iLab for Penn State Researchers

RRID: SCR_024458

Provides advanced, highly automated instrumentation and expert support for studying macromolecular binding, thermodynamics, folding, and biophysical properties with minimal sample requirements. It offers collaborative assistance across techniques such as multi-angle light scattering, multi-wavelength analytical ultracentrifugation, microcalorimetry, circular dichroism, and single-molecule force measurements to support comprehensive analysis of molecular structure, stability, and interactions.

iLab - Biomolecular Interaction Facility

RRID: SCR_024459

A pilot-scale bioprocessing facility for microbial fermentation integrated with downstream operations to recover and purify produced biomolecules.

iLab - CLS Behring Fermentation Facility

RRID:SCR_024456

Offers a comprehensive suite of semi-automated workflows, specializing in single-particle analysis and cryo-electron tomography (cryo-ET) of vitrified specimens. This facility empowers researchers to leverage cutting-edge imaging technologies for high-resolution structural studies, ranging from isolated proteins and viruses to complex cellular and subcellular environments.

iLab - Cry-Electron Microscopy Facility

RRID: SCR_024460

Equipped with advanced flow cytometers and cell sorters for multiparametric, single-cell analysis and deep immunophenotyping of immune cells. This facility engages in instrument training, project collaboration, and consultation for experiment design and data analysis.

iLab - Flow Cytometry Facility

RRID: SCR_023645

Facilitating cutting-edge research using next-generation sequencing and traditional genomics instruments and techniques. This facility supports DNA/RNA sequencing, offering high-throughput, short read, long-read, single-cell, and spatial technologies.

iLab - Genomics Facility

RRID: SCR_024461

Offers advanced ultra-high-field MRI infrastructure and expertise to develop and apply cutting-edge imaging methods for studying biological systems and materials. A micro-computed tomography system complements these capabilities by enabling multimodal imaging approaches.

iLab - High Field MRI Facility

RRID: SCR_023864

Identify and quantify the small (<1kDa) molecules present in plant and animal biofluids and tissue extracts, as identifying perturbations in the amounts of particular metabolites can offer insights into the underlying biological processes involved in their production.

iLab - Metabolomics Facility

RRID: SCR_024457

This facility is located in a “quiet lab” area in the 297,000 square foot, state-of-the-art Millennium Science Complex, which provides superior conditions for imaging. The facility currently provides services for instrumentation, training, consultation, and hands-on work to users on and off the campus with electron microscopy, optical microscopy, and histology.

iLab - Microscopy Facility

RRID: SCR_024462

Providing high-resolution mass spectrometry services for a wide range of analytes, from small molecules to proteins and polymers. A dedicated proteomics instrument, Thermo Orbitrap Eclipse is well suited for any of the current proteomics workflows including TMT Pro.

iLab - Proteomics & Mass Spectrometry Facility

RRID: SCR_024463

Delivers hands-on training in mammalian cell culture to students, faculty, staff, and external personnel, while providing researchers across numerous Penn State disciplines access to a twenty first-century lab environment.

iLab - Sartorius Cell Culture Facility

RRID: SCR_024464

Provides advanced instrumentation, training, and expert support to enable researchers to perform structural studies, from protein characterization and binding analysis to crystallization, diffraction, and molecular modeling. Its staff collaborates with investigators throughout the research process, offering guidance, technical expertise, and access to specialized techniques such as small-angle X-ray scattering and synchrotron sources.

iLab - X-Ray Crystallography