Chromatin state dynamics during the Plasmodium falciparum intraerythrocytic development cycle
Alan S. Brown, Manuel Llinás, Shaun Mahony,
Dec 2026,
In: BMC genomics
Date: Dec 2026
Natural triterpenic phenolic esters target PfA-M17 in Plasmodium falciparum
Lúcia Mamede, Gabriel W. Rangel, Marjorie Schmitt, Sebastien Albrecht, Martin Spichty, Joanne Bero, Claire Beaufay, Isabelle Florent, Manuel Llinás, Michel Frédérich, Joëlle Quetin-Leclercq,
Dec 2026,
In: Malaria journal
Date: Dec 2026
A single valine to leucine switch disrupts Plasmodium falciparum AP2-G DNA binding and reveals GDV1’s role in ap2-g activation
Surendra K. Prajapati, Jeffrey X. Dong, Belinda J. Morahan, Thoai Dotrang, Michelle C. Barbeau, April E. Williams, Daniel Hupalo, Matthew D. Wilkerson, Clifton L. Dalgard, Bjorn F.C. Kafsack, Manuel Llinás, Kim C. Williamson,
Dec 2026,
In: Nature communications
Date: Dec 2026
Metabolomics reveals potentiated metabolic perturbations induced by antimalarial drug combinations against Plasmodium falciparum in vitro
Francois Eya'ane Meva, Tarrick Qahash, Justin Arinaga, Manuel Llinás,
Sep 2026,
In: Experimental Parasitology
Date: Sep 2026
ATAD3 megadalton complex in Plasmodium falciparum is essential for mitochondrial and cellular viability
Ijeoma C. Okoye, Ian M. Lamb, Yee Wai Cheung, Joanne M. Morrisey, Manish Sharma, Rajat Kumar, Swati Dass, Anurag Shukla, River S. Rell, Michael W. Mather, Manuel Llinás, Yi Wei Chang, Akhil B. Vaidya,
Jun 2026,
In: PLoS pathogens
Date: Jun 2026
A Novel Class of Orally Bioavailable Phenylglycine–Benzoxaborole Conjugates with Antimalarial Activity and Potentially Novel Mechanism of Action
Mokhitli Morake, Dale Taylor, Dina Coertzen, Mathew Njoroge, Liezl Krugmann, Meta Leshabane, Shanté da Rocha, Tarrick Qahash, Gareth Girling, Rachael Coyle, Marcus C.S. Lee, Sergio Wittlin, Manuel Llinás, Lyn Marie Birkholtz, Gregory S. Basarab, Kelly Chibale,
Jan 8 2026,
In: ACS Medicinal Chemistry Letters
Date: Jan 8 2026
Effect of Stereochemistry on the Antiplasmodial Activity and Metabolomic Profile of Novel Tadalafil Analogues
Esraa A. Elhalawaty, Howida A. Alseedy, John G. Woodland, Kathryn J. Wicht, Tarryn Swart, Gabriel W. Rangel, Heinrich C. Hoppe, Kelly Chibale, Manuel Llinás, Ashraf H. Abadi, Nermin S. Ahmed,
2026,
In: ACS Medicinal Chemistry Letters
Date: 2026
Degradation of ribosomal RNA during Plasmodium falciparum gametocytogenesis
Janne Grünebast, Ritwik Singhal, Robin Bromley, Sachie Kanatani, Kaylee Watson, Sophie Olson, Franck Dumetz, Tales Vicari Pascini, Abhai Tripathi, Julie C. Dunning Hotopp, Photini Sinnis, Manuel Llinás, David Serre,
Nov 12 2025,
In: mBio
Date: Nov 12 2025
The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4-Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria
John G. Woodland, Dina Coertzen, Kathryn J. Wicht, Virginia Franco Hidalgo, Charisse Flerida A. Pasaje, Luiz C. Godoy, Tarrick Qahash, Mmakwena M. Mmonwa, Godwin A. Dziwornu, Lynn Wambua, Sarah Harries, Constance M. Korkor, Mathew Njoroge, Liezl Krugmann, Dale Taylor, Meta Leshabane, Henrico Langeve...,
Jul 7 2025,
In: Angewandte Chemie - International Edition
Date: Jul 7 2025
