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The BIOSTAT Cplus is a sterilizable-in-place (SIP) fermenter/bioreactor developed for the cultivation of microorganisms and cell cultures.

Uses

• Sterilization in place capability
• Capable of online temperature, pH, DO, antifoam, level, turbidity, and redox measurements

Specifications

• Two independent 30 L Biostat Cplus stainless steel reactors with working volumes of 15-30 L
• Control of pH (2-12), temperature (up to 90 ℃), DO, foam, level, and feed integrated into system
• BioPAT Xgas Online off-gas analysis (O2 and CO2 monitoring) for each vessel
  Online turbidity and total biomass monitoring (0 – 6 AU) (BioPAT-Fundalux optical probes)
• Four integrated peristaltic pump heads for each vessel
• Gassing system with 2 mass flow controllers (Air/O2/N2) and 1 flow meter
  Automatic pressure control
  

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Overview

• Control unit connects to two vessels 50 and 100 L
• Independent control
• 50 L vessel working volumes of 13-50L / 100 L vessel working volumes of 24-100L
• Sterilization in place capability
• Three load cells for each vessel weight measurement
• Automatic mobile CIP system available
• Control system for pH (2-12), temperature (up to 90^oC fermentation temperature), DO, foam, and pressure.

Specifications and Features

• BioPAT Xgas Online off-gas analysis (O₂ and CO₂ monitoring) for each vessel
• Online turbidity and total biomass monitoring (0 – 6 AU) (BioPAT-Fundalux optical probes)
• Online glucose/lactate monitoring with software integration for automated glucose control (BioPAT-TRACE).
• Five integrated peristaltic pump heads for each vessel
• Gassing system with 2 mass flow controllers (Air/O2/N2) and 1 flow meter
• Automatic pressure control

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Fully instrumented fermentation system with a capacity from 200 to 500 liters

Uses

• This system allows users to produce larger amounts of biomass under complex control systems

Specifications

• BioPAT Xgas Online off-gas analysis (O2 and CO2 monitoring)
• Online turbidity and total biomass monitoring (0 – 6 AU) (BioPAT-Fundalux optical probes)
• Online glucose/lactate monitoring with software integration for automated glucose control (BioPAT-TRACE)
• Gassing system with 2 mass flow controllers (Air/O2)
• Automatic pressure control
• Differential pressure level control

Details

• The operating system is integrated with BioPAT MFCS software to record data and use other SCADA capabilities

An instrument that delivers shear-based disruption to microbial cell samples

Specifications

• Operates at pressures up to 25,000 psi
• Requires a minimum sample size of 14 ml
• Is suitable for laboratory and benchtop applications
• Achieves unmatched size reduction/disruption performance at lower process pressure
• Limits sample temperature rise during processing, ensuring minimal heat denaturation of sensitive materials
• Results in higher product yields after sterile filtration with tighter particle size distribution

Microfluidics M-110EH-30 Microfluidizer Processor

Uses

• Micro-mixing of emulsions and dispersions
• Cell disruption
• Particle size reduction
• Deagglomeration

Details

• Contains a hydraulic power system, a high-pressure single-acting intensifier pump, an interaction chamber (where size reduction of the product occurs), an auxiliary processing module, and a cooling unit that returns the product to ambient temperature.
• Within the processor, the product is pressurized and acted upon by high-velocity contact with channel walls as well as collision upon itself.

High throughput sample processing possible with refrigeration capability

Specifications

Available rotors:

• JLA-17 14 x 50ml max; 39,500g max
• JLA-16.250 6 x 250ml max; 38,400g max
• JLA-10.500 6 x 500ml max; 18,600g max
• JLA-8.100 6 x 1,000ml max; 15,970g max

The Sharples T-1-P Super Centrifuge is a bench-top centrifuge used in clarification mode to harvest bacteria as cell paste from fermentation broth.

Specifications

• Supply and drain nozzles allow for continuous separation
• Maximum wet-cell paste capacity: 250 grams

The Sharples AS-16 Centrifuge is used in clarification mode to harvest bacteria as cell paste from fermentation broth.

