howard, Kaixun Huang, Hwa Young Kim, Ick Young Kim, Josef Köhrle, Alain Krol, Gregory V. Kryukov, Byeong Jae Lee, Byung Cheon Lee, Xin Gen Lei, Qiong Liu, Alain Lescure, Alexei V. Lobanov, Joseph Loscalzo, Matilde Maiorino, Marco Mariotti, K. Sandeep Prabhu, Margaret P. Rayman, Sharon Rozovsky, Gustavo Salinas, Edward E. Schmidt, Lutz Schomburg, Ulrich Schweizer, Miljan Simonović, Roger A. Sunde, Petra A. Tsuji, Susan Tweedie, F. Fulvio Ursini, Philip D. Whanger, Yan Zhang, 2016, Journal of Biological Chemistry on p. 24036-24040

Is selenium a potential treatment for cancer metastasis?

Yu Chi Chen, K. Sandeep Prabhu, Andrea M. Mastro, 2013, Nutrients on p. 1149-1168

Selenium and inflammatory bowel disease

A Kudva, Ashley Shay, K. Sandeep Prabhu, 2015, American Journal of Physiology on p. G71-G77

Crucial role of macrophage selenoproteins in experimental colitis

Naveen Kaushal, Avinash K. Kudva, Andrew D. Patterson, Christopher Chiaro, Mary J. Kennett, Dhimant Desai, Shantu Amin, Bradley A. Carlson, Margherita T. Cantorna, K. Sandeep Prabhu, 2014, Journal of Immunology on p. 3683-3692

Dietary selenium supplementation modifies breast tumor growth and metastasis

Yu Chi Chen, K. Sandeep Prabhu, Arunangshu Das, Andrea M. Mastro, 2013, International Journal of Cancer on p. 2054-2064

Selenium

K. Sandeep Prabhu, Xin Gen Lei, 2016, Advances in nutrition (Bethesda, Md.) on p. 415-417

Epigenetic regulation of inflammatory gene expression in macrophages by selenium

Vivek Narayan, Kodihalli C. Ravindra, Chang Liao, Naveen Kaushal, Bradley A. Carlson, K. Sandeep Prabhu, 2015, Nutrition Reports International on p. 138-145

The microbiome and obesity-An established risk for certain types of cancer

Connie J. Rogers, Kumble Sandeep Prabhu, Matam Vijay-Kumar, 2014, Cancer Journal from Scientific American on p. 176-180

Selenium and selenoproteins in gut inflammation—A review

Shaneice K. Nettleford, K. Sandeep Prabhu, 2018, Antioxidants

Selenium and selenoproteins in prostanoid metabolism and immunity

F Qian, Sougat Misra, K. Sandeep Prabhu, 2019, Critical Reviews in Biochemistry and Molecular Biology on p. 484-516