Justin Pritchard

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Sajid M. Hossain, Yiyun Rao, Jahid O. Hossain, Justin R. Pritchard, Boyang Zhao, Dec 2025, In: BMC bioinformatics
Date: Dec 2025

Efficient mathematical methodology to determine multistep mutant burden in spatially growing cell populations
Natalia L. Komarova, Justin R. Pritchard, Dominik Wodarz, Sep 1 2025, In: PNAS Nexus
Date: Sep 1 2025

A side-by-side comparison of variant function measurements using deep mutational scanning and base editing
Ivan Sokirniy, Haider Inam, Marta Tomaszkiewicz, Joshua Reynolds, David McCandlish, Justin Pritchard, Aug 12 2025, In: Nucleic acids research
Date: Aug 12 2025

Programming tumor evolution with selection gene drives to proactively combat drug resistance
Scott M. Leighow, Joshua A. Reynolds, Ivan Sokirniy, Shun Yao, Zeyu Yang, Haider Inam, Dominik Wodarz, Marco Archetti, Justin Pritchard, 2024, In: Nature Biotechnology
Date: 2024

How soluble misfolded proteins bypass chaperones at the molecular level
Ritaban Halder, Daniel A. Nissley, Ian Sitarik, Yang Jiang, Yiyun Rao, Quyen V. Vu, Mai Suan Li, Justin Pritchard, Edward P. O’Brien, Dec 2023, In: Nature communications
Date: Dec 2023

Incorporating mutational heterogeneity to identify genes that are enriched for synonymous mutations in cancer
Yiyun Rao, Nabeel Ahmed, Justin Pritchard, Edward P. O’Brien, Dec 2023, In: BMC bioinformatics
Date: Dec 2023

Excessive concentrations of kinase inhibitors in translational studies impede effective drug repurposing
Chuan Liu, Scott M. Leighow, Kyle McIlroy, Mengrou Lu, Kady A. Dennis, Kerry Abello, Donovan J. Brown, Connor J. Moore, Anushka Shah, Haider Inam, Victor M. Rivera, Justin R. Pritchard, Oct 17 2023, In: Cell Reports Medicine
Date: Oct 17 2023

Novel fourth generation-like CAR^miR cells release therapeutic miRNA via exosomes and enhance glioblastoma cell killing activity
Amar Yeware, Angelica Helton, Yicheng Dong, Cheng Dong, Justin Pritchard, Shin Mineishi, Kentaro Minagawa, Todd Schell, Daniel Hayes, Oct 2023, In: Biochemical Engineering Journal
Date: Oct 2023

An engineered N-acyltransferase-LOV2 domain fusion protein enables light-inducible allosteric control of enzymatic activity
J. A. Reynolds, Y. L. Vishweshwaraiah, V. R. Chirasani, J. R. Pritchard, N. V. Dokholyan, Apr 2023, In: Journal of Biological Chemistry
Date: Apr 2023

The role of migration in mutant dynamics in fragmented populations
Jesse Kreger, Donovan Brown, Natalia L. Komarova, Dominik Wodarz, Justin Pritchard, Feb 2023, In: Journal of Evolutionary Biology
Date: Feb 2023

A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress
Peter M. Bruno, Yunpeng Liu, Ga Young Park, Junko Murai, Catherine E. Koch, Timothy J. Eisen, Justin R. Pritchard, Yves Pommier, Stephen J. Lippard, Michael T. Hemann, Apr 1 2017, In: Nature Medicine
Citations: 455

Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform
Jeremy M. Rock, Forrest F. Hopkins, Alejandro Chavez, Marieme Diallo, Michael R. Chase, Elias R. Gerrick, Justin R. Pritchard, George M. Church, Eric J. Rubin, Christopher M. Sassetti, Dirk Schnappinger, Sarah M. Fortune, Feb 6 2017, In: Nature Microbiology
Citations: 431

Defining principles of combination drug mechanisms of action
Justin R. Pritchard, Peter M. Bruno, Luke A. Gilberta, Kelsey L. Caprona, Douglas A. Lauffenburger, Michael T. Hemann, Jan 8 2013, In: Proceedings of the National Academy of Sciences of the United States of America
Citations: 151

The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning
Peter M. Bruno, Mengrou Lu, Kady A. Dennis, Haider Inam, Connor J. Moore, John Sheehe, Stephen J. Elledge, Michael T. Hemann, Justin R. Pritchard, Feb 25 2020, In: Proceedings of the National Academy of Sciences of the United States of America
Citations: 136

ARTIST
Justin R. Pritchard, Michael C. Chao, Sören Abel, Brigid M. Davis, Catherine Baranowski, Yanjia J. Zhang, Eric J. Rubin, Matthew K. Waldor, Nov 1 2014, In: PLoS genetics
Citations: 125

Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus
Laura Laencina, Violaine Dubois, Vincent Le Moigne, Albertus Viljoen, Laleh Majlessi, Justin Pritchard, Audrey Bernut, Laura Piel, Anne Laure Roux, Jean Louis Gaillard, Bérengère Lombard, Damarys Loew, Eric J. Rubin, Roland Brosch, Laurent Kremer, Jean Louis Herrmann, Fabienne Girard-Misguich, Jan 30 2018, In: Proceedings of the National Academy of Sciences of the United States of America
Citations: 121

High-resolution definition of the Vibrio cholerae essential gene set with hidden Markov model-based analyses of transposon-insertion sequencing data
Michael C. Chao, Justin R. Pritchard, Yanjia J. Zhang, Eric J. Rubin, Jonathan Livny, Brigid M. Davis, Matthew K. Waldor, Oct 2013, In: Nucleic acids research
Citations: 116

Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution
Boyang Zhao, Joseph C. Sedlak, Raja Srinivas, Pau Creixell, Justin R. Pritchard, Bruce Tidor, Douglas A. Lauffenburger, Michael T. Hemann, Mar 24 2016, In: Cell
Citations: 102

Understanding resistance to combination chemotherapy
Justin R. Pritchard, Douglas A. Lauffenburger, Michael T. Hemann, Oct 2012, In: Drug Resistance Updates
Citations: 91

A mammalian functional-genetic approach to characterizing cancer therapeutics
Hai Jiang, Justin R. Pritchard, Richard T. Williams, Douglas A. Lauffenburger, Michael T. Hemann, Feb 2011, In: Nature Chemical Biology
Citations: 87

• Integrative and Biomedical Physiology IGDP
• Molecular, Cellular, and Integrative Biosciences IGDP

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