Uses
Study macromolecular folding stability:
- Effects of protein mutagenesis and engineering
- Effects of buffer, pH, salt, additives
- Effects of post-translational modification
- Reversibility of unfolding, by changes in ΔH
- Presence of multiple unfolding domains
- Stability contributions of individual domains
- Formation of protein complexes
- Stability of oligonucelotides
- Effects of lipid, nucleic acid, or other biopolymer on protein stability
Specifications
- Operating temperature range: -10°C to 130°C
- Minimum response time (high gain): 5 seconds
- Cell design: Tantalum 130 µl capillary type
- Short term noise: 0.6µcal/°C
- Baseline reliability: 1.5 µcal/°C
Acknowledgement
Users of this instrument are required to acknowledge the Huck Institutes’ Biomolecular Interactions Core Facility (RRID: SCR_024458) in any resulting publications. Please review the acknowledgment and co-authorship guidelines for full details.
Acknowledgement of the Biomolecular Interactions Core Facility must include the use of the core's unique RRID (SCR_024458)