Edward Gunther

Different Oncogenes and Reproductive Histories Shape the Progression of Distinct Premalignant Clones in Multistage Mouse Breast Cancer Models
Maryknoll P. Linscott, Jerry R. Ren, Shelley A. Gestl, Edward J. Gunther, Jul 2024, In: American Journal of Pathology
Date: Jul 2024

A multistage murine breast cancer model reveals long-lived premalignant clones refractory to parity-induced protection
Shuo Li, Shelley A. Gestl, Edward J. Gunther, 2020, In: Cancer Prevention Research
Date: 2020

Evolution of Relapse-Proficient Subclones Constrained by Collateral Sensitivity to Oncogene Overdose in Wnt-Driven Mammary Cancer
Ross R. Keller, Edward J. Gunther, Jan 22 2019, In: Cell Reports
Date: Jan 22 2019

Carcinogen-specific mutations in preferred Ras-Raf pathway oncogenes directed by strand bias
Ross R. Keller, Shelley A. Gestl, Amy Q. Lu, Alicia Hoke, David J. Feith, Edward J. Gunther, Aug 1 2016, In: Carcinogenesis
Date: Aug 1 2016

Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers
Allison S. Cleary, Travis L. Leonard, Shelley A. Gestl, Edward J. Gunther, 2014, In: Nature
Date: 2014

Basal but not luminal mammary epithelial cells require PI3K/mTOR signaling for Ras-driven overgrowth
Kristin A. Plichta, Jessica L. Mathers, Shelley A. Gestl, Adam B. Glick, Edward J. Gunther, Nov 15 2012, In: Cancer Research
Date: Nov 15 2012

A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis
Wenwen Jia, Shuwen Wang, James W. Horner, Ning Wang, Huayan Wang, Edward J. Gunther, Ronald A. De Pinho, Jiyue Zhu, Mar 2011, In: FASEB Journal
Date: Mar 2011

P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis
Peter R. McHenry, James C. Sears, Matthew P. Herrick, Peggy Chang, Brandy M. Heckman-Stoddard, Megan Rybarczyk, Lewis A. Chodosh, Edward J. Gunther, Susan G. Hilsenbeck, Jeffrey M. Rosen, Tracy Vargo-Gogola, Sep 22 2010, In: Breast Cancer Research
Date: Sep 22 2010

Targeting the activator protein 1 transcription factor for the prevention of estrogen receptor-negative mammary tumors
Qiang Shen, Ivan P. Uray, Yuxin Li, Yun Zhang, Jamal Hill, Xiao Chun Xu, Matthew R. Young, Edward J. Gunther, Susan G. Hilsenbeck, Nancy H. Colburn, Lewis A. Chodosh, Powel H. Brown, Jun 2008, In: Cancer Prevention Research
Date: Jun 2008

Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19^Arf/p53 pathway lesions but not p16^Ink4a loss
Michael T. Debies, Shelley A. Gestl, Jessica L. Mathers, Oliver R. Mikse, Travis L. Leonard, Susan E. Moody, Lewis A. Chodosh, Robert D. Cardiff, Edward J. Gunther, Jan 2 2008, In: Journal of Clinical Investigation
Date: Jan 2 2008

Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers
Allison S. Cleary, Travis L. Leonard, Shelley A. Gestl, Edward J. Gunther, 2014, In: Nature
Citations: 410

c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations
Celina M. D'Cruz, Edward J. Gunther, Robert B. Boxer, Jennifer L. Hartman, Louis Sintasath, Susan E. Moody, James D. Cox, Seung I. Ha, George K. Belka, Alexander Golant, Robert D. Cardiff, Lewis A. Chodosh, 2001, In: Nature Medicine
Citations: 362

Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis
Susan E. Moody, Christopher J. Sarkisian, Kristina T. Hahn, Edward J. Gunther, Steven Pickup, Katherine D. Dugan, Nathalie Innocent, Robert D. Cardiff, Mitchell D. Schnall, Lewis A. Chodosh, Dec 2002, In: Cancer Cell
Citations: 303

Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis
Edward J. Gunther, Susan E. Moody, George K. Belka, Kristina T. Hahn, Nathalie Innocent, Katherine D. Dugan, Robert D. Cardiff, Lewis A. Chodosh, Feb 15 2003, In: Genes and Development
Citations: 196

A novel doxycycline-inducible system for the transgenic analysis of mammary gland biology
Edward J. Gunther, George K. Belka, Gerald B.W. Wertheim, James Wang, Jennifer L. Hartman, Robert B. Boxer, Lewis A. Chodosh, 2002, In: FASEB Journal
Citations: 184

Targeted mutagenesis of DNA using triple helix-forming oligonucleotides linked to psoralen
Pamela A. Havre, Edward J. Gunther, Francis P. Gasparro, Peter M. Glazer, Aug 15 1993, In: Proceedings of the National Academy of Sciences of the United States of America
Citations: 143

Transgenic overexpression of IGF-IR disrupts mammary ductal morphogenesis and induces tumor formation
R. A. Jones, C. I. Campbell, E. J. Gunther, L. A. Chodosh, J. J. Petrik, R. Khokha, R. A. Moorehead, Mar 8 2007, In: Oncogene
Citations: 120

Deregulated estrogen receptor α expression in mammary epithelial cells of transgenic mice results in the development of ductal carcinoma In situ
M. Silvina Frech, Ewa D. Halama, Maddalena T. Tilli, Baljit Singh, Edward J. Gunther, Lewis A. Chodosh, Jodi A. Flaws, Priscilla A. Furth, Feb 1 2005, In: Cancer Research
Citations: 86

Mutagenesis by 8-Methoxypsoralen and 5-Methylangelicin Photoadducts in Mouse Fibroblasts
Edward J. Gunther, Toni M. Yeasky, Peter M. Glazer, Francis P. Gasparro, Mar 15 1995, In: Cancer Research
Citations: 63

Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19^Arf/p53 pathway lesions but not p16^Ink4a loss
Michael T. Debies, Shelley A. Gestl, Jessica L. Mathers, Oliver R. Mikse, Travis L. Leonard, Susan E. Moody, Lewis A. Chodosh, Robert D. Cardiff, Edward J. Gunther, Jan 2 2008, In: Journal of Clinical Investigation
Citations: 51

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