PTPR family deletions are associated with greater genomic structural instability in young adult tongue cancer
Pallavi Kulkarni, Kimberly Chan, Christopher Tseng, Emily N. Milarachi, David Goldrich, Brandon LaBarge, Vonn Walter, Neerav Goyal, Joseph M. Curry, Alban Linnenbach, James R. Broach, David Goldenberg,
May 2026,
In: Oral Oncology
Date: May 2026
TDP-43 loss induces cryptic polyadenylation in ALS/FTD
Sam Bryce-Smith, Anna Leigh Brown, Max Z.Y.J. Chien, Dario Dattilo, Puja R. Mehta, Francesca Mattedi, Simone Barattucci, Alla Mikheenko, Matteo Zanovello, Flaminia Pellegrini, Sara Emad El-Agamy, Matthew Yome, Sarah E. Hill, Yue A. Qi, Kai Sun, Eugeni Ryadnov, Yixuan Wan, Mary Rozenman, Daphne Kolle...,
Nov 2025,
In: Nature Neuroscience
Date: Nov 2025
Poor surgical outcomes following Paenibacillus infant infectious hydrocephalus
Jessica E. Ericson, Davis Natukwatsa, Peter Ssenyonga, Justin Onen, John Mugamba, Ronald Mulondo, Sarah U. Morton, Mercedeh Movassagh, Kelsey Templeton, Christine Hehnly, Edith Mbabazi-Kabachelor, Abhaya V. Kulkarni, Benjamin C. Warf, James R. Broach, Joseph N. Paulson, Steven J. Schiff,
Aug 2025,
In: Journal of Neurosurgery: Pediatrics
Date: Aug 2025
Current challenges and potential opportunities for interception and prevention of head and neck cancer
Karam El-Bayoumy, Neil Christensen, James Broach, Craig Meyers, Douglas Stairs, Mitchell Machtay, Jiafen Hu, Zachary T. Bitzer, Todd D. Schell, Kun-Ming Chen, Yuan-Wan Sun, Dhimant Desai, Vonn Walter, Junjia Zhu,
Feb 1 2025,
In: Carcinogenesis
Date: Feb 1 2025
Genome Instability Precedes Viral Integration in Human Papillomavirus–Transformed Tonsillar Keratinocytes
Kimberly Chan, Christopher Tseng, Emily Milarachi, David Goldrich, Lisa Schneper, Kathryn Sheldon, Cesar Aliaga, Samina Alam, Sreejata Chatterjee, Karam El-Bayoumy, Craig Meyers, David Goldenberg, James R. Broach,
Feb 1 2025,
In: Molecular Cancer Research
Date: Feb 1 2025
Critical roles of IKAROS and HDAC1 in regulation of heterochromatin and tumor suppression in T-cell acute lymphoblastic leukemia
Yali Ding, Bing He, Daniel Bogush, Joseph Schramm, Chingakham Singh, Katarina Dovat, Julia Randazzo, Diwakar Tukaramrao, Jeremy Hengst, Charyguly Annageldiyev, Avinash Kudva, Dhimant Desai, Arati Sharma, Vladimir S. Spiegelman, Suming Huang, Chi T. Viet, Glenn Dorsam, Giselle Saulnier Scholler, Jame...,
2025,
In: Leukemia
Date: 2025
A framework for sharing of clinical and genetic data for precision medicine applications
Ahmed Elhussein, Ulugbek Baymuradov, Peter Gregersen, Katharine Nicholson, Kerstin Lindblad-Toh, Orit Rozenblatt-Rosen, Kendall Van Keuren-Jensen, Rita Sattler, Yossef Lerner, Steven Altschuler, Lani Wu, Vilas Menon, Corey McMillan, John Ravits, Vivian Drory, Iris Broce, Brent Harris, Zhang Bin Zhan...,
Dec 2024,
In: Nature Medicine
Date: Dec 2024
Rare variant analyses validate known ALS genes in a multi-ethnic population and identifies ANTXR2 as a candidate in PLS
Tess D. Pottinger, Joshua E. Motelow, Gundula Povysil, Cristiane A.Martins Moreno, Zhong Ren, Hemali Phatnani, Avindra Nath, Joshua Dubnau, Nikolaos A. Patsopoulos, Molly G. Hammell, Terry Heiman-Patterson, Daniel J. MacGowan, Eran Hornstein, Suvankar Pal, Steve Parrott, Siddharthan Chandran, Timoth...,
