Wen Jiang

Discovery and Mechanism of 16-19F, a Novel Synthetic Lethal Inhibitor of the PRMT5•MTA Complex in MTAP-Deleted Cancer Cells
Zhihang Shen, Xiaozhi Yang, Gustavo Seabra, Xueyong Xu, Jiawei Dong, Jason Orr Brant, Wei Zhou, Juan Guan, Wen Jiang, Chenglong Li, Jun 20 2025, In: ACS chemical biology
Date: Jun 20 2025

Macrocyclic β-arch peptides that mimic the structure and function of disease-associated tau folds
Isaac J. Angera, Xueyong Xu, Benjamin H. Rajewski, Grace I. Hallinan, Xiaoqi Zhang, Bernardino Ghetti, Ruben Vidal, Wen Jiang, Juan R. Del Valle, Jun 2025, In: Nature Chemistry
Date: Jun 2025

Pseudovirus nanoparticles targeting the receptor binding HA1 domains of influenza viruses elicited high HA1-specific antibody responses and protected mice against mortality caused by influenza virus challenges
Ming Xia, Pengwei Huang, Frank S. Vago, Wen Jiang, Ming Tan, Feb 6 2025, In: Vaccine
Date: Feb 6 2025

A Nanoparticle Comprising the Receptor-Binding Domains of Norovirus and Plasmodium as a Combination Vaccine Candidate
Ming Xia, Pengwei Huang, Frank S. Vago, Wen Jiang, Xi Jiang, Ming Tan, Jan 2025, In: Vaccines
Date: Jan 2025

Cryo-EM structures of cotton wool plaques’ amyloid β and of tau filaments in dominantly inherited Alzheimer disease
Md Rejaul Hoq, Anllely Fernandez, Frank S. Vago, Grace I. Hallinan, Sakshibeedu R. Bharath, Daoyi Li, Kadir A. Ozcan, Holly J. Garringer, Wen Jiang, Ruben Vidal, Bernardino Ghetti, Dec 2024, In: Acta Neuropathologica
Date: Dec 2024

A Pseudovirus Nanoparticle Displaying the Vaccinia Virus L1 Protein Elicited High Neutralizing Antibody Titers and Provided Complete Protection to Mice against Mortality Caused by a Vaccinia Virus Challenge
Pengwei Huang, Ming Xia, Frank S. Vago, Wen Jiang, Ming Tan, Aug 2024, In: Vaccines
Date: Aug 2024

Cryo-EM structures of amyloid-β and tau filaments in Down syndrome
Anllely Fernandez, Md Rejaul Hoq, Grace I. Hallinan, Daoyi Li, Sakshibeedu R. Bharath, Frank S. Vago, Xiaoqi Zhang, Kadir A. Ozcan, Kathy L. Newell, Holly J. Garringer, Wen Jiang, Bernardino Ghetti, Ruben Vidal, Jun 2024, In: Nature Structural and Molecular Biology
Date: Jun 2024

A Viral Protein 4-Based Trivalent Nanoparticle Vaccine Elicited High and Broad Immune Responses and Protective Immunity against the Predominant Rotaviruses
Ming Xia, Pengwei Huang, Frank Vago, Takahiro Kawagishi, Siyuan Ding, Harry B. Greenberg, Wen Jiang, Ming Tan, Feb 27 2024, In: ACS nano
Date: Feb 27 2024

The 2.6 Å Structure of a Tulane Virus Variant with Minor Mutations Leading to Receptor Change
Chen Sun, Pengwei Huang, Xueyong Xu, Frank S. Vago, Kunpeng Li, Thomas Klose, Xi Jason Jiang, Wen Jiang, Jan 2024, In: Biomolecules
Date: Jan 2024

Classification of helical polymers with deep-learning language models
Daoyi Li, Wen Jiang, Dec 2023, In: Journal of Structural Biology
Date: Dec 2023

EMAN2
Guang Tang, Liwei Peng, Philip R. Baldwin, Deepinder S. Mann, Wen Jiang, Ian Rees, Steven J. Ludtke, Jan 2007, In: Journal of Structural Biology
Citations: 2,490

Hierarchical self-assembly of DNA into symmetric supramolecular polyhedra
Yu He, Tao Ye, Min Su, Chuan Zhang, Alexander E. Ribbe, Wen Jiang, Chengde Mao, Mar 13 2008, In: Nature
Citations: 1,232

Outcome of the first electron microscopy validation task force meeting
Richard Henderson, Andrej Sali, Matthew L. Baker, Bridget Carragher, Batsal Devkota, Kenneth H. Downing, Edward H. Egelman, Zukang Feng, Joachim Frank, Nikolaus Grigorieff, Wen Jiang, Steven J. Ludtke, Ohad Medalia, Pawel A. Penczek, Peter B. Rosenthal, Michael G. Rossmann, Michael F. Schmid, Gunnar..., Feb 8 2012, In: Structure
Citations: 433

Conformational flexibility facilitates self-assembly of complex DNA nanostructures
Chuan Zhang, Min Su, Yu He, Xin Zhao, Ping An Fang, Alexander E. Ribbe, Wen Jiang, Chengde Mao, Aug 5 2008, In: Proceedings of the National Academy of Sciences of the United States of America
Citations: 280

Structure of epsilon15 bacteriophage reveals genome organization and DNA packaging/injection apparatus
Wen Jiang, Juan Chang, Joanita Jakana, Peter Weigele, Jonathan King, Wah Chiu, Feb 2 2006, In: Nature
Citations: 275

Bridging the information gap
Wen Jiang, Matthew L. Baker, Steven J. Ludtke, Wah Chiu, May 18 2001, In: Journal of Molecular Biology
Citations: 268

Common ancestry of herpesviruses and tailed DNA bacteriophages
Matthew L. Baker, Wen Jiang, Frazer J. Rixon, Wah Chiu, Dec 2005, In: Journal of virology
Citations: 239

Scavenging effects of Salvia miltiorrhiza on free radicals and its protection for myocardial mitochondrial membranes from ischemia-reperfusion injury
Bao Lu Zhao, Wen Jiang, Yan Zhao, Jing Wu Hou, Wen Juan Xin, 1996, In: Biochemistry and Molecular Biology International
Citations: 215

Structural basis for scaffolding-mediated assembly and maturation of a dsDNA virus
Dong Hua Chen, Matthew L. Baker, Corey F. Hryc, Frank DiMaio, Joanita Jakana, Weimin Wu, Matthew Dougherty, Cameron Haase-Pettingell, Michael F. Schmid, Wen Jiang, David Baker, Jonathan A. King, Wah Chiu, Jan 25 2011, In: Proceedings of the National Academy of Sciences of the United States of America
Citations: 194

Backbone structure of the infectious ε15 virus capsid revealed by electron cryomicroscopy
Wen Jiang, Matthew L. Baker, Joanita Jakana, Peter R. Weigele, Jonathan King, Wah Chiu, Feb 28 2008, In: Nature
Citations: 192

Core Facilities

• Cryo-Electron Microscopy Facility

Centers & Institutes

• Center for AI and Mathematical Biology
• Center for Structural Biology

• Bioinformatics and Genomics IGDP
• Molecular, Cellular, and Integrative Biosciences IGDP

• Department of Biochemistry and Molecular Biology
• Elsevier Pure Profile