Rajeswaran Mani
Assistant Director of Core Facilities for Public Engagement and Outreach; Director, Flow Cytometry Facility; Assistant Research Professor
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W124A Millennium Science Complex
University Park, PA - rpm5900@psu.edu
- 814-865-6595
Huck Affiliations
Most Recent Publications
Reactive Oxygen Species-Triggered Hydrogen Sulfide Release and Cancer-Selective Antiproliferative Effect of Anethole Dithiolethione-Containing Polymeric Micelles
André J. van der Vlies, Rajeswaran Mani, Masoud Ghasemi, Bernadette M. Adair, James H. Adair, Enrique Daniel Gomez, Urara Hasegawa, 2023, Advanced healthcare materials
PP2A is a therapeutically targetable driver of cell fate decisions via a c-Myc/p21 axis in human and murine acute myeloid leukemia
Swagata Goswami, Rajeswaran Mani, Jessica Nunes, Chi Ling Chiang, Kevan Zapolnik, Eileen Hu, Frank Frissora, Xiaokui Mo, Logan A. Walker, Pearlly Yan, Ralf Bundschuh, Larry Beaver, Raymond Devine, Yo Ting Tsai, Ann Ventura, Zhiliang Xie, Min Chen, Rosa Lapalombella, Alison Walker, Alice Mims, Karilyn Larkin, Nicole Grieselhuber, Chad Bennett, Mitch Phelps, Erin Hertlein, Gregory Behbehani, Sumithira Vasu, John C. Byrd, Natarajan Muthusamy, 2022, Blood on p. 1340-1358
The ROR1 antibody-drug conjugate huXBR1-402-G5-PNU effectively targets ROR11 leukemia
Eileen Y. Hu, Priscilla Do, Swagata Goswami, Jessica Nunes, Chi Ling Chiang, Sara Elgamal, Ann M. Ventura, Carolyn Cheney, Kevan Zapolnik, Erich Williams, Rajeswaran Mani, Frank Frissora, Xiaokui Mo, Lorenz Waldmeier, Roger R. Beerli, Haiyong Peng, Christoph Rader, Meixiao Long, Ulf Grawunder, John C. Byrd, Natarajan Muthusamy, 2021, Blood advances on p. 3152-3162
Pharmacokinetics and Tolerability of the Novel Non-immunosuppressive Fingolimod Derivative, OSU-2S, in Dogs and Comparisons with Data in Mice and Rats
Zhiliang Xie, Min Chen, Swagata Goswami, Rajes Mani, Dasheng Wang, Samuel K. Kulp, Chris C. Coss, Larry J. Schaaf, Fengyu Cui, John C. Byrd, Ryan N. Jennings, Karsten K. Schober, Carrie Freed, Stephanie Lewis, Raphael Malbrue, Natarajan Muthusamy, Chad Bennett, William C. Kisseberth, Mitch A. Phelps, 2020, AAPS Journal
Fc-engineered anti-CD33 monoclonal antibody potentiates cytotoxicity of membrane-bound interleukin-21 expanded natural killer cells in acute myeloid leukemia
Rajeswaran Mani, Girish Rajgolikar, Jessica Nunes, Kevan Zapolnik, Ronni Wasmuth, Xiaokui Mo, John C. Byrd, Dean A. Lee, Natarajan Muthusamy, Sumithira Vasu, 2020, Cytotherapy on p. 369-376
Selective and potent CDK8/19 inhibitors enhance NK-cell activity and promote tumor surveillance
Marco H. Hofmann, Rajeswaran Mani, Harald Engelhardt, Maria A. Impagnatiello, Sebastian Carotta, Marc Kerenyi, Seila Lorenzo-Herrero, Jark Böttcher, Dirk Scharn, Heribert Arnhof, Andreas Zoephel, Renate Schnitzer, Thomas Gerstberger, Michael P. Sanderson, Girish Rajgolikar, Swagata Goswami, Sumithira Vasu, Peter Ettmayer, Segundo Gonzalez, Mark Pearson, Darryl B. McConnell, Norbert Kraut, Natarajan Muthusamy, Jürgen Moll, 2020, Molecular Cancer Therapeutics on p. 1018-1030
ROR1-targeted delivery of miR-29b induces cell cycle arrest and therapeutic benefit in vivo in a CLL mouse model
Chi Ling Chiang, Swagata Goswami, Frank W. Frissora, Zhiliang Xie, Pearlly S. Yan, Ralf Bundschuh, Logan A. Walker, Xiaomeng Huang, Rajeswaran Mani, Xiaokui M. Mo, Sivasubramanian Baskar, Christoph Rader, Mitch A. Phelps, Guido Marcucci, John C. Byrd, L. James Lee, Natarajan Muthusamy, 2019, Blood on p. 432-444
