Anthony Schmitt

Professor of Molecular Immunology and Infectious Diseases

220 ASI Building
University Park, PA 16802
aps13@psu.edu
814-863-6781

Bio & Links
Publications

Research Summary

The process of paramyxovirus particle formation by budding: identifying and characterizing viral proteins used in budding, and learning how these manipulate host budding machinery to allow virus release.

Huck Affiliations

Integrative and Biomedical Physiology

Molecular, Cellular, and Integrative Biosciences

Publication Tags

Proteins Parainfluenza Virus 5 Virion Hendra Virus Respirovirus Viruses Mutation Cells Virus Like Particles Nucleocapsid Proteins Nipah Virus Mammalian Orthorubulavirus 5 Virus Assembly Tail Point Mutation Ubiquitin Viral Fusion Proteins Hendra Henipavirus Glycoproteins Amino Acids Ribonucleoproteins Viral Proteins Cell Fusion Nipah Henipavirus Viral Matrix Proteins

Most Recent Publications

RetroCHMP3 blocks budding of enveloped viruses without blocking cytokinesis

Lara Rheinemann, Diane Miller Downhour, Kate Bredbenner, Gaelle Mercenne, Kristen A. Davenport, Phuong Tieu Schmitt, Christina R. Necessary, John McCullough, Anthony P. Schmitt, Sanford M. Simon, Wesley I. Sundquist, Nels C. Elde, 2021, Cell on p. 5419-5431.e16

Paramyxovirus-like particles as protein delivery vehicles

Santosh Panthi, Phuong Tieu Schmitt, F. Jeffrey Lorenz, Brent A. Stanfield, Anthony P. Schmitt, 2021, Journal of Virology

Angiomotin-like 1 links paramyxovirus M proteins to NEDD4 family ubiquitin ligases

Greeshma Ray, Phuong Tieu Schmitt, Anthony P. Schmitt, 2019, Viruses

The HSV-1 mechanisms of cell-to-cell spread and fusion are critically dependent on host PTP1B

Jillian C. Carmichael, Hiroki Yokota, Rebecca C. Craven, Anthony Schmitt, John W. Wills, 2018, PLoS Pathogens

Mutations in the transmembrane domain and cytoplasmic tail of Hendra virus fusion protein disrupt viruslike- particle assembly

Nicolás Cifuentes-Muñoz, Weina Sun, Greeshma Ray, Phuong Tieu Schmitt, Stacy Webb, Kathleen Gibson, Rebecca Ellis Dutch, Anthony P. Schmitt, 2017, Journal of Virology

C-terminal DxD-containing sequences within paramyxovirus nucleocapsid proteins determine matrix protein compatibility and can direct foreign proteins into budding particles

Greeshma Ray, Phuong Tieu Schmitt, Anthony P. Schmitt, 2016, Journal of Virology on p. 3650-3660

Paramyxovirus glycoprotein incorporation, assembly and budding: A three way dance for infectious particle production

Farah El Najjar, Anthony P. Schmitt, Rebecca Ellis Dutch, 2014, Viruses on p. 3019-3054

Matrix proteins of Nipah and Hendra viruses interact with beta subunits of AP-3 complexes

Weina Sun, Thomas S. McCrory, Wei Young Khaw, Stephanie Petzing, Terrell Myers, Anthony P. Schmitt, 2014, Journal of Virology on p. 13099-13110

Point mutations in the paramyxovirus f protein that enhance fusion activity shift the mechanism of complement-mediated virus neutralization

John B. Johnson, Anthony P. Schmitt, Griffith D. Parks, 2013, Journal of Virology on p. 9250-9259

Role of ubiquitin in parainfluenza virus 5 particle formation

Megan S. Harrison, Phuong Tieu Schmitt, Zifei Pei, Anthony P. Schmitt, 2012, Journal of Virology on p. 3474-3485

Most-Cited Papers