Cannabinoid-Induced Immunogenic Cell Death of Colorectal Cancer Cells Through De Novo Synthesis of Ceramide Is Partially Mediated by CB2 Receptor
Jeremy A. Hengst, Victor J. Ruiz-Velasco, Wesley M. Raup-Konsavage, Kent E. Vrana, Jong Yun,
Dec 2024,
In: Cancers
Date: Dec 2024
Fanning the Flames of Endoplasmic Reticulum (ER) Stress
Jeremy A. Hengst, Asvelt J. Nduwumwami, Arati Sharma, Jong K. Yun,
Mar 1 2024,
In: Molecular pharmacology
Date: Mar 1 2024
Characterization of Anticancer Effects of the Analogs of DJ4, a Novel Selective Inhibitor of ROCK and MRCK Kinases
Vijay Pralhad Kale, Jeremy A. Hengst, Arati K. Sharma, Upendarrao Golla, Sinisa Dovat, Shantu G. Amin, Jong K. Yun, Dhimant H. Desai,
Aug 2023,
In: Pharmaceuticals
Date: Aug 2023
Regulatory Role of Sphingosine-1-Phosphate and C16:0 Ceramide, in Immunogenic Cell Death of Colon Cancer Cells Induced by Bak/Bax-Activation
Jeremy A. Hengst, Asvelt J. Nduwumwami, Jong K. Yun,
Nov 2022,
In: Cancers
Date: Nov 2022
Inhibition of Sphingosine Kinase Activity Enhances Immunogenic Cell Surface Exposure of Calreticulin Induced by the Synthetic Cannabinoid 5-epi-CP-55,940
Jeremy A. Hengst, Asvelt J. Nduwumwami, Wesley M. Raup-Konsavage, Kent E. Vrana, Jong K. Yun,
Oct 1 2022,
In: Cannabis and Cannabinoid Research
Date: Oct 1 2022
Sphingosine kinase inhibition enhances dimerization of calreticulin at the cell surface in mitoxantrone-induced immunogenic cell death
Asvelt J. Nduwumwami, Jeremy A. Hengst, Jong K. Yun,
Sep 1 2021,
In: Journal of Pharmacology and Experimental Therapeutics
Date: Sep 1 2021
Development of SKI-349, a dual-targeted inhibitor of sphingosine kinase and microtubule polymerization
Jeremy A. Hengst, Shailaja Hegde, Robert F. Paulson, Jong K. Yun,
Oct 15 2020,
In: Bioorganic and Medicinal Chemistry Letters
Date: Oct 15 2020
Analysis of selective target engagement by small-molecule sphingosine kinase inhibitors using the Cellular Thermal Shift Assay (CETSA)
Jeremy A. Hengst, Taryn E. Dick, Charles D. Smith, Jong K. Yun,
2020,
In: Cancer Biology and Therapy
Date: 2020
Transdifferentiation of Human Circulating Monocytes Into Neuronal-Like Cells in 20 Days and Without Reprograming
Alfredo Bellon, Amelie Wegener, Adam R. Lescallette, Michael Valente, Seung Kwon Yang, Robert Gardette, Julien Matricon, Faycal Mouaffak, Paula Watts, Lene Vimeux, Jong K. Yun, Yuka Imamura Kawasawa, Gary A. Clawson, Elisabeta Blandin, Boris Chaumette, Therese M. Jay, Marie Odile Krebs, Vincent Feui...,
Sep 19 2018,
In: Frontiers in Molecular Neuroscience
Date: Sep 19 2018
SKI-178: A multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models
Jeremy Hengst, Taryn E. Dick, Arati Sharma, Kenichiro Doi, Shailaja Hegde, Su Fern Tan, Laura Geffert, Todd E. Fox, Arun K. Sharma, Dhimant Desai, Shantu Amin, Mark Kester, Thomas P. Loughran, Robert Paulson, David Claxton, Hong-Gang Wang, Jong Yun,
2017,
In: Cancer Translational Medicine
Date: 2017
Discovery and evaluation of inhibitors of human sphingosine kinase
