Christopher Chen

Assistant Professor of Neural and Behavioral Sciences

500 University Drive, MC: H109
Hershey, PA 17033
He/Him/His
chc5230@psu.edu

Bio & Links
Publications

Research Summary

Understanding cerebellar nonmotor functions by examining its connections with the rest of the brain.

Huck Affiliations

Neuroscience Institute

Most Recent Publications

Characterization of direct Purkinje cell outputs to the brainstem

Christopher Chen, Zhiyi Yao, Shuting Wu, Wade Regehr, 2025, eLife

Implications of variable synaptic weights for rate and temporal coding of cerebellar outputs

Shuting Wu, Asem Wardak, Mehak M. Khan, Christopher H. Chen, Wade G. Regehr, 2024, eLife

A Purkinje cell to parabrachial nucleus pathway enables broad cerebellar influence over the forebrain

Christopher H. Chen, Leannah N. Newman, Amanda P. Stark, Katherine E. Bond, Dawei Zhang, Stefano Nardone, Charles R. Vanderburg, Naeem M. Nadaf, Zhiyi Yao, Kefiloe Mutume, Isabella Flaquer, Bradford B. Lowell, Evan Z. Macosko, Wade G. Regehr, 2023, Nature Neuroscience on p. 1929-1941

Cerebellar granule cell signaling is indispensable for normal motor performance

Joon Hyuk Lee, Mehak M. Khan, Amanda P. Stark, Soobin Seo, Aliya Norton, Zhiyi Yao, Christopher H. Chen, Wade G. Regehr, 2023, Cell Reports

Unusually Slow Spike Frequency Adaptation in Deep Cerebellar Nuclei Neurons Preserves Linear Transformations on the Subsecond Timescale

Mehak M. Khan, Shuting Wu, Christopher H. Chen, Wade G. Regehr, 2022, Journal of Neuroscience on p. 7581-7593

Mechanism of stress-induced attacks in an episodic neurologic disorder

Heather D. Snell, Ariel Vitenzon, Esra Tara, Chris Chen, Jaafar Tindi, Bryen A. Jordan, Kamran Khodakhah, 2022, Science advances

Climbing fiber synapses rapidly and transiently inhibit neighboring Purkinje cells via ephaptic coupling

Kyung Seok Han, Christopher H. Chen, Mehak M. Khan, Chong Guo, Wade G. Regehr, 2020, Nature Neuroscience on p. 1399-1409

Title: Cerebellar purkinje cell activity modulates aggressive behavior

Skyler L. Jackman, Christopher H. Chen, Heather L. Offermann, Iain R. Drew, Bailey M. Harrison, Anna M. Bowman, Katelyn M. Flick, Isabella Flaquer, Wade G. Regehr, 2020, eLife

In Vivo Targeted Expression of Optogenetic Proteins Using Silk/AAV Films

Skyler Jackman, Christopher Chen, Wade Regehr, 2019, Journal of Visualized Experiments

Cerebellar modulation of the reward circuitry and social behavior

Ilaria Carta, Christopher H. Chen, Amanda L. Schott, Schnaude Dorizan, Kamran Khodakhah, 2019, Science

Most-Cited Papers

Cerebellar modulation of the reward circuitry and social behavior

Ilaria Carta, Christopher H. Chen, Amanda L. Schott, Schnaude Dorizan, Kamran Khodakhah, 2019, Science

Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington's disease

Aldrin E. Molero, Eduardo E. Arteaga-Bracho, Christopher H. Chen, Maria Gulinello, Michael L. Winchester, Nandini Pichamoorthy, Solen Gokhan, Kamran Khodakhah, Mark F. Mehler, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 5736-5741

Ephaptic Coupling Promotes Synchronous Firing of Cerebellar Purkinje Cells

Kyung Seok Han, Chong Guo, Christopher H. Chen, Laurens Witter, Tomas Osorno, Wade G. Regehr, 2018, Neuron on p. 564-578.e3

Intracerebroventricular administration of TNF-like weak inducer of apoptosis induces depression-like behavior and cognitive dysfunction in non-autoimmune mice

Jing Wen, Christopher Holden Chen, Ariel Stock, Jessica Doerner, Maria Gulinello, Chaim Putterman, 2016, Brain, Behavior, and Immunity on p. 27-37