Xiaojun (Lance) Lian

Collagen hydrogel tube microbioreactors for cell and tissue manufacturing
Yakun Yang, Xinran Wu, Ying Pan, Yong Wang, Xiaojun Lian, Cheng Dong, Wansheng Liu, Shue Wang, Yuguo Lei, Mar 1 2026, In: Biofabrication
Date: Mar 1 2026

Size-Modulated Mesoderm-Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids
Plansky Hoang, David W. McKellar, Andrew Kowalczewski, Nhu Y. Mai, Meng Chai, Xiaojun L. Lian, Yi Zheng, Jeffrey Amack, Nathan Tucker, Iwijn De Vlaminck, Huaxiao Yang, Benjamin D. Cosgrove, Zhen Ma, 2026, In: Advanced Science
Date: 2026

Forward programming of hPSCs to neutrophils using chemically defined media
Hayley E. Hall, Xiaoping Bao, Cheng Dong, Xiaojun Lance Lian, Dec 2025, In: Stem Cell Research and Therapy
Date: Dec 2025

Ultrasound Control of Gene Expression in Human iPSCs via Heat Shock Promoters
Alessandro R. Howells, Kama Bell, Hyeonu Heo, Tahir Haideri, Yun Jing, Xiaojun Lance Lian, Nov 2025, In: Biotechnology and bioengineering
Date: Nov 2025

Bioprinted optoelectronically active cardiac tissues
Faheem Ershad, Zhoulyu Rao, Sushila Maharajan, Fernanda C.Paccola Mesquita, Junkyu Ha, Lei Gonzalez, Tahir Haideri, Ernesto Curty Da Costa, Angel Moctezuma-Ramirez, Yuqi Wang, Seonmin Jang, Yuntao Lu, Shubham Patel, Xiaoyang Wang, Yifan Tao, Joshua Weygant, Carlos Ezio Garciamendez-Mijares, Luis Car..., Jan 24 2025, In: Science Advances
Date: Jan 24 2025

Ultrathin rubbery bio-optoelectronic stimulators for untethered cardiac stimulation
Zhoulyu Rao, Faheem Ershad, Ying Shi Guan, Fernanda C. Paccola Mesquita, Ernesto Curty da Costa, Marco A. Morales-Garza, Angel Moctezuma-Ramirez, Bin Kan, Yuntao Lu, Shubham Patel, Hyunseok Shim, Kuan Cheng, Wenjie Wu, Tahir Haideri, Xiaojun Lance Lian, Alamgir Karim, Jian Yang, Abdelmotagaly Elgala..., Dec 6 2024, In: Science Advances
Date: Dec 6 2024

Soft Polyethylene Glycol Hydrogels Support Human PSC Pluripotency and Morphogenesis
Michael P. Seitz, Yuanhui Song, Xiaojun Lance Lian, Zhen Ma, Era Jain, Jul 8 2024, In: ACS Biomaterials Science and Engineering
Date: Jul 8 2024

MAGIK
Tahir Haideri, Jirong Lin, Xiaoping Bao, Xiaojun Lance Lian, May 14 2024, In: Stem Cell Reports
Date: May 14 2024

Direct programming of human pluripotent stem cells into endothelial progenitors with SOX17 and FGF2
Michael W. Ream, Lauren N. Randolph, Yuqian Jiang, Yun Chang, Xiaoping Bao, Xiaojun Lance Lian, Apr 9 2024, In: Stem Cell Reports
Date: Apr 9 2024

CAR-neutrophil mediated delivery of tumor-microenvironment responsive nanodrugs for glioblastoma chemo-immunotherapy
Yun Chang, Xuechao Cai, Ramizah Syahirah, Yuxing Yao, Yang Xu, Gyuhyung Jin, Vijesh J. Bhute, Sandra Torregrosa-Allen, Bennett D. Elzey, You Yeon Won, Qing Deng, Xiaojun Lance Lian, Xiaoguang Wang, Omolola Eniola-Adefeso, Xiaoping Bao, Dec 2023, In: Nature communications
Date: Dec 2023

Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions
Xiaojun Lian, Jianhua Zhang, Samira M. Azarin, Kexian Zhu, Laurie B. Hazeltine, Xiaoping Bao, Cheston Hsiao, Timothy J. Kamp, Sean P. Palecek, Jan 2013, In: Nature Protocols
Citations: 1,482

Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling
Xiaojun Lian, Cheston Hsiao, Gisela Wilson, Kexian Zhu, Laurie B. Hazeltine, Samira M. Azarin, Kunil K. Raval, Jianhua Zhang, Timothy J. Kamp, Sean P. Palecek, Jul 3 2012, In: Proceedings of the National Academy of Sciences of the United States of America
Citations: 1,438

Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells
Jianhua Zhang, Matthew Klos, Gisela F. Wilson, Amanda M. Herman, Xiaojun Lian, Kunil K. Raval, Matthew R. Barron, Luqia Hou, Andrew G. Soerens, Junying Yu, Sean P. Palecek, Gary E. Lyons, James A. Thomson, Todd J. Herron, José Jalife, Timothy J. Kamp, Oct 12 2012, In: Circulation research
Citations: 395

Efficient differentiation of human pluripotent stem cells to endothelial progenitors via small-molecule activation of WNT signaling
Xiaojun Lian, Xiaoping Bao, Abraham Al-Ahmad, Jialu Liu, Yue Wu, Wentao Dong, Kaitlin K. Dunn, Eric V. Shusta, Sean P. Palecek, 2014, In: Stem Cell Reports
Citations: 288

Laser-induced graphene non-enzymatic glucose sensors for on-body measurements
Jia Zhu, Shangbin Liu, Zhihui Hu, Xianzhe Zhang, Ning Yi, Kairui Tang, Michael Gregory Dexheimer, Xiaojun Lian, Qing Wang, Jian Yang, Jennifer Gray, Huanyu Cheng, Dec 1 2021, In: Biosensors and Bioelectronics
Citations: 217

CAR-neutrophil mediated delivery of tumor-microenvironment responsive nanodrugs for glioblastoma chemo-immunotherapy
Yun Chang, Xuechao Cai, Ramizah Syahirah, Yuxing Yao, Yang Xu, Gyuhyung Jin, Vijesh J. Bhute, Sandra Torregrosa-Allen, Bennett D. Elzey, You Yeon Won, Qing Deng, Xiaojun Lance Lian, Xiaoguang Wang, Omolola Eniola-Adefeso, Xiaoping Bao, Dec 2023, In: Nature communications
Citations: 193

Effects of substrate mechanics on contractility of cardiomyocytes generated from human pluripotent stem cells
Laurie B. Hazeltine, Chelsey S. Simmons, Max R. Salick, Xiaojun Lian, Mehmet G. Badur, Wenqing Han, Stephanie M. Delgado, Tetsuro Wakatsuki, Wendy C. Crone, Beth L. Pruitt, Sean P. Palecek, 2012, In: International Journal of Cell Biology
Citations: 160

Chemically defined, albumin-free human cardiomyocyte generation
Xiaojun Lian, Xiaoping Bao, Misha Zilberter, Mattias Westman, André Fisahn, Cheston Hsiao, Laurie B. Hazeltine, Kaitlin K. Dunn, Timothy J. Kamp, Sean P. Palecek, Jun 30 2015, In: Nature methods
Citations: 136

Sequence-Specific Recognition of HIV-1 DNA with Solid-State CRISPR-Cas12a-Assisted Nanopores (SCAN)
Reza Nouri, Yuqian Jiang, Xiaojun Lance Lian, Weihua Guan, May 22 2020, In: ACS Sensors
Citations: 120

Engineering chimeric antigen receptor neutrophils from human pluripotent stem cells for targeted cancer immunotherapy
Yun Chang, Ramizah Syahirah, Xuepeng Wang, Gyuhyung Jin, Sandra Torregrosa-Allen, Bennett D. Elzey, Sydney N. Hummel, Tianqi Wang, Can Li, Xiaojun Lian, Qing Deng, Hal E. Broxmeyer, Xiaoping Bao, Jul 19 2022, In: Cell Reports
Citations: 98

Centers & Institutes

• Center for Computational Biology and Bioinformatics

• Integrative and Biomedical Physiology IGDP
• Molecular, Cellular, and Integrative Biosciences IGDP

• Human Stem Cell Engineering Lab
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• Elsevier Pure Profile