Faculty

Ramesh Ramachandran

Professor of Molecular Endocrinology

Wm Henning Bldg
University Park

Email rur11@psu.edu
Phone 814-865-5202

Overview

The influence of hypothalamic neurotransmitters, hormones, and their receptors on avian reproduction.

Areas of Expertise

Chicken Keyphrases
Adiponectin Keyphrases
Broiler Chicken Veterinary Science and Veterinary Medicine
Pituitary Gland Veterinary Science and Veterinary Medicine
Broiler Breeder Hen Keyphrases
Turkey (Bird) Veterinary Science and Veterinary Medicine
Metformin Keyphrases
Gene Expression Keyphrases

Metformin alters liver metabolism to sustain egg production in the reproductively aging broiler breeder hen
Evelyn Anne Weaver, Nathan Patrick Connolly, Tae Hyun Kim, Ramesh Ramachandran, Jul 1 2025, In: Biology of reproduction
Date: Jul 1 2025

Metformin improves ovarian function and increases egg production in broiler breeder hens
Evelyn A. Weaver, Ramesh Ramachandran, Mar 2023, In: Reproduction
Date: Mar 2023

Feeding laying hens docosa hexaenoic acid-rich microalgae oil at 40 g/kg diet causes hypotriglyceridemia, depresses egg production, and attenuates expression of key genes affecting hepatic triglyceride synthesis and secretion, but is rescued by dietary co-supplementation of high-oleic sunflower oil
Robert G. Elkin, Ahmed S.A. El-Zenary, Rebecca Bomberger, Abiel B. Haile, Evelyn A. Weaver, Ramesh Ramachandran, Kevin J. Harvatine, Feb 2023, In: Poultry science
Date: Feb 2023

Metformin modulates the gut microbiome in broiler breeder hens
Emily Van Syoc, Evelyn Weaver, Connie J. Rogers, Justin D. Silverman, Ramesh Ramachandran, Erika Ganda, Sep 14 2022, In: Frontiers in Physiology
Date: Sep 14 2022

Ad libitum feeding alters mRNA abundance in the ovarian cortex of broiler breeder hens
Kate Anthony, Tyler Bruce Garner, Ramesh Ramachandran, Francisco Javier Diaz, Apr 2022, In: Reproduction and Fertility
Date: Apr 2022

Metformin affects the transcriptomic profile of chicken ovarian cancer cells
Lalitha Gopalan, Aswathy Sebastian, Craig A. Praul, Istvan Albert, Ramesh Ramachandran, Jan 2022, In: Genes
Date: Jan 2022

Evaluation of the central effects of systemic lentiviral-mediated leptin delivery in streptozotocin-induced diabetic rats
Kimberly A. Clark, Andrew C. Shin, Madhu P. Sirivelu, Ramya C. Mohankumar, Sreenivasa R. Maddineni, Ramesh Ramachandran, Puliyur S. Mohankumar, Sheba M.J. Mohankumar, Dec 1 2021, In: International journal of molecular sciences
Date: Dec 1 2021

Metformin attenuates steroidogenesis in ovarian follicles of the broiler breeder hen
Evelyn A. Weaver, Ramesh Ramachandran, Nov 2020, In: Reproduction
Date: Nov 2020

Should I Lay or Should I Grow
Charlene Hanlon, Ramesh Ramachandran, Martin J. Zuidhof, Grégoy Y. Bédécarrats, Jun 26 2020, In: Frontiers in Physiology
Date: Jun 26 2020

Adiponectin and its receptor genes' expression in response to Marek's disease virus infection of White Leghorns
Ying Bai, Ping Yuan, Huanmin Zhang, Ramesh Ramachandran, Ning Yang, Jiuzhou Song, 2020, In: Poultry science
Date: 2020

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Mice lacking D<sub>5</sub> dopamine receptors have increased sympathetic tone and are hypertensive
Tom R. Hollon, Martin J. Bek, Jean E. Lachowicz, Marjorie A. Ariano, Eva Mezey, Ramesh Ramachandran, Scott R. Wersinger, Patricio Soares-da-Silva, Zhi Fang Liu, Alexander Grinberg, John Drago, W. Scott Young, Heiner Westphal, Pedro A. Jose, David R. Sibley, Dec 15 2002, In: Journal of Neuroscience
Citations: 145

Adiponectin gene is expressed in multiple tissues in the chicken
Sreenivasa Maddineni, Shana Metzger, Olga Ocón, Gilbert Hendricks, Ramesh Ramachandran, Oct 2005, In: Endocrinology
Citations: 120

Gonadotropin-inhibitory hormone (GnIH) receptor gene is expressed in the chicken ovary
Sreenivasa R. Maddineni, Olga M. Ocón-Grove, Susan M. Krzysik-Walker, Gilbert L. Hendricks, Ramesh Ramachandran, Feb 2008, In: Reproduction
Citations: 98

Characterization of the AMP-activated protein kinase pathway in chickens
Monika Proszkowiec-Weglarz, Mark P. Richards, Ramesh Ramachandran, John P. McMurtry, Jan 2006, In: Comparative Biochemistry and Physiology Part - B: Biochemistry and Molecular Biology
Citations: 84

Is visfatin an adipokine or myokine? Evidence for greater visfatin expression in skeletal muscle than visceral fat in chickens
Susan M. Krzysik-Walker, Olga M. Ocón-Grove, Sreenivasa R. Maddineni, Gilbert L. Hendricks, Ramesh Ramachandran, Apr 2008, In: Endocrinology
Citations: 83

Molecular cloning and tissue expression of chicken AdipoR1 and AdipoR2 complementary deoxyribonucleic acids
Ramesh Ramachandran, Olga M. Ocón-Grove, Shana L. Metzger, Jul 2007, In: Domestic Animal Endocrinology
Citations: 82

Adiponectin and its receptors are expressed in the chicken testis
Olga M. Ocón-Grove, Susan M. Krzysik-Walker, Sreenivasa R. Maddineni, Gilbert L. Hendricks, Ramesh Ramachandran, Nov 2008, In: Reproduction
Citations: 79

Gonadotrophin-Inhibitory hormone receptor expression in the chicken pituitary gland
S. Maddineni, O. M. Ocón-grove, S. M. Krzysik-Walker, G. L. Hendricks, J. A. Proudman, Ramesh Ramachandran, 2008, In: Journal of Neuroendocrinology
Citations: 78

Gonadotropin-inhibitory hormone receptor signaling and its impact on reproduction in chickens
Grégoy Y. Bédécarrats, Heather McFarlane, Sreenivasa R. Maddineni, Ramesh Ramachandran, Sep 1 2009, In: General and Comparative Endocrinology
Citations: 72

Unique profile of chicken adiponectin, a predominantly heavy molecular weight multimer, and relationship to visceral adiposity
Gilbert L. Hendricks, Jill A. Hadley, Susan M. Krzysik-Walker, K. Sandeep Prabhu, Regina Vasilatos-Younken, Ramesh Ramachandran, Jul 2009, In: Endocrinology
Citations: 54

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Centers & Institutes