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Study first author Michelle Zavala-Paez, doctoral candidate in Penn State’s Intercollege Graduate Degree Program in Ecology, selects the main shoot of a hybrid Populus tree to collect the first fully expanded leaf for physiological measurements. Credit: Penn State. Creative Commons

Dec 18, 2025

Genetic teamwork may be the secret to climate-resilient plants, researchers find

A plant’s success may depend on how well the three sets of genetic instructions it carries in its cells cooperate, according to a new study led by plant scientists at Penn State.

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A new high-throughput study that used publicly available data shows that E. coli proteins containing a structure called a non-covalent lasso entanglement (NCLE) are more likely to misfold and, if they are essential to the bacteria’s survival, more likely to be repaired by chaperones — the cell’s quality control machinery. Image shows that misfolded (outlined in red) essential proteins (bottom) containing NCLEs are more likely to be repaired (outlined in green) by cellular chaperones (dark grey) than non-essential proteins (top). Credit: Ian Sitarik/O’Brien Lab / Penn State. Creative Commons

Dec 16, 2025

For certain life-essential proteins in E. coli, repair is more likely

Proteins need to fold into specific shapes to perform their functions in cells, but they occasionally misfold, which can prevent them from properly functioning and even lead to disease. A new study by researchers at Penn State found that, in E. coli, proteins containing a widespread structural 3D pattern, known as a motif, are more likely to misfold than proteins that lack it.

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Researchers at Penn State found that two proteins thought to operate in harmony to regulate the genetic information-carrying messenger molecules called mRNA actually work in opposition: one protein destabilizes mRNA while the other steadies it. Credit: wildpixel/Getty Images. All Rights Reserved.

Dec 16, 2025

Opposing forces in cells could hold clues to treating disease

A newly revealed molecular tug-of-war may have implications for better understanding how a multitude of diseases and disorders — including cancers, neurodegenerative diseases and immune disorders — originate, as well as how to potentially treat them, according to researchers at Penn State.

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Dec 15, 2025

The stories that defined 2025 for the One Health Microbiome Center at Penn State

The One Health Microbiome Center (OHMC) at Penn State in the Huck Institutes of the Life Sciences is one of the largest and most active organizations in the field and provides centralized resources to Penn State, the nation and the world.

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Researchers used advanced imaging techniques, conducted at Penn State’s publicly funded Core Facilities, to study the architecture of the Turnip Crinkle Virus (TCV). This plant pathogen has an icosahedral — or 20-sided — shell that is the same structure as many human pathogens, such as enteroviruses, noroviruses, poliovirus, hepatitis B virus and the virus that causes chickenpox. Pictured are Varun Venkatakrishnan, left, a Penn State doctoral student, and Ganesh Anand, associate professor of chemistry, biochemistry and molecular biology at Penn State. Credit: Michelle Bixby / Penn State. Creative Commons

Dec 12, 2025

Unique bond identified as key to viral infection speed

Viruses are typically described as tiny, perfectly geometric shells that pack genetic material with mathematical precision, but new research led by scientists at Penn State revealed a deliberate imbalance in their shape that helps them infect their hosts.

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Jessica Grembi and Nazifa Tabassum visited Bangladesh this summer as part of the ongoing research project. Credit: Penn State. Creative Commons

Dec 12, 2025

Investigating the microbiome’s role in intestinal disorder in pregnancy

Jessica Grembi, an assistant professor of pharmacology in Penn State's College of Agricultural Sciences, has received a $500,000 grant from the Gates Foundation to investigate the role of the microbiome in environmental enteropathy — a condition characterized by inflammation of the small intestine that affects nutrient absorption.

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A new study has uncovered several instances of wood warblers — like the magnolia warbler pictured here — passing color-related genes to other species of wood warblers, including those that are not closely related. Credit: Davey Walters. All Rights Reserved.

Dec 11, 2025

Warblers borrow color-related genes from evolutionary neighbors, study finds

Wood warblers, also called New World warblers, are some of the most colorful birds in North America, with more than a hundred species in the family ranging in color from yellow, orange and red to blue, green and pink. A new study led by researchers at Penn State has uncovered several instances of the birds passing color-related genes to other species of wood warblers, including those that are not closely related.

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Dec 11, 2025

Mentorship and communication take center stage at training summit

Huck Institutes’ annual T32 summit underscores benefits of professional development alongside scientific training.

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New research shows how artificial oil-in-water droplets embark on a “treasure hunt,” extending filopodia-like arms toward chemical riches hidden in their environment. The glowing chest symbolizes chemical cues that direct growth and sensing, echoing the way living cells explore their surroundings. Credit: Sanjana Krishna Mari, Sen Laboratory / Penn State. Creative Commons

Dec 09, 2025

In brief: Like living cells, oil-in-water droplets reach out with 'arms'

Oil-in-water droplets respond to chemical cues by forming arm-like extensions that resemble filopodia, which are used by living cells to sense and explore their environment. A research team led by chemists at Penn State studies the droplets to glimpse how matter may have transitioned to life billions of years ago.

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Francisco Dini-Andreote and Andrew Patterson are both faculty in Penn State’s College of Agricultural Sciences. Credit: Penn State. Creative Commons

Dec 08, 2025

Two College of Ag Sciences faculty earn spots on highly cited researchers list

Francisco Dini-Andreote and Andrew Patterson in Penn State’s College of Agricultural Sciences are among the most highly cited researchers in 2025, according to the Clarivate Analytics Web of Science Group.

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