Hexosamine biosynthesis disruption impairs GPI production and arrests Plasmodium falciparum growth at schizont stages
María Pía Alberione, Yunuen Avalos-Padilla, Gabriel W. Rangel, Miriam Ramírez, Tais Romero-Uruñuela, Àngel Fenollar, Jonathan Ortega-Barrionuevo, Marcell Crispim, Terry K. Smith, Manuel Llinás, Luis Izquierdo,
Jul 2025,
In: PLoS pathogens
Date: Jul 2025
The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum
Zbynek Bozdech, Manuel Llinás, Brian Lee Pulliam, Edith D. Wong, Jingchun Zhu, Joseph L. DeRisi,
2003,
In: PLoS biology
Citations: 1,372
A transcriptional switch underlies commitment to sexual development in malaria parasites
Björn F.C. Kafsack, Núria Rovira-Graells, Taane G. Clark, Cristina Bancells, Valerie M. Crowley, Susana G. Campino, April E. Williams, Laura G. Drought, Dominic P. Kwiatkowski, David A. Baker, Alfred Cortés, Manuel Llinás,
2014,
In: Nature
Citations: 398
A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium
Abhinav Sinha, Katie R. Hughes, Katarzyna K. Modrzynska, Thomas D. Otto, Claudia Pfander, Nicholas J. Dickens, Agnieszka A. Religa, Ellen Bushell, Anne L. Graham, Rachael Cameron, Bjorn F.C. Kafsack, April E. Williams, Manuel Llinás, Matthew Berriman, Oliver Billker, Andrew P. Waters,
2014,
In: Nature
Citations: 334
New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq
Thomas D. Otto, Daniel Wilinski, Sammy Assefa, Thomas M. Keane, Louis R. Sarry, Ulrike Böhme, Jacob Lemieux, Bart Barrell, Arnab Pain, Matthew Berriman, Chris Newbold, Manuel Llinás,
Apr 2010,
In: Molecular Microbiology
Citations: 320
Comparative whole genome transcriptome analysis of three Plasmodium falciparum strains
Manuel Llinás, Zbynek Bozdech, Edith D. Wong, Alex T. Adai, Joseph L. DeRisi,
Mar 2006,
In: Nucleic acids research
Citations: 262
Host-Parasite Interactions Revealed by Plasmodium falciparum Metabolomics
Kellen L. Olszewski, Joanne M. Morrisey, Daniel Wilinski, James M. Burns, Akhil B. Vaidya, Joshua D. Rabinowitz, Manuel Llinás,
Feb 19 2009,
In: Cell Host and Microbe
Citations: 252
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond
Wesley C. Van Voorhis, John H. Adams, Roberto Adelfio, Vida Ahyong, Myles H. Akabas, Pietro Alano, Aintzane Alday, Yesmalie Alemán Resto, Aishah Alsibaee, Ainhoa Alzualde, Katherine T. Andrews, Simon V. Avery, Vicky M. Avery, Lawrence Ayong, Mark Baker, Stephen Baker, Choukri Ben Mamoun, Sangeeta B...,
Jul 2016,
In: PLoS pathogens
Citations: 240
Identification and Genome-Wide Prediction of DNA Binding Specificities for the ApiAP2 family of regulators from the malaria parasite
Tracey L. Campbell, Erandi K. de Silva, Kellen L. Olszewski, Olivier Elemento, Manuel Llinás,
Oct 2010,
In: PLoS pathogens
Citations: 214
Solution structure of syrian hamster prion protein rPrP(90-231)
He Liu, Shauna Farr-Jones, Nikolai B. Ulyanov, Manuel Llinas, Susan Marqusee, Darlene Groth, Fred E. Cohen, Stanley B. Prusiner, Thomas L. James,
Apr 27 1999,
In: Biochemistry
Citations: 205
Specific DNA-binding by Apicomplexan AP2 transcription factors
Erandi K. De Silva, Andrew R. Gehrke, Kellen Olszewski, Ilsa León, Jasdave S. Chahal, Martha L. Bulyk, Manuel Llinás,
Jun 17 2008,
In: Proceedings of the National Academy of Sciences of the United States of America
Citations: 202
