PIKFYVE inhibition mitigates disease in models of diverse forms of ALS Erratum to
Shu Ting Hung, Gabriel R. Linares, Wen Hsuan Chang, Yunsun Eoh, Gopinath Krishnan, Stacee Mendonca, Sarah Hong, Yingxiao Shi, Manuel Santana, Chuol Kueth, Samantha Macklin-Isquierdo, Sarah Perry, Sarah Duhaime, Claudia Maios, Jonathan Chang, Joscany Perez, Alexander Couto, Jesse Lai, Yichen Li, Samu...,
Feb 5 2026,
In: Cell
Date: Feb 5 2026
Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits
R. Keating Godfrey, Eric Alsop, Reed T. Bjork, Brijesh S. Chauhan, Hillary C. Ruvalcaba, Jerry Antone, Lauren M. Gittings, Allison F. Michael, Christi Williams, Grace Hala’ufia, Alexander D. Blythe, Megan Hall, Rita Sattler, Kendall Van Keuren-Jensen, Daniela C. Zarnescu,
Dec 2023,
In: Acta Neuropathologica Communications
Date: Dec 2023
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS
Shu Ting Hung, Gabriel R. Linares, Wen Hsuan Chang, Yunsun Eoh, Gopinath Krishnan, Stacee Mendonca, Sarah Hong, Yingxiao Shi, Manuel Santana, Chuol Kueth, Samantha Macklin-Isquierdo, Sarah Perry, Sarah Duhaime, Claudia Maios, Jonathan Chang, Joscany Perez, Alexander Couto, Jesse Lai, Yichen Li, Samu...,
Feb 16 2023,
In: Cell
Date: Feb 16 2023
Dysregulation of Translation in TDP-43 Proteinopathies
Reed T. Bjork, Nicholas P. Mortimore, Suvithanandhini Loganathan, Daniela C. Zarnescu,
Mar 7 2022,
In: Frontiers in Neuroscience
Date: Mar 7 2022
TDP-43 Proteinopathy Causes Broad Metabolic Alterations including TCA Cycle Intermediates and Dopamine Levels in Drosophila Models of ALS
Suvithanandhini Loganathan, Bryce A. Wilson, Sara B. Carey, Ernesto Manzo, Archi Joardar, Berrak Ugur, Daniela C. Zarnescu,
Feb 2022,
In: Metabolites
Date: Feb 2022
TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6
Erik M. Lehmkuhl, Suvithanandhini Loganathan, Eric Alsop, Alexander D. Blythe, Tina Kovalik, Nicholas P. Mortimore, Dianne Barrameda, Chuol Kueth, Randall J. Eck, Bhavani B. Siddegowda, Archi Joardar, Hannah Ball, Maria E. Macias, Robert Bowser, Kendall Van Keuren-Jensen, Daniela C. Zarnescu,
Dec 2021,
In: Acta Neuropathologica Communications
Date: Dec 2021
Measuring Glucose Uptake in Drosophila Models of TDP-43 Proteinopathy
Suvithanandhini Loganathan, Hannah E. Ball, Ernesto Manzo, Daniela C. Zarnescu,
Aug 2021,
In: Journal of Visualized Experiments
Date: Aug 2021
Author Correction
Sheng Chih Jin, Sara A. Lewis, Somayeh Bakhtiari, Xue Zeng, Michael C. Sierant, Sheetal Shetty, Sandra M. Nordlie, Aureliane Elie, Mark A. Corbett, Bethany Y. Norton, Clare L. van Eyk, Shozeb Haider, Brandon S. Guida, Helen Magee, James Liu, Stephen Pastore, John B. Vincent, Janice Brunstrom-Hernand...,
Mar 2021,
In: Nature Genetics
Date: Mar 2021
The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease
Nadine Bakkar, Alexander Starr, Benjamin E. Rabichow, Ileana Lorenzini, Zachary T. McEachin, Robert Kraft, Matthew Chaung, Sam Macklin-Isquierdo, Taylor Wingfield, Briggs Carhart, Nathan Zahler, Wen Hsuan Chang, Gary J. Bassell, Alexandre Betourne, Nicholas Boulis, Samuel V. Alworth, Justin K. Ichid...,
Feb 2021,
In: Neurobiology of Disease
Date: Feb 2021
Think globally, act locally
Daniela C. Zarnescu,
Dec 7 2020,