Dec 2024,
In: BMC genomics
Date: Dec 2024
Mechanism-free repurposing of drugs for C9orf72-related ALS/FTD using large-scale genomic data
Sara Saez-Atienzar, Cleide dos Santos Souza, Ruth Chia, Selina N. Beal, Ileana Lorenzini, Ruili Huang, Jennifer Levy, Camelia Burciu, Jinhui Ding, J. Raphael Gibbs, Ashley Jones, Ramita Dewan, Viviana Pensato, Silvia Peverelli, Lucia Corrado, Joke J.F.A. van Vugt, Wouter van Rheenen, Ceren Tunca, El...,
Nov 13 2024,
In: Cell Genomics
Date: Nov 13 2024
Mitochondrial genome variants associated with amyotrophic lateral sclerosis and their haplogroup distribution
Marcelo R.S. Briones, João H. Campos, Renata C. Ferreira, Lisa Schneper, Ilda M. Santos, Fernando M. Antoneli, James R. Broach,
Oct 2024,
In: Muscle and Nerve
Date: Oct 2024
In yeast, RAS proteins are controlling elements of adenylate cyclase
Takashi Toda, Isao Uno, Tatsuo Ishikawa, Scott Powers, Tohru Kataoka, Daniel Broek, Scott Cameron, James Broach, Kunihiro Matsumoto, Michael Wigler,
Jan 1985,
In: Cell
Citations: 818
Transformation in yeast
James R. Broach, Jeffrey N. Strathern, James B. Hicks,
Dec 1979,
In: Gene
Citations: 744
Transcriptional silencing in yeast is associated with reduced nucleosome acetylation
Miriam Braunstein, Alan B. Rose, Scott G. Holmes, C. David Allis, James R. Broach,
1993,
In: Genes and Development
Citations: 731
Sch9 Is a Major Target of TORC1 in Saccharomyces cerevisiae
Jörg Urban, Alexandre Soulard, Alexandre Huber, Soyeon Lippman, Debdyuti Mukhopadhyay, Olivier Deloche, Valeria Wanke, Dorothea Anrather, Gustav Ammerer, Howard Riezman, James R. Broach, Claudio De Virgilio, Michael N. Hall, Robbie Loewith,
Jun 8 2007,
In: Molecular cell
Citations: 675
Genome-wide Analyses Identify KIF5A as a Novel ALS Gene
Aude Nicolas, Kevin P. Kenna, Alan E. Renton, Nicola Ticozzi, Faraz Faghri, Ruth Chia, Janice A. Dominov, Brendan J. Kenna, Mike A. Nalls, Pamela Keagle, Alberto M. Rivera, Wouter van Rheenen, Natalie A. Murphy, Joke J.F.A. van Vugt, Joshua T. Geiger, Rick A. Van der Spek, Hannah A. Pliner, Shankar...,
Mar 21 2018,
In: Neuron
Citations: 562
Nutritional control of growth and development in yeast
James R. Broach,
Sep 1 2012,
In: Genetics
Citations: 546
A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size
Paul Jorgensen, Ivan Rupeš, Jeffrey R. Sharom, Lisa Schneper, James R. Broach, Mike Tyers,
Oct 15 2004,
In: Genes and Development
Citations: 537
How Saccharomyces responds to nutrients
Shadia Zaman, Soyeon Im Lippman, Xin Zhao, James R. Broach,
2008,
In: Annual review of genetics
Citations: 458
TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
Anna Leigh Brown, Oscar G. Wilkins, Matthew J. Keuss, Sarah E. Hill, Matteo Zanovello, Weaverly Colleen Lee, Alexander Bampton, Flora C.Y. Lee, Laura Masino, Yue A. Qi, Sam Bryce-Smith, Ariana Gatt, Martina Hallegger, Delphine Fagegaltier, Hemali Phatnani, Hemali Phatnani, Justin Kwan, Dhruv Sareen,...,
Mar 3 2022,
In: Nature
Citations: 348
Efficient transcriptional silencing in Saccharomyces cerevisiae requires a heterochromatin histone acetylation pattern
Miriam Braunstein, Richard E. Sobel, C. David Allis, Bryan M. Turner, James R. Broach,
1996,
In: Molecular and cellular biology
Citations: 338