From Src Oncogene to WW Domain: Deciphering the HIPPO Tumor Suppressor Pathway in Mammals

Marius Sudol, Weis Center for Research

October 14, 2009 @ 05:00 pm to 06:00 pm

101 ASI

Event Website

Dr. Marius Sudol is a Staff Scientist at the Weis Center for Research in Pennsylvania, and an Adjunct Faculty at the Department of Medicine of Mount Sinai School of Medicine in New York City._ Dr. Sudol was instrumental in the delineation and characterization of one of the smallest protein-protein interaction modules, the WW domain. His work also implicated the WW domain in signaling pathways underlying several human diseases including hypertension and cancer. He earned a Ph.D. at The Rockefeller University in New York in 1983 and stayed at his Alma Mater as a postdoctoral fellow and faculty member until his move to Mount Sinai in 1995._ Dr. Sudol has published 109 research articles and is credited as inventor on two biotechnology patents._ He also participated in the generation of the first protein interaction map for the human modular protein domain._ The data from NIH and Celera genome projects were used to initiate functional mapping of the WW domain complexes using repertoires of expressed human WW domains and their cognate peptide ligands._ His current work is focused on the details of signaling mechanisms that use the WW domain complexes and underlie human diseases._ In particular, his laboratory studies the HIPPO tumor suppressor pathway, which is regulated by a string of multiple WW domain complexes.

Contact

Avery August
axa45@psu.edu
863-3539