Thomas Spratt

Translesion-synthesis-mediated bypass of DNA lesions occurs predominantly behind replication forks restarted by PrimPol
Ashna Dhoonmoon, Julia R. Ambrose, Sonal Garg, Cynthia Lascarez-Espana, Abbey Rebok, Thomas E. Spratt, George Lucian Moldovan, Claudia M. Nicolae, Mar 25 2025, In: Cell Reports
Date: Mar 25 2025

Catalytic-Dependent Role of DNA Polymerase κ in Nucleotide Excision Repair
Abbey Rebok, Mariela C. Torres, Julia R. Ambrose, Thomas E. Spratt, 2025, In: Chemical research in toxicology
Date: 2025

Repair Mechanisms and Initiation in Carcinogenesis
Abbey M. Rebok, Thomas E. Spratt, Jan 1 2025, In: Comprehensive Toxicology
Date: Jan 1 2025

Activity of DNA polymerase κ across the genome in human fibroblasts
Mariela C. Torres, Abbey Rebok, Dongxiao Sun, Thomas E. Spratt, Jul 9 2024, In: Proceedings of the National Academy of Sciences of the United States of America
Date: Jul 9 2024

Stephen S. Hecht Has Played a Major Role in Investigating Tobacco Carcinogenesis
Thomas E. Spratt, 2023, In: Chemical research in toxicology
Date: 2023

Active Site Interactions Impact Phosphoryl Transfer during Replication of Damaged and Undamaged DNA by Escherichia coli DNA Polymerase i
A. S. Prakasha Gowda, Thomas E. Spratt, Nov 20 2017, In: Chemical research in toxicology
Date: Nov 20 2017

Mutagenic Replication of N²-Deoxyguanosine Benzo[a]pyrene Adducts by Escherichia coli DNA Polymerase i and Sulfolobus solfataricus DNA Polymerase IV
A. S.Prakasha Gowda, Jacek Krzeminski, Shantu Amin, Zucai Suo, Thomas E. Spratt, May 15 2017, In: Chemical research in toxicology
Date: May 15 2017

N²-Substituted 2′-Deoxyguanosine Triphosphate Derivatives as Selective Substrates for Human DNA Polymerase κ
A. S.Prakasha Gowda, Marietta Lee, Thomas E. Spratt, Mar 1 2017, In: Angewandte Chemie - International Edition
Date: Mar 1 2017

Honokiol Inhibits DNA Polymerases β and λ and Increases Bleomycin Sensitivity of Human Cancer Cells
A. S.Prakasha Gowda, Zucai Suo, Thomas E. Spratt, Feb 20 2017, In: Chemical research in toxicology
Date: Feb 20 2017

DNA Polymerase ν Rapidly Bypasses O⁶-Methyl-dG but Not O⁶-[4-(3-Pyridyl)-4-oxobutyl-dG and O²-Alkyl-dTs
A. S.Prakasha Gowda, Thomas E. Spratt, Nov 21 2016, In: Chemical research in toxicology
Date: Nov 21 2016

Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress
Y. Cheng, X. Ren, A. S.P. Gowda, Y. Shan, L. Zhang, Y. S. Yuan, R. Patel, H. Wu, K. Huber-Keener, J. W. Yang, D. Liu, T. E. Spratt, J. M. Yang, Jul 2013, In: Cell Death and Disease
Citations: 203

Evidence for 4-(3-pyridyl)-4-oxobutylation of DNA in F344 rats treated with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and n'-nitrosonornicotine
Stephen S. Hecht, Thomas E. Spratt, Neil Trushin, Jan 1988, In: Carcinogenesis
Citations: 131

Pyridyloxobutyl adduct O⁶-[4-oxo-4-(3-pyridyl)butyl]guanine is present in 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone-treated DNA and is a substrate for O⁶-alkylguanine-DNA alkyltransferase
Lijuan Wang, Thomas E. Spratt, Xiao Keng Liu, Stephen S. Hecht, Anthony E. Pegg, Lisa A. Peterson, May 1997, In: Chemical research in toxicology
Citations: 106

In vitro epsilon RNA-dependent protein priming activity of human hepatitis B virus polymerase
Scott A. Jones, Rajeev Boregowd, Thomas E. Spratt, Jianming Hu, May 2012, In: Journal of virology
Citations: 75

An unprecedented nucleic acid capture mechanism for excision of DNA damage
Emily H. Rubinson, A. S.Prakasha Gowda, Thomas E. Spratt, Barry Gold, Brandt F. Eichman, Nov 18 2010, In: Nature
Citations: 68

Identification of hydrogen bonds between Escherichia coli DNA polymerase I (Klenow fragment) and the minor groove of DNA by amino acid substitution of the polymerase and atomic substitution of the DNA
T. E. Spratt, Mar 6 2001, In: Biochemistry
Citations: 66

Different mechanisms for the photoinduced production of oxidative dna damage by fluoroquinolones differing in photostability
Thomas E. Spratt, Sherri S. Schultz, Douglas E. Levy, Di Chen, Gerhardt Schlüter, Gary M. Williams, 1999, In: Chemical research in toxicology
Citations: 61

Glucuronidation of tobacco-specific nitrosamines by UGT2B10
Gang Chen, Ryan W. Dellinger, Dongxiao Sun, Thomas E. Spratt, Philip Lazarus, May 2008, In: Drug Metabolism and Disposition
Citations: 60

Solvolysis of Model Compounds for α-Hydroxylation of N’-Nitrosonornlcotine and 4-(Methylnitrosamino)-1-(3-pyrldyl)-1-butanone
Thomas E. Spratt, Lisa A. Peterson, William L. Confer, Stephen S. Hecht, 1990, In: Chemical research in toxicology
Citations: 53

Evidence for a Watson-Crick hydrogen bonding requirement in DNA synthesis by human DNA polymerase κ
William T. Wolfle, M. Todd Washington, Eric T. Kool, Thomas E. Spratt, Sandra A. Helquist, Louise Prakash, Satya Prakash, Aug 2005, In: Molecular and cellular biology
Citations: 52

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