Faculty

Laura Carrel

Professor of Biochemistry and Molecular Biology

Hershey Med Ctr
University Park

Email luc3@psu.edu

Overview

Genetic, epigenetic, and genomic regulation of expression on the mammalian X chromosome.

Areas of Expertise

X-Inactivation Biochemistry, Genetics and Molecular Biology
X Chromosome Biochemistry, Genetics and Molecular Biology
X Chromosome Keyphrases
X-inactivation Keyphrases
X Chromosome Inactivation Keyphrases
Inactive X Chromosome Keyphrases
Chromosome Biochemistry, Genetics and Molecular Biology
X-linked Genes Keyphrases

Integrative modeling to improve bleeding risk prediction in adult female hemophilia A carriers
Peter H. Cygan, Elizabeth A. Weidman, Xi Wang, Lan Kong, M. Elaine Eyster, Laura Carrel, 2026, In: Journal of Thrombosis and Haemostasis
Date: 2026

Integrating axis quantitative trait loci looks beyond cell types and offers insights into brain-related traits
Lida Wang, Shuang Gao, Siyuan Chen, Havell Markus, Gao Wang, Laura Carrel, Xiang Zhan, Dajiang J. Liu, Bibo Jiang, Dec 2025, In: Nature communications
Date: Dec 2025

Integrating electronic health records and GWAS summary statistics to predict the progression of autoimmune diseases from preclinical stages
Chen Wang, Havell Markus, Avantika R. Diwadkar, Chachrit Khunsriraksakul, Laura Carrel, Bingshan Li, Xue Zhong, Xingyan Wang, Xiaowei Zhan, Galen T. Foulke, Nancy Olsen, Dajiang Liu, Bibo Jiang, Dec 2025, In: Nature communications
Date: Dec 2025

An atlas of single-cell eQTLs dissects autoimmune disease genes and identifies novel drug classes for treatment
Lida Wang, Havell Markus, Dieyi Chen, Siyuan Chen, Fan Zhang, Shuang Gao, Chachrit Khunsriraksakul, Fang Chen, Nancy Olsen, Galen Foulke, Bibo Jiang, Laura Carrel, Dajiang J. Liu, Apr 9 2025, In: Cell Genomics
Date: Apr 9 2025

Complete sequencing of ape genomes
Dong Ahn Yoo, Arang Rhie, Prajna Hebbar, Francesca Antonacci, Glennis A. Logsdon, Steven J. Solar, Dmitry Antipov, Brandon D. Pickett, Yana Safonova, Francesco Montinaro, Yanting Luo, Joanna Malukiewicz, Jessica M. Storer, Jiadong Lin, Abigail N. Sequeira, Riley J. Mangan, Glenn Hickey, Graciela Mon..., 2025, In: Nature
Date: 2025

Patterns of X-linked inheritance
Sanjana Basava, Charles J. Billington, Laura Carrel, Leslie G. Biesecker, William B. Dobyns, 2025, In: Genetics in Medicine
Date: 2025

Dissecting heritability, environmental risk, and air pollution causal effects using > 50 million individuals in MarketScan
Daniel McGuire, Havell Markus, Lina Yang, Jingyu Xu, Austin Montgomery, Arthur Berg, Qunhua Li, Laura Carrel, Dajiang J. Liu, Bibo Jiang, Dec 2024, In: Nature communications
Date: Dec 2024

Integrating single cell expression quantitative trait loci summary statistics to understand complex trait risk genes
Lida Wang, Chachrit Khunsriraksakul, Havell Markus, Dieyi Chen, Fan Zhang, Fang Chen, Xiaowei Zhan, Laura Carrel, Dajiang J. Liu, Bibo Jiang, Dec 2024, In: Nature communications
Date: Dec 2024

