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Thermo Orbitrap Astral

The performance characteristics of this instrument make it ideally suited for accurate and precise quantitation at an unprecedented depth of coverage and higher throughput

Metabolomics Facility

319 Huck Life Sciences Building
432 Science Drive
University Park, PA 16802

Uses

  • Global metabolomics
  • Global lipidomics
  • Isotope-tracing
  • Small compound identifications

Specifications

  • High resolution quadrupole mass filter, Orbitrap mass analyzer and a Astral mass analyzer
  • Maximum Orbitrap mass analyzer resolution of up to 480,000 FWHM at m/z 200
  • Maximum Astral mass analyzer resolution up to 80,000 FWHM at m/z 524
  • MS/MS acquisition rates of up to 40 Hz with 7,500 resolution at m/z 200 for the Orbitrap mass analyzer
  • MS/MS acquisition rates of up to 200 Hz in the Astral mass analyzer with 80,000 resolution at m/z 524
  • Mass Range: Standard mass range of m/z 40–6,000
  • Orbitrap Mass Accuracy: <3ppm RMS drift (external calibration over 24 hours)
  • Astral Mass Accuracy: <5 ppm RMS drift (external calibration over 24 hours)
  • Orbitrap Dynamic Range: >5,000 within a single microscan
  • Astral Dynamic Range: >1,000 within a single microscan
  • MS/MS Electrospray Ionization (ESI) Orbitrap Sensitivity: MS/MS: 50 fg reserpine on column S/N 100:1 SIM: 50 fg reserpine on column S/N 150:1

Acknowledgement

Users of this instrument are required to acknowledge the Huck Institutes’ Metabolomics Core Facility (RRID: SCR_023864) in any resulting publications. Please review the acknowledgment and co-authorship guidelines for full details.