Bordetella

It is rare to manage to get such a disparate group of people with a common interest into a room together. Sharing information between the different disciplines, and mutual education in the different methods and thinking processes being brought to bear on the disease, were two of the most valuable aspects of the meeting. - Duncan Maskell, Head of Department and Marks & Spencer Professor of Farm Animal Health, Food Science & Food Safety Centre for Veterinary Science, Department of Veterinary Medicine, University of Cambridge Schedule: Friday 9:00 AM: Immunity Bryan Grenfell and Duncan Maskell - Welcome and Introduction Paul Mann - Innate Immunity / Differential stimulation Girish Kirimanjeswara - Adaptive immunity / Differential sensitivity Mylisa Pilone - Bacterial virulence factors and immune evasion / Accute vs. persistent Reka Albert - Model synthesizing data 11:00 AM to 12:30 PM: Between host dynamics James Cherry - Epidemiology: review of empirical story Pejman Rohani & Aaron King - Host-pathogen dynamics: Multi-annual cycles, disease interference 1:30 PM to 2:30 PM: Strain Dynamics Olivier Restif (discussion leader) - Current Bordetella Strains Olivier Restif: Models - expanding the epidemiological models to incorporate strain dynamics 3:00 PM to 5:00 PM: Evolution Andrew Preston & Duncan Maskell- Comparative genomics and trade offs between persistence and virulence Olivier Restif - Co-evolution of Bordetellae: Effect of strain dynamics on co-evolution Dan Wolfe - Non reciprocal cross immunity: B. pertussis and B. parapertussis in the same host populations by Schedule: Saturday 9:00 AM to 10:00 AM: Host dynamics Ottar Bjornstad & Eric Harvill - Synthesis of previous day's talks and discussions taken from session syntheses _ How host dynamics can shape evolution of strains Additional perspectives 10:00 AM to 10:30 AM: Identification of topic areas for group discussions Experimental, epidemiological, strain sampling/comparison, other scale/level of examination, etc. Identify group members based on expertise. 11:00 AM - 12:30 PM: Focus in break-out group discussions Identify pressing questions in each area. 1:30 PM - 3:00 PM: Discussion groups report back to entire group. Whole group discussion, chaired by Duncan Maskell Summary - Future research directions

Contact

  Eric Harvill
  eth10@psu.edu