Faculty

Joseph Reese

463A North Frear Laboratory
University Park, PA 16802

Gene regulation in cell cycle and DNA damage control; regulation of DNA damage-induced transcription.

CCR4-NOT is required for suppressing pervasive transcription and retrotransposable elements
Shardul Kulkarni, Alexis Morrissey, Aswathy Sebastian, Oluwasegun T. Akinniyi, Cheryl A. Keller Capone, Istvan Albert, Shaun Mahony, Joseph C. Reese, Aug 2026, In: Journal of Biological Chemistry
Date: Aug 2026

Degradation factor 1, Def1, regulates mRNA translation and decay through Ccr4–Not-dependent ubiquitylation of the ribosome
Oluwasegun T. Akinniyi, Aswathy Sebastian, Shardul Kulkarni, Istvan Albert, Joseph C. Reese, Jun 2026, In: RNA
Date: Jun 2026

Gene expression analysis and proximity labeling reveal post-transcriptional functions of the yeast RNA polymerase II regulator Def1
Oluwasegun T. Akinniyi, Shardul Kulkarni, Mikayla M. Hribal, Cheryl A. Keller, Belinda M. Giardine, Joseph C. Reese, Feb 2026, In: Journal of Biological Chemistry
Date: Feb 2026

Auxin-induced depletion of human CCR4-NOT subunits reveals opposing functions of CNOT1 and CNOT4 in mRNA metabolism
Shardul Kulkarni, Courtney Smith, Oluwasegun T. Akinniyi, Belinda M. Giardine, Cheryl A. Keller, Alexei Arnaoutov, Joseph C. Reese, Dec 2025, In: Journal of Biological Chemistry
Date: Dec 2025

Characterization of BioID tagging systems in budding yeast and exploring the interactome of the Ccr4-Not complex
Jeffrey Pfannenstein, Misha Tyryshkin, Moira E. Gulden, Emma H. Doud, Amber L. Mosley, Joseph C. Reese, Nov 2024, In: G3: Genes, Genomes, Genetics
Date: Nov 2024

New roles for elongation factors in RNA polymerase II ubiquitylation and degradation
Joseph C. Reese, Sep 2023, In: Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
Date: Sep 2023

DEF1
Oluwasegun T. Akinniyi, Joseph C. Reese, Nov 2021, In: DNA Repair
Date: Nov 2021

Nucleosome Dynamics during Transcription Elongation
Mai T. Huynh, Satya P. Yadav, Joseph C. Reese, Tae Hee Lee, 2020, In: ACS chemical biology
Date: 2020

Ccr4–not maintains genomic integrity by controlling the ubiquitylation and degradation of arrested RNAPII
Haoyang Jiang, Marley Wolgast, Laura M. Beebe, Joseph C. Reese, Jun 1 2019, In: Genes and Development
Date: Jun 1 2019

Biochemical methods to characterize RNA polymerase II elongation complexes
J. Brooks Crickard, Joseph C. Reese, Apr 15 2019, In: Methods
Date: Apr 15 2019

A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation
Patrick A. Grant, David Schieltz, Marilyn G. Pray-Grant, David J. Steger, Joseph C. Reese, John R. Yates, Jerry L. Workman, Jul 10 1998, In: Cell
Citations: 399

Transcription activation in cells lacking TAF(II)s
S. S. Walker, Joseph C. Reese, L. M. Apone, M. R. Green, Sep 25 1996, In: Nature
Citations: 213

Yeast TAF<sub>II</sub>s in a multisubunit complex required for activated transcription
Joseph C. Reese, Lynne Apone, Scott S. Walker, Loree A. Griffin, Michael R. Green, 1994, In: Nature
Citations: 151

Ccr4-Not complex
Jason E. Miller, Joseph C. Reese, Jul 2012, In: Critical Reviews in Biochemistry and Molecular Biology
Citations: 145

The multifunctional Ccr4-Not complex directly promotes transcription elongation
Jennifer A. Kruk, Arnob Dutta, Jianhua Fu, David S. Gilmour, Joseph C. Reese, Mar 15 2011, In: Genes and Development
Citations: 137

Yeast TAF(II)90 is required for cell-cycle progression through G<sub>2</sub>/M but not for general transcription activation
Lynne M. Apone, Ching Man A. Virbasius, Joseph C. Reese, Michael R. Green, 1996, In: Genes and Development
Citations: 130

Yeast TAF(II)145 required for transcription of G1/S cyclin genes and regulated by the cellular growth state
Scott S. Walker, Wu Cheng Shen, Joseph C. Reese, Lynne M. Apone, Michael R. Green, Aug 22 1997, In: Cell
Citations: 129

Promoter targeting of chromatin-modifying complexes.
A. H. Hassan, K. E. Neely, M. Vignali, J. C. Reese, J. L. Workman, 2001, In: Frontiers in bioscience : a journal and virtual library
Citations: 125

Differential DNA-binding abilites of estrogen receptor occupied with two classes of antiestrogens
Joseph C. Reese, Benita S. Katzenellenbogen, Dec 11 1991, In: Nucleic acids research
Citations: 120

Examination of the DNA-Binding Ability of Estrogen Receptor in Whole Cells
Joseph C. Reese, Benita S. Katzenellenbogen, Oct 1992, In: Molecular and cellular biology
Citations: 111

Centers & Institutes