The complete sequence and comparative analysis of ape sex chromosomes
Kateryna D. Makova, Brandon D. Pickett, Robert S. Harris, Gabrielle A. Hartley, Monika Cechova, Karol Pal, Sergey Nurk, Dong Ahn Yoo, Qiuhui Li, Prajna Hebbar, Barbara C. McGrath, Francesca Antonacci, Margaux Aubel, Arjun Biddanda, Matthew Borchers, Erich Bornberg-Bauer, Gerard G. Bouffard, Shelise ..., Jun 13 2024, In: Nature
Date: Jun 13 2024

Multi-ancestry and multi-trait genome-wide association meta-analyses inform clinical risk prediction for systemic lupus erythematosus
Chachrit Khunsriraksakul, Qinmengge Li, Havell Markus, Matthew T. Patrick, Renan Sauteraud, Daniel McGuire, Xingyan Wang, Chen Wang, Lida Wang, Siyuan Chen, Ganesh Shenoy, Bingshan Li, Xue Zhong, Nancy J. Olsen, Laura Carrel, Lam C. Tsoi, Bibo Jiang, Dajiang J. Liu, Dec 2023, In: Nature communications
Date: Dec 2023

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X-inactivation profile reveals extensive variability in X-linked gene expression in females
Laura Carrel, Huntington F. Willard, Mar 17 2005, In: Nature
Citations: 1,765

The DNA sequence of the human X chromosome
Mark T. Ross, Darren V. Grafham, Alison J. Coffey, Steven Scherer, Kirsten McLay, Donna Muzny, Matthias Platzer, Gareth R. Howell, Christine Burrows, Christine P. Bird, Adam Prankish, Frances L. Lovell, Kevin L. Howe, Jennifer L. Ashurst, Robert S. Fulton, Ralf Sudbrak, Gaiping Wen, Matthew C. Jones..., Mar 17 2005, In: Nature
Citations: 923

Molecular evidence for a relationship between LINE-1 elements and X chromosome inactivation
Jeffrey A. Bailey, Laura Carrel, Aravinda Chakravarti, Evan E. Eichler, Jun 6 2000, In: Proceedings of the National Academy of Sciences of the United States of America
Citations: 362

A first-generation X-inactivation profile of the human X chromosome
Laura Carrel, Amy A. Cottle, Karrie C. Goglin, Huntington F. Willard, Dec 7 1999, In: Proceedings of the National Academy of Sciences of the United States of America
Citations: 322

Genes that escape from X inactivation
Joel B. Berletch, Fan Yang, Jun Xu, Laura Carrel, Christine M. Disteche, Aug 2011, In: Human genetics
Citations: 300

The UTX gene escapes X inactivation in mice and humans
Andy Greenfield, Laura Carrel, David Pennisi, Christophe Philippe, Nandita Quaderi, Pamela Siggers, Kirsten Steiner, Patrick P.L. Tam, Anthony P. Monaco, Huntington F. Willard, Peter Koopman, Apr 1998, In: Human molecular genetics
Citations: 230

Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation
Aaron Y.L. Cheung, Lindsay M. Horvath, Daria Grafodatskaya, Peter Pasceri, Rosanna Weksberg, Akitsu Hotta, Laura Carrel, James Ellis, Jun 2011, In: Human molecular genetics
Citations: 229

Heterogeneous gene expression from the inactive X chromosome
Laura Carrel, Huntington F. Willard, Jun 22 1999, In: Proceedings of the National Academy of Sciences of the United States of America
Citations: 138

An ectopic human XIST gene can induce chromosome inactivation in postdifferentiation human HT-1080 cells
Lisa L. Hall, Meg Byron, Kosuke Sakai, Laura Carrel, Huntington F. Willard, Jeanne B. Lawrence, Jun 25 2002, In: Proceedings of the National Academy of Sciences of the United States of America
Citations: 116

A novel transmembrane transporter encoded by the XPCT gene in xq13.2
Ronald G. Lafrenière, Laura Carrel, Huntington F. Willard, Jul 1994, In: Human molecular genetics
Citations: 105

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Centers & Institutes