Student

Ritwik Singhal

Graduate Student

Adviser: Manuel Llinás

Email rbs5758@psu.edu

Centers & Institutes

Center for Infectious Disease Dynamics

Molecular, Cellular, and Integrative Biosciences IGDP

New research lends insight into the regulatory control of gene expression in the deadliest of the malaria parasites, Plasmodium falciparum, and provides opportunities for the development of new therapeutic approaches against the disease. PfSnf2L, in red, is an essential malaria parasite protein for developing from the asexual ring to the sexual transmission stage — shown at top with the arrow illustrating the trajectory of various stages of sexual development. When the PfSnf2L enzyme is inhibited by the small molecule, NH125, in green, this leads to disordered DNA packaging. Changes in DNA packaging with active — the white line — and inactive PfSnf2L enzyme — the blue line — are depicted. When the DNA packaging is disrupted, the necessary information for parasite development can no longer be read out and the malaria parasites die thereby blocking transmission. Credit: Längst and Kannan Venugopal/Marti laboratory. All Rights Reserved.

February 19, 2025

Disrupting parasite gene regulation reveals new malaria intervention strategy

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