Faculty

Keith Cheng

Distinguished Professor of Pathology and Laboratory Medicine, of Biochemistry and Molecular Biology, and of Pharmacology

H059 Pathology
Hershey, PA

Email kcc2@psu.edu
Phone 717-531-5635

Overview

Computational phenomics, image informatics, and "Geometry of Life" based on x-ray histotomography, population, genomic, and functional genomic analyses of complex traits in human and zebrafish; web-based science resources.

Areas of Expertise

Zebrafish Keyphrases
Zebra Fish Biochemistry, Genetics and Molecular Biology
Histology Keyphrases
Genetics Biochemistry, Genetics and Molecular Biology
Zebrafish (Danio Rerio) Embryo Keyphrases
Pigmentation Biochemistry, Genetics and Molecular Biology
Microcomputed Tomography Keyphrases
Skin Color Biochemistry, Genetics and Molecular Biology

A web-based histology atlas for the freshwater sentinel species Daphnia magna
Mee S. Ngu, Daniel J. Vanselow, Carolyn R. Zaino, Alex Y. Lin, Jean E. Copper, Margaret J. Beaton, Luisa Orsini, John K. Colbourne, Keith Cheng, Khai C. Ang, Jan 1 2025, In: Science of the Total Environment
Date: Jan 1 2025

Developmental mouse brain common coordinate framework
Fae N. Kronman, Josephine K. Liwang, Rebecca Betty, Daniel J. Vanselow, Yuan Ting Wu, Nicholas J. Tustison, Ashwin Bhandiwad, Steffy B. Manjila, Jennifer A. Minteer, Donghui Shin, Choong Heon Lee, Rohan Patil, Jeffrey T. Duda, Jian Xue, Yingxi Lin, Keith C. Cheng, Luis Puelles, James C. Gee, Jiangya..., Dec 2024, In: Nature communications
Date: Dec 2024

Staining and resin embedding of whole Daphnia magna samples for micro-CT imaging enabling 3D visualization of cells, tissues, and organs
Mee S. Ngu, Daniel J. Vanselow, Andrew L. Sugarman, Rachelle A. Saint-Fort, Carolyn R. Zaino, Maksim A. Yakovlev, Keith C. Cheng, Khai C. Ang, Nov 2024, In: PloS one
Date: Nov 2024

Monitoring mouse papillomavirus-associated cancer development using longitudinal Pap smear screening
Hannah M. Atkins, Aysegul Aksakal Uslu, Jingwei J. Li, Debra A. Shearer, Sarah A. Brendle, Chen Han, Michael Kozak, Paul Lopez, Deesha Nayar, Karla K. Balogh, Catherine Abendroth, Jean Copper, Keith C. Cheng, Neil D. Christensen, Yusheng Zhu, Stefanie Avril, Adam D. Burgener, Thomas T. Murooka, Jiaf..., Aug 14 2024, In: mBio
Date: Aug 14 2024

Prehistoric human migration between Sundaland and South Asia was driven by sea-level rise
Hie Lim Kim, Tanghua Li, Namrata Kalsi, Hung Tran The Nguyen, Timothy A. Shaw, Khai C. Ang, Keith C. Cheng, Aakrosh Ratan, W. Richard Peltier, Dhrubajyoti Samanta, Mahesh Pratapneni, Stephan C. Schuster, Benjamin P. Horton, Dec 2023, In: Communications Biology
Date: Dec 2023

Sinogram domain angular upsampling of sparse-view micro-CT with dense residual hierarchical transformer and attention-weighted loss
Amogh Subbakrishna Adishesha, Daniel J. Vanselow, Patrick La Riviere, Keith C. Cheng, Sharon X. Huang, Dec 2023, In: Computer Methods and Programs in Biomedicine
Date: Dec 2023

Native American genetic ancestry and pigmentation allele contributions to skin color in a Caribbean population
Khai C. Ang, Victor A. Canfield, Tiffany C. Foster, Thaddeus D. Harbaugh, Kathryn A. Early, Rachel L. Harter, Katherine P. Reid, Shou Ling Leong, Yuka I. Kawasawa, Dajiang J. Liu, John W. Hawley, Keith C. Cheng, Jun 9 2023, In: eLife
Date: Jun 9 2023

Promoting validation and cross-phylogenetic integration in model organism research
Keith C. Cheng, Rebecca D. Burdine, Mary E. Dickinson, Stephen C. Ekker, Alex Y. Lin, K. C.Kent Lloyd, Cathleen M. Lutz, Calum A. MacRae, John H. Morrison, David H. O'Connor, John H. Postlethwait, Crystal D. Rogers, Susan Sanchez, Julie H. Simpson, William S. Talbot, Douglas C. Wallace, Jill M. Weim..., Sep 2022, In: DMM Disease Models and Mechanisms
Date: Sep 2022

Whole-Brain Wiring Diagram of Oxytocin System in Adult Mice
Seoyoung Son, Steffy B. Manjila, Kyra T. Newmaster, Yuan Ting Wu, Daniel J. Vanselow, Matt Ciarletta, Todd E. Anthony, Keith C. Cheng, Yongsoo Kim, Jun 22 2022, In: Journal of Neuroscience
Date: Jun 22 2022

Quantitative relationship between cerebrovascular network and neuronal cell types in mice
Yuan ting Wu, Hannah C. Bennett, Uree Chon, Daniel J. Vanselow, Qingguang Zhang, Rodrigo Muñoz-Castañeda, Keith C. Cheng, Pavel Osten, Patrick J. Drew, Yongsoo Kim, Jun 21 2022, In: Cell Reports
Date: Jun 21 2022

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8-hydroxyguanine, an abundant form of oxidative DNA damage, causes G → T and A → C substitutions
Keith Cheng, D. S. Cahill, H. Kasai, S. Nishimura, L. A. Loeb, 1992, In: Journal of Biological Chemistry
Citations: 1,823

Genetics
Rebecca L. Lamason, Manzoor Ali P.K. Mohideen, Jason R. Mest, Andrew C. Wong, Heather L. Norton, Michele C. Aros, Michael J. Jurynec, Xianyun Mao, Vanessa R. Humphreville, Jasper E. Humbert, Soniya Sinha, Jessica L. Moore, Pudur Jagadeeswaran, Wei Zhao, Gang Ning, Izabela Makalowska, Paul M. McKeigu..., Dec 16 2005, In: Science
Citations: 923

The GenomeAsia 100K Project enables genetic discoveries across Asia
Jeffrey D. Wall, Eric W. Stawiski, Aakrosh Ratan, Hie Lim Kim, Changhoon Kim, Ravi Gupta, Kushal Suryamohan, Elena S. Gusareva, Rikky Wenang Purbojati, Tushar Bhangale, Vadim Stepanov, Vladimir Kharkov, Markus S. Schröder, Vedam Ramprasad, Jennifer Tom, Steffen Durinck, Qixin Bei, Jiani Li, Joseph ..., Dec 5 2019, In: Nature
Citations: 371

Genetic evidence for the convergent evolution of light skin in Europeans and East Asians
Heather L. Norton, Rick A. Kittles, Esteban Parra, Paul McKeigue, Xianyun Mao, Keith Cheng, Victor A. Canfield, Daniel G. Bradley, Brian McEvoy, Mark D. Shriver, Mar 2007, In: Molecular biology and evolution
Citations: 328

Life spans and senescent phenotypes in two strains of Zebrafish (Danio rerio)
Glenn S. Gerhard, Elizabeth J. Kauffman, Xujun Wang, Richard Stewart, Jessica L. Moore, Claudia J. Kasales, Eugene Demidenko, Keith C. Cheng, Aug 2002, In: Experimental Gerontology
Citations: 235

Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes
An Chi, Julio C. Valencia, Zhang Zhi Hu, Hidenori Watabe, Hiroshi Yamaguchi, Nancy J. Mangini, Hongzhan Huang, Victor A. Canfield, Keith C. Cheng, Feng Yang, Riichiro Abe, Shoichi Yamagishi, Jeffrey Shabanowitz, Vincent J. Hearing, Cathy Wu, Ettore Appella, Donald F. Hunt, Nov 2006, In: Journal of Proteome Research
Citations: 176

Genomic instability and tumor progression
Keith C. Cheng, Lawrence A. Loeb, 1993, In: Advances in Cancer Research
Citations: 172

The vinyl chloride DNA derivative N<sup>2</sup>,3-ethenoguanine produces G → A transitions in Escherichia coli
K. C. Cheng, B. D. Preston, D. S. Cahill, M. K. Dosanjh, B. Singer, L. A. Loeb, 1991, In: Proceedings of the National Academy of Sciences of the United States of America
Citations: 154

Dual mechanism of brain injury and novel treatment strategy in maple syrup urine disease
William J. Zinnanti, Jelena Lazovic, Kathleen Griffin, Kristen J. Skvorak, Harbhajan S. Paul, Gregg E. Homanics, Maria C. Bewley, Keith C. Cheng, Kathryn F. Lanoue, John M. Flanagan, Apr 2009, In: Brain
Citations: 143

Selective synthetic augmentation with HistoGAN for improved histopathology image classification
Yuan Xue, Jiarong Ye, Qianying Zhou, L. Rodney Long, Sameer Antani, Zhiyun Xue, Carl Cornwell, Richard Zaino, Keith C. Cheng, Xiaolei Huang, Jan 2021, In: Medical Image Analysis
Citations: 139

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