Specifications

• Supply and drain nozzles allow for continuous separation
• Maximum wet-cell paste capacity: 3.5 kilograms

The ÄKTA Pure 150L FPLC & Frac-950 Fraction Collector possesses broad capabilities and flexibility; high levels of automation; a simple user interface; and accurate, reproducible, and reliable operation for all liquid chromatography techniques.

Specifications

• Works with sample loads from micrograms to grams
• System can be selected to use flow rates up to 150 ml/min (system pump pressure up to 5 MPa)
• Automation, system configuration, media screening, and method optimization through UNICORN, a software package for control and supervision of the ÄKTA explorer chromatography system
• Wide variety of fractionation techniques using Frac-950 for collection during different stages of separation

Rotavapor system for solvent recovery and/or sample concentration via solvent removal.

Specifications

• System is equipped with chiller for condenser loop, a vacuum pump for lowering heating requirements, and water bath to provide heat (max 95C)
• Evaporation flasks of 250mL, 1000mL, and 4000mL are available for use with the system
• Line available to add additional material to evaporation flask without opening/releasing vacuum or system

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Uses

• Processing temperature-sensitive products (such as foods, flavors, drugs and viable microbial cells) to a uniform particle size

Details

• Can process up to one liter per hour of an aqueous solution/slurry, with a solvent concentration of up to 20%
• Product recovery is usually greater than 70%

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FreeZone 18 Liter Console Freeze Dryers are designed for lyophilizing moderate to large sample loads or numerous small container batches.

Specifications

• Collector Temperature: -50° C, -58° F
• Ice Holding Capacity: 18L
• Plug Type: Schuko
• Style: Console
• Vacuum Pump Displacement Required: 98 L/min or larger displacement

Details

• This system includes a bulk tray dryer unit with the option of heating trays
• Six ports are available for attaching bottles containing samples/material to be dried

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Benchtop crossflow filtration system optimized for ultrafiltration and diafiltration.

Specifications

• Total membrane area from 0.02 - 0.14 m2 possible to load
• Flow rates of 1-100 L/hr at 3 bar
• Features include:
  • Load cell for monitoring recirculation tank level
  • Conductivity probe for recirculation tank
  • Permeate balance to monitor the collection of filtrate
  • Diafiltration peristaltic pump to load product or buffer

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The SARTOFLOW Advanced is a modular benchtop crossflow system optimized for ultrafiltration, microfiltration, and diafiltration.

Uses

• Purification of vaccines, monoclonal antibodies, and recombinant proteins

Specifications

• Ultra low loop volume of 200 mL for small batches
• Total membrane area from 0.1 - 2.1 m2
• Flow rates of 700 L/hr at 4 bar
• Features include:
  • Load cell for monitoring recirculation tank level
  • Temperature monitoring of the recirculation tank (with cooling)
  • Conductivity probe for recirculation tank
  • Permeate balance to monitor the collection of filtrate
  • External pump to load product or buffer

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Uses

• Easy and cost-effective method to measure the following chemistries in a wide range of application areas: Glucose, Lactate, Glutamate, Glutamine, Glycerol, Xylose, Choline, Hydrogen Peroxide, Sucrose, Ethanol, Methanol, Lactose, Galactose

Specifications

• Analyze specific results in 60 seconds or less
• Proprietary immobilized enzyme electrodes
• Unique fluidics resist clogging
• Trusted measurement technology
• Automated sample handling

Details

• The system is equipped with the YSI 2960 Online Sampler for the monitoring and optimization of your bioprocess
• Intuitive graphical user interface
• USB port for data retrieval
• Ability to measure samples from a variety of sample holders including 96 well plates and microcentrifuge tubes

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Uses

• Biomass hydrolysis

Details

• This system uses steam to create hydrolyzing conditions to break down various lignocellulosic feedstocks at temperatures (and pressures) to 190°C (11.5 bar).
• A novel series of screws allow continuous processing of feedstock with retention times of 2 to 15 minutes, allowing the treatment of 50 kg biomass/day.
• The biomass can be pretreated with dilute acid or other pretreatment solutions prior to hydrolysis.

Demonstration Video

Watch a video demonstration, below, of the SüPR•2G in operation.