Joseph Wang

Negative cooperativity drives activity of capsid-directed antivirals against hepatitis B virus
Caleb J. Valkner, Nora Gibes, Marina Sicheng Xie, Smita Nair, Shiv Kumar, Samson Francis, Balasubramanian Venkatakrishnan, Irina Tsvetkova, Angela Patterson, Michael VanNieuwenhze, Bogdan Dragnea, Joseph Che Yen Wang, Adam Zlotnick, Jun 2026, In: Science Advances
Date: Jun 2026

Protocol for purifying recombinant HBV capsids from HepG2 cells and comparative phosphorylation analysis by phosphate-affinity SDS-PAGE
Katie Culhane, Shiv Kumar, Jianming Hu, Che-Yen "Joseph" Wang, Mar 20 2026, In: STAR Protocols
Date: Mar 20 2026

Bilayer or Not
Haitao Liu, Sonal Garg, Jianming Hu, Joseph Che Yen Wang, Feb 2025, In: Journal of Medical Virology
Date: Feb 2025

Genetically Engineered, Multichromophore Virus-Like Nanoparticles with Ultranarrow Distribution of Emission Intensity
Irina B. Tsvetkova, Nora Roos, Lohra M. Miller, Nadia DiNunno, Marcel Conrady, Domenic Ebert, Hauke Lilie, Liam W. Scott, Martin F. Jarrold, Joseph Che Yen Wang, Claudia Simon, Bogdan Dragnea, Jan 14 2025, In: ACS nano
Date: Jan 14 2025

Unveiling the Molecular Architecture of HBV Spherical Subviral Particles
Sonal Garg, Alyssa Ochetto, Jianming Hu, Joseph Che Yen Wang, Jan 2025, In: Viruses
Date: Jan 2025

A narrow ratio of nucleic acid to SARS-CoV-2 N-protein enables phase separation
Patrick M. Laughlin, Kimberly Young, Giovanni Gonzalez-Gutierrez, Joseph C.Y. Wang, Adam Zlotnick, Nov 2024, In: Journal of Biological Chemistry
Date: Nov 2024

Charge Detection Mass Spectrometry Reveals Favored Structures in the Assembly of Virus-Like Particles
Lohra M. Miller, Benjamin E. Draper, Joseph C.Y. Wang, Martin F. Jarrold, Aug 13 2024, In: Analytical Chemistry
Date: Aug 13 2024

Cryo-EM structure and molecular dynamic simulations explain the enhanced stability and ATP activity of the pathological chaperonin mutant
Aiza Syed, Jihang Zhai, Baolin Guo, Yuan Zhao, Joseph Che Yen Wang, Lingling Chen, May 2 2024, In: Structure
Date: May 2 2024

Structure of the Hepatitis B virus capsid quasi-6-fold with a trapped C-terminal domain reveals capsid movements associated with domain exit
Christine Kim, Christopher J. Schlicksup, Carolina Pérez-Segura, Jodi A. Hadden-Perilla, Joseph Che Yen Wang, Adam Zlotnick, Sep 2023, In: Journal of Biological Chemistry
Date: Sep 2023

Protein Structure Predictions, Atomic Model Building, and Validation Using a Cryo-EM Density Map from Hepatitis B Virus Spherical Subviral Particle
Nadia DiNunno, Emily N. Bianchini, Haitao Liu, Joseph Che Yen Wang, Jul 20 2023, In: Bio-protocol
Date: Jul 20 2023

Retraction of DNA-bound type IV competence pili initiates DNA uptake during natural transformation in Vibrio cholerae
Courtney K. Ellison, Triana N. Dalia, Alfredo Vidal Ceballos, Joseph Che Yen Wang, Nicolas Biais, Yves V. Brun, Ankur B. Dalia, Jul 1 2018, In: Nature Microbiology
Citations: 209

Structure of hepatitis E virion-sized particle reveals an RNA-dependent viral assembly pathway
Li Xing, Tian Cheng Li, Naoyuki Mayazaki, Martha N. Simon, Joseph S. Wall, Mary Moore, Che Yen Wang, Naokazu Takeda, Takaji Wakita, Tatsuo Miyamura, R. Holland Cheng, Oct 22 2010, In: Journal of Biological Chemistry
Citations: 143

Essential elements of the capsid protein for self-assembly into empty virus-like particles of hepatitis E virus
Tian Cheng Li, Naokazu Takeda, Tatsuo Miyamura, Yoshiharu Matsuura, Joseph C.Y. Wang, Helena Engvall, Lena Hammar, Li Xing, R. Holland Cheng, Oct 2005, In: Journal of virology
Citations: 125

Detection of late intermediates in virus capsid assembly by charge detection mass spectrometry
Elizabeth E. Pierson, David Z. Keifer, Lisa Selzer, Lye Siang Lee, Nathan C. Contino, Joseph C.Y. Wang, Adam Zlotnick, Martin F. Jarrold, Mar 5 2014, In: Journal of the American Chemical Society
Citations: 119

Designing two self-assembly mechanisms into one viral capsid protein
Mark B. Van Eldijk, Joseph C.Y. Wang, Inge J. Minten, Chenglei Li, Adam Zlotnick, Roeland J.M. Nolte, Jeroen J.L.M. Cornelissen, Jan C.M. Van Hest, Nov 14 2012, In: Journal of the American Chemical Society
Citations: 100

Regulation of bronchoalveolar lavage fluids cell function by the immunomodulatory agents from Cordyceps sinensis
Yuh Chi Kuo, Wei Jern Tsai, Jir Yenn Wang, Shi Chung Chang, Ching Yuang Lin, Ming Shi Shiao, Jan 19 2001, In: Life Sciences
Citations: 100

Spatial configuration of hepatitis e virus antigenic domain
Li Xing, Joseph C. Wang, Tian Cheng Li, Yasuhiro Yasutomi, James Lara, Yury Khudyakov, Darren Schofield, Suzanne U. Emerson, Robert H. Purcell, Naokazu Takeda, Tatsuo Miyamura, R. Holland Cheng, Jan 2011, In: Journal of virology
Citations: 94

Hepatitis B virus core protein allosteric modulators can distort and disrupt intact capsids
Christopher John Schlicksup, Joseph Che Yen Wang, Samson Francis, Balasubramanian Venkatakrishnan, William W. Turner, Michael Vannieuwenhze, Adam Zlotnick, Jan 29 2018, In: eLife
Citations: 83

A kinase Chaperones Hepatitis b virus capsid assembly and captures capsid dynamics in vitro
Chao Chen, Joseph Che Yen Wang, Adam Zlotnick, Nov 2011, In: PLoS pathogens
Citations: 70

Differential assembly of Hepatitis B Virus core protein on single- and double-stranded nucleic acid suggest the dsDNA-filled core is spring-loaded
Mary S. Dhason, Joseph C.Y. Wang, Michael F. Hagan, Adam Zlotnick, Aug 15 2012, In: Virology
Citations: 66

Centers & Institutes

• One Health Microbiome Center

• Cryo-EM Virus Lab
• Department of Cell and Biological Systems
• Elsevier Pure Profile