In: Journal of Cell Biology
Date: Dec 7 2020
Biochemical and genetic interaction between the fragile X mental retardation protein 3nd the microRNA pathway
Peng Jin, Daniela C. Zarnescu, Spephanie Ceman, Mika Nakamoto, Julie Mowrey, Thomas A. Jongens, David L. Nelson, Kevin Moses, Stephen T. Warren,
Feb 2004,
In: Nature Neuroscience
Citations: 533
TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD
Ching Chieh Chou, Yi Zhang, Mfon E. Umoh, Spencer W. Vaughan, Ileana Lorenzini, Feilin Liu, Melissa Sayegh, Paul G. Donlin-Asp, Yu Han Chen, Duc M. Duong, Nicholas T. Seyfried, Maureen A. Powers, Thomas Kukar, Chadwick M. Hales, Marla Gearing, Nigel J. Cairns, Kevin B. Boylan, Dennis W. Dickson, Ros...,
Feb 1 2018,
In: Nature Neuroscience
Citations: 471
RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in Drosophila
Peng Jin, Daniela C. Zarnescu, Fuping Zhang, Christopher E. Pearson, John C. Lucchesi, Kevin Moses, Stephen T. Warren,
Aug 28 2003,
In: Neuron
Citations: 323
Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila
Shuang Chang, Steven M. Bray, Zigang Li, Daniela C. Zarnescu, Chuan He, Peng Jin, Stephen T. Warren,
Apr 2008,
In: Nature Chemical Biology
Citations: 233
Crumbs interacts with moesin and β<sub>Heavy</sub>-spectrin in the apical membrane skeleton of Drosophila
Emmanuelle Médina, Janice Williams, Elizabeth Klipfell, Daniela Zarnescu, Graham Thomas, André Le Bivic,
Sep 2 2002,
In: Journal of Cell Biology
Citations: 161
Mutations disrupting neuritogenesis genes confer risk for cerebral palsy
Sheng Chih Jin, Sara A. Lewis, Somayeh Bakhtiari, Xue Zeng, Michael C. Sierant, Sheetal Shetty, Sandra M. Nordlie, Aureliane Elie, Mark A. Corbett, Bethany Y. Norton, Clare L. van Eyk, Shozeb Haider, Brandon S. Guida, Helen Magee, James Liu, Stephen Pastore, John B. Vincent, Janice Brunstrom-Hernand...,
Oct 1 2020,
In: Nature Genetics
Citations: 159
Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS
Patricia S. Estes, Ashley Boehringer, Rebecca Zwick, Jonathan E. Tang, Brianna Grigsby, Daniela C. Zarnescu,
Jun 2011,
In: Human molecular genetics
Citations: 135
FUTSCH/MAP1B mRNA is a translational target of TDP-43 and is neuroprotective in a Drosophila model of amyotrophic lateral sclerosis
Alyssa N. Coyne, Bhavani Bagevalu Siddegowda, Patricia S. Estes, Jeffrey Johannesmeyer, Tina Kovalik, Scott G. Daniel, Antony Pearson, Robert Bowser, Daniela C. Zarnescu,
Nov 26 2014,
In: Journal of Neuroscience
Citations: 130
Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS
Ernesto Manzo, Ileana Lorenzini, Dianne Barrameda, Abigail G. O’Conner, Jordan M. Barrows, Alexander Starr, Tina Kovalik, Benjamin E. Rabichow, Erik M. Lehmkuhl, Dakotah D. Shreiner, Archi Joardar, Jean Charles Liévens, Robert Bowser, Rita Sattler, Daniela C. Zarnescu,
Jun 2019,
In: eLife
Citations: 95
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS
Shu Ting Hung, Gabriel R. Linares, Wen Hsuan Chang, Yunsun Eoh, Gopinath Krishnan, Stacee Mendonca, Sarah Hong, Yingxiao Shi, Manuel Santana, Chuol Kueth, Samantha Macklin-Isquierdo, Sarah Perry, Sarah Duhaime, Claudia Maios, Jonathan Chang, Joscany Perez, Alexander Couto, Jesse Lai, Yichen Li, Samu...,
Feb 16 2023,
In: Cell
Citations: 91