Abstract 1541: Evaluation of ROR1 targeted antibody drug conjugate in ROR1 positive leukemia
Eileen Hu, Priscilla Do, Rajeswaran Mani, Frank Frissora, Rebecca Pearson, Gerard Lozanski, Haiyong Peng, Lorenz Waldmeier, Roger Beerli, Christoph Rader, Ulf Grawunder, John Byrd, Natarajan Muthusamy, 2019, Cancer Research on p. 1541-1541
Par-4 overexpression impedes leukemogenesis in the Em-TCL1 leukemia model through downregulation of NF-kB signaling
J. T. Greene, Rajeswaran Mani, Rahul Ramaswamy, Frank Frissora, Max Yano, Kevan Zapolnik, Bonnie Harrington, Ronni Wasmuth, Minh Tran, Xiaokui Mo, Mary McKenna, Vivek M. Rangnekar, John C. Byrd, Subbarao Bondada, Natarajan Muthusamy, 2019, Blood advances on p. 1255-1266
The interleukin-3 receptor CD123 targeted SL-401 mediates potent cytotoxic activity against CD34 <sup>+</sup> CD123 <sup>+</sup> cells from acute myeloid leukemia/myelodysplastic syndrome patients and healthy donors
Rajeswaran Mani, Swagata Goswami, Bhavani Gopalakrishnan, Rahul Ramaswamy, Ronni Wasmuth, Minh Tran, Xiaokui Mo, Amber Gordon, Donna Bucci, David M. Lucas, Alice Mims, Christopher Brooks, Adrienne Dorrance, Alison Walker, William Blum, John C. Byrd, Gerard Lozanski, Sumithira Vasu, Natarajan Muthusamy, 2018, Haematologica on p. 1288-1297
Most-Cited Papers
Decitabine enhances anti-CD33 monoclonal antibody BI 836858-mediated natural killer ADCC against AML blasts
Sumithira Vasu, Shun He, Carolyn Cheney, Bhavani Gopalakrishnan, Rajeswaran Mani, Gerard Lozanski, Xiaokui Mo, Veronica Groh, Susan P. Whitman, Renate Konopitzky, Christian Kössl, Donna Bucci, David M. Lucas, Jianhua Yu, Michael A. Caligiuri, William Blum, Paul J. Adam, Eric Borges, Bjoern Rueter, Karl Heinz Heider, Guido Marcucci, Natarajan Muthusamy, 2016, Blood on p. 2879-2889
The interleukin-3 receptor CD123 targeted SL-401 mediates potent cytotoxic activity against CD34 <sup>+</sup> CD123 <sup>+</sup> cells from acute myeloid leukemia/myelodysplastic syndrome patients and healthy donors
Rajeswaran Mani, Swagata Goswami, Bhavani Gopalakrishnan, Rahul Ramaswamy, Ronni Wasmuth, Minh Tran, Xiaokui Mo, Amber Gordon, Donna Bucci, David M. Lucas, Alice Mims, Christopher Brooks, Adrienne Dorrance, Alison Walker, William Blum, John C. Byrd, Gerard Lozanski, Sumithira Vasu, Natarajan Muthusamy, 2018, Haematologica on p. 1288-1297
Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B-cell cytotoxicity in chronic lymphocytic leukemia
R. Mani, Y. Mao, F. W. Frissora, C. L. Chiang, J. Wang, Y. Zhao, Y. Wu, B. Yu, R. Yan, X. Mo, L. Yu, J. Flynn, J. Jones, L. Andritsos, S. Baskar, C. Rader, M. A. Phelps, C. S. Chen, R. J. Lee, J. C. Byrd, L. J. Lee, N. Muthusamy, 2015, Leukemia on p. 346-355
Selective and potent CDK8/19 inhibitors enhance NK-cell activity and promote tumor surveillance
Marco H. Hofmann, Rajeswaran Mani, Harald Engelhardt, Maria A. Impagnatiello, Sebastian Carotta, Marc Kerenyi, Seila Lorenzo-Herrero, Jark Böttcher, Dirk Scharn, Heribert Arnhof, Andreas Zoephel, Renate Schnitzer, Thomas Gerstberger, Michael P. Sanderson, Girish Rajgolikar, Swagata Goswami, Sumithira Vasu, Peter Ettmayer, Segundo Gonzalez, Mark Pearson, Darryl B. McConnell, Norbert Kraut, Natarajan Muthusamy, Jürgen Moll, 2020, Molecular Cancer Therapeutics on p. 1018-1030
ROR1-targeted delivery of miR-29b induces cell cycle arrest and therapeutic benefit in vivo in a CLL mouse model
Chi Ling Chiang, Swagata Goswami, Frank W. Frissora, Zhiliang Xie, Pearlly S. Yan, Ralf Bundschuh, Logan A. Walker, Xiaomeng Huang, Rajeswaran Mani, Xiaokui M. Mo, Sivasubramanian Baskar, Christoph Rader, Mitch A. Phelps, Guido Marcucci, John C. Byrd, L. James Lee, Natarajan Muthusamy, 2019, Blood on p. 432-444
The ROR1 antibody-drug conjugate huXBR1-402-G5-PNU effectively targets ROR11 leukemia
Eileen Y. Hu, Priscilla Do, Swagata Goswami, Jessica Nunes, Chi Ling Chiang, Sara Elgamal, Ann M. Ventura, Carolyn Cheney, Kevan Zapolnik, Erich Williams, Rajeswaran Mani, Frank Frissora, Xiaokui Mo, Lorenz Waldmeier, Roger R. Beerli, Haiyong Peng, Christoph Rader, Meixiao Long, Ulf Grawunder, John C. Byrd, Natarajan Muthusamy, 2021, Blood advances on p. 3152-3162
ROR1-targeted delivery of OSU-2S, a nonimmunosuppressive FTY720 derivative, exerts potent cytotoxicity in mantle-cell lymphoma in vitro and in vivo
Rajeswaran Mani, Chi Ling Chiang, Frank W. Frissora, Ribai Yan, Xiaokui Mo, Sivasubramanian Baskar, Christoph Rader, Rebecca Klisovic, Mitch A. Phelps, Ching Shih Chen, Robert J. Lee, John C. Byrd, Robert Baiocchi, L. James Lee, Natarajan Muthusamy, 2015, Experimental Hematology on p. 770-774.e2
PP2A is a therapeutically targetable driver of cell fate decisions via a c-Myc/p21 axis in human and murine acute myeloid leukemia
Swagata Goswami, Rajeswaran Mani, Jessica Nunes, Chi Ling Chiang, Kevan Zapolnik, Eileen Hu, Frank Frissora, Xiaokui Mo, Logan A. Walker, Pearlly Yan, Ralf Bundschuh, Larry Beaver, Raymond Devine, Yo Ting Tsai, Ann Ventura, Zhiliang Xie, Min Chen, Rosa Lapalombella, Alison Walker, Alice Mims, Karilyn Larkin, Nicole Grieselhuber, Chad Bennett, Mitch Phelps, Erin Hertlein, Gregory Behbehani, Sumithira Vasu, John C. Byrd, Natarajan Muthusamy, 2022, Blood on p. 1340-1358
Oxidative stress-induced JNK/AP-1 signaling is a major pathway involved in selective apoptosis of myelodysplastic syndrome cells by Withaferin-A
Karine Z. Oben, Sara S. Alhakeem, Mary K. McKenna, Jason A. Brandon, Rajeswaran Mani, Sunil K. Noothi, Liu Jinpeng, Shailaja Akunuru, Sanjit K. Dhar, Inder P. Singh, Ying Liang, Chi Wang, Ahmed Abdel-Latif, Harold F. Stills, Daret K. St. Clair, Hartmut Geiger, Natarajan Muthusamy, Kaoru Tohyama, Ramesh C. Gupta, Subbarao Bondada, 2017, Oncotarget on p. 77436-77452
Reactive Oxygen Species-Triggered Hydrogen Sulfide Release and Cancer-Selective Antiproliferative Effect of Anethole Dithiolethione-Containing Polymeric Micelles
André J. van der Vlies, Rajeswaran Mani, Masoud Ghasemi, Bernadette M. Adair, James H. Adair, Enrique Daniel Gomez, Urara Hasegawa, 2023, Advanced healthcare materials
News Articles Featuring Rajeswaran Mani
Feb 10, 2025
Sustainable Labs Program increases participant engagement, welcomes new labs
Two upcoming virtual sessions will cover how labs can learn more and join next year’s cohort.
Full Article
Jul 30, 2024
Craig Praul named director of Huck Core Facilities
Joining Praul on the new leadership team are Rajeswaran Mani, director of the Flow Cytometry Facility, and financial specialist Kelly Foster.
Full Article
Nov 02, 2022
Flow Cytometry Core Facility provides cell analysis expertise to scientists
The Penn State Flow Cytometry Core Facility on the University Park campus, is equipped with flow cytometers and cell sorters that enable researchers to examine suspended cells within the size range of the submicron to 50 micron. One micron is one thousandth of a millimeter.
Full Article