Justin Pritchard

Huck Early Career Entrepreneurial Professorship; Assistant Professor of Biomedical Engineering;

Justin Pritchard

Research Summary

Using systems and synthetic biology approaches to understand and control drug resistance.

Graduate Students

Huck Affiliations

Links

Publication Tags

Neoplasms Genome Growth Pharmaceutical Preparations Mutation Genes Mycobacterium Platinum Therapeutics Oxaliplatin Cisplatin Vibrio Cholerae Infiltration Infection Mycobacterium Tuberculosis Essential Genes Datasets Analysis Carboplatin Amoeba Transposons Ribosomes Clustered Regularly Interspaced Short Palindromic Repeats Leukemia Fitness

Most Recent Papers

Evolution of the nonsense-mediated decay pathway is associated with decreased cytolytic immune infiltration

Boyang Zhao, Justin R. Pritchard, 2019, PLoS computational biology

Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus

Laura Laencina, Violaine Dubois, Vincent Le Moigne, Albertus Viljoen, Laleh Majlessi, Justin Pritchard, Audrey Bernut, Laura Piel, Anne Laure Roux, Jean Louis Gaillard, Bérengère Lombard, Damarys Loew, Eric J. Rubin, Roland Brosch, Laurent Kremer, Jean Louis Herrmann, Fabienne Girard-Misguich, 2018, Proceedings of the National Academy of Sciences of the United States of America on p. E1002-E1011

A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress

Peter M. Bruno, Yunpeng Liu, Ga Young Park, Junko Murai, Catherine E. Koch, Timothy J. Eisen, Justin R. Pritchard, Yves Pommier, Stephen J. Lippard, Michael T. Hemann, 2017, Nature Medicine on p. 461-471

Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform

Jeremy M. Rock, Forrest F. Hopkins, Alejandro Chavez, Marieme Diallo, Michael R. Chase, Elias R. Gerrick, Justin R. Pritchard, George M. Church, Eric J. Rubin, Christopher M. Sassetti, Dirk Schnappinger, Sarah M. Fortune, 2017, Nature Microbiology

Inherited Disease Genetics Improves the Identification of Cancer-Associated Genes

Boyang Zhao, Justin R. Pritchard, 2016, PLoS genetics

Acquisition of a single EZH2 D1 domain mutation confers acquired resistance to EZH2-targeted inhibitors

Theresa Baker, Sujata Nerle, Justin Pritchard, Boyang Zhao, Victor M. Rivera, Andrew Garner, Francois Gonzalvez, 2015, Oncotarget on p. 32646-32655

A genome-scale in vivo loss-of-function screen identifies phf6 as a lineage-specific regulator of leukemia cell growth

Corbin E. Meacham, Lee N. Lawton, Yadira M. Soto-Feliciano, Justin R. Pritchard, Brian A. Joughin, Tobias Ehrenberger, Nina Fenouille, Johannes Zuber, Richard T. Williams, Richard A. Young, Michael T. Hemann, 2015, Genes and Development on p. 483-488

ARTIST

Justin R. Pritchard, Michael C. Chao, Sören Abel, Brigid M. Davis, Catherine Baranowski, Yanjia J. Zhang, Eric J. Rubin, Matthew K. Waldor, 2014, PLoS genetics

Disruption of Mycobacterium avium subsp. paratuberculosis-specific genes impairs in vivo fitness

Joyce Wang, Justin R. Pritchard, Louis Kreitmann, Alexandre Montpetit, Marcel A. Behr, 2014, BMC genomics

High-resolution definition of the Vibrio cholerae essential gene set with hidden Markov model-based analyses of transposon-insertion sequencing data

Michael C. Chao, Justin R. Pritchard, Yanjia J. Zhang, Eric J. Rubin, Jonathan Livny, Brigid M. Davis, Matthew K. Waldor, 2013, Nucleic acids research on p. 9033-9048

Most-Cited Papers

A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress

Peter M. Bruno, Yunpeng Liu, Ga Young Park, Junko Murai, Catherine E. Koch, Timothy J. Eisen, Justin R. Pritchard, Yves Pommier, Stephen J. Lippard, Michael T. Hemann, 2017, Nature Medicine on p. 461-471

Defining principles of combination drug mechanisms of action

Justin R. Pritchard, Peter M. Bruno, Luke A. Gilberta, Kelsey L. Caprona, Douglas A. Lauffenburger, Michael T. Hemann, 2013, Proceedings of the National Academy of Sciences of the United States of America on p. E170-E179

High-resolution definition of the Vibrio cholerae essential gene set with hidden Markov model-based analyses of transposon-insertion sequencing data

Michael C. Chao, Justin R. Pritchard, Yanjia J. Zhang, Eric J. Rubin, Jonathan Livny, Brigid M. Davis, Matthew K. Waldor, 2013, Nucleic acids research on p. 9033-9048

Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform

Jeremy M. Rock, Forrest F. Hopkins, Alejandro Chavez, Marieme Diallo, Michael R. Chase, Elias R. Gerrick, Justin R. Pritchard, George M. Church, Eric J. Rubin, Christopher M. Sassetti, Dirk Schnappinger, Sarah M. Fortune, 2017, Nature Microbiology

A mammalian functional-genetic approach to characterizing cancer therapeutics

Hai Jiang, Justin R. Pritchard, Richard T. Williams, Douglas A. Lauffenburger, Michael T. Hemann, 2011, Nature Chemical Biology on p. 92-100

ARTIST

Justin R. Pritchard, Michael C. Chao, Sören Abel, Brigid M. Davis, Catherine Baranowski, Yanjia J. Zhang, Eric J. Rubin, Matthew K. Waldor, 2014, PLoS genetics

Acquisition of a single EZH2 D1 domain mutation confers acquired resistance to EZH2-targeted inhibitors

Theresa Baker, Sujata Nerle, Justin Pritchard, Boyang Zhao, Victor M. Rivera, Andrew Garner, Francois Gonzalvez, 2015, Oncotarget on p. 32646-32655

A genome-scale in vivo loss-of-function screen identifies phf6 as a lineage-specific regulator of leukemia cell growth

Corbin E. Meacham, Lee N. Lawton, Yadira M. Soto-Feliciano, Justin R. Pritchard, Brian A. Joughin, Tobias Ehrenberger, Nina Fenouille, Johannes Zuber, Richard T. Williams, Richard A. Young, Michael T. Hemann, 2015, Genes and Development on p. 483-488

Predicting cancer drug mechanisms of action using molecular network signatures

Justin R. Pritchard, Peter M. Bruno, Michael T. Hemann, Douglas A. Lauffenburger, 2013, Molecular BioSystems on p. 1604-1619

Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus

Laura Laencina, Violaine Dubois, Vincent Le Moigne, Albertus Viljoen, Laleh Majlessi, Justin Pritchard, Audrey Bernut, Laura Piel, Anne Laure Roux, Jean Louis Gaillard, Bérengère Lombard, Damarys Loew, Eric J. Rubin, Roland Brosch, Laurent Kremer, Jean Louis Herrmann, Fabienne Girard-Misguich, 2018, Proceedings of the National Academy of Sciences of the United States of America on p. E1002-E1011