Faculty

Nanyin Zhang

Huck Chair in Brain Imaging
Professor of Bioengineering
Huck Co-Hire with College of Engineering

W341 Millennium Science Building
University Park, PA

Email nuz2@psu.edu
Phone 814-867-4791

Overview

Investigating the pathophysiology of brain disorders using neuroimaging, behavioral and optogenetic methods.

Areas of Expertise

Functional Magnetic Resonance Imaging Neuroscience
Functional Magnetic Resonance Imaging Keyphrases
Functional Connectivity Neuroscience
Awake Rat Keyphrases
Resting-state Functional Connectivity Keyphrases
Functional Connectivity Keyphrases
Resting-State Functional Connectivity Neuroscience
Rat Brain Keyphrases

Machine Learning-Enhanced Hyperspectral Raman Imaging for Label-Free Molecular Atlas of Alzheimer’s Brain
Ziyang Wang, Jeewan C. Ranasinghe, Dennis C.Y. Chan, Ashley Gomm, Rudolph E. Tanzi, Can Zhang, Nanyin Zhang, Shengxi Huang, Jan 14 2026, In: ACS Applied Materials and Interfaces
Date: Jan 14 2026

3D-Printable, Honeycomb-Inspired Tissue-Like Bioelectrodes for Patient-Specific Neural Interface
Marzia Momin, Luyi Feng, Xiaoai Chen, Salahuddin Ahmed, Basma AlMahmood, Li Pang Huang, Jiashu Ren, Xinyi Wang, Hyunjin Lee, Samuel R. Cramer, Nanyin Zhang, Sulin Zhang, Tao Zhou, 2026, In: Advanced Materials
Date: 2026

Functional MRI reveals regional changes of brain activity in rats following longitudinal focal high-density theta burst stimulation (hdTBS)
Charlotte Qiong Li, Samantha Hoffman, Hieu Nguyen, Antonia Vrana, Aidan Carney, Ying Duan, Zilu Ma, Nanyin Zhang, Yihong Yang, Hanbing Lu, Jul 25 2025, In: Imaging Neuroscience
Date: Jul 25 2025

Charting the path in rodent functional neuroimaging
Alessandro Gozzi, Alexia Stuefer, Filomena Grazia Alvino, Valeria Bedin, Christopher Cover, Chaewon Kang, Alberto Galbusera, Rita Gil, Silvia Gini, Elizabeth de Guzman, Gabriel Desrosiers-Grégoire, Daniel Gutierrez-Barragan, Francesca Mandino, Jean Charles Mariani, Edoardo Micotti, Henning Reimann,..., May 28 2025, In: Imaging Neuroscience
Date: May 28 2025

Sex-specific signatures of GLP-1 and amylin on resting state brain activity and functional connectivity in awake rats
Tanzil M. Arefin, Stina Börchers, Doris Olekanma, Samuel R. Cramer, Morgan R. Sotzen, Nanyin Zhang, Karolina P. Skibicka, May 15 2025, In: Neuropharmacology
Date: May 15 2025

Machine Learning Interpretation of Optical Spectroscopy Using Peak-Sensitive Logistic Regression
Ziyang Wang, Jeewan C. Ranasinghe, Wenjing Wu, Dennis C.Y. Chan, Ashley Gomm, Rudolph E. Tanzi, Can Zhang, Nanyin Zhang, Genevera I. Allen, Shengxi Huang, Apr 29 2025, In: ACS nano
Date: Apr 29 2025

Neuroimaging Model of Visceral Manipulation in an Awake Rat
Samuel R. Cramer, Xu Han, Dennis C.Y. Chan, Thomas Neuberger, Nanyin Zhang, Feb 26 2025, In: Journal of Neuroscience
Date: Feb 26 2025

Sequential Deactivation Across the Hippocampus-Thalamus-mPFC Pathway During Loss of Consciousness
Xiaoai Chen, Samuel R. Cramer, Dennis C.Y. Chan, Xu Han, Nanyin Zhang, Nov 13 2024, In: Advanced Science
Date: Nov 13 2024

Multiparametric Brain Hemodynamics Imaging Using a Combined Ultrafast Ultrasound and Photoacoustic System
Haoyang Chen, Shubham Mirg, Prameth Gaddale, Sumit Agrawal, Menghan Li, Van Nguyen, Tianbao Xu, Qiong Li, Jinyun Liu, Wenyu Tu, Xiao Liu, Patrick J. Drew, Nanyin Zhang, Bruce J. Gluckman, Sri Rajasekhar Kothapalli, 2024, In: Advanced Science
Date: 2024

Biodegradable Citrate-Based Polymers Enable 5D Monitoring of Implant Evolution
Dingying Shan, Dingbowen Wang, Yuncong Ma, Zhifeng Liang, Dino J. Ravnic, Nanying Zhang, Jian Yang, 2024, In: Advanced Functional Materials
Date: 2024

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Rodent models of post-traumatic stress disorder
Alexander Verbitsky, David Dopfel, Nanyin Zhang, Dec 1 2020, In: Translational psychiatry
Citations: 211

Tightly coupled brain activity and cerebral ATP metabolic rate
Fei Du, Xiao Hong Zhu, Yi Zhang, Michael Friedman, Nanyin Zhang, Kâmil Uǧurbil, Wei Chen, Apr 29 2008, In: Proceedings of the National Academy of Sciences of the United States of America
Citations: 197

Co-activation patterns in resting-state fMRI signals
Xiao Liu, Nanyin Zhang, Catie Chang, Jeff H. Duyn, Jan 1 2018, In: NeuroImage
Citations: 186

Time to wake up
Yu Rong Gao, Yuncong Ma, Qingguang Zhang, Aaron T. Winder, Zhifeng Liang, Lilith Antinori, Patrick J. Drew, Nanyin Zhang, Apr 29 2016, In: NeuroImage
Citations: 173

Uncovering intrinsic connectional architecture of functional networks in awake rat brain
Zhifeng Liang, Jean King, Nanyin Zhang, Mar 9 2011, In: Journal of Neuroscience
Citations: 166

Intrinsic organization of the anesthetized brain
Zhifeng Liang, Jean King, Nanyin Zhang, Jul 25 2012, In: Journal of Neuroscience
Citations: 143

Development of <sup>17</sup>O NMR approach for fast imaging of cerebral metabolic rate of oxygen in rat brain at high field
Xiao Hong Zhu, Yi Zhang, Run Xia Tian, Hao Lei, Nanyin Zhang, Xiaoliang Zhang, Hellmut Merkle, Kamil Ugurbil, Wei Chen, Oct 1 2002, In: Proceedings of the National Academy of Sciences of the United States of America
Citations: 129

Anticorrelated resting-state functional connectivity in awake rat brain
Zhifeng Liang, Jean King, Nanyin Zhang, Jan 16 2012, In: NeuroImage
Citations: 125

In vivo <sup>17</sup>O NMR approaches for brain study at high field
Xiao Hong Zhu, Nanyin Zhang, Yi Zhang, Xiaoliang Zhang, Kamil Ugurbil, Wei Chen, Apr 2005, In: NMR in Biomedicine
Citations: 111

Mapping resting-state brain networks in conscious animals
Nanyin Zhang, Pallavi Rane, Wei Huang, Zhifeng Liang, David Kennedy, Jean A. Frazier, Jean King, Jun 2010, In: Journal of Neuroscience Methods
Citations: 110

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Centers & Institutes