Faculty

Istvan Albert

Research Professor of Bioinformatics
Huck Co-Hire with Eberly College of Science

W237 Millennium Science Complex
University Park, PA 16802

Email iua1@psu.edu
Phone 814-865-2281

Overview

Bioinformatics, large scale biological data analysis, microarrays and sequence analysis. Scientific programming, algorithm development. Database-driven web development.

Areas of Expertise

Jamming Keyphrases
Granular Drag Keyphrases
Drag Force Keyphrases
Granular Media Keyphrases
Genomics Biochemistry, Genetics and Molecular Biology
Infection Immunology and Microbiology
Infectious Disease Immunology and Microbiology
Nucleosome Biochemistry, Genetics and Molecular Biology

CCR4-NOT is required for suppressing pervasive transcription and retrotransposable elements
Shardul Kulkarni, Alexis Morrissey, Aswathy Sebastian, Oluwasegun T. Akinniyi, Cheryl A. Keller Capone, Istvan Albert, Shaun Mahony, Joseph C. Reese, Aug 2026, In: Journal of Biological Chemistry
Date: Aug 2026

Degradation factor 1, Def1, regulates mRNA translation and decay through Ccr4–Not-dependent ubiquitylation of the ribosome
Oluwasegun T. Akinniyi, Aswathy Sebastian, Shardul Kulkarni, Istvan Albert, Joseph C. Reese, Jun 2026, In: RNA
Date: Jun 2026

Cellular Snowballing
Zaman Ataie, Sina Kheirabadi, Changhao Li, Aneesh Risbud, Aswathy Sebastian, Istvan Albert, Sulin Zhang, Amir Sheikhi, 2026, In: Advanced Science
Date: 2026

Epigenetic Modifiers to Treat Retinal Degenerative Diseases
Evgenya Y. Popova, Lisa Schneper, Aswathy Sebastian, Istvan Albert, Joyce Tombran-Tink, Colin J. Barnstable, Jul 2025, In: Cells
Date: Jul 2025

Reduced Susceptibility to Phytophthora in Non-Transgenic Cacao Progeny Through CRISPR–Cas9 Mediated TcNPR3 Mutagenesis
Mark J. Guiltinan, Lena Landherr, Siela N. Maximova, Dante DelVecchio, Aswathy Sebastian, Istvan Albert, 2025, In: Plant Biotechnology Journal
Date: 2025

Direct testing of natural twister ribozymes from over a thousand organisms reveals a broad tolerance for structural imperfections
Lauren N. McKinley, McCauley O. Meyer, Aswathy Sebastian, Benjamin K. Chang, Kyle J. Messina, Istvan Albert, Philip C. Bevilacqua, Dec 11 2024, In: Nucleic acids research
Date: Dec 11 2024

CPLANE protein INTU regulates growth and patterning of the mouse lungs through cilia-dependent Hh signaling
Huiqing Zeng, Shimaa Ali, Aswathy Sebastian, Adriana Sophia Ramos-Medero, Istvan Albert, Charlotte Dean, Aimin Liu, Nov 2024, In: Developmental biology
Date: Nov 2024

Alcohol and fear conditioning produce strain-specific changes in the dorsal hippocampal transcriptome of adolescent C57BL/6J and DBA/2J mice
Laurel R. Seemiller, Lisa R. Goldberg, Aswathy Sebastian, Sue Rutherford Siegel, Craig Praul, Dana Zeid, Istvan Albert, Jacob Beierle, Camron D. Bryant, Thomas J. Gould, Nov 2024, In: Alcoholism: Clinical and Experimental Research
Date: Nov 2024

Long-read genome assembly and gene model annotations for the rodent malaria parasite Plasmodium yoelii 17XNL
Mitchell J. Godin, Aswathy Sebastian, Istvan Albert, Scott E. Lindner, Jul 2023, In: Journal of Biological Chemistry
Date: Jul 2023

Loss of selenoprotein W in murine macrophages alters the hierarchy of selenoprotein expression, redox tone, and mitochondrial functions during inflammation
Sougat Misra, Tai Jung Lee, Aswathy Sebastian, John McGuigan, Chang Liao, Imhoi Koo, Andrew D. Patterson, Randall M. Rossi, Molly A. Hall, Istvan Albert, K. Sandeep Prabhu, Feb 2023, In: Redox Biology
Date: Feb 2023

View All Publications →

Galaxy
Belinda Giardine, Cathy Riemer, Ross C. Hardison, Richard Burhans, Laura Elnitski, Prachi Shah, Yi Zhang, Daniel Blankenberg, Istvan Albert, James Taylor, Webb Miller, W. James Kent, Anton Nekrutenko, Oct 2005, In: Genome Research
Citations: 1,671

Structural vulnerability of the North American power grid
Réka Albert, István Albert, Gary L. Nakarado, Feb 2004, In: Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
Citations: 1,291

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity
Fei Li, Changtao Jiang, Kristopher W. Krausz, Yunfei Li, Istvan Albert, Haiping Hao, Kristin M. Fabre, James B. Mitchell, Andrew D. Patterson, Frank J. Gonzalez, Sep 24 2013, In: Nature communications
Citations: 680

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
Changtao Jiang, Cen Xie, Fei Li, Limin Zhang, Robert G. Nichols, Kristopher W. Krausz, Jingwei Cai, Yunpeng Qi, Zhong Ze Fang, Shogo Takahashi, Naoki Tanaka, Dhimant Desai, Shantu G. Amin, Istvan Albert, Andrew D. Patterson, Frank J. Gonzalez, Jan 2 2015, In: Journal of Clinical Investigation
Citations: 656

Nucleosome organization in the Drosophila genome
Travis N. Mavrich, Cizhong Jiang, Ilya P. Ioshikhes, Xiaoyong Li, Bryan J. Venters, Sara J. Zanton, Lynn P. Tomsho, Ji Qi, Robert L. Glaser, Stephan C. Schuster, David S. Gilmour, Istvan Albert, B. Franklin Pugh, May 15 2008, In: Nature
Citations: 609

Translational and rotational settings of H2A.Z nucleosomes across the Saccharomyces cerevisiae genome
Istvan Albert, Travis N. Mavrich, Lynn P. Tomsho, Ji Qi, Sara J. Zanton, Stephan C. Schuster, B. Franklin Pugh, Mar 29 2007, In: Nature
Citations: 582

A barrier nucleosome model for statistical positioning of nucleosomes throughout the yeast genome
Travis N. Mavrich, Ilya P. Ioshikhes, Bryan J. Venters, Cizhong Jiang, Lynn P. Tomsho, Ji Qi, Stephan C. Schuster, Istvan Albert, B. Franklin Pugh, Jul 2008, In: Genome Research
Citations: 562

Getting to know you
Al Mamunur Rashid, Istvan Albert, Dan Cosley, Shyong K. Lam, Sean M. McNee, Joseph A. Konstan, John Riedl, 2002, In:
Citations: 470

MovieLens unplugged
Bradley N. Miller, Istvan Albert, Shyong K. Lam, Joseph A. Konstan, John Riedl, 2003, In:
Citations: 434

Is seeing believing? How recommender interfaces affect users' opinions
Dan Cosley, Shyong K. Lam, Istvan Albert, Joseph A. Konstan, John Riedl, 2003, In:
Citations: 430

View All Publications →

Centers & Institutes

Bioinformatics and Genomics IGDP

The novel Cleavage High-throughput Assay (CHiTA) developed at Penn State provides a scarless method to characterize thousands of diverse small self-cleaving RNA enzymes, called twister ribozymes, in a single experiment. The image shows 2D models of some of the tested ribozymes that had imperfections in their helical and loop elements but were still active, demonstrating that twister ribozyme's ability to self-cleave is tolerant of these slight structural imperfections. Credit: Lauren McKinley and Philip Bevilacqua / Penn State. Creative Commons

November 05, 2024

Istvan Albert

Overview

Areas of Expertise

Testing thousands of RNA enzymes helps find first ‘twister ribozyme’ in mammals

Legal Statements