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Kathleen M Mulder

Research interests

Mulder Lab Research Interests

We have identified the TGFβ receptor-interacting protein km23-1/dynlrb1, which plays an important role in TGFβ signal transduction, as well as in dynein-mediated intracellular transport of signaling cargoes to specialized locales. km23-1 also functions as a critical platform for the assembly of small GTPases, underlying its critical roles in cell signaling, motility, polarity, and in coupling TGFß receptor activation to activation of Ras effector pathways downstream. We are also investigating mechanisms of TGF-beta signaling in cancer and non-cancer cells, involving cell signaling, cell migration/invasion, actin cytoskeleton, motor proteins, intracellular trafficking, Ras, MAPKs, Smads, and dynein. Additional studies address how these events are altered in human cancers, as well as how km23-1 can be targeted therapeutically. The overall focus of the Mulder Lab is the identification of novel signal transduction-based therapeutics for human colon and pancreatic cancer.


Apply now: Post-Doctoral Position in Molecular and Cellular Cancer Research

Seeking recent PhD graduates for a post-doctoral scholar position in the Mulder Lab, Biochemistry & Molecular Biology, Penn State Hershey College of Medicine. Research pertains to TGFß, cell signaling, anti-cancer therapeutics & diagnostics, cancer invasion, RhoA signaling, cell migration, motor proteins, intracellular trafficking, actin cytoskeleton. Requirements include a PhD in a relevant field and relevant peer-reviewed molecular/cell biology publications in English. Prefer applicants with expertise in studies related to actin-based cell motility and immunofluorescence analyses. Must be a US citizen or permanent resident. Send CV to Dr. Kathleen M. Mulder kmm15@psu.edu

http://www.futurity.org/health-medicine/protein-helps-colon-cancer-move-and-invade/

http://www.eurekalert.org/pub_releases/2013-06/ps-pii062713.php

http://news.psu.edu/story/280300/2013/06/27/research/protein-involved-colon-cancer-cells-ability-invade-other-cells

http://med.psu.edu/web/college/education/nondegree/postdocs/mulder

http://www.sciencedaily.com/releases/2012/12/121218121425.htm

http://www.medicalnewstoday.com/releases/254273.php

http://scicasts.com/cancer/5186-research-indicates-spread-of-cancer-cells-may-be-slowed-by-targeting-of-protein

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Mulder Lab Research Interests

We have identified the TGFβ receptor-interacting protein km23-1/dynlrb1, which plays an important role in TGFβ signal transduction, as well as in dynein-mediated intracellular transport of signaling cargoes to specialized locales. km23-1 also functions as a critical platform for the assembly of small GTPases, underlying its critical roles in cell signaling, motility, polarity, and in coupling TGFß receptor activation to activation of Ras effector pathways downstream. We are also investigating mechanisms of TGF-beta signaling in cancer and non-cancer cells, involving cell signaling, cell migration/invasion, actin cytoskeleton, motor proteins, intracellular trafficking, Ras, MAPKs, Smads, and dynein. Additional studies address how these events are altered in human cancers, as well as how km23-1 can be targeted therapeutically. The overall focus of the Mulder Lab is the identification of novel signal transduction-based therapeutics for human colon and pancreatic cancer.


Apply now: Post-Doctoral Position in Molecular and Cellular Cancer Research

Seeking recent PhD graduates for a post-doctoral scholar position in the Mulder Lab, Biochemistry & Molecular Biology, Penn State Hershey College of Medicine. Research pertains to TGFß, cell signaling, anti-cancer therapeutics & diagnostics, cancer invasion, RhoA signaling, cell migration, motor proteins, intracellular trafficking, actin cytoskeleton. Requirements include a PhD in a relevant field and relevant peer-reviewed molecular/cell biology publications in English. Prefer applicants with expertise in studies related to actin-based cell motility and immunofluorescence analyses. Must be a US citizen or permanent resident. Send CV to Dr. Kathleen M. Mulder kmm15@psu.edu

http://www.futurity.org/health-medicine/protein-helps-colon-cancer-move-and-invade/

http://www.eurekalert.org/pub_releases/2013-06/ps-pii062713.php

http://news.psu.edu/story/280300/2013/06/27/research/protein-involved-colon-cancer-cells-ability-invade-other-cells

http://med.psu.edu/web/college/education/nondegree/postdocs/mulder

http://www.sciencedaily.com/releases/2012/12/121218121425.htm

http://www.medicalnewstoday.com/releases/254273.php

http://scicasts.com/cancer/5186-research-indicates-spread-of-cancer-cells-may-be-slowed-by-targeting-of-protein