Kevin J. French, Randy S. Schrecengost, Brian D. Lee, Yan Zhuang, Staci N. Smith, Justin L. Eberly, Jong K. Yun, Charles D. Smith,
Sep 15 2003,
In: Cancer Research
Citations: 577
Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis
Megan M. Young, Yoshinori Takahashi, Osman Khan, Sungman Park, Tsukasa Hori, Jong Yun, Arun K. Sharma, Shantu Amin, Chang Deng Hu, Jianke Zhang, Mark Kester, Hong Gang Wang,
Apr 6 2012,
In: Journal of Biological Chemistry
Citations: 342
Network model of survival signaling in large granular lymphocyte leukemia
Ranran Zhang, Mithun Vinod Shah, Jun Yang, Susan B. Nyland, Xin Liu, Jong K. Yun, Réka Albert, Thomas P. Loughran,
Oct 21 2008,
In: Proceedings of the National Academy of Sciences of the United States of America
Citations: 323
Encapsulation of organic molecules in calcium phosphate nanocomposite particles for intracellular imaging and drug delivery
Thomas T. Morgan, Hari S. Muddana, Erhan I. Altinoǧlu, Sarah M. Rouse, Amra Tabaković, Tristan Tabouillot, Timothy J. Russin, Sriram S. Shanmugavelandy, Peter J. Butler, Peter C. Eklund, Jong K. Yun, Mark Kester, James H. Adair,
Dec 2008,
In: Nano letters
Citations: 293
Antitumor activity of sphingosine kinase inhibitors
Kevin J. French, John J. Upson, Staci N. Keller, Yan Zhuang, Jong K. Yun, Charles D. Smith,
2006,
In: Journal of Pharmacology and Experimental Therapeutics
Citations: 230
Ceramide directly activates protein kinase C ζ to regulate a stress-activated protein kinase signaling complex
Nicole A. Bourbon, Jong Yun, Mark Kester,
Nov 10 2000,
In: Journal of Biological Chemistry
Citations: 210
Ceramide recruits and activates protein kinase C ζ (PKCζ) within structured membrane microdomains
Todd E. Fox, Kristy L. Houck, Sean M. O'Neill, Murali Nagarajan, Thomas C. Stover, Pawel T. Pomianowski, Onur Unal, Jong K. Yun, Stanley J. Naides, Mark Kester,
Apr 27 2007,
In: Journal of Biological Chemistry
Citations: 173
Acid ceramidase is upregulated in AML and represents a novel therapeutic target
Su Fern Tan, Xin Liu, Todd E. Fox, Brian M. Barth, Arati Sharma, Stephen D. Turner, Andy Awwad, Alden Dewey, Kenichiro Doi, Barbara Spitzer, Mithun Vinod Shah, Samy A.F. Morad, Dhimant Desai, Shantu Amin, Junjia Zhu, Jason Liao, Jong Yun, Mark Kester, David F. Claxton, Hong Gang Wang, Myles C. Cabot...,
2016,
In: Oncotarget
Citations: 88
Adhesion and cytokine production by monocytes on poly(2‐methacryloyloxyethyl phosphorylcholine‐co‐alkyl methacrylate)‐coated polymers
K. M. Defife, J. K. Yun, A. Azeez, S. Stack, K. Ishihara, N. Nakabayashi, E. Colton, J. M. Anderson,
Apr 1995,
In: Journal of Biomedical Materials Research
Citations: 83
Human monocyte/macrophage adhesion and cytokine production on surface‐modified poly(tetrafluoroethylene/hexafluoropropylene) polymers with and without protein preadsorption
J. K. Yun, K. DeFife, E. Colton, S. Stack, A. Azeez, L. Cahalan, M. Verhoeven, P. Cahalan, J. M. Anderson,
Feb 1995,
In: Journal of Biomedical Materials Research
Citations: 68
