As a joint venture between the Huck Institutes of the Life Sciences and the Materials Research Institute, this microscope is a uniquely configured instrument. Life science applications are fully supported, allowing fully automated atomic resolution single particle and high contrast tomography tilt series data collection. Additional microscopy components permit a full range of material science applications including EELS, STEM, and DPC. Since the microscope is one of a kind, offering uncompromised data collection for the life sciences while incorporating material science applications, it is uniquely suited to combine technical approaches. We are proud to provide cryo-electron microscopy capabilities and associated services to the Penn State community as well as those researchers